| Chain sequence(s) |
A: PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ B: PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | P | A | -1.0690 | |
| 3 | Y | A | -1.1434 | |
| 4 | T | A | 0.0000 | |
| 5 | V | A | 0.0000 | |
| 6 | V | A | 0.0000 | |
| 7 | Y | A | 0.0000 | |
| 8 | F | A | 0.8066 | |
| 9 | P | A | 0.3220 | |
| 10 | V | A | -0.1092 | |
| 11 | R | A | -0.4815 | |
| 12 | G | A | -0.2782 | |
| 13 | R | A | -0.3798 | |
| 14 | C | A | 0.0000 | |
| 15 | A | A | 0.0000 | |
| 16 | A | A | 0.0000 | |
| 17 | L | A | 0.0000 | |
| 18 | R | A | 0.0000 | |
| 19 | M | A | 0.0000 | |
| 20 | L | A | 0.0000 | |
| 21 | L | A | 0.0000 | |
| 22 | A | A | -0.8290 | |
| 23 | D | A | 0.0000 | |
| 24 | Q | A | -0.8280 | |
| 25 | G | A | -1.0806 | |
| 26 | Q | A | -0.7055 | |
| 27 | S | A | -0.7889 | |
| 28 | W | A | -1.3607 | |
| 29 | K | A | -2.4120 | |
| 30 | E | A | -2.1255 | |
| 31 | E | A | -1.8185 | |
| 32 | V | A | 0.7007 | |
| 33 | V | A | 0.0000 | |
| 34 | T | A | 0.2278 | |
| 35 | V | A | 0.5221 | |
| 36 | E | A | -1.8593 | |
| 37 | T | A | -1.2513 | |
| 38 | W | A | -1.3391 | |
| 39 | Q | A | -2.4036 | |
| 40 | E | A | -2.8471 | |
| 41 | G | A | -2.0414 | |
| 42 | S | A | -1.1864 | |
| 43 | L | A | -0.9987 | |
| 44 | K | A | -1.6276 | |
| 45 | A | A | -0.7975 | |
| 46 | S | A | -0.5118 | |
| 47 | C | A | 0.0000 | |
| 48 | L | A | -0.2345 | |
| 49 | Y | A | -0.5696 | |
| 50 | G | A | -0.6931 | |
| 51 | Q | A | -0.6400 | |
| 52 | L | A | 0.0000 | |
| 53 | P | A | 0.0000 | |
| 54 | K | A | -0.5699 | |
| 55 | F | A | 0.0000 | |
| 56 | Q | A | -1.3140 | |
| 57 | D | A | -1.4057 | |
| 58 | G | A | -1.6563 | |
| 59 | D | A | -2.1593 | |
| 60 | L | A | -1.2937 | |
| 61 | T | A | -0.8283 | |
| 62 | L | A | 0.0000 | |
| 63 | Y | A | -0.0274 | |
| 64 | Q | A | 0.0000 | |
| 65 | S | A | 0.0000 | |
| 66 | N | A | -0.2624 | |
| 67 | T | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | L | A | 0.0000 | |
| 70 | R | A | 0.0000 | |
| 71 | H | A | 0.0000 | |
| 72 | L | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | R | A | -1.2725 | |
| 75 | T | A | -0.8542 | |
| 76 | L | A | -0.3213 | |
| 77 | G | A | -1.0865 | |
| 78 | L | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | G | A | -2.4252 | |
| 81 | K | A | -3.1380 | |
| 82 | D | A | -2.5739 | |
| 83 | Q | A | -2.4737 | |
| 84 | Q | A | -2.1940 | |
| 85 | E | A | -1.7149 | |
| 86 | A | A | 0.0000 | |
| 87 | A | A | 0.0000 | |
| 88 | L | A | -0.0829 | |
| 89 | V | A | 0.0000 | |
| 90 | D | A | 0.0000 | |
| 91 | M | A | 0.0000 | |
| 92 | V | A | 0.0000 | |
| 93 | N | A | 0.0000 | |
| 94 | D | A | -0.4844 | |
| 95 | G | A | 0.0000 | |
| 96 | V | A | 0.0000 | |
| 97 | E | A | -0.8497 | |
| 98 | D | A | -1.2555 | |
| 99 | L | A | 0.0000 | |
| 100 | R | A | 0.0000 | |
| 101 | C | A | -0.5088 | |
| 102 | K | A | -1.2186 | |
| 103 | Y | A | 0.0000 | |
| 104 | I | A | 0.0579 | |
| 105 | S | A | -0.2935 | |
| 106 | L | A | 0.0000 | |
| 107 | I | A | 0.0000 | |
| 108 | Y | A | 0.0696 | |
| 109 | T | A | -0.4301 | |
| 110 | N | A | -1.5704 | |
| 111 | Y | A | -1.7324 | |
| 112 | E | A | -2.4809 | |
| 113 | A | A | -1.9166 | |
| 114 | G | A | -2.1623 | |
| 115 | K | A | -2.6154 | |
| 116 | D | A | -3.3667 | |
| 117 | D | A | -3.1643 | |
| 118 | Y | A | -1.9803 | |
| 119 | V | A | -1.5871 | |
| 120 | K | A | -2.6731 | |
| 121 | A | A | -1.5956 | |
| 122 | L | A | 0.0000 | |
| 123 | P | A | -1.1224 | |
| 124 | G | A | -1.3759 | |
| 125 | Q | A | -1.3489 | |
| 126 | L | A | 0.0000 | |
| 127 | K | A | -1.9894 | |
| 128 | P | A | -0.9715 | |
| 129 | F | A | 0.0000 | |
| 130 | E | A | -0.9640 | |
| 131 | T | A | -0.8545 | |
| 132 | L | A | -0.6344 | |
| 133 | L | A | 0.0000 | |
| 134 | S | A | -1.3355 | |
| 135 | Q | A | -1.6704 | |
| 136 | N | A | -1.9027 | |
| 137 | Q | A | -2.3622 | |
| 138 | G | A | -1.8198 | |
| 139 | G | A | 0.0000 | |
| 140 | K | A | -2.3889 | |
| 141 | T | A | -1.9107 | |
| 142 | F | A | -1.2437 | |
| 143 | I | A | 0.0000 | |
| 144 | V | A | 0.0000 | |
| 145 | G | A | -1.9542 | |
| 146 | D | A | -3.0005 | |
| 147 | Q | A | -2.4216 | |
| 148 | I | A | 0.0000 | |
| 149 | S | A | 0.0000 | |
| 150 | F | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | D | A | 0.0000 | |
| 153 | Y | A | 0.0000 | |
| 154 | N | A | 0.0000 | |
| 155 | L | A | 0.0000 | |
| 156 | L | A | 0.0000 | |
| 157 | D | A | 0.0000 | |
| 158 | L | A | 0.0000 | |
| 159 | L | A | 0.0000 | |
| 160 | L | A | 0.3650 | |
| 161 | I | A | 0.0000 | |
| 162 | H | A | 0.0000 | |
| 163 | E | A | -0.4054 | |
| 164 | V | A | 0.4910 | |
| 165 | L | A | 0.0000 | |
| 166 | A | A | 0.0000 | |
| 167 | P | A | -0.5137 | |
| 168 | G | A | -1.0944 | |
| 169 | C | A | -0.8784 | |
| 170 | L | A | 0.0000 | |
| 171 | D | A | -2.0085 | |
| 172 | A | A | -1.1574 | |
| 173 | F | A | 0.0000 | |
| 174 | P | A | -0.5537 | |
| 175 | L | A | -0.4397 | |
| 176 | L | A | 0.0000 | |
| 177 | S | A | -0.6167 | |
| 178 | A | A | -0.4607 | |
| 179 | Y | A | 0.0000 | |
| 180 | V | A | -0.1178 | |
| 181 | G | A | -0.7472 | |
| 182 | R | A | -1.1898 | |
| 183 | L | A | 0.0000 | |
| 184 | S | A | -1.0314 | |
| 185 | A | A | -1.2297 | |
| 186 | R | A | -1.5403 | |
| 187 | P | A | -1.6243 | |
| 188 | K | A | -2.1774 | |
| 189 | L | A | 0.0000 | |
| 190 | K | A | -2.1517 | |
| 191 | A | A | -1.1374 | |
| 192 | F | A | -0.8555 | |
| 193 | L | A | -0.4710 | |
| 194 | A | A | -0.3999 | |
| 195 | S | A | -0.7312 | |
| 196 | P | A | -1.0810 | |
| 197 | E | A | -1.8852 | |
| 198 | Y | A | 0.0000 | |
| 199 | V | A | -0.0729 | |
| 200 | N | A | -1.2469 | |
| 201 | L | A | -0.5673 | |
| 202 | P | A | -0.7412 | |
| 203 | I | A | 0.0000 | |
| 204 | N | A | 0.0000 | |
| 205 | G | A | -0.9596 | |
| 206 | N | A | -1.5778 | |
| 207 | G | A | -1.6017 | |
