Project name: Ig1_aggre

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCQASGYRFSNFVIHWVRQAPGQRFEWMGWINPYNGNKEFSAKFQDRVTFTADTSANTAYMELRSLRSADTAVYYCARVGPYSWDDSPQDNYYMDVWGKGTTVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; K: QVQLVQSGAEVKKPGASVKVSCQASGYRFSNFVIHWVRQAPGQRFEWMGWINPYNGNKEFSAKFQDRVTFTADTSANTAYMELRSLRSADTAVYYCARVGPYSWDDSPQDNYYMDVWGKGTTVIVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS; M: EIVLTQSPGTLSLSPGERATFSCRSSHSIRSRRVAWYQHKPGQAPRLVIHGVSNRASGISDRFSGSGSGTDFTLTITRVEPEDFALYYCQVYGASSYTFGQGTKLERKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC; L: EIVLTQSPGTLSLSPGERATFSCRSSHSIRSRRVAWYQHKPGQAPRLVIHGVSNRASGISDRFSGSGSGTDFTLTITRVEPEDFALYYCQVYGASSYTFGQGTKLERKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1555
• Maximal score value: 1.5605
• Average score: -0.8594
• Total score value: -1143.8521

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4963
2	V	H	-1.1203
3	Q	H	-1.1641
4	L	H	0.0000
5	V	H	0.6087
6	Q	H	-0.0237
7	S	H	-0.7950
8	G	H	-0.7777
9	A	H	-0.7773
10	E	H	-1.6925
11	V	H	-0.4531
12	K	H	-2.0004
13	K	H	-2.5983
14	P	H	-2.4393
15	G	H	-2.1754
16	A	H	-1.8033
17	S	H	-2.1851
18	V	H	0.0000
19	K	H	-2.4448
20	V	H	0.0000
21	S	H	-0.4813
22	C	H	0.0000
23	Q	H	-0.9300
24	A	H	0.0000
25	S	H	-1.3223
26	G	H	-1.4424
27	Y	H	-1.6030
28	R	H	-2.3928
29	F	H	0.0000
30	S	H	-1.1994
31	N	H	-1.4959
32	F	H	0.0000
33	V	H	0.0000
34	I	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.9391
40	A	H	-0.8932
41	P	H	-0.9853
42	G	H	-1.4621
43	Q	H	-2.1326
44	R	H	-1.9039
45	F	H	0.0000
46	E	H	-1.0070
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	W	H	0.0000
51	I	H	0.0000
52	N	H	-1.2312
52A	P	H	0.0000
53	Y	H	-0.0395
54	N	H	-1.3216
55	G	H	-1.4892
56	N	H	-2.2614
57	K	H	-2.1595
58	E	H	-1.7188
59	F	H	-1.3658
60	S	H	-1.2791
61	A	H	-1.5349
62	K	H	-2.3562
63	F	H	0.0000
64	Q	H	-2.6337
65	D	H	-2.9917
66	R	H	-2.4573
67	V	H	0.0000
68	T	H	-1.2648
69	F	H	0.0000
70	T	H	-0.5434
71	A	H	-0.7664
72	D	H	-1.0191
73	T	H	-0.9157
74	S	H	-0.6891
75	A	H	-0.8488
76	N	H	-1.5751
77	T	H	0.0000
78	A	H	0.0000
79	Y	H	-0.5570
80	M	H	0.0000
81	E	H	-1.8773
82	L	H	0.0000
82A	R	H	-3.0046
82B	S	H	-2.0923
82C	L	H	0.0000
83	R	H	-2.8522
84	S	H	-1.5915
85	A	H	-0.6396
86	D	H	0.0000
87	T	H	-0.2784
88	A	H	0.0000
89	V	H	0.0112
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	V	H	0.0000
96	G	H	0.0000
97	P	H	-0.0301
98	Y	H	0.2520
99	S	H	-0.1316
100	W	H	0.0525
100A	D	H	-1.7647
100B	D	H	-1.8166
100C	S	H	-1.1554
100D	P	H	-0.9296
100E	Q	H	-0.7908
100F	D	H	-1.3627
100G	N	H	0.0000
100H	Y	H	0.0000
100I	Y	H	0.0000
100J	M	H	0.0000
101	D	H	-0.4078
102	V	H	-0.2152
103	W	H	0.0000
104	G	H	0.0000
105	K	H	-1.7885
106	G	H	-0.8775
107	T	H	0.0000
108	T	H	-0.4029
109	V	H	0.0000
110	I	H	-0.5983
111	V	H	0.0000
112	S	H	-1.2614
113	S	H	-1.2123
114	A	H	-0.7905
115	S	H	-0.7143
116	T	H	-0.7607
117	K	H	-1.3454
118	G	H	-1.3489
119	P	H	-0.6439
120	S	H	-0.1717
121	V	H	0.0000
122	F	H	-0.4438
123	P	H	-1.1177
124	L	H	0.0000
125	A	H	-1.1832
126	P	H	-1.0738
127	S	H	-1.3920
128	S	H	-1.2380
129	K	H	-1.9630
130	S	H	-1.3712
133	T	H	-1.0840
134	S	H	-0.8885
135	G	H	-0.8651
136	G	H	-0.8973
137	T	H	-0.5855
138	A	H	-0.5128
139	A	H	0.0000
140	L	H	0.0000
141	G	H	0.0000
142	C	H	0.0000
143	L	H	0.0000
144	V	H	0.0000
145	K	H	0.0000
146	D	H	-0.4305
147	Y	H	0.0000
148	F	H	0.0000
149	P	H	0.0000
150	E	H	-1.0356
151	P	H	-0.9353
152	V	H	-0.6817
153	T	H	-0.5168
154	V	H	-0.1811
156	S	H	-0.4145
157	W	H	0.0000
162	N	H	-0.8025
163	S	H	-0.7279
164	G	H	-0.6079
165	A	H	-0.2861
166	L	H	-0.0563
167	T	H	-0.2203
168	S	H	-0.2262
169	G	H	-0.2744
171	V	H	0.0878
172	H	H	-0.1180
173	T	H	0.0359
174	F	H	0.0000
175	P	H	-0.3765
176	A	H	0.0238
177	V	H	0.2228
178	L	H	0.8619
179	Q	H	0.1612
180	S	H	-0.1041
182	S	H	-0.2223
183	G	H	-0.0266
184	L	H	-0.0030
185	Y	H	0.3291
186	S	H	0.1062
187	L	H	0.0000
188	S	H	0.0000
189	S	H	0.0000
190	V	H	0.0000
191	V	H	0.0000
192	T	H	-0.1368
193	V	H	0.0000
194	P	H	-0.4732
195	S	H	-0.6222
196	S	H	-0.5154
197	S	H	-0.6429
198	L	H	-0.8029
199	G	H	-1.0291
200	T	H	-0.8281
203	Q	H	-1.4636
205	T	H	-1.1793
206	Y	H	0.0000
207	I	H	-1.1856
208	C	H	0.0000
209	N	H	-1.4787
210	V	H	0.0000
211	N	H	-1.6557
212	H	H	0.0000
213	K	H	-2.7529
214	P	H	-1.6846
215	S	H	-1.9005
216	N	H	-2.5741
217	T	H	-2.0405
218	K	H	-2.5709
219	V	H	-1.4344
220	D	H	-2.4682
221	K	H	-1.9242
222	K	H	-2.3531
225	A	H	0.0000
226	E	H	-2.9521
227	P	H	-2.1018
228	K	H	-2.6052
229	S	H	-1.8243
230	C	H	-1.3587
232	D	H	-2.9989
235	K	H	-3.3490
236	T	H	-2.3629
237	H	H	-2.3919
238	T	H	-1.4105
239	C	H	-0.1855
240	P	H	-0.4159
