| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVGIGVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGLGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHQPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -1.8252 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.2359 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.8216 | |
| 8 | G | A | -0.7035 | |
| 9 | P | A | -0.6872 | |
| 10 | G | A | -0.5596 | |
| 11 | L | A | -0.5193 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1526 | |
| 14 | P | A | -1.4418 | |
| 15 | S | A | -1.2417 | |
| 16 | E | A | -1.5796 | |
| 17 | T | A | -1.2965 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -1.0705 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7317 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1271 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3048 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.1858 | |
| 31 | S | A | 0.0136 | |
| 32 | G | A | 0.1241 | |
| 33 | Y | A | 0.1671 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8091 | |
| 40 | P | A | -0.9916 | |
| 41 | P | A | -1.1113 | |
| 42 | G | A | -1.5000 | |
| 43 | K | A | -2.3705 | |
| 44 | G | A | -1.5327 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6543 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | -0.0105 | |
| 53 | Y | A | 0.5840 | |
| 54 | S | A | -0.4387 | |
| 55 | G | A | -0.9200 | |
| 56 | D | A | -1.6320 | |
| 57 | T | A | -0.5403 | |
| 58 | Y | A | 0.1052 | |
| 59 | Y | A | 0.0632 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -1.1500 | |
| 62 | S | A | -1.1234 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0231 | |
| 65 | S | A | -1.3080 | |
| 66 | R | A | -1.4876 | |
| 67 | V | A | 0.0000 | |
| 68 | G | A | -0.8468 | |
| 69 | I | A | 0.0000 | |
| 70 | G | A | -0.6626 | |
| 71 | V | A | -0.1624 | |
| 72 | D | A | -1.0750 | |
| 73 | T | A | -1.0878 | |
| 74 | S | A | -1.3043 | |
| 75 | K | A | -2.1044 | |
| 76 | N | A | -1.4189 | |
| 77 | Q | A | -1.2149 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5836 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.9435 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.1131 | |
| 84 | S | A | -0.9425 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5547 | |
| 87 | A | A | -0.2042 | |
| 88 | A | A | 0.0287 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0306 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.4249 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6591 | |
| 98 | Y | A | -0.0555 | |
| 99 | G | A | -0.0618 | |
| 100 | S | A | -0.0177 | |
| 101 | Y | A | 0.2963 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4052 | |
| 105 | Y | A | -0.4920 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | L | A | 0.8682 | |
| 109 | G | A | 0.3454 | |
| 110 | T | A | 0.0625 | |
| 111 | T | A | 0.0315 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.3035 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8291 | |
| 116 | S | A | -0.9372 | |
| 117 | A | A | -0.5494 | |
| 118 | S | A | -0.6635 | |
| 119 | T | A | -0.7611 | |
| 120 | K | A | -1.1995 | |
| 121 | G | A | -1.3208 | |
| 122 | P | A | -0.6090 | |
| 123 | S | A | -0.5027 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3997 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8944 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4428 | |
| 131 | S | A | -0.5233 | |
| 132 | R | A | -0.8389 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8771 | |
| 135 | S | A | -1.3531 | |
| 136 | E | A | -2.0785 | |
| 137 | S | A | -1.3103 | |
| 138 | T | A | -0.9392 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2738 | |
| 147 | D | A | -0.3566 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5912 | |
| 152 | P | A | -0.6979 | |
| 153 | V | A | -0.6209 | |
| 154 | T | A | -0.5282 | |
| 155 | V | A | -0.3166 | |
| 156 | S | A | -0.4507 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0256 | |
| 159 | S | A | -0.7664 | |
| 160 | G | A | -0.5943 | |
| 161 | A | A | -0.2860 | |
| 162 | L | A | -0.1397 | |
| 163 | T | A | -0.2492 | |
| 164 | S | A | -0.2751 | |
| 165 | G | A | -0.3935 | |
| 166 | V | A | 0.0661 | |
| 167 | H | A | -0.2458 | |
| 168 | T | A | 0.0031 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3388 | |
| 171 | A | A | 0.2546 | |
| 172 | V | A | 0.6195 | |
| 173 | L | A | 1.4119 | |
| 174 | Q | A | 0.3967 | |
| 175 | S | A | 0.0113 | |
| 176 | S | A | -0.1528 | |
| 177 | G | A | 0.1344 | |
| 178 | L | A | 0.2320 | |
| 179 | Y | A | 0.5266 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1888 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6360 | |
| 189 | S | A | -0.6818 | |
| 190 | S | A | -0.5487 | |
| 191 | S | A | -0.6669 | |
| 192 | L | A | -0.8189 | |
| 193 | G | A | -1.1785 | |
| 194 | T | A | -0.9145 | |
| 195 | K | A | -1.6684 | |
| 196 | T | A | -1.5153 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7206 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.7915 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.6998 | |
| 205 | P | A | -1.6689 | |
| 206 | S | A | -1.8337 | |
| 207 | N | A | -2.5160 | |
| 208 | T | A | -2.0451 | |
| 209 | K | A | -2.6389 | |
| 210 | V | A | -1.9897 | |
| 211 | D | A | -2.9296 | |
| 212 | K | A | -2.7139 | |
| 213 | R | A | -3.1216 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6293 | |
| 216 | S | A | -1.1006 | |
| 217 | D | B | -1.6544 | |
| 218 | I | B | -0.5371 | |
| 219 | V | B | 0.7449 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4889 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3561 | |
| 224 | P | B | -0.2338 | |
| 225 | L | B | 0.0824 | |
| 226 | S | B | -0.5513 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0220 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6765 | |
| 231 | P | B | -2.0364 | |
| 232 | G | B | -1.9039 | |
| 233 | Q | B | -2.3099 | |
| 234 | P | B | -2.1037 | |
| 235 | A | B | -1.2813 | |
| 236 | S | B | -0.7920 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8820 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1253 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8599 | |
| 243 | Q | B | -1.3806 | |
| 244 | S | B | -0.7157 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.4856 | |
| 247 | H | B | -0.6523 | |
| 248 | S | B | -0.9638 | |
| 249 | N | B | -1.6922 | |
| 250 | G | B | -1.2152 | |
| 251 | N | B | -1.0940 | |
| 252 | T | B | -0.2998 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1847 | |
| 260 | K | B | -1.8738 | |
| 261 | P | B | -1.4949 | |
| 262 | G | B | -1.3803 | |
| 263 | Q | B | -1.4694 | |
| 264 | S | B | -0.5925 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2765 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4232 | |
| 271 | K | B | -0.7904 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9491 | |
| 274 | N | B | -1.3122 | |
| 275 | R | B | -1.7751 | |
| 276 | F | B | -0.6807 | |
| 277 | S | B | -0.5970 | |
| 278 | G | B | -0.8124 | |
| 279 | V | B | -0.9085 | |
| 280 | P | B | -1.2737 | |
| 281 | D | B | -2.2273 | |
| 282 | R | B | -2.0433 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3331 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7784 | |
| 287 | G | B | -0.9788 | |
| 288 | S | B | -0.6479 | |
| 289 | G | B | -0.6132 | |
| 290 | T | B | -1.3641 | |
| 291 | D | B | -1.9938 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9928 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5636 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2778 | |
| 298 | R | B | -3.0421 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6303 | |
| 301 | A | B | -2.3198 | |
| 302 | E | B | -2.4920 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.8017 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -1.1488 | |
| 315 | Q | B | -1.3472 | |
| 316 | P | B | 0.0000 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | -0.2505 | |
| 319 | F | B | 0.1323 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2429 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.8204 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7187 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5685 | |
| 329 | R | B | -1.1125 | |
| 330 | T | B | -0.2061 | |
| 331 | V | B | 0.0318 | |
| 332 | A | B | -0.2263 | |
| 333 | A | B | -0.2178 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1361 | |
| 336 | V | B | -0.1387 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6985 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.6622 | |
| 343 | D | B | -3.1616 | |
| 344 | E | B | -3.1729 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.2776 | |
| 347 | K | B | -2.8268 | |
| 348 | S | B | -1.8048 | |
| 349 | G | B | -1.0667 | |
| 350 | T | B | -1.1246 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0859 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.8649 | |
| 363 | R | B | -3.2029 | |
| 364 | E | B | -3.2848 | |
| 365 | A | B | -2.3927 | |
| 366 | K | B | -2.4507 | |
| 367 | V | B | -1.0655 | |
| 368 | Q | B | -0.5386 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.7949 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1184 | |
| 373 | N | B | -1.6637 | |
| 374 | A | B | -0.3892 | |
| 375 | L | B | 0.7024 | |
| 376 | Q | B | -0.1948 | |
| 377 | S | B | -0.4603 | |
| 378 | G | B | -0.8870 | |
| 379 | N | B | -0.7848 | |
| 380 | S | B | -1.1320 | |
| 381 | Q | B | -1.4505 | |
| 382 | E | B | -1.9895 | |
| 383 | S | B | -0.8972 | |
| 384 | V | B | -0.8475 | |
| 385 | T | B | -1.2749 | |
| 386 | E | B | -2.3661 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2672 | |
| 389 | S | B | -2.4330 | |
| 390 | K | B | -2.7209 | |
| 391 | D | B | -1.9601 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.6698 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4447 | |
| 402 | L | B | -0.8074 | |
| 403 | S | B | -1.4001 | |
| 404 | K | B | -2.1909 | |
| 405 | A | B | -2.1799 | |
| 406 | D | B | -3.0378 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.8263 | |
| 409 | K | B | -3.8757 | |
| 410 | H | B | -3.3264 | |
| 411 | K | B | -3.4442 | |
| 412 | V | B | -2.1744 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.8206 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.8132 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2026 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.8317 | |
| 421 | G | B | -0.5714 | |
| 422 | L | B | -0.3112 | |
| 423 | S | B | -0.4380 | |
| 424 | S | B | -0.4241 | |
| 425 | P | B | -0.5369 | |
| 426 | V | B | 0.1634 | |
| 427 | T | B | -0.3343 | |
| 428 | K | B | -0.6305 | |
| 429 | S | B | -0.9506 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5481 | |
| 432 | R | B | -2.9723 | |
| 433 | G | B | -2.3215 | |
| 434 | E | B | -2.2394 | |
| 435 | C | B | -0.7212 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine