Project name: c9de3d52ea15a5b

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSKELEFKNGKCIFNGMNMAKTTVQYTDPTRCTAYFCEPGKHEMIIKGCPPPDDYDYEAYYDPTRWPDCCEAYKGGGGSHQLIKCSQNYSAEVMGVVTRDAIIGSQMTAKIKLRVYDTILKELKLRVTLFTPEGTVVPCIEHFGSCVYDVCEDVPDDKKTMWTTKCPVKPGTYWRNLIFRVSPKLLKHIGSGHLIAALMLESKGKKLSCQALGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5902
• Maximal score value: 1.8374
• Average score: -0.7958
• Total score value: -404.2566

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	0.0000
2	H	A	0.0000
3	H	A	-0.7436
4	E	A	-1.0177
5	G	A	0.0000
6	Q	A	0.0000
7	P	A	-0.1419
8	R	A	0.0000
9	S	A	0.0000
10	V	A	0.0000
11	C	A	-0.0863
12	A	A	0.0000
13	L	A	0.0000
14	E	A	-0.6350
15	E	A	0.0000
16	N	A	0.0000
17	A	A	0.0000
18	K	A	0.0000
19	R	A	0.0000
20	A	A	0.0000
21	L	A	0.0000
22	I	A	0.0000
23	S	A	0.0000
24	C	A	0.0000
25	V	A	0.0000
26	Q	A	-0.3960
27	T	A	-0.3129
28	H	A	-1.0120
29	L	A	-0.9111
30	T	A	-1.0592
31	A	A	-1.2009
32	D	A	-2.3175
33	T	A	0.0000
34	T	A	-1.4728
35	Q	A	-2.0979
36	K	A	-1.8848
37	L	A	0.0000
38	S	A	-1.4376
39	A	A	-1.7622
40	V	A	0.0000
41	K	A	-2.3823
42	D	A	-3.0759
43	Q	A	-2.6946
44	L	A	0.0000
45	H	A	-2.3552
46	C	A	0.0000
47	D	A	-1.8724
48	D	A	-1.6866
49	V	A	0.0000
50	Y	A	0.0000
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	0.0000
56	I	A	0.0000
57	C	A	0.0000
58	D	A	-2.4570
59	R	A	-2.8716
60	N	A	-2.9790
61	N	A	-2.4846
62	G	A	-1.8890
63	T	A	-1.7491
64	L	A	-1.3027
65	E	A	-2.2387
66	H	A	-2.0484
67	P	A	0.0000
68	S	A	-1.2376
69	N	A	-1.4349
70	E	A	-0.8216
71	F	A	1.3061
72	F	A	0.6391
73	S	A	-0.4084
74	N	A	-1.2506
75	A	A	-0.7129
76	E	A	-0.7550
77	K	A	0.0000
78	T	A	-0.7670
79	D	A	-0.5369
80	I	A	0.0000
81	R	A	0.0000
82	S	A	-0.4979
83	A	A	0.0000
84	V	A	0.0000
85	V	A	-0.0459
86	T	A	0.0000
87	C	A	0.0000
88	R	A	0.0000
89	E	A	0.0000
90	N	A	0.0000
91	L	A	0.0000
92	Q	A	0.0000
93	R	A	0.0000
94	Q	A	-0.2435
95	A	A	0.0000
96	E	A	0.0000
97	A	A	0.0000
98	A	A	-0.6703
99	K	A	-1.1968
100	T	A	0.0000
101	S	A	-0.9284
102	G	A	-1.2585
103	G	A	-1.0039
104	G	A	-1.1123
105	G	A	-1.1544
106	S	A	0.0000
107	K	A	-0.9822
108	E	A	0.0000
109	L	A	0.0000
110	E	A	0.0000
111	F	A	0.0000
112	K	A	0.0000
113	N	A	0.0000
114	G	A	0.0000
115	K	A	-0.4057
116	C	A	0.0000
117	I	A	0.1193
118	F	A	0.0000
119	N	A	0.0000
120	G	A	0.0000
121	M	A	-0.0895
122	N	A	0.0000
123	M	A	0.0000
124	A	A	-2.0610
125	K	A	-2.3041
126	T	A	-1.1649
127	T	A	-0.6546
128	V	A	-0.7482
129	Q	A	-1.4458
130	Y	A	0.0000
131	T	A	-0.9706
132	D	A	-1.0854
133	P	A	-0.8664
134	T	A	-0.8434
135	R	A	-1.0552
136	C	A	-0.6576
137	T	A	0.0000
138	A	A	0.0000
139	Y	A	0.0000
140	F	A	0.0000
141	C	A	0.0000
142	E	A	-1.3940
143	P	A	-1.4600
144	G	A	-1.7151
145	K	A	-2.4528
146	H	A	-2.3434
147	E	A	0.0000
148	M	A	-0.7759
149	I	A	-0.7262
150	I	A	0.0000
151	K	A	-1.9140
152	G	A	-0.9285
153	C	A	0.0000
154	P	A	-0.6751