241	P	H	0.0113
242	C	H	0.4021
243	P	H	-0.1256
244	A	H	-0.9057
245	P	H	-1.1036
246	E	H	-1.4119
247	L	H	1.1275
248	L	H	1.1090
249	G	H	-0.1047
250	G	H	-0.5137
251	P	H	0.0000
252	S	H	0.0606
253	V	H	0.0000
254	F	H	1.3412
255	L	H	1.0799
256	F	H	1.2668
257	P	H	-0.0769
258	P	H	0.0000
259	K	H	-2.2479
260	P	H	-1.4217
261	K	H	-1.1312
262	D	H	0.0000
263	T	H	0.0000
264	L	H	0.0000
265	M	H	0.2330
266	I	H	1.2363
267	S	H	-0.1495
268	R	H	-1.6545
269	T	H	-0.8546
270	P	H	0.0000
271	E	H	-1.2135
272	V	H	0.0000
273	T	H	0.5127
274	C	H	0.0000
275	V	H	0.0000
276	V	H	0.0000
277	V	H	-0.8095
278	D	H	-1.3895
279	V	H	0.0000
280	S	H	-1.7888
281	H	H	-2.0617
282	E	H	-2.8674
283	D	H	-2.4122
284	P	H	-2.3143
285	E	H	-2.9242
286	V	H	-1.8602
287	K	H	-2.1499
288	F	H	-1.2085
289	N	H	-1.3621
290	W	H	0.0000
291	Y	H	-1.1002
292	V	H	-0.8772
295	D	H	-1.8873
296	G	H	-0.8117
299	V	H	0.4370
300	E	H	-1.4002
301	V	H	-0.9022
302	H	H	-2.0612
303	N	H	-2.1955
304	A	H	-1.6750
305	K	H	-2.5092
306	T	H	-2.0883
307	K	H	-2.8983
308	P	H	-2.5633
309	R	H	-3.8088
310	E	H	-4.1555
311	E	H	-3.3741
312	Q	H	-1.9379
313	Y	H	0.3303
314	N	H	-0.5823
317	S	H	-0.8825
318	T	H	0.0000
319	Y	H	-2.6472
320	R	H	-3.0849
321	V	H	0.0000
322	V	H	0.0000
323	S	H	0.0000
324	V	H	-0.8542
325	L	H	0.0000
326	T	H	-0.6747
327	V	H	0.0000
328	L	H	0.1204
329	H	H	-0.5919
330	Q	H	-1.6033
331	D	H	-1.7264
332	W	H	0.0000
333	L	H	-1.2381
334	N	H	-2.1514
335	G	H	-1.9970
336	K	H	-2.0050
337	E	H	-2.1749
338	Y	H	0.0000
339	K	H	-1.4881
340	C	H	0.0000
341	K	H	-1.4726
342	V	H	0.0000
343	S	H	-1.3153
344	N	H	0.0000
345	K	H	-2.5145
346	A	H	-1.6214
347	L	H	0.0000
348	P	H	-1.0465
349	A	H	-0.6866
350	P	H	-0.6311
351	I	H	-0.4060
352	E	H	-1.4740
353	K	H	-0.9642
354	T	H	-0.8417
355	I	H	-0.1822
357	S	H	-1.0652
358	K	H	-1.2944
359	A	H	-1.0160
360	K	H	-2.2421
361	G	H	-1.7994
363	Q	H	-1.8183
364	P	H	-1.7480
365	R	H	-1.8693
366	E	H	-2.4267
367	P	H	0.0000
368	Q	H	-1.1871
369	V	H	0.0000
370	Y	H	0.0000
371	T	H	-0.7919
372	L	H	0.0000
373	P	H	-0.4443
374	P	H	-0.9396
375	S	H	-1.5154
376	R	H	-2.6969
377	D	H	-2.8246
378	E	H	0.0000
381	L	H	-1.9231
382	T	H	-1.7295
383	K	H	-2.3976
384	N	H	-2.6491
385	Q	H	-2.5271
386	V	H	0.0000
387	S	H	0.0000
388	L	H	0.0000
389	T	H	0.0000
390	C	H	0.0000
391	L	H	0.0000
392	V	H	0.0000
393	K	H	-0.4871
