Project name: cdecb14943bde12
Status: done
submitted: 2018-12-13 07:44:08, status changed: 2018-12-13 07:52:32
Settings
|
Chain sequence(s)
|
B: DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.1892
-
Maximal score value
-
1.4467
-
Average score
-
-0.7739
-
Total score value
-
-213.6048
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 448 |
D |
B |
-2.6492 |
|
| 449 |
D |
B |
-2.8355 |
|
| 450 |
W |
B |
-1.4733 |
|
| 451 |
E |
B |
-1.6413 |
|
| 452 |
I |
B |
0.0000 |
|
| 453 |
P |
B |
-1.8761 |
|
| 454 |
D |
B |
-3.0970 |
|
| 455 |
G |
B |
-1.9783 |
|
| 456 |
Q |
B |
-1.9597 |
|
| 457 |
I |
B |
-1.2781 |
|
| 458 |
T |
B |
-0.9938 |
|
| 459 |
V |
B |
-0.4672 |
|
| 460 |
G |
B |
-1.1016 |
|
| 461 |
Q |
B |
-1.7080 |
|
| 462 |
R |
B |
-1.4992 |
|
| 463 |
I |
B |
0.5732 |
|
| 464 |
G |
B |
0.1788 |
|
| 465 |
S |
B |
-0.1425 |
|
| 466 |
G |
B |
-0.5181 |
|
| 467 |
S |
B |
-0.7873 |
|
| 468 |
F |
B |
-0.5332 |
|
| 469 |
G |
B |
0.0000 |
|
| 470 |
T |
B |
-0.0773 |
|
| 471 |
V |
B |
0.2414 |
|
| 472 |
Y |
B |
-0.4983 |
|
| 473 |
K |
B |
-1.4339 |
|
| 474 |
G |
B |
0.0000 |
|
| 475 |
K |
B |
-2.7534 |
|
| 476 |
W |
B |
-1.8275 |
|
| 477 |
H |
B |
-2.0285 |
|
| 478 |
G |
B |
-2.2509 |
|
| 479 |
D |
B |
-3.1054 |
|
| 480 |
V |
B |
0.0000 |
|
| 481 |
A |
B |
-0.5676 |
|
| 482 |
V |
B |
0.0000 |
|
| 483 |
K |
B |
-0.1248 |
|
| 484 |
M |
B |
-0.1647 |
|
| 485 |
L |
B |
0.0000 |
|
| 486 |
N |
B |
-0.7574 |
|
| 487 |
V |
B |
-0.2757 |
|
| 488 |
T |
B |
-0.2969 |
|
| 489 |
A |
B |
-0.4330 |
|
| 490 |
P |
B |
-0.5175 |
|
| 491 |
T |
B |
-0.5860 |
|
| 492 |
P |
B |
-1.2282 |
|
| 493 |
Q |
B |
-1.8187 |
|
| 494 |
Q |
B |
-1.5234 |
|
| 495 |
L |
B |
-0.9833 |
|
| 496 |
Q |
B |
-2.0989 |
|
| 497 |
A |
B |
-1.7686 |
|
| 498 |
F |
B |
0.0000 |
|
| 499 |
K |
B |
-1.7879 |
|
| 500 |
N |
B |
-1.7982 |
|
| 501 |
E |
B |
0.0000 |
|
| 502 |
V |
B |
0.0000 |
|
| 503 |
G |
B |
-1.2321 |
|
| 504 |
V |
B |
-0.8301 |
|
| 505 |
L |
B |
-0.9563 |
|
| 506 |
R |
B |
-2.2026 |
|
| 507 |
K |
B |
-2.2220 |
|
| 508 |
T |
B |
0.0000 |
|
| 509 |
R |
B |
-1.8058 |
|
| 510 |
H |
B |
-0.2124 |
|
| 511 |
V |
B |
1.3807 |
|
| 512 |
N |
B |
0.0000 |
|
| 513 |
I |
B |
0.0000 |
|
| 514 |
L |
B |
0.6227 |
|
| 515 |
L |
B |
0.9417 |
|
| 516 |
F |
B |
0.1187 |
|
| 517 |
M |
B |
0.4631 |
|
| 518 |
G |
B |
0.0000 |
|
| 519 |
Y |
B |
0.0000 |
|
| 520 |
S |
B |
0.0000 |
|
| 521 |
T |
B |
-1.4927 |
|
| 522 |
K |
B |
-2.7227 |
|
| 523 |
P |
B |
-1.9820 |
|
| 524 |
Q |
B |
-1.6950 |
|
| 525 |
L |
B |
0.0000 |
|
| 526 |
A |
B |
0.0000 |
|
| 527 |
I |
B |
0.0000 |
|
| 528 |
V |
B |
0.0000 |
|
| 529 |
T |
B |
0.2264 |
|
| 530 |
Q |
B |
-0.3846 |
|
| 531 |
W |
B |
-1.0046 |
|