155	P	A	-1.0254
156	P	A	-1.6218
157	D	A	-2.7845
158	D	A	-2.7842
159	Y	A	-1.9393
160	D	A	-2.2013
161	Y	A	-0.6434
162	E	A	-1.9050
163	A	A	0.0000
164	Y	A	-0.4390
165	Y	A	-0.8868
166	D	A	-1.6760
167	P	A	-1.1265
168	T	A	-1.2963
169	R	A	-2.3486
170	W	A	-1.1686
171	P	A	-0.8878
172	D	A	-1.0161
173	C	A	0.0000
174	C	A	0.0000
175	E	A	-1.2119
176	A	A	0.0000
177	Y	A	-1.5472
178	K	A	-2.6382
179	G	A	-1.8023
180	G	A	-1.5242
181	G	A	-1.4781
182	G	A	-1.8114
183	S	A	-1.4488
184	H	A	-0.5073
185	Q	A	-0.4836
186	L	A	0.0000
187	I	A	-0.0016
188	K	A	-1.5186
189	C	A	0.0000
190	S	A	-1.3321
191	Q	A	-2.3254
192	N	A	-2.0630
193	Y	A	-0.8341
194	S	A	0.0000
195	A	A	0.0000
196	E	A	-0.9873
197	V	A	0.0000
198	M	A	0.0147
199	G	A	0.0017
200	V	A	0.0000
201	V	A	0.4510
202	T	A	0.0000
203	R	A	-2.6874
204	D	A	-2.5070
205	A	A	-1.6514
206	I	A	0.0000
207	I	A	1.1387
208	G	A	0.0334
209	S	A	-0.8537
210	Q	A	-1.9245
211	M	A	0.0000
212	T	A	-1.2426
213	A	A	-0.4917
214	K	A	-0.6650
215	I	A	0.0000
216	K	A	-0.7463
217	L	A	0.0000
218	R	A	-2.0096
219	V	A	0.0000
220	Y	A	-0.8241
221	D	A	-1.6236
222	T	A	-0.8223
223	I	A	0.0000
224	L	A	-1.0249
225	K	A	-2.5352
226	E	A	-3.3031
227	L	A	0.0000
228	K	A	-2.0032
229	L	A	0.0000
230	R	A	-1.0314
231	V	A	0.0000
232	T	A	0.1622
233	L	A	0.0000
234	F	A	0.8583
235	T	A	0.0000
236	P	A	-1.1922
237	E	A	-2.3947
238	G	A	-1.9085
239	T	A	-0.9160
240	V	A	0.0971
241	V	A	0.0000
242	P	A	-0.0883
243	C	A	0.0000
244	I	A	0.0936
245	E	A	-1.4900
246	H	A	-0.8451
247	F	A	0.8328
248	G	A	-0.0353
249	S	A	-0.2957
250	C	A	0.3128
251	V	A	0.2422
252	Y	A	-0.4576
253	D	A	-1.7747
254	V	A	-1.6678
255	C	A	-2.2859
256	E	A	-2.8754
257	D	A	-2.7871
258	V	A	-2.4715
259	P	A	-2.7624
260	D	A	-3.2619
261	D	A	-3.4736
262	K	A	-3.5902
263	K	A	-3.0963
264	T	A	-1.7484
265	M	A	-0.6679
266	W	A	-0.1414
267	T	A	-0.7357
268	T	A	-1.5218
269	K	A	-2.4463
270	C	A	0.0000
271	P	A	-1.2363
272	V	A	-0.8215
273	K	A	-1.9865
274	P	A	-1.5207
275	G	A	-1.6044
276	T	A	-0.5934
277	Y	A	0.0435
278	W	A	0.4461
279	R	A	-0.3390
280	N	A	-0.9855
281	L	A	-0.0424
282	I	A	-0.0944
283	F	A	-0.6270
284	R	A	-2.0513
285	V	A	0.0000
286	S	A	-1.5334
287	P	A	-1.7993
288	K	A	-2.5234
289	L	A	-1.6402
290	L	A	-1.4594
291	K	A	-2.9562
292	H	A	-2.6480
293	I	A	-1.1447
294	G	A	-0.7598
295	S	A	-0.5604
296	G	A	-1.3427
297	H	A	-1.2385
298	L	A	0.0000
299	I	A	1.0610
300	A	A	0.6864
301	A	A	0.3073
302	L	A	0.0000
303	M	A	-0.6376
304	L	A	0.0000
305	E	A	-3.0080
306	S	A	0.0000
307	K	A	-3.1771
308	G	A	-2.7669
309	K	A	-3.4118
310	K	A	-3.2546
311	L	A	-1.9849
312	S	A	0.0000
313	C	A	-0.6719
314	Q	A	0.0000
315	A	A	0.1724
316	L	A	0.5182
317	G	A	0.4637
318	G	A	-0.1780
319	G	A	-0.6991
320	G	A	-1.3452
321	S	A	-1.4596
322	S	A	-1.8770
323	E	A	-2.8235
324	I	A	0.0000
325	K	A	-2.8757
326	Y	A	0.0000
327	H	A	-1.4381
328	N	A	0.0000
329	Y	A	-0.9752
330	N	A	-1.8868
331	S	A	-1.2830
332	N	A	0.0000
333	G	A	-1.1498
334	F	A	0.0000
335	N	A	-2.1009
336	P	A	-1.9677
337	K	A	-2.6033
338	G	A	-1.8978
339	P	A	-1.1992
340	G	A	-0.6298
341	P	A	-0.1061
342	G	A	0.0000
343	I	A	0.2672
344	L	A	0.0000
345	F	A	0.0000
346	G	A	0.0000
347	D	A	0.0000
348	A	A	0.0000
349	F	A	0.0000
350	I	A	0.0000
351	P	A	-0.6128
352	A	A	0.0957
353	I	A	1.1074
354	V	A	1.8374
355	Q	A	0.0000
356	P	A	0.4146
357	V	A	0.6702
358	S	A	0.0769
359	Q	A	-0.1983
360	I	A	0.4548
361	F	A	0.1048
362	P	A	-0.3861
363	G	A	-0.6949
364	P	A	-0.7369
365	G	A	-1.0234
366	P	A	-0.8244
367	G	A	0.0000
368	I	A	0.0000
369	L	A	0.0000
370	F	A	0.0000
371	N	A	0.0000
372	S	A	0.0000
373	L	A	-0.3115
374	Q	A	0.0000
375	Y	A	0.0000
376	T	A	0.0000
377	N	A	0.0000
378	V	A	-0.2949
379	V	A	0.0000
380	K	A	-1.4035
381	D	A	-1.8743
382	Y	A	-0.9050
383	W	A	0.0000
384	G	A	0.0000
385	N	A	-1.0655
386	D	A	-0.2967
387	L	A	0.8887
388	G	A	-0.2355
389	P	A	-1.2360
390	G	A	-1.3281
391	P	A	-1.1567
392	G	A	-1.8970
393	K	A	-2.2382
394	E	A	-2.5968
395	T	A	-1.5966
396	V	A	-0.6546
397	L	A	0.0000
398	R	A	-0.9427
399	V	A	0.0000
400	A	A	-1.0954
401	V	A	0.0000
402	T	A	0.0000
403	A	A	0.0000
404	Q	A	-0.8185
405	H	A	0.0000
406	P	A	0.0000
407	K	A	0.0000
408	P	A	0.3763
409	A	A	0.0000
410	S	A	0.0259
411	L	A	-0.0066
412	M	A	0.0000
413	G	A	0.0000
414	P	A	0.1131
415	G	A	-0.0187
416	P	A	-0.2722
417	G	A	-0.1615
418	Y	A	0.8101
419	D	A	0.1203
420	A	A	-0.3098
421	G	A	0.0000
422	I	A	0.0000
423	E	A	0.0000
424	L	A	0.0000
425	A	A	0.0000
426	H	A	0.0000
427	L	A	0.0000
428	L	A	0.0000
429	A	A	0.0000
430	F	A	0.0000
431	N	A	0.0000
432	K	A	0.0000
433	Y	A	1.0589
434	G	A	-0.2795
435	P	A	-1.0816
436	G	A	-0.5147
437	P	A	-0.7364
438	G	A	-1.1982
439	H	A	-1.3761
440	D	A	-1.9883
441	K	A	-1.9385
442	K	A	-2.5887
443	Q	A	-2.5278
444	F	A	0.0000
445	A	A	-1.1288
446	A	A	-0.5006
447	L	A	0.0000
448	M	A	0.0000
449	L	A	0.0000
450	Y	A	0.0000
451	E	A	0.0000
452	E	A	-2.0687
453	D	A	-2.6423
454	G	A	-1.4227
455	T	A	-1.4054
456	L	A	-0.7835
457	R	A	-1.1503
458	V	A	0.0000
459	E	A	0.0000
460	G	A	0.0000
461	V	A	0.0000
462	G	A	0.0000
463	P	A	-1.6548
464	G	A	-1.5754
465	P	A	-1.6914
466	G	A	-2.0433
467	K	A	-3.1648
468	R	A	-3.1344
469	H	A	-2.7004
470	G	A	-2.0892
471	K	A	-2.1157
472	R	A	-2.4353
473	L	A	-1.8259
474	R	A	-2.5287
475	V	A	0.0000
476	T	A	0.0000
477	K	A	-0.6926
478	V	A	0.0000
479	I	A	0.0000
480	P	A	0.0000
481	H	A	0.0000
482	A	A	-0.9577
483	K	A	-1.9180
484	Y	A	-1.6489
485	N	A	-2.4214
486	E	A	-2.2312
487	K	A	-2.8186
488	S	A	-2.3898
489	E	A	-2.8261
490	A	A	-1.7999
491	A	A	0.0000
492	A	A	-2.1991
493	K	A	-2.7381
494	F	A	-1.4838
495	Y	A	-1.0982
496	P	A	0.0000
497	S	A	0.0000
498	Y	A	0.0000
499	H	A	-1.1799
500	S	A	0.0000
501	T	A	-1.9592
502	P	A	-1.8597
503	Q	A	-2.2377
504	R	A	-2.6977
505	P	A	-1.5613
506	G	A	-1.1898
507	T	A	-1.0893
508	P	A	-0.8037