Project name: Tau441

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5033
• Maximal score value: 1.9104
• Average score: -1.0226
• Total score value: -450.9611

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.0350
2	A	A	-1.3198
3	E	A	-2.3552
4	P	A	-2.3128
5	R	A	-3.0773
6	Q	A	-2.5428
7	E	A	-1.8223
8	F	A	0.0000
9	E	A	0.0000
10	V	A	0.0000
11	M	A	-1.3991
12	E	A	-2.5265
13	D	A	-2.7518
14	H	A	-1.7701
15	A	A	-1.4672
16	G	A	-1.5593
17	T	A	-1.2810
18	Y	A	-1.3393
19	G	A	0.0000
20	L	A	-1.0977
21	G	A	-1.7436
22	D	A	-2.6060
23	R	A	-2.0665
24	K	A	-1.5631
25	D	A	-1.1389
26	Q	A	-0.6990
27	G	A	0.0000
28	G	A	0.0296
29	Y	A	1.0634
30	T	A	0.8415
31	M	A	0.6175
32	H	A	-0.8503
33	Q	A	-2.3551
34	D	A	-3.2305
35	Q	A	0.0000
36	E	A	-2.6363
37	G	A	-2.8339
38	D	A	-3.2531
39	T	A	-2.4832
40	D	A	-2.5918
41	A	A	-1.7345
42	G	A	-1.0232
43	L	A	-0.1576
44	K	A	-1.9465
45	E	A	-2.6095
46	S	A	-1.1443
47	P	A	-0.0762
48	L	A	0.8447
49	Q	A	0.0000
50	T	A	0.0000
51	P	A	0.0000
52	T	A	-2.9015
53	E	A	-3.5033
54	D	A	-2.3360
55	G	A	-1.8516
56	S	A	-1.5816
57	E	A	-2.8090
58	E	A	-2.5029
59	P	A	-1.7591
60	G	A	-1.6468
61	S	A	-1.8452
62	E	A	-2.4450
63	T	A	-2.0448
64	S	A	-1.7440
65	D	A	-2.0286
66	A	A	-1.3629
67	K	A	-2.0276
68	S	A	-0.9775
69	T	A	-0.9379
70	P	A	-1.3670
71	T	A	0.0000
72	A	A	0.0000
73	E	A	-2.2349
74	D	A	-1.5824
75	V	A	-0.3960
76	T	A	-0.4694
77	A	A	0.3484
78	P	A	0.6148
79	L	A	1.3501
80	V	A	0.4248
81	D	A	-1.8358
82	E	A	-2.3962
83	G	A	-1.8417
84	A	A	-1.4605
85	P	A	-1.4287
86	G	A	-1.8105
87	K	A	-2.7855
88	Q	A	-2.1562
89	A	A	-1.4344
90	A	A	-1.2995
91	A	A	-1.2357
92	Q	A	-1.5921
93	P	A	-1.6552
94	H	A	-2.0620
95	T	A	-1.9237
96	E	A	-2.7468
97	I	A	-1.3373
98	P	A	-1.9488
99	E	A	-2.7301
100	G	A	-2.0947
101	T	A	-1.8485
102	T	A	-1.6987
103	A	A	-2.2997
104	E	A	-3.0780
105	E	A	-2.6723
106	A	A	-1.9767
107	G	A	-1.8440
108	I	A	-1.2595
109	G	A	-2.2615
110	D	A	-2.7510
111	T	A	-1.8991
112	P	A	-1.3089
113	S	A	-1.2950
114	L	A	-1.4689
115	E	A	-2.1723
116	D	A	-2.5172
117	E	A	-1.6008
118	A	A	0.0000
119	A	A	-0.3399
120	G	A	-1.0343
121	H	A	-1.0302
122	V	A	0.8794
123	T	A	-0.3505
124	Q	A	-0.5341
125	A	A	-0.6942
126	R	A	0.0000
127	M	A	0.4641
128	V	A	0.3125
129	S	A	-0.8591
130	K	A	-1.9288
131	S	A	-1.6676
132	K	A	-2.2504
133	D	A	-3.2108
134	G	A	-1.8545
135	T	A	-1.3533
136	G	A	-1.5857
137	S	A	-2.3935
138	D	A	-3.1529
139	D	A	-3.4977
140	K	A	-2.7595
141	K	A	0.0000
142	A	A	-1.0045