394	G	H	-0.9807
395	F	H	0.0000
396	Y	H	-0.9666
397	P	H	0.0000
398	S	H	-0.3439
399	D	H	-1.1768
400	I	H	0.0000
401	A	H	-0.5471
402	V	H	-0.2415
405	E	H	-0.8794
406	W	H	0.0000
407	E	H	-1.5118
408	S	H	0.0000
410	N	H	-1.8176
411	G	H	-1.8617
414	Q	H	-2.2996
415	P	H	-1.9853
416	E	H	-1.9866
417	N	H	-2.3520
418	N	H	-2.0912
419	Y	H	-1.2641
420	K	H	-1.0871
421	T	H	-0.3407
422	T	H	0.0000
423	P	H	-0.1915
424	P	H	0.0278
425	V	H	0.3376
426	L	H	0.3952
427	D	H	-0.5930
428	S	H	-1.1560
430	D	H	-1.8584
433	G	H	-0.8498
434	S	H	0.0000
435	F	H	0.0935
436	F	H	0.0000
437	L	H	0.0000
438	Y	H	0.0000
439	S	H	0.0000
440	K	H	0.0000
441	L	H	0.0000
442	T	H	-1.1439
443	V	H	0.0000
444	D	H	-2.4781
445	K	H	-2.4748
446	S	H	-2.0582
447	R	H	-1.8014
448	W	H	0.0000
449	Q	H	-2.3773
450	Q	H	-2.3199
451	G	H	-1.5069
452	N	H	-0.8287
453	V	H	0.7425
454	F	H	0.0000
455	S	H	-0.6099
456	C	H	0.0000
457	S	H	0.0000
458	V	H	0.0000
459	M	H	0.0000
460	H	H	0.0000
461	E	H	-1.4806
462	A	H	-1.6506
463	L	H	-1.5675
464	H	H	-1.8816
465	N	H	-1.8174
466	H	H	-1.4092
467	Y	H	-0.6012
468	T	H	-0.7867
469	Q	H	-1.1430
470	K	H	-1.0559
471	S	H	-0.3593
472	L	H	0.0000
473	S	H	0.0278
474	L	H	-0.5851
475	S	H	-0.7539
476	P	H	-0.9832
477	G	H	-1.6494
478	K	H	-2.5131
1	Q	K	-1.2293
2	V	K	-0.6043
3	Q	K	-0.8373
4	L	K	0.0000
5	V	K	-0.4846
6	Q	K	-0.7237
7	S	K	-0.8302
8	G	K	-0.5780
9	A	K	-0.1122
10	E	K	-0.2450
11	V	K	0.2513
12	K	K	-1.3112
13	K	K	-2.3586
14	P	K	-2.2525
15	G	K	-2.0306
16	A	K	-1.6545
17	S	K	-2.0026
18	V	K	0.0000
19	K	K	-2.0862
20	V	K	0.0000
21	S	K	-0.6459
22	C	K	0.0000
23	Q	K	-1.3024
24	A	K	0.0000
25	S	K	-1.1454
26	G	K	-1.1335
27	Y	K	-1.3650
28	R	K	-2.2738
29	F	K	0.0000
30	S	K	-1.1656
31	N	K	-1.4114
32	F	K	-0.3800
33	V	K	0.0000
34	I	K	0.0000
35	H	K	0.0000
36	W	K	0.0000
37	V	K	0.0000
38	R	K	0.0000
39	Q	K	-0.8630
40	A	K	-0.8661
41	P	K	-0.9615
42	G	K	-1.4310
43	Q	K	-2.0707
44	R	K	-1.7871
45	F	K	0.0000
46	E	K	-0.9471
47	W	K	0.0000
48	M	K	0.0000
49	G	K	0.0000
50	W	K	-0.4692
51	I	K	0.0000
52	N	K	-1.0850
52A	P	K	0.0000
53	Y	K	0.0036
54	N	K	-1.4801
55	G	K	-1.5660
56	N	K	-2.1184
57	K	K	-1.7977
58	E	K	-1.2658
59	F	K	-0.9571
60	S	K	-1.1563
61	A	K	-1.4812
62	K	K	-2.3207
63	F	K	0.0000
64	Q	K	-2.5374
65	D	K	-2.9574
66	R	K	-2.3433
67	V	K	0.0000
68	T	K	-1.1652
69	F	K	0.0000