| 208 | K | A | -1.7659 | |
| 209 | Q | A | -1.3577 | |
| 2 | P | B | -1.0713 | |
| 3 | Y | B | -1.1217 | |
| 4 | T | B | 0.0000 | |
| 5 | V | B | 0.0000 | |
| 6 | V | B | 0.0000 | |
| 7 | Y | B | 0.0000 | |
| 8 | F | B | 0.8580 | |
| 9 | P | B | 0.3677 | |
| 10 | V | B | -0.1214 | |
| 11 | R | B | -0.5024 | |
| 12 | G | B | -0.2888 | |
| 13 | R | B | -0.3781 | |
| 14 | C | B | 0.0000 | |
| 15 | A | B | 0.0000 | |
| 16 | A | B | 0.0000 | |
| 17 | L | B | 0.0000 | |
| 18 | R | B | 0.0000 | |
| 19 | M | B | 0.0000 | |
| 20 | L | B | 0.0000 | |
| 21 | L | B | 0.0000 | |
| 22 | A | B | -0.7582 | |
| 23 | D | B | 0.0000 | |
| 24 | Q | B | -0.8000 | |
| 25 | G | B | -1.0454 | |
| 26 | Q | B | -0.7128 | |
| 27 | S | B | -0.7942 | |
| 28 | W | B | -1.2896 | |
| 29 | K | B | -2.2585 | |
| 30 | E | B | -1.8149 | |
| 31 | E | B | -1.4918 | |
| 32 | V | B | 0.8802 | |
| 33 | V | B | 0.0000 | |
| 34 | T | B | 0.4334 | |
| 35 | V | B | 0.5197 | |
| 36 | E | B | -1.8300 | |
| 37 | T | B | -1.2263 | |
| 38 | W | B | -1.3352 | |
| 39 | Q | B | -2.3854 | |
| 40 | E | B | -2.8235 | |
| 41 | G | B | -2.0239 | |
| 42 | S | B | -1.1790 | |
| 43 | L | B | -0.9873 | |
| 44 | K | B | -1.5839 | |
| 45 | A | B | -0.7755 | |
| 46 | S | B | -0.4955 | |
| 47 | C | B | 0.0000 | |
| 48 | L | B | -0.2113 | |
| 49 | Y | B | -0.4704 | |
| 50 | G | B | -0.6469 | |
| 51 | Q | B | -0.6162 | |
| 52 | L | B | 0.0000 | |
| 53 | P | B | 0.0000 | |
| 54 | K | B | -0.5614 | |
| 55 | F | B | 0.0000 | |
| 56 | Q | B | -1.3013 | |
| 57 | D | B | -1.2771 | |
| 58 | G | B | -1.6397 | |
| 59 | D | B | -2.1398 | |
| 60 | L | B | -1.2209 | |
| 61 | T | B | -0.7856 | |
| 62 | L | B | 0.0000 | |
| 63 | Y | B | -0.0060 | |
| 64 | Q | B | 0.0000 | |
| 65 | S | B | 0.0000 | |
| 66 | N | B | -0.2535 | |
| 67 | T | B | 0.0000 | |
| 68 | I | B | 0.0000 | |
| 69 | L | B | 0.0000 | |
| 70 | R | B | 0.0000 | |
| 71 | H | B | 0.0000 | |
| 72 | L | B | 0.0000 | |
| 73 | G | B | 0.0000 | |
| 74 | R | B | -0.6150 | |
| 75 | T | B | -0.4379 | |
| 76 | L | B | 0.0109 | |
| 77 | G | B | -0.7755 | |
| 78 | L | B | 0.0000 | |
| 79 | Y | B | -0.9797 | |
| 80 | G | B | -2.3993 | |
| 81 | K | B | -3.2453 | |
| 82 | D | B | -2.8159 | |
| 83 | Q | B | -2.7783 | |
| 84 | Q | B | -2.4042 | |
| 85 | E | B | -1.8717 | |
| 86 | A | B | -1.6147 | |
| 87 | A | B | 0.0000 | |
| 88 | L | B | -0.3076 | |
| 89 | V | B | 0.0000 | |
| 90 | D | B | 0.0000 | |
| 91 | M | B | 0.0000 | |
| 92 | V | B | 0.0000 | |
| 93 | N | B | 0.0000 | |
| 94 | D | B | -0.6262 | |
| 95 | G | B | 0.0000 | |
| 96 | V | B | 0.0000 | |
| 97 | E | B | -1.0887 | |
| 98 | D | B | -1.6979 | |
| 99 | L | B | 0.0000 | |
| 100 | R | B | 0.0000 | |
| 101 | C | B | -0.5204 | |
| 102 | K | B | -1.1259 | |
| 103 | Y | B | 0.0000 | |
| 104 | I | B | 0.2585 | |
| 105 | S | B | -0.0891 | |
| 106 | L | B | 0.0000 | |
| 107 | I | B | 0.0000 | |