143	K	A	-0.8167
144	G	A	-1.4164
145	A	A	-1.7834
146	D	A	-3.0968
147	G	A	-2.6395
148	K	A	-2.6945
149	T	A	-2.0538
150	K	A	-1.7065
151	I	A	0.2674
152	A	A	-0.1062
153	T	A	-0.3727
154	P	A	-1.3178
155	R	A	-2.5415
156	G	A	-1.8656
157	A	A	-1.0916
158	A	A	-1.0259
159	P	A	-0.9882
160	P	A	-1.3355
161	G	A	-1.9175
162	Q	A	-2.6634
163	K	A	-2.3856
164	G	A	-2.2671
165	Q	A	-2.5529
166	A	A	-2.1430
167	N	A	-2.4171
168	A	A	-1.2203
169	T	A	-0.9745
170	R	A	-1.1728
171	I	A	0.5722
172	P	A	0.0181
173	A	A	-0.7961
174	K	A	-1.7061
175	T	A	-0.8819
176	P	A	-1.0201
177	P	A	-0.8660
178	A	A	-0.7526
179	P	A	-1.4374
180	K	A	-1.9552
181	T	A	-1.1144
182	P	A	-1.1336
183	P	A	-1.3853
184	S	A	0.0000
185	S	A	-0.5839
186	G	A	-1.1296
187	E	A	-1.7171
188	P	A	-1.8159
189	P	A	-1.7484
190	K	A	-2.4939
191	S	A	-2.0965
192	G	A	-1.4374
193	D	A	-1.9380
194	R	A	-2.5280
195	S	A	0.0000
196	G	A	-1.0924
197	Y	A	0.0000
198	S	A	-0.5385
199	S	A	0.0000
200	P	A	-0.7580
201	G	A	-0.9576
202	S	A	-0.4935
203	P	A	-0.5508
204	G	A	-1.1961
205	T	A	-0.9701
206	P	A	-1.0471
207	G	A	-0.6426
208	S	A	0.0000
209	R	A	-1.2043
210	S	A	-1.2050
211	R	A	-2.0597
212	T	A	-1.2692
213	P	A	-1.1284
214	S	A	-0.8577
215	L	A	-0.8712
216	P	A	0.0000
217	T	A	-1.7285
218	P	A	-1.6550
219	P	A	-0.8509
220	T	A	-0.8646
221	R	A	-2.0009
222	E	A	-2.4050
223	P	A	0.0000
224	K	A	-2.9816
225	K	A	-1.9751
226	V	A	-0.4326
227	A	A	0.4352
228	V	A	1.9104
229	V	A	1.7516
230	R	A	-0.8835
231	T	A	-1.1646
232	P	A	-1.1092
233	P	A	-1.3923
234	K	A	-1.9402
235	S	A	0.0000
236	P	A	0.0000
237	S	A	-0.5111
238	S	A	-0.8519
239	A	A	-0.7455
240	K	A	-0.9129
241	S	A	-1.4691
242	R	A	-2.0597
243	L	A	-0.6583
244	Q	A	-1.2262
245	T	A	-0.5678
246	A	A	-0.1551
247	P	A	-0.3321
248	V	A	-0.1392
249	P	A	0.0000
250	M	A	0.0000
251	P	A	-1.1258
252	D	A	-1.6616
253	L	A	-0.1784
254	K	A	-1.1660
255	N	A	-1.5180
256	V	A	-0.8732
257	K	A	-2.0123
258	S	A	-1.6734
259	K	A	-1.3040
260	I	A	0.2785
261	G	A	-1.1561
262	S	A	-1.1956
263	T	A	-1.0333
264	E	A	-2.0661
265	N	A	-2.2656
266	L	A	-1.0680
267	K	A	-2.3971
268	H	A	-2.2580
269	Q	A	-2.0608
270	P	A	-1.7040
271	G	A	-1.8648
272	G	A	-0.7344
273	G	A	0.1202
274	K	A	0.5277
275	V	A	1.4937
276	Q	A	-0.7919
277	I	A	-0.2360
278	I	A	0.0000
279	N	A	-2.2536
280	K	A	-2.7378
281	K	A	-1.8622
282	L	A	-0.7863
283	D	A	0.0000
284	L	A	-1.0934
285	S	A	-1.0552
286	N	A	-1.6621
287	V	A	-0.6711
288	Q	A	-1.2010
289	S	A	-1.2436
290	K	A	-1.3175
291	C	A	-1.2935
292	G	A	0.0000
293	S	A	-1.6406
294	K	A	-2.6145
295	D	A	-2.1383
296	N	A	-1.1687
297	I	A	-0.5118
298	K	A	-0.8513
299	H	A	0.0000
300	V	A	0.0000
301	P	A	0.1380
302	G	A	-0.7784
303	G	A	-0.7292
304	G	A	-0.3975
305	S	A	0.0801
306	V	A	1.4736
307	Q	A	0.3269
308	I	A	0.0000
309	V	A	1.0505
310	Y	A	1.1144
311	K	A	-0.3544
312	P	A	0.5357
313	V	A	1.7016
314	D	A	0.2905
315	L	A	0.8021
316	S	A	-0.2882
317	K	A	-1.5158
318	V	A	-0.1696
319	T	A	0.0000
320	S	A	-0.8466
321	K	A	-1.4246
322	C	A	-0.4652
323	G	A	0.0434
324	S	A	0.0000
325	L	A	0.0709
326	G	A	-0.5843
327	N	A	-0.6295
328	I	A	0.2330
329	H	A	-1.0505
330	H	A	-1.4548
331	K	A	-1.0133
332	P	A	-0.9258
333	G	A	-1.3294
334	G	A	-1.3526
335	G	A	-1.6490
336	Q	A	-2.4344
337	V	A	-1.4920
338	E	A	-1.0765
339	V	A	0.0246
340	K	A	-1.7493
341	S	A	-1.6270
342	E	A	-2.2349
343	K	A	-0.7427
344	L	A	0.6681
345	D	A	0.5572
346	F	A	1.3217
347	K	A	-0.0775
348	D	A	-1.0619
349	R	A	-1.1729
350	V	A	0.1670
351	Q	A	-1.4714
352	S	A	-0.9786
353	K	A	-1.1014
354	I	A	0.7113
355	G	A	0.1004
356	S	A	0.2129
357	L	A	0.5751
358	D	A	-0.6019
359	N	A	-0.3857
360	I	A	1.2127
361	T	A	0.3156
362	H	A	0.1428
363	V	A	1.4174
364	P	A	0.3249
365	G	A	-0.6776
366	G	A	-1.3065
367	G	A	-1.3136
368	N	A	-1.8650
369	K	A	-1.7248
370	K	A	-1.7802
371	I	A	-0.2601
372	E	A	-1.9198
373	T	A	-1.5483
374	H	A	-1.7389
375	K	A	-1.4267
376	L	A	0.7267
377	T	A	0.5434
378	F	A	0.5763
379	R	A	-1.8940
380	E	A	-2.9623
381	N	A	-2.5468
382	A	A	-1.8050
383	K	A	-2.1193
384	A	A	-1.2760
385	K	A	-1.9487
386	T	A	-1.4053
387	D	A	-1.7294
388	H	A	-1.8984
389	G	A	-0.9172
390	A	A	-0.4413
391	E	A	-0.7856
392	I	A	0.3277
393	V	A	0.4334
394	Y	A	-0.6058
395	K	A	-1.4618
396	S	A	-0.1993
397	P	A	0.4981
398	V	A	1.3907
399	V	A	1.7441
400	S	A	0.2550
401	G	A	-0.0934
402	D	A	-0.5152
403	T	A	-0.6166
404	S	A	-0.5665
405	P	A	-0.8380
406	R	A	-1.9530
407	H	A	-1.2394
408	L	A	0.1557
409	S	A	-0.5383
410	N	A	-1.2743
411	V	A	-0.6507
412	S	A	-0.7377
413	S	A	-0.5858
414	T	A	0.0163
415	G	A	0.0000
416	S	A	0.4774
417	I	A	1.5382
418	D	A	-0.2849
419	M	A	0.7412
420	V	A	0.1638
421	D	A	-1.2850
422	S	A	0.0000
423	P	A	-0.4190
424	Q	A	-0.9569
425	L	A	0.0000
426	A	A	0.4814
427	T	A	0.1904
428	L	A	0.6373
429	A	A	-0.3900
430	D	A	-1.8807
431	E	A	-1.7268
432	V	A	0.2701
433	S	A	-0.3738
434	A	A	-0.1894
435	S	A	-0.2334
436	L	A	-0.6364
437	A	A	-0.8880
438	K	A	-1.9336
439	Q	A	-1.0660
440	G	A	-0.6011
441	L	A	0.6824