| 532 |
C |
B |
-1.5087 |
|
| 533 |
E |
B |
-3.0194 |
|
| 534 |
G |
B |
-2.1868 |
|
| 535 |
S |
B |
-1.0883 |
|
| 536 |
S |
B |
-0.3905 |
|
| 537 |
L |
B |
0.0000 |
|
| 538 |
Y |
B |
0.2701 |
|
| 539 |
H |
B |
0.2508 |
|
| 540 |
H |
B |
0.0000 |
|
| 541 |
L |
B |
0.0000 |
|
| 542 |
H |
B |
0.2242 |
|
| 543 |
I |
B |
1.4467 |
|
| 544 |
I |
B |
0.9776 |
|
| 545 |
E |
B |
-1.2386 |
|
| 546 |
T |
B |
-1.2803 |
|
| 547 |
K |
B |
-2.3621 |
|
| 548 |
F |
B |
-1.4781 |
|
| 549 |
E |
B |
-1.6939 |
|
| 550 |
M |
B |
0.0000 |
|
| 551 |
I |
B |
1.0503 |
|
| 552 |
K |
B |
-0.0745 |
|
| 553 |
L |
B |
0.0000 |
|
| 554 |
I |
B |
0.0000 |
|
| 555 |
D |
B |
-0.4700 |
|
| 556 |
I |
B |
0.0000 |
|
| 557 |
A |
B |
0.0000 |
|
| 558 |
R |
B |
-1.3931 |
|
| 559 |
Q |
B |
-0.7748 |
|
| 560 |
T |
B |
0.0000 |
|
| 561 |
A |
B |
0.0000 |
|
| 562 |
Q |
B |
-0.7311 |
|
| 563 |
G |
B |
0.0000 |
|
| 564 |
M |
B |
0.0000 |
|
| 565 |
D |
B |
-0.6274 |
|
| 566 |
Y |
B |
-0.5929 |
|
| 567 |
L |
B |
0.0000 |
|
| 568 |
H |
B |
0.0000 |
|
| 569 |
A |
B |
-0.3796 |
|
| 570 |
K |
B |
-0.8893 |
|
| 571 |
S |
B |
-0.4815 |
|
| 572 |
I |
B |
0.0000 |
|
| 573 |
I |
B |
0.0046 |
|
| 574 |
H |
B |
0.0000 |
|
| 575 |
R |
B |
-0.9335 |
|
| 576 |
D |
B |
-0.9525 |
|
| 577 |
L |
B |
0.0000 |
|
| 578 |
K |
B |
-0.5706 |
|
| 579 |
S |
B |
0.0000 |
|
| 580 |
N |
B |
-0.6245 |
|
| 581 |
N |
B |
0.0000 |
|
| 582 |
I |
B |
0.0000 |
|
| 583 |
F |
B |
-0.3466 |
|
| 584 |
L |
B |
0.0000 |
|
| 585 |
H |
B |
-1.7544 |
|
| 586 |
E |
B |
-2.8179 |
|
| 587 |
D |
B |
-2.1261 |
|
| 588 |
L |
B |
0.0636 |
|
| 589 |
T |
B |
0.0897 |
|
| 590 |
V |
B |
0.0000 |
|
| 591 |
K |
B |
0.0000 |
|
| 592 |
I |
B |
0.0000 |
|
| 593 |
G |
B |
0.0000 |
|
| 594 |
D |
B |
-1.9174 |
|
| 595 |
F |
B |
0.0000 |
|
| 596 |
G |
B |
-0.7673 |
|
| 597 |
L |
B |
0.0000 |
|
| 598 |
A |
B |
-0.7894 |
|
| 599 |
T |
B |
-0.8134 |
|
| 600 |
V |
B |
0.0000 |
|
| 601 |
K |
B |
-1.1139 |
|
| 602 |
S |
B |
-1.2700 |
|
| 603 |
R |
B |
-2.1589 |
|
| 604 |
W |
B |
0.0000 |
|
| 605 |
S |
B |
-0.9161 |
|
| 606 |
G |
B |
-0.7085 |
|
| 607 |
S |
B |
-0.3017 |
|
| 608 |
H |
B |
0.0000 |
|
| 609 |
Q |
B |
-0.3772 |
|
| 610 |
F |
B |
0.8601 |
|
| 611 |
E |
B |
-1.0255 |
|
| 612 |
Q |
B |
-0.6231 |
|
| 613 |
L |
B |
0.3893 |
|
| 614 |
S |
B |
-0.3434 |
|
| 615 |
G |
B |
-0.5424 |
|
| 616 |
S |
B |
0.0000 |
|
| 617 |
I |
B |
0.0000 |
|
| 618 |
L |
B |
0.1244 |
|
| 619 |
W |
B |
0.0000 |
|
| 620 |
M |
B |
0.0583 |
|
| 621 |
A |
B |
0.0000 |
|
| 622 |
P |
B |
0.0000 |
|
| 623 |
E |
B |
0.0000 |
|
| 624 |
V |
B |
0.0000 |
|
| 625 |
I |
B |
0.0000 |
|
| 626 |
R |
B |
-1.0422 |
|
| 627 |
M |
B |
-0.9477 |
|
| 628 |
Q |
B |
-2.2139 |
|
| 629 |
D |
B |
-2.8888 |
|
| 630 |
K |
B |
-2.9630 |
|
| 631 |
N |
B |
-2.4063 |
|
| 632 |
P |
B |
0.0000 |
|
| 633 |
Y |
B |
-0.5798 |
|
| 634 |
S |
B |
-0.1748 |
|
| 635 |
F |
B |
0.2292 |
|
| 636 |
Q |
B |
-0.9528 |
|
| 637 |
S |
B |
0.0000 |
|
| 638 |
D |
B |
0.0000 |
|
| 639 |
V |
B |
0.0000 |
|
| 640 |
Y |
B |
0.0000 |
|
| 641 |
A |
B |
0.0000 |
|
| 642 |
F |
B |
0.0000 |
|
| 643 |
G |
B |
0.0000 |
|
| 644 |
I |
B |
0.0000 |
|
| 645 |
V |
B |
0.0000 |
|
| 646 |
L |
B |
0.0000 |
|
| 647 |
Y |
B |
0.0000 |
|
| 648 |
E |
B |
0.0000 |
|
| 649 |
L |
B |
0.0000 |
|
| 650 |
M |
B |
0.0000 |
|
| 651 |
T |
B |
-0.7943 |
|
| 652 |
G |
B |
-1.0666 |
|
| 653 |
Q |
B |
-0.7897 |
|
| 654 |
L |
B |
-0.0615 |
|
| 655 |
P |
B |
0.0000 |
|
| 656 |
Y |
B |
-0.8720 |
|
| 657 |
S |
B |
-0.9079 |
|
| 658 |
N |
B |
-1.5988 |
|
| 659 |
I |
B |
-1.8343 |
|
| 660 |
N |
B |
-2.7757 |
|
| 661 |
N |
B |
-3.3499 |
|
| 662 |
R |
B |
-3.0230 |
|
| 663 |
D |
B |
-2.7408 |
|
| 664 |
Q |
B |
-1.7994 |
|
| 665 |
I |
B |
0.0000 |
|
| 666 |
I |
B |
-0.3979 |
|
| 667 |
F |
B |
0.5160 |
|
| 668 |
M |
B |
0.2063 |
|
| 669 |
V |
B |
0.0000 |
|
| 670 |
G |
B |
0.0000 |
|
| 671 |
R |
B |
-1.2988 |
|
| 672 |
G |
B |
-0.7410 |
|
| 673 |
Y |
B |
0.8620 |
|
| 674 |
L |
B |
0.2624 |
|
| 675 |
S |
B |
-0.6576 |
|
| 676 |
P |
B |
0.0000 |
|
| 677 |
D |
B |
-1.8596 |
|
| 678 |
L |
B |
-1.3424 |
|
| 679 |
S |
B |
-1.1913 |
|
| 680 |
K |
B |
-1.5089 |
|
| 681 |
V |
B |
-1.3983 |
|
| 682 |
R |
B |
-1.4430 |
|
| 683 |
S |
B |
-1.4611 |
|
| 684 |
N |
B |
-1.7545 |
|
| 685 |
C |
B |
-1.2416 |
|
| 686 |
P |
B |
-1.6541 |
|
| 687 |
K |
B |
-2.6143 |
|
| 688 |
A |
B |
-1.4858 |
|
| 689 |
M |
B |
0.0000 |
|
| 690 |
K |
B |
-2.4510 |
|
| 691 |
R |
B |
-2.9515 |
|
| 692 |
L |
B |
0.0000 |
|
| 693 |
M |
B |
0.0000 |
|
| 694 |
A |
B |
-1.9416 |
|
| 695 |
E |
B |
-2.5054 |
|
| 696 |
C |
B |
0.0000 |
|
| 697 |
L |
B |
0.0000 |
|
| 698 |
K |
B |
-3.4695 |
|
| 699 |
K |
B |
-3.7804 |
|
| 700 |
K |
B |
-4.1892 |
|
| 701 |
R |
B |
-3.8632 |
|
| 702 |
D |
B |
-3.7179 |
|
| 703 |
E |
B |
-3.4422 |
|
| 704 |
R |
B |
0.0000 |
|
| 705 |
P |
B |
-1.2321 |
|
| 706 |
L |
B |
-0.3497 |
|
| 707 |
F |
B |
0.0000 |
|
| 708 |
P |
B |
-0.8195 |
|
| 709 |
Q |
B |
-1.3408 |
|
| 710 |
I |
B |
0.0000 |
|
| 711 |
L |
B |
-0.8060 |
|
| 712 |
A |
B |
-0.6007 |
|
| 713 |
S |
B |
-0.2700 |
|
| 714 |
I |
B |
0.0000 |
|
| 715 |
E |
B |
-1.2995 |
|
| 716 |
L |
B |
0.3506 |
|
| 717 |
L |
B |
0.0000 |
|
| 718 |
A |
B |
-0.6653 |
|
| 719 |
R |
B |
-1.9560 |
|
| 720 |
S |
B |
-1.1368 |
|
| 721 |
L |
B |
-0.4911 |
|
| 722 |
P |
B |
-1.0096 |
|
| 723 |
K |
B |
-2.0218 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine