Project name: Tau PHF

Status: done

submitted: 2019-02-23 17:10:11, status changed: 2019-02-23 17:45:45
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Chain sequence(s) A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
C: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
B: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
E: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
D: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
G: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
F: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
I: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
H: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
J: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-5.4465
Maximal score value
2.6938
Average score
-0.7799
Total score value
-569.3287

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
306 V A 1.9559
307 Q A 0.6014
308 I A 1.4917
309 V A 1.3222
310 Y A 0.4192
311 K A -1.1160
312 P A -0.2377
313 V A 0.9122
314 D A -0.1705
315 L A 0.8502
316 S A -0.6838
317 K A -1.5642
318 V A -1.1064
319 T A -1.3543
320 S A -1.5863
321 K A -2.4684
322 C A -1.1747
323 G A -1.0702
324 S A -0.6371
325 L A -0.0062
326 G A -0.7192
327 N A -1.4371
328 I A -0.6604
329 H A -1.2883
330 H A -0.9492
331 K A -1.5091
332 P A -1.0005
333 G A -1.0684
334 G A -0.9997
335 G A -1.0522
336 Q A -1.7452
337 V A -1.0802
338 E A -2.2548
339 V A -1.6106
340 K A -2.9786
341 S A -2.6600
342 E A -3.6338
343 K A -3.4799
344 L A -1.9408
345 D A -2.7791
346 F A -2.9059
347 K A -4.0942
348 D A -3.9418
349 R A -4.1420
350 V A -2.6759
351 Q A -2.7125
352 S A -1.5744
353 K A -2.0968
354 I A -1.0186
355 G A -1.0090
356 S A -0.8404
357 L A -0.2107
358 D A -0.2583
359 N A -0.0293
360 I A 1.1342
361 T A 0.0000
362 H A -0.5802
363 V A -0.1178
364 P A -0.4054
365 G A 0.0000
366 G A -1.2031
367 G A -1.0886
368 N A -1.5843
369 K A -2.3599
370 K A -1.5869
371 I A -0.2803
372 E A -0.8244
373 T A -0.7865
374 H A -1.2437
375 K A -2.0708
376 L A -0.3053
377 T A 0.5525
378 F A 1.8588
306 V B 1.8639
307 Q B 0.5190
308 I B 1.5160
309 V B 1.3347
310 Y B 0.4166
311 K B -1.1380
312 P B -0.2623
313 V B 0.8956
314 D B -0.1437
315 L B 0.8537
316 S B -0.7267
317 K B -1.7026
318 V B -1.1939
319 T B -1.3090
320 S B -1.4118
321 K B -2.2389
322 C B -0.9785
323 G B -0.9308
324 S B -0.5317
325 L B 0.2191
326 G B -0.5948
327 N B -1.4019
328 I B -0.6059
329 H B -1.1887
330 H B -0.7819
331 K B -1.2185
332 P B -0.9543
333 G B -0.9276
334 G B -0.7139
335 G B -0.6113
336 Q B -0.8782
337 V B -0.7651
338 E B -2.1352
339 V B -1.5026
340 K B -2.8460
341 S B -2.4728
342 E B -3.4226
343 K B -3.3613
344 L B -1.9614
345 D B -2.8263
346 F B -3.0584
347 K B -4.5364
348 D B -4.7690
349 R B -4.5037
350 V B -2.8778
351 Q B -2.8042
352 S B -1.5448
353 K B -2.0838
354 I B -0.9869
355 G B -0.9282
356 S B -0.7976
357 L B -0.0674
358 D B -0.3722
359 N B -0.0220
360 I B 1.2096
361 T B 0.0000
362 H B -0.4737
363 V B -0.0460
364 P B -0.3700
365 G B 0.0000
366 G B -1.0612
367 G B -1.0944
368 N B -1.5898
369 K B -2.3404
370 K B -1.5509
371 I B -0.1919
372 E B -0.8771
373 T B -0.8042
374 H B -1.2654
375 K B -2.0872
376 L B -0.1857
377 T B 0.7807
378 F B 2.3700
306 V C 2.5540
307 Q C 1.1333
308 I C 0.0000
309 V C 0.4193
310 Y C 0.0000
311 K C -0.7502
312 P C 0.0000
313 V C 0.5808
314 D C 0.0000
315 L C 0.7371
316 S C 0.0000
317 K C -1.1195
318 V C 0.0000
319 T C -1.6083
320 S C 0.0000
321 K C -2.9882
322 C C 0.0000
323 G C -1.2840
324 S C -0.6500
325 L C 0.0000
326 G C -0.7377
327 N C -1.1754
328 I C 0.0000
329 H C -0.9555
330 H C 0.0000
331 K C 0.0000
332 P C 0.0000
333 G C 0.0000
334 G C 0.0000
335 G C 0.0000
336 Q C 0.0000
337 V C 0.0000
338 E C -1.4777
339 V C 0.0000
340 K C -2.6847
341 S C -2.8535
342 E C -3.3995
343 K C -3.4300
344 L C 0.0000
345 D C -2.9099
346 F C 0.0000
347 K C -4.2566
348 D C -4.6361
349 R C -5.2257
350 V C 0.0000
351 Q C -2.8283
352 S C 0.0000
353 K C -1.3855
354 I C 0.0000
355 G C 0.0000
356 S C 0.0000
357 L C 0.0000
358 D C 0.0000
359 N C 0.0000
360 I C 0.5020
361 T C 0.0000
362 H C -0.3487
363 V C 0.0000
364 P C 0.0000
365 G C 0.0000
366 G C 0.0000
367 G C -0.9294
368 N C 0.0000
369 K C -1.7244
370 K C 0.0000
371 I C -0.1439
372 E C 0.0000
373 T C -0.5795
374 H C 0.0000
375 K C -1.6322
376 L C 0.0000
377 T C 0.6045
378 F C 1.9462
306 V D 2.2780
307 Q D 1.0018
308 I D 0.0000
309 V D 0.3778
310 Y D 0.0000
311 K D -0.7796
312 P D 0.0000
313 V D 0.4562
314 D D 0.0000
315 L D 0.7672
316 S D -0.7223
317 K D -1.5682
318 V D 0.0000
319 T D -1.6158
320 S D 0.0000
321 K D -2.3937
322 C D 0.0000
323 G D -1.1452
324 S D -0.5427
325 L D 0.0000
326 G D -0.7295
327 N D -1.2140
328 I D 0.0000
329 H D -0.9452
330 H D 0.0000
331 K D 0.0000
332 P D 0.0000
333 G D 0.0000
334 G D 0.0000
335 G D 0.0000
336 Q D 0.0000
337 V D 0.0000
338 E D -1.4833
339 V D 0.0000
340 K D -2.5374
341 S D 0.0000
342 E D -3.0699
343 K D -3.1992
344 L D 0.0000
345 D D -3.0611
346 F D 0.0000
347 K D -4.5996
348 D D -4.9583
349 R D -5.4465
350 V D 0.0000
351 Q D -2.8090
352 S D 0.0000
353 K D -1.3708
354 I D 0.0000
355 G D 0.0000
356 S D 0.0000
357 L D 0.0000
358 D D 0.0000
359 N D 0.0000
360 I D 0.5117
361 T D 0.0000
362 H D -0.3449
363 V D 0.0000
364 P D 0.0000
365 G D 0.0000
366 G D 0.0000
367 G D -0.9412
368 N D 0.0000
369 K D -1.7542
370 K D 0.0000
371 I D -0.0995
372 E D 0.0000
373 T D -0.5955
374 H D 0.0000
375 K D -1.6975
376 L D 0.0000
377 T D 0.5972
378 F D 1.8823
306 V E 2.6938
307 Q E 0.8613
308 I E 0.0000
309 V E 0.2391
310 Y E 0.0000
311 K E -1.1352
312 P E 0.0000
313 V E 0.5892
314 D E 0.0000
315 L E 1.1162
316 S E 0.0000
317 K E -1.3200
318 V E 0.0000
319 T E 0.0000
320 S E 0.0000
321 K E -2.6481
322 C E 0.0000
323 G E -1.2963
324 S E -0.6260
325 L E 0.0000
326 G E -0.8228
327 N E -1.1786
328 I E 0.0000
329 H E -0.5889
330 H E 0.0000
331 K E 0.0000
332 P E 0.0000
333 G E 0.0000
334 G E 0.0000
335 G E 0.0000
336 Q E 0.0000
337 V E 0.0000
338 E E 0.0000
339 V E 0.0000
340 K E -1.9709
341 S E -2.5605
342 E E -3.0996
343 K E -3.0164
344 L E 0.0000
345 D E -2.6741
346 F E 0.0000
347 K E -3.8879
348 D E -4.3445
349 R E -5.0607
350 V E 0.0000
351 Q E -2.4695
352 S E 0.0000
353 K E -1.1136
354 I E 0.0000
355 G E 0.0000
356 S E 0.0000
357 L E 0.0000
358 D E 0.0000
359 N E 0.0000
360 I E 0.4883
361 T E 0.0000
362 H E -0.5187
363 V E 0.0000
364 P E 0.0000
365 G E 0.0000
366 G E 0.0000
367 G E -0.6211
368 N E 0.0000
369 K E -1.5246
370 K E 0.0000
371 I E 0.2656
372 E E 0.0000
373 T E -0.3870
374 H E 0.0000
375 K E -1.4138
376 L E 0.0000
377 T E 0.5680
378 F E 1.7621
306 V F 2.5977
307 Q F 0.7335
308 I F 0.0000
309 V F 0.1846
310 Y F 0.0000
311 K F -1.2592
312 P F 0.0000
313 V F 0.6041
314 D F 0.0000
315 L F 1.0553
316 S F 0.0000
317 K F -1.7919
318 V F 0.0000
319 T F -1.3986
320 S F 0.0000
321 K F -2.5584
322 C F 0.0000
323 G F -1.2792
324 S F -0.6913
325 L F 0.0000
326 G F -0.9225
327 N F -1.3829
328 I F 0.0000
329 H F -0.6676
330 H F 0.0000
331 K F 0.0000
332 P F 0.0000
333 G F 0.0000
334 G F 0.0000
335 G F 0.0000
336 Q F 0.0000
337 V F 0.0000
338 E F -1.0405
339 V F 0.0000
340 K F -2.4057
341 S F -2.6266
342 E F -3.1506
343 K F -2.9251
344 L F 0.0000
345 D F -2.8493
346 F F 0.0000
347 K F -4.4242
348 D F -4.9206
349 R F -5.2248
350 V F 0.0000
351 Q F -2.4990
352 S F 0.0000
353 K F -1.0454
354 I F 0.0000
355 G F 0.0000
356 S F 0.0000
357 L F 0.0000
358 D F 0.0000
359 N F 0.0000
360 I F 0.4878
361 T F 0.0000
362 H F -0.5023
363 V F 0.0000
364 P F 0.0000
365 G F 0.0000
366 G F 0.0000
367 G F -0.7097
368 N F 0.0000
369 K F -1.8242
370 K F 0.0000
371 I F 0.3020
372 E F 0.0000
373 T F -0.3181
374 H F 0.0000
375 K F -1.5702
376 L F 0.0000
377 T F 0.4948
378 F F 1.8415
306 V G 2.5721
307 Q G 0.9170
308 I G 0.0000
309 V G -0.0964
310 Y G 0.0000
311 K G -1.2757
312 P G 0.0000
313 V G 0.2537
314 D G 0.0000
315 L G 0.5688
316 S G 0.0000
317 K G -1.1331
318 V G 0.0000
319 T G -1.3283
320 S G 0.0000
321 K G -2.5605
322 C G 0.0000
323 G G -1.1518
324 S G -0.7194
325 L G 0.0000
326 G G -0.9974
327 N G -1.3535
328 I G 0.0000
329 H G -0.7739
330 H G 0.0000
331 K G 0.0000
332 P G 0.0000
333 G G 0.0000
334 G G 0.0000
335 G G 0.0000
336 Q G 0.0000
337 V G 0.0000
338 E G -0.9409
339 V G 0.0000
340 K G -2.4065
341 S G -2.9424
342 E G -3.8566
343 K G -3.6725
344 L G 0.0000
345 D G -2.5961
346 F G 0.0000
347 K G -3.9142
348 D G -4.1683
349 R G -5.1773
350 V G 0.0000
351 Q G -2.6887
352 S G 0.0000
353 K G -1.1459
354 I G 0.0000
355 G G 0.0000
356 S G 0.0000
357 L G 0.0000
358 D G -0.6255
359 N G 0.0000
360 I G -0.1128
361 T G 0.0000
362 H G -0.4405
363 V G 0.0000
364 P G 0.0000
365 G G 0.0000
366 G G 0.0000
367 G G -0.9222
368 N G 0.0000
369 K G -2.1439
370 K G 0.0000
371 I G -0.5704
372 E G 0.0000
373 T G -0.9935
374 H G 0.0000
375 K G -1.8001
376 L G 0.0000
377 T G 0.8328
378 F G 2.1288
306 V H 2.5982
307 Q H 1.0066
308 I H 0.0000
309 V H -0.1728
310 Y H 0.0000
311 K H -0.9875
312 P H 0.0000
313 V H 0.6431
314 D H 0.0000
315 L H 0.7898
316 S H 0.0000
317 K H -1.4214
318 V H 0.0000
319 T H -1.5310
320 S H 0.0000
321 K H -2.8119
322 C H 0.0000
323 G H -1.3414
324 S H -0.7788
325 L H 0.0000
326 G H -1.0656
327 N H -1.4234
328 I H 0.0000
329 H H -1.0190
330 H H 0.0000
331 K H -1.0862
332 P H 0.0000
333 G H 0.0000
334 G H 0.0000
335 G H 0.0000
336 Q H 0.0000
337 V H 0.0000
338 E H -0.9652
339 V H 0.0000
340 K H -2.7407
341 S H 0.0000
342 E H -3.7157
343 K H -3.3730
344 L H 0.0000
345 D H -2.4678
346 F H 0.0000
347 K H -4.2295
348 D H -4.7247
349 R H -5.3903
350 V H 0.0000
351 Q H -2.5208
352 S H -1.0697
353 K H -0.8065
354 I H 0.0000
355 G H 0.0000
356 S H 0.0000
357 L H 0.0000
358 D H 0.0000
359 N H 0.0000
360 I H -0.1545
361 T H 0.0000
362 H H -0.4420
363 V H 0.0000
364 P H 0.0000
365 G H 0.0000
366 G H 0.0000
367 G H -1.0253
368 N H 0.0000
369 K H -2.6041
370 K H 0.0000
371 I H -0.5210
372 E H 0.0000
373 T H -0.6425
374 H H 0.0000
375 K H -1.7800
376 L H 0.0000
377 T H 0.8463
378 F H 2.3565
306 V I 1.9743
307 Q I 0.2559
308 I I 1.0815
309 V I -0.0431
310 Y I -0.0822
311 K I -1.5724
312 P I -0.9298
313 V I 0.3870
314 D I -0.4457
315 L I 0.6768
316 S I -0.7692
317 K I -1.5567
318 V I -1.4234
319 T I -1.2208
320 S I -1.3755
321 K I -2.0533
322 C I -1.2562
323 G I -1.1069
324 S I -0.8227
325 L I -0.5042
326 G I -1.2451
327 N I -1.6450
328 I I -0.7404
329 H I -0.9112
330 H I -0.4986
331 K I -0.8728
332 P I -0.5838
333 G I 0.0000
334 G I -0.6077
335 G I 0.0000
336 Q I -0.6360
337 V I -0.2766
338 E I -1.1952
339 V I -1.0804
340 K I -2.6160
341 S I -3.0695
342 E I -3.7848
343 K I -3.6610
344 L I -2.4710
345 D I -2.4858
346 F I -1.9375
347 K I -3.7605
348 D I -4.2748
349 R I -4.3896
350 V I -3.0080
351 Q I -2.6371
352 S I -1.3873
353 K I -1.7107
354 I I -0.1369
355 G I -0.5532
356 S I -0.7245
357 L I -0.4214
358 D I -1.6180
359 N I -1.0270
360 I I -0.0817
361 T I -0.1898
362 H I -0.7875
363 V I -0.1335
364 P I -0.4893
365 G I -0.7850
366 G I -0.7988
367 G I -1.0374
368 N I -2.0223
369 K I -2.7853
370 K I -2.5336
371 I I -1.2249
372 E I -1.7598
373 T I -1.4257
374 H I -2.1542
375 K I -2.2568
376 L I -0.0417
377 T I 1.0003
378 F I 2.5077
306 V J 2.0428
307 Q J 0.3428
308 I J 1.1750
309 V J 0.0261
310 Y J 0.0021
311 K J -1.3062
312 P J -0.4295
313 V J 1.0923
314 D J 0.2535
315 L J 1.1402
316 S J -0.5866
317 K J -1.3444
318 V J -1.4374
319 T J -1.3051
320 S J -1.5711
321 K J -2.5244
322 C J -1.5277
323 G J -1.2603
324 S J -0.9223
325 L J -0.5789
326 G J -1.3014
327 N J -1.6779
328 I J -0.7439
329 H J -1.2169
330 H J -1.1031
331 K J -2.0478
332 P J -1.2716
333 G J -0.8489
334 G J -0.9086
335 G J -0.3389
336 Q J -0.4363
337 V J -0.0224
338 E J -0.7009
339 V J -0.9250
340 K J -2.7641
341 S J -2.9955
342 E J -3.5686
343 K J -3.1310
344 L J -2.2026
345 D J -2.3626
346 F J -1.9610
347 K J -3.8820
348 D J -4.5028
349 R J -4.5052
350 V J -3.0619
351 Q J -2.4478
352 S J -0.9632
353 K J -0.8057
354 I J 0.3341
355 G J -0.0374
356 S J -0.1370
357 L J 0.0602
358 D J -1.3955
359 N J -1.1454
360 I J -0.1665
361 T J -0.2466
362 H J -0.7728
363 V J -0.0234
364 P J -0.4364
365 G J -0.8200
366 G J -0.8670
367 G J -1.0852
368 N J -2.2643
369 K J -3.0850
370 K J -2.7680
371 I J -1.0350
372 E J -0.9215
373 T J -0.8374
374 H J -1.4481
375 K J -2.1561
376 L J -0.2613
377 T J 0.8951
378 F J 2.5608

 

Laboratory of Theory of Biopolymers 2015