70	T	K	-0.5324
71	A	K	-0.5879
72	D	K	-1.2788
73	T	K	-0.8814
74	S	K	-0.7340
75	A	K	-0.9435
76	N	K	-1.6191
77	T	K	0.0000
78	A	K	0.0000
79	Y	K	-0.5110
80	M	K	0.0000
81	E	K	-1.6639
82	L	K	0.0000
82A	R	K	-2.9589
82B	S	K	-2.2046
82C	L	K	0.0000
83	R	K	-2.7520
84	S	K	-1.5172
85	A	K	-0.6987
86	D	K	0.0000
87	T	K	-0.3508
88	A	K	0.0000
89	V	K	0.0163
90	Y	K	0.0000
91	Y	K	0.0000
92	C	K	0.0000
93	A	K	0.0000
94	R	K	0.0000
95	V	K	0.0000
96	G	K	0.0000
97	P	K	0.0262
98	Y	K	0.5946
99	S	K	0.1185
100	W	K	0.2736
100A	D	K	-1.4550
100B	D	K	-1.1760
100C	S	K	-0.9324
100D	P	K	-0.7392
100E	Q	K	-0.7988
100F	D	K	-1.3636
100G	N	K	0.0000
100H	Y	K	0.0000
100I	Y	K	0.0000
100J	M	K	0.0000
101	D	K	-0.5893
102	V	K	-0.2601
103	W	K	0.0000
104	G	K	0.0000
105	K	K	-2.0338
106	G	K	-1.0772
107	T	K	0.0000
108	T	K	-0.0914
109	V	K	0.0000
110	I	K	0.0000
111	V	K	0.0000
112	S	K	-1.1763
113	S	K	-1.1303
114	A	K	-0.8106
115	S	K	-0.7813
116	T	K	-0.9053
117	K	K	-1.6690
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135	L	M	0.0000
136	L	M	0.0000
137	N	M	0.0000
138	N	M	-1.1324
139	F	M	0.0000
140	Y	M	0.0000
141	P	M	-1.3810
142	R	M	-2.6878
143	E	M	-3.0014
144	A	M	-2.2617
145	K	M	-2.4730
146	V	M	-1.2336
147	Q	M	-0.8323
148	W	M	0.0000
149	K	M	-1.0289
150	V	M	0.0000
151	D	M	-1.9999
152	N	M	-1.6288
153	A	M	-0.3510
154	L	M	0.7157
155	Q	M	-0.4616
156	S	M	-0.7263
157	G	M	-1.3476
158	N	M	-1.6865
159	S	M	-1.7852
160	Q	M	-2.1381
161	E	M	-2.4365
162	S	M	-0.9964
163	V	M	-0.9964
164	T	M	-1.1892
165	E	M	-2.2683
166	Q	M	-2.1020
167	D	M	-2.2401
168	S	M	-2.1102
169	K	M	-2.6471
170	D	M	-2.3975
171	S	M	0.0000
172	T	M	0.0000
173	Y	M	0.0000
174	S	M	0.0000
175	L	M	0.0000
176	S	M	0.0000
177	S	M	0.0000
178	T	M	0.0000
179	L	M	0.0000
180	T	M	-0.6356
181	L	M	-0.9043
182	S	M	-1.3939
183	K	M	-2.4765
184	A	M	-1.9770
185	D	M	-3.0571
186	Y	M	0.0000
187	E	M	-3.4164
188	K	M	-3.6448
189	H	M	-3.2678
190	K	M	-3.1826
191	V	M	-2.0631
192	Y	M	0.0000
193	A	M	-1.0812
194	C	M	0.0000
195	E	M	-1.1710
196	V	M	0.0000
197	T	M	-1.4939
198	H	M	0.0000
199	Q	M	-1.9151
200	G	M	-0.6467
201	L	M	-0.7366
202	R	M	-2.0424
203	S	M	-1.2007
204	P	M	-0.9227
205	V	M	-0.2359
206	T	M	-0.7093
207	K	M	-1.0447
208	S	M	-0.9336
209	F	M	-0.9017
210	N	M	-2.1128
211	R	M	-2.3259
212	G	M	-2.1157
213	E	M	-2.1112
214	C	M	-0.8384