Project name: ce3052ef9290045

Chain sequence(s)	A: AQVLTQTASSVSAAVGGTVTISCQSSQSVYNKNWLGWYQQKPGQPPRLLIYGASTLASGVPSRFSGSGSGTQFTLTISDVQCDDAATYYCAGGYSNNIVSFGGGTRVVVEVATLAPTVLIFPPSPAELATGTATIVCVANKYFPDGTVTWQVDGKPLTTGIETSKTPQNSDDCTYNLSSTLTLKSDEYNSHDEYTCQVAQGSGSPVVQSFNRGDCGGGGSGGGGSGGGGSGGGGSDYKDDDDKDYKDDDDKDYKDDDDK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.2016
• Maximal score value: 1.9214
• Average score: -0.8046
• Total score value: -208.3923

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	0.1747
2	Q	A	0.2989
3	V	A	1.3118
4	L	A	0.0000
5	T	A	-0.3685
6	Q	A	0.0000
7	T	A	-0.4658
8	A	A	-0.1113
9	S	A	-0.3306
10	S	A	-0.0557
11	V	A	0.4211
12	S	A	0.2405
13	A	A	0.1285
14	A	A	0.0908
15	V	A	-0.2866
16	G	A	-0.8226
17	G	A	-0.7515
18	T	A	-0.9026
19	V	A	0.0000
20	T	A	-0.1266
21	I	A	0.0000
22	S	A	-0.6573
23	C	A	0.0000
24	Q	A	-1.6435
25	S	A	0.0000
26	S	A	-0.7283
27	Q	A	-1.0014
28	S	A	-0.5355
29	V	A	0.2103
30	Y	A	0.4123
31	N	A	-1.2706
32	K	A	-1.8953
33	N	A	0.0000
34	W	A	-0.0857
35	L	A	0.0000
36	G	A	0.0000
37	W	A	0.0000
38	Y	A	0.2254
39	Q	A	0.0000
40	Q	A	-1.2086
41	K	A	-1.4612
42	P	A	-1.1178
43	G	A	-1.3075
44	Q	A	-1.8956
45	P	A	-1.4100
46	P	A	-1.2694
47	R	A	-1.3257
48	L	A	0.3235
49	L	A	0.0000
50	I	A	0.0000
51	Y	A	1.2493
52	G	A	0.2728
53	A	A	0.0000
54	S	A	0.0226
55	T	A	0.3061
56	L	A	0.6064
57	A	A	0.2707
58	S	A	-0.1774
59	G	A	-0.4388
60	V	A	-0.3194
61	P	A	-0.5550
62	S	A	-0.9376
63	R	A	-1.7722
64	F	A	0.0000
65	S	A	-0.5590
66	G	A	-0.1779
67	S	A	-0.5875
68	G	A	-1.1311
69	S	A	-1.5243
70	G	A	-1.3703
71	T	A	-1.5676
72	Q	A	-1.7901
73	F	A	0.0000
74	T	A	-0.6925
75	L	A	0.0000
76	T	A	-0.5984
77	I	A	0.0000
78	S	A	-1.4853
79	D	A	-1.9296
80	V	A	0.0000
81	Q	A	-1.7101
82	C	A	-1.8719
83	D	A	-2.6128
84	D	A	0.0000
85	A	A	-1.0146
86	A	A	0.0000
87	T	A	-0.1941
88	Y	A	0.0000
89	Y	A	0.0764
90	C	A	0.0000
91	A	A	0.6945
92	G	A	0.7284
93	G	A	0.4502
94	Y	A	0.4812
95	S	A	-0.2104
96	N	A	-1.1917
97	N	A	-0.8883
98	I	A	1.2148
99	V	A	0.8988
100	S	A	0.4351
101	F	A	0.0000
102	G	A	-0.3312
103	G	A	-0.3146
104	G	A	0.0000
105	T	A	-0.0527
106	R	A	0.0000
107	V	A	0.3982
108	V	A	0.0000
109	V	A	0.7783
110	E	A	0.1050
111	V	A	1.6564
112	A	A	1.2573
113	T	A	0.6694
114	L	A	0.7650
115	A	A	0.0000
116	P	A	0.0047
117	T	A	0.8101
118	V	A	1.9214
119	L	A	1.6205
120	I	A	1.7923
121	F	A	1.2726
122	P	A	0.0000
123	P	A	0.0065
124	S	A	-0.1378
125	P	A	-0.1005
126	A	A	-0.0891
127	E	A	-0.5050
128	L	A	1.1586
129	A	A	0.2921
130	T	A	-0.6335
131	G	A	-1.1455
132	T	A	0.0000
133	A	A	0.0000
134	T	A	0.0000
135	I	A	1.1821
136	V	A	0.0000
137	C	A	0.7986
138	V	A	0.0000
139	A	A	-0.6048
140	N	A	-1.3882
141	K	A	0.0000
142	Y	A	0.0000
143	F	A	1.3175
144	P	A	-0.6224
145	D	A	-1.6531
146	G	A	-1.1164
147	T	A	-0.6448
148	V	A	0.0361
149	T	A	0.0717
150	W	A	0.0000
151	Q	A	-1.2502
152	V	A	0.0000
153	D	A	-2.0883
154	G	A	-1.9035
155	K	A	-2.3055
156	P	A	-1.2712
157	L	A	-0.4500
158	T	A	-0.3647
159	T	A	-0.2440
160	G	A	-0.3997
161	I	A	-0.4119
162	E	A	-1.6803
163	T	A	-1.2370
164	S	A	-1.6081
165	K	A	-2.2641
166	T	A	-1.3495
167	P	A	-1.1091
168	Q	A	-1.3882
169	N	A	-2.5601
170	S	A	-2.6016
171	D	A	-3.4128
172	D	A	-3.4765
173	C	A	0.0000
174	T	A	-1.3472
175	Y	A	0.0000
176	N	A	-1.4812
177	L	A	0.0000
178	S	A	-0.5182
179	S	A	0.0000
180	T	A	-0.2491
181	L	A	0.0000
182	T	A	-0.6821
183	L	A	-1.3256
184	K	A	-2.7347
185	S	A	0.0000
186	D	A	-3.1604
187	E	A	-2.6421
188	Y	A	0.0000
189	N	A	-2.4460
190	S	A	-1.8960
191	H	A	-2.1371
192	D	A	-2.4678
193	E	A	-2.4124
194	Y	A	0.0000
195	T	A	0.0000
196	C	A	0.0000
197	Q	A	0.0844
198	V	A	0.0000
199	A	A	-0.3520
200	Q	A	-0.6100
201	G	A	-0.6529
202	S	A	-0.3105
203	G	A	-0.7025
204	S	A	-0.2160
205	P	A	0.0488
206	V	A	0.7769
207	V	A	1.5901
208	Q	A	0.7999
209	S	A	0.2921
210	F	A	-0.5152
211	N	A	-1.9312
212	R	A	-2.0696
213	G	A	-1.9873
214	D	A	-2.3368
215	C	A	-0.8034
216	G	A	-0.6573
217	G	A	-0.0254
218	G	A	0.0000
219	G	A	0.0000
220	S	A	-0.7468
221	G	A	-0.9892
222	G	A	-1.1124
223	G	A	-1.1325
224	G	A	-1.0774
225	S	A	-0.9421
226	G	A	-1.1129
227	G	A	-1.1091
228	G	A	-1.1302
229	G	A	-1.1522
230	S	A	-1.0682
231	G	A	-1.1751
232	G	A	-1.1761
233	G	A	-1.2858
234	G	A	-1.2632
235	S	A	-1.1518
236	D	A	-2.0327
237	Y	A	-1.2753
238	K	A	-3.5406
239	D	A	-3.9994
240	D	A	-4.6091
241	D	A	-4.8863
242	D	A	-4.5661
243	K	A	-4.0437
244	D	A	-3.2836
245	Y	A	-2.6131
246	K	A	-4.2436
247	D	A	-3.8719
248	D	A	-4.9838
249	D	A	-5.2016
250	D	A	-5.0031
251	K	A	-4.5646
252	D	A	-3.7104
253	Y	A	-1.9874
254	K	A	-3.8294
255	D	A	-4.1924
256	D	A	-4.1897
257	D	A	-4.3240
258	D	A	-3.9064
259	K	A	-3.2318