Project name: c927becc1f11fdd

Chain sequence(s)	A: HHSSGLEVLFQGPGSDAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFCAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1
• Maximal score value: 2.047
• Average score: -1.4201
• Total score value: -666.0091

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	H	A	-1.6900
2	H	A	-1.6868
3	S	A	-0.9240
4	S	A	-0.9621
5	G	A	-0.7017
6	L	A	0.3684
7	E	A	-0.1535
8	V	A	1.8818
9	L	A	2.0470
10	F	A	1.6906
11	Q	A	-0.2551
12	G	A	-0.9764
13	P	A	-1.0572
14	G	A	-1.1404
15	S	A	-1.9513
16	D	A	-2.3776
17	A	A	-1.8592
18	P	A	-2.4438
19	E	A	-3.3802
20	E	A	-3.9686
21	E	A	-3.7431
22	D	A	-3.5162
23	H	A	-3.3355
24	V	A	0.0000
25	L	A	-1.9664
26	V	A	-1.5560
27	L	A	0.0000
28	R	A	-1.8666
29	K	A	-2.8008
30	S	A	-1.9076
31	N	A	-1.9189
32	F	A	0.0000
33	A	A	-1.4598
34	E	A	-1.8903
35	A	A	0.0000
36	L	A	0.0000
37	A	A	-1.6413
38	A	A	-1.0337
39	H	A	-1.7995
40	K	A	-2.6872
41	Y	A	-1.5944
42	L	A	0.0000
43	L	A	0.0000
44	V	A	0.0000
45	E	A	0.0000
46	F	A	0.0000
47	Y	A	-0.2391
48	A	A	0.0000
49	P	A	-0.1222
50	W	A	0.6362
51	C	A	-0.2937
52	G	A	-1.1587
53	H	A	-1.6554
54	C	A	0.0000
55	K	A	-1.9436
56	A	A	-1.5736
57	L	A	0.0000
58	A	A	-1.5228
59	P	A	-1.7017
60	E	A	-2.6159
61	Y	A	0.0000
62	A	A	-2.1038
63	K	A	-3.2186
64	A	A	0.0000
65	A	A	0.0000
66	G	A	-2.5361
67	K	A	-2.4629
68	L	A	0.0000
69	K	A	-3.3558
70	A	A	-2.0544
71	E	A	-3.0142
72	G	A	-2.4929
73	S	A	-2.3785
74	E	A	-2.7720
75	I	A	0.0000
76	R	A	-1.4413
77	L	A	0.0000
78	A	A	0.0000
79	K	A	-0.6472
80	V	A	0.0000
81	D	A	-1.0937
82	A	A	0.0000
83	T	A	-1.2635
84	E	A	-2.6066
85	E	A	-2.5535
86	S	A	-2.5597
87	D	A	-3.2996
88	L	A	0.0000
89	A	A	0.0000
90	Q	A	-2.9936
91	Q	A	-2.3923
92	Y	A	-1.5820
93	G	A	-1.9592
94	V	A	0.0000
95	R	A	-2.3203
96	G	A	-1.2272
97	Y	A	-0.3899
98	P	A	-0.6278
99	T	A	-0.7403
100	I	A	0.0000
101	K	A	-1.1534
102	F	A	0.0000
103	F	A	0.0000
104	R	A	-2.1087
105	N	A	-2.6662
106	G	A	-2.3106
107	D	A	-2.4956
108	T	A	-1.1550
109	A	A	-0.7084
110	S	A	-1.2141
111	P	A	-1.3075
112	K	A	-1.7888
113	E	A	-2.2222
114	Y	A	0.0000
115	T	A	-0.9202
116	A	A	-1.2363
117	G	A	-2.2606
118	R	A	-3.5248
119	E	A	-4.1000
120	A	A	0.0000
121	D	A	-3.7254
122	D	A	-3.3374
123	I	A	0.0000
124	V	A	0.0000
125	N	A	-2.3337
126	W	A	0.0000
127	L	A	0.0000
128	K	A	-2.6028
129	K	A	-2.9368
130	R	A	-2.2948
131	T	A	-1.9588
132	G	A	-1.3060
133	P	A	-0.9727
134	A	A	-1.1084
135	A	A	0.0000
136	T	A	-0.1756
137	T	A	-0.3188
138	L	A	0.0000
139	P	A	-1.1961
140	D	A	-2.1215
141	G	A	-1.6423
142	A	A	-0.7395
143	A	A	-0.9475
144	A	A	0.0000
145	E	A	-1.8245
146	S	A	-1.2418
147	L	A	-0.8696
148	V	A	-1.5898
149	E	A	-2.7038
150	S	A	-1.7433
151	S	A	-2.0021
152	E	A	-2.7379
153	V	A	0.0000
154	A	A	0.0000
155	V	A	0.0000
156	I	A	0.0000
157	G	A	0.0000
158	F	A	0.0000
159	F	A	0.0000
160	K	A	-3.2262
161	D	A	-3.1889
162	V	A	-1.9686
163	E	A	-3.0502
164	S	A	-2.9286
165	D	A	-3.0257
166	S	A	-2.4595
167	A	A	0.0000
168	K	A	-2.9522
169	Q	A	-2.3945
170	F	A	0.0000
171	L	A	-1.2876
172	Q	A	-1.5645
173	A	A	0.0000
174	A	A	0.0000
175	E	A	-1.3476
176	A	A	-0.9306
177	I	A	-1.2997
178	D	A	-2.7840
179	D	A	-2.5043
180	I	A	0.0000
181	P	A	-0.9038
182	F	A	0.0000
183	G	A	0.0000
184	I	A	0.0000
185	T	A	0.0000
186	S	A	-1.8857
187	N	A	-1.9715
188	S	A	-2.1863
189	D	A	-2.8835
190	V	A	0.0000
191	F	A	0.0000
192	S	A	-2.3793
193	K	A	-2.3791
194	Y	A	0.0000
195	Q	A	-2.3015
196	L	A	-2.2838
197	D	A	-2.9502
198	K	A	-3.3056
199	D	A	-2.5541
200	G	A	-1.9787
201	V	A	0.0000
202	V	A	0.0000
203	L	A	0.0000
204	F	A	0.0000
205	K	A	0.0000
206	K	A	-3.1820
207	F	A	-2.1410
208	D	A	-2.8711
209	E	A	-3.0815
210	G	A	-2.3219
211	R	A	-2.0656
212	N	A	-1.6303
213	N	A	-1.7896
214	F	A	-1.7103
215	E	A	-2.7061
216	G	A	-2.2766
217	E	A	-2.7356
218	V	A	-2.2875
219	T	A	-2.3749
220	K	A	-2.5731
221	E	A	-3.0673
222	N	A	-2.8823
223	L	A	0.0000
224	L	A	-1.8505
225	D	A	-2.9377
226	F	A	-2.1515
227	I	A	0.0000
228	K	A	-2.0784
229	H	A	-2.3663
230	N	A	-1.4192
231	Q	A	-0.9471
232	L	A	-0.4467
233	P	A	-0.7419
234	L	A	-0.9232
235	V	A	-0.5752
236	I	A	0.0000
237	E	A	-1.5802
238	A	A	-0.0783
239	P	A	0.0703
240	K	A	-0.3518
241	I	A	0.2199
242	F	A	1.2154
243	G	A	-0.2268
244	G	A	-1.0219
245	E	A	-2.1234
246	I	A	-1.5557
247	K	A	-1.7821
248	T	A	-1.2672
249	H	A	-0.4066
250	I	A	0.0000
251	L	A	-0.0274
252	L	A	0.0000
253	F	A	0.0000
254	L	A	0.0000
255	P	A	-1.8349
256	K	A	-2.6180
257	S	A	-1.5459
258	V	A	-1.2889
259	S	A	-1.5110
260	D	A	-2.6710
261	Y	A	-2.1675
262	D	A	-2.8436
263	G	A	-2.1012
264	K	A	-1.8195
265	L	A	-1.5016
266	S	A	-1.6483
267	N	A	-1.6840
268	F	A	0.0000
269	K	A	-1.9746
270	T	A	-1.6569
271	A	A	0.0000
272	A	A	0.0000
273	E	A	-2.5498
274	S	A	-1.9684
275	F	A	0.0000
276	K	A	-2.8022
277	G	A	-2.3221
278	K	A	-2.5661
279	I	A	0.0000
280	L	A	-0.8063
281	F	A	0.0000
282	I	A	0.0000
283	F	A	-0.3549
284	I	A	-0.8084
285	D	A	-1.9593
286	S	A	0.0000
287	D	A	-3.1774
288	H	A	-2.8511
289	T	A	-2.4766
290	D	A	-3.0244
291	N	A	-2.7215
292	Q	A	-3.5595
293	R	A	-2.8740
294	I	A	-1.3808
295	L	A	0.0000
296	E	A	-2.9027
297	F	A	-0.9638
298	F	A	0.0000
299	G	A	-1.7208
300	L	A	0.0000
301	K	A	-3.8104
302	K	A	-3.7915
303	E	A	-3.7680
304	E	A	-3.5217
305	C	A	-2.1871
306	P	A	-1.0788
307	A	A	-1.1953
308	V	A	0.0000
309	R	A	-0.4075
310	L	A	0.0000
311	I	A	0.0000
312	T	A	-0.6716
313	L	A	-0.7895
314	E	A	-1.9672
315	M	A	-0.7696
316	T	A	-0.7681
317	K	A	-0.3739
318	Y	A	-0.8738
319	K	A	-1.4987
320	P	A	-2.3355
321	E	A	-3.0620
322	S	A	-2.5118
323	E	A	-3.0901
324	E	A	-2.8960
325	L	A	-1.5755
326	T	A	-1.7955
327	A	A	0.0000
328	E	A	-2.8680
329	R	A	-3.2519
330	I	A	0.0000
331	T	A	-1.9891
332	E	A	-2.3825
333	F	A	0.0000
334	C	A	0.0000
335	H	A	-1.5609
336	R	A	-2.2058
337	F	A	-1.4020
338	L	A	-0.8875
339	E	A	-2.3269
340	G	A	-2.2878
341	K	A	-2.9156
342	I	A	0.0000
343	K	A	-2.5157
344	P	A	-1.4544
345	H	A	-0.7759
346	L	A	-0.4682
347	M	A	-0.6349
348	S	A	-1.3528
349	Q	A	-2.0729
350	E	A	-2.6471
351	L	A	-1.8225
352	P	A	-2.0741
353	E	A	-3.3238
354	D	A	-3.8009
355	W	A	-2.5984
356	D	A	-3.4114
357	K	A	-3.8366
358	Q	A	-3.4496
359	P	A	-3.0782
360	V	A	0.0000
361	K	A	-1.7701
362	V	A	-0.8751
363	L	A	0.0000
364	V	A	0.0000
365	G	A	-1.8381
366	K	A	-2.5069
367	N	A	0.0000
368	F	A	0.0000
369	E	A	-2.0860
370	D	A	-2.5531
371	V	A	-1.6275
372	A	A	0.0000
373	F	A	-2.1978
374	D	A	-3.0025
375	E	A	-3.9625
376	K	A	-3.5040
377	K	A	-2.4582
378	N	A	-1.4988
379	V	A	0.0000
380	F	A	0.0000
381	V	A	0.0000
382	E	A	0.0000
383	F	A	0.0000
384	C	A	-0.4209
385	A	A	0.0000
386	P	A	-0.1894
387	W	A	-0.0955
388	C	A	-0.7190
389	G	A	-1.6631
390	H	A	-2.0357
391	C	A	0.0000
392	K	A	-2.6729
393	Q	A	-2.4861
394	L	A	0.0000
395	A	A	-1.6586
396	P	A	-1.4404
397	I	A	-1.4172
398	W	A	0.0000
399	D	A	-2.7611
400	K	A	-2.4667
401	L	A	0.0000
402	G	A	0.0000
403	E	A	-3.5999
404	T	A	-2.2968
405	Y	A	-2.5200
406	K	A	-3.7521
407	D	A	-3.6314
408	H	A	-2.9388
409	E	A	-3.2771
410	N	A	-2.5764
411	I	A	-1.7774
412	V	A	-0.8962
413	I	A	0.0000
414	A	A	0.0000
415	K	A	-0.6794
416	M	A	0.0000
417	D	A	-0.5591
418	S	A	0.0000
419	T	A	0.0000
420	A	A	-0.6955
421	N	A	0.0000
422	E	A	-0.7826
423	V	A	0.0000
424	E	A	-1.9273
425	A	A	-1.1764
426	V	A	0.0000
427	K	A	-1.0637
428	V	A	-0.3350
429	H	A	-1.0757
430	S	A	-0.4305
431	F	A	-0.1799
432	P	A	0.0000
433	T	A	-0.6136
434	L	A	0.0000
435	K	A	-0.8917
436	F	A	0.0000
437	F	A	0.0000
438	P	A	-1.3921
439	A	A	-2.3885
440	S	A	-2.2736
441	A	A	-2.0179
442	D	A	-3.2961
443	R	A	-2.8117
444	T	A	-1.0089
445	V	A	-0.2315
446	I	A	-0.7359
447	D	A	-1.9091
448	Y	A	0.0000
449	N	A	-2.4453
450	G	A	-2.5180
451	E	A	-3.1102
452	R	A	-2.5626
453	T	A	-1.8304
454	L	A	-1.8200
455	D	A	-2.8321
456	G	A	-2.9550
457	F	A	0.0000
458	K	A	-2.6578
459	K	A	-3.7068
460	F	A	0.0000
461	L	A	0.0000
462	E	A	-3.1196
463	S	A	-2.6117
464	G	A	-2.0361
465	G	A	-2.2700
466	Q	A	-2.6581
467	D	A	-3.2553
468	G	A	-2.9518
469	A	A	-2.1637