| 108 | Y | B | 0.3889 | |
| 109 | T | B | -0.3805 | |
| 110 | N | B | -1.5089 | |
| 111 | Y | B | -1.7247 | |
| 112 | E | B | -2.5972 | |
| 113 | A | B | -1.9520 | |
| 114 | G | B | -2.2441 | |
| 115 | K | B | -2.7217 | |
| 116 | D | B | -3.4363 | |
| 117 | D | B | -3.2480 | |
| 118 | Y | B | 0.0000 | |
| 119 | V | B | -1.6869 | |
| 120 | K | B | -2.7486 | |
| 121 | A | B | -1.7043 | |
| 122 | L | B | 0.0000 | |
| 123 | P | B | -1.2099 | |
| 124 | G | B | -1.4580 | |
| 125 | Q | B | -1.5602 | |
| 126 | L | B | 0.0000 | |
| 127 | K | B | -1.9836 | |
| 128 | P | B | -0.9685 | |
| 129 | F | B | 0.0000 | |
| 130 | E | B | -0.9399 | |
| 131 | T | B | -0.8338 | |
| 132 | L | B | -0.6600 | |
| 133 | L | B | 0.0000 | |
| 134 | S | B | -1.3821 | |
| 135 | Q | B | -1.7346 | |
| 136 | N | B | -2.0307 | |
| 137 | Q | B | -2.5457 | |
| 138 | G | B | -1.9133 | |
| 139 | G | B | 0.0000 | |
| 140 | K | B | -2.4447 | |
| 141 | T | B | -1.9584 | |
| 142 | F | B | -1.2788 | |
| 143 | I | B | 0.0000 | |
| 144 | V | B | 0.0000 | |
| 145 | G | B | -2.0245 | |
| 146 | D | B | -3.0384 | |
| 147 | Q | B | -2.4079 | |
| 148 | I | B | 0.0000 | |
| 149 | S | B | 0.0000 | |
| 150 | F | B | 0.0000 | |
| 151 | A | B | 0.0000 | |
| 152 | D | B | 0.0000 | |
| 153 | Y | B | 0.0000 | |
| 154 | N | B | 0.0000 | |
| 155 | L | B | 0.0000 | |
| 156 | L | B | 0.0000 | |
| 157 | D | B | 0.0000 | |
| 158 | L | B | 0.0000 | |
| 159 | L | B | 0.0000 | |
| 160 | L | B | 0.1720 | |
| 161 | I | B | 0.0000 | |
| 162 | H | B | 0.0000 | |
| 163 | E | B | -0.8118 | |
| 164 | V | B | 0.2694 | |
| 165 | L | B | 0.0000 | |
| 166 | A | B | 0.0000 | |
| 167 | P | B | -0.6874 | |
| 168 | G | B | -1.2433 | |
| 169 | C | B | -0.9905 | |
| 170 | L | B | 0.0000 | |
| 171 | D | B | -2.0652 | |
| 172 | A | B | -1.1344 | |
| 173 | F | B | 0.0000 | |
| 174 | P | B | -0.5806 | |
| 175 | L | B | -0.4736 | |
| 176 | L | B | 0.0000 | |
| 177 | S | B | -0.7221 | |
| 178 | A | B | -0.7204 | |
| 179 | Y | B | 0.0000 | |
| 180 | V | B | 0.0000 | |
| 181 | G | B | -0.8421 | |
| 182 | R | B | -1.2510 | |
| 183 | L | B | 0.0000 | |
| 184 | S | B | -1.0096 | |
| 185 | A | B | -1.1710 | |
| 186 | R | B | -1.3973 | |
| 187 | P | B | -1.4299 | |
| 188 | K | B | -1.8650 | |
| 189 | L | B | 0.0000 | |
| 190 | K | B | -1.9201 | |
| 191 | A | B | -0.9722 | |
| 192 | F | B | -0.7373 | |
| 193 | L | B | -0.3927 | |
| 194 | A | B | -0.3675 | |
| 195 | S | B | -0.7147 | |
| 196 | P | B | -1.0906 | |
| 197 | E | B | -1.8952 | |
| 198 | Y | B | 0.0000 | |
| 199 | V | B | -0.0971 | |
| 200 | N | B | -1.2633 | |
| 201 | L | B | -0.5984 | |
| 202 | P | B | -0.7724 | |
| 203 | I | B | 0.0000 | |
| 204 | N | B | 0.0000 | |
| 205 | G | B | -0.9417 | |
| 206 | N | B | -1.5414 | |
| 207 | G | B | -1.5942 | |
| 208 | K | B | -1.9529 | |
| 209 | Q | B | -1.4389 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine