Project name: Ganolasa

Chain sequence(s)	A: SVIIEMFEWNWDSVAAECTNFIGPAGYGFVQVNPPQEHVQGDSWWTDYQAVSYQLTSKHGNRDQFANMVKTCHSAGVGVIVDTLWNHMSGLDSGTGNAGSSFTKYNYPGIYQNQDFHSCRHGINNWNDANEVQTCELAGLADLATETEYVRSRLAEYGNDLLSLDVDGLRLDAAKHIAVGDISNILSRLNRNGKNLYITQEVVFGGGQPVTPNEYTQTGDVQEFRFVDALRDAFTHKTQLSDLQNLDNRGWVPSGQANVLVANHDTERNSGNLKSTSPSNIYTLANIFMLAHPYGTPTVLSGFSFLDSNTNAGPPNGGAGTCAGSAGANGWLCQHRWQAIAGMVGFRN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8582
• Maximal score value: 1.3583
• Average score: -0.7391
• Total score value: -257.1983

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-0.5215
3	V	A	0.0000
4	I	A	0.0000
5	I	A	0.0000
6	E	A	0.0000
7	M	A	0.0000
8	F	A	0.0000
9	E	A	0.0000
10	W	A	0.0000
11	N	A	-1.3411
12	W	A	0.0000
13	D	A	-2.2559
14	S	A	0.0000
15	V	A	0.0000
16	A	A	-1.3871
17	A	A	-0.7523
18	E	A	0.0000
19	C	A	0.0000
20	T	A	-0.8001
21	N	A	-1.2207
22	F	A	-0.5890
23	I	A	0.0000
24	G	A	-0.6530
25	P	A	-0.5947
26	A	A	-0.6909
27	G	A	-0.7404
28	Y	A	0.0000
29	G	A	-0.2828
30	F	A	0.0915
31	V	A	0.0000
32	Q	A	0.0000
33	V	A	0.0000
34	N	A	0.0000
35	P	A	0.0000
36	P	A	0.0000
37	Q	A	0.0000
38	E	A	0.0000
39	H	A	0.0000
40	V	A	-1.2747
41	Q	A	-2.0568
42	G	A	-1.9583
43	D	A	-2.5223
44	S	A	-1.5873
45	W	A	-0.7292
46	W	A	-0.1313
47	T	A	0.0000
48	D	A	0.0000
49	Y	A	0.0000
50	Q	A	-0.2391
51	A	A	0.0000
52	V	A	0.0000
53	S	A	0.0000
54	Y	A	-0.6992
55	Q	A	-1.5697
56	L	A	0.0000
57	T	A	-1.7231
58	S	A	0.0000
59	K	A	-1.4631
60	H	A	0.0000
61	G	A	-1.9113
62	N	A	-2.7869
63	R	A	-3.4619
64	D	A	-3.4271
65	Q	A	-3.2159
66	F	A	0.0000
67	A	A	-2.3752
68	N	A	-2.9750
69	M	A	0.0000
70	V	A	0.0000
71	K	A	-2.2308
72	T	A	-1.4758
73	C	A	0.0000
74	H	A	-1.2815
75	S	A	-0.9259
76	A	A	-0.8757
77	G	A	-0.8760
78	V	A	0.0000
79	G	A	-0.5547
80	V	A	0.0000
81	I	A	0.0000
82	V	A	0.0000
83	D	A	0.0000
84	T	A	0.0000
85	L	A	0.0000
86	W	A	0.0000
87	N	A	0.0000
88	H	A	0.0000
89	M	A	0.0000
90	S	A	0.0000
91	G	A	-0.9827
92	L	A	-0.5428
93	D	A	-1.8822
94	S	A	-1.5303
95	G	A	-1.0911
96	T	A	-0.9234
97	G	A	0.0000
98	N	A	-1.4419
99	A	A	-1.0177
100	G	A	-0.8432
101	S	A	-0.6612
102	S	A	-0.6560
103	F	A	0.0000
104	T	A	-1.6851
105	K	A	-2.4813
106	Y	A	-2.1012
107	N	A	-2.3253
108	Y	A	0.0000
109	P	A	-0.8582
110	G	A	-0.6998
111	I	A	-0.3871
112	Y	A	0.0000
113	Q	A	-2.4646
114	N	A	-2.5233
115	Q	A	-2.1144
116	D	A	0.0000
117	F	A	0.0000
118	H	A	-0.9172
119	S	A	-0.7461
120	C	A	-0.8998
121	R	A	-1.5939
122	H	A	0.0000
123	G	A	-0.2544
124	I	A	1.0420
125	N	A	-0.7746
126	N	A	-0.9507
127	W	A	-0.2615
128	N	A	-1.6958
129	D	A	-1.7990
130	A	A	-1.4843
131	N	A	-1.9802
132	E	A	-1.8901
133	V	A	0.0000
134	Q	A	-0.8363
135	T	A	-0.9940
136	C	A	0.0000
137	E	A	0.0000
138	L	A	-0.0547
139	A	A	0.0010
140	G	A	0.0000
141	L	A	0.0000
142	A	A	0.0000
143	D	A	0.0000
144	L	A	0.0000
145	A	A	0.0000
146	T	A	0.0000
147	E	A	-2.5381
148	T	A	-1.9679
149	E	A	-2.4723
150	Y	A	-1.0900
151	V	A	0.0000
152	R	A	-2.1167
153	S	A	-1.9083
154	R	A	-1.8637
155	L	A	0.0000
156	A	A	0.0000
157	E	A	-2.8909
158	Y	A	0.0000
159	G	A	0.0000
160	N	A	-2.5472
161	D	A	-2.3707
162	L	A	0.0000
163	L	A	-1.0609
164	S	A	-0.9296
165	L	A	-1.0289
166	D	A	-1.2858
167	V	A	0.0000
168	D	A	-0.8122
169	G	A	0.0000
170	L	A	0.0000
171	R	A	0.0000
172	L	A	0.0000
173	D	A	0.0000
174	A	A	0.0000
175	A	A	0.0000
176	K	A	-0.2651
177	H	A	0.0000
178	I	A	0.0000
179	A	A	-0.6412
180	V	A	-0.4506
181	G	A	-0.8936
182	D	A	-1.4380
183	I	A	0.0000
184	S	A	-0.9512
185	N	A	-1.9049
186	I	A	0.0000
187	L	A	-1.4783
188	S	A	-2.0264
189	R	A	-2.9992
190	L	A	0.0000
191	N	A	-3.5983
192	R	A	-3.8582
193	N	A	-3.3681
194	G	A	-2.8734
195	K	A	-3.0037
196	N	A	-2.4722
197	L	A	0.0000
198	Y	A	-0.1822
199	I	A	0.0000
200	T	A	0.0000
201	Q	A	0.0000
202	E	A	-0.1777
203	V	A	0.0000
204	V	A	-0.3707
205	F	A	-0.6271
206	G	A	-1.0398
207	G	A	-0.7151
208	G	A	-0.7938
209	Q	A	-0.6900
210	P	A	-0.8548
211	V	A	0.0000
212	T	A	-0.8151
213	P	A	0.0000
214	N	A	-1.8052
215	E	A	-1.4750
216	Y	A	0.0000
217	T	A	-1.4125
218	Q	A	-1.6202
219	T	A	0.0000
220	G	A	-0.6981
221	D	A	-0.7092
222	V	A	0.0000
223	Q	A	0.0000
224	E	A	0.0000
225	F	A	0.0000
226	R	A	-1.3005
227	F	A	0.0000
228	V	A	0.0000
229	D	A	-1.3625
230	A	A	-1.0125
231	L	A	0.0000
232	R	A	0.0000
233	D	A	-1.6935
234	A	A	-1.3782
235	F	A	-0.3981
236	T	A	-1.2434
237	H	A	-2.1775
238	K	A	-2.4682
239	T	A	-1.9981
240	Q	A	-1.8659
241	L	A	-0.8134
242	S	A	-1.6230
243	D	A	-2.6023
244	L	A	0.0000
245	Q	A	-2.6371
246	N	A	-3.2785
247	L	A	0.0000
248	D	A	-3.1023
249	N	A	-3.2508
250	R	A	-3.0051
251	G	A	-1.9923
252	W	A	0.0000
253	V	A	0.0000
254	P	A	-1.1399
255	S	A	-0.8874
256	G	A	-0.8542
257	Q	A	-1.1190
258	A	A	0.0000
259	N	A	0.0000
260	V	A	0.0000
261	L	A	0.0000
262	V	A	0.0000
263	A	A	0.0000
264	N	A	0.0000
265	H	A	-0.5665
266	D	A	-1.3210
267	T	A	-1.8617
268	E	A	-3.0922
269	R	A	-2.9180
270	N	A	-2.0587
271	S	A	-1.5536
272	G	A	-1.0561
273	N	A	-1.0191
274	L	A	-0.5624
275	K	A	-0.2971
276	S	A	-0.1338
277	T	A	-0.3041
278	S	A	-0.3565
279	P	A	-0.2453
280	S	A	-0.4864
281	N	A	-0.6655
282	I	A	0.7217
283	Y	A	0.0000
284	T	A	0.2750
285	L	A	1.1588
286	A	A	0.0000
287	N	A	0.0000
288	I	A	1.3583
289	F	A	0.9191
290	M	A	0.0000
291	L	A	0.0000
292	A	A	0.3969
293	H	A	-0.2482
294	P	A	-0.5413
295	Y	A	0.0000
296	G	A	-0.6340
297	T	A	-0.3280
298	P	A	0.0000
299	T	A	0.0000
300	V	A	0.0000
301	L	A	0.0000
302	S	A	0.0000
303	G	A	0.0717
304	F	A	0.0000
305	S	A	-0.0342
306	F	A	0.2453
307	L	A	0.4994
308	D	A	-1.3746
309	S	A	-1.2863
310	N	A	-1.9782
311	T	A	-1.5464
312	N	A	-1.7498
313	A	A	0.0000
314	G	A	-0.7669
315	P	A	-0.8770
316	P	A	-0.9716
317	N	A	-1.5661
318	G	A	-1.3286
319	G	A	-0.8249
320	A	A	-0.5281
321	G	A	-0.3823
322	T	A	0.1484
323	C	A	0.5738
324	A	A	0.0893
325	G	A	-0.4166
326	S	A	-0.7290
327	A	A	-0.6017
328	G	A	-0.7710
329	A	A	-0.7726
330	N	A	-0.9923
331	G	A	-0.7175
332	W	A	0.0000
333	L	A	-0.4117
334	C	A	0.0000
335	Q	A	0.0000
336	H	A	0.0000
337	R	A	-1.0054
338	W	A	-0.8161
339	Q	A	-1.4049
340	A	A	-0.6937
341	I	A	0.0000
342	A	A	-0.5077
343	G	A	-0.5801
344	M	A	0.2885
345	V	A	0.0000
346	G	A	-0.2250
347	F	A	1.1753
348	R	A	-0.2481
349	N	A	-1.0979