Project name: ced60311d8c9b2e

Chain sequence(s)	A: QSVEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYASWAKGRFTISKTSTTVVLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVGAAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGKSGYSSSGGGGSDYKDDDDK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.6951
• Maximal score value: 2.1469
• Average score: -0.6772
• Total score value: -308.8221

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.2583
2	S	A	-1.3003
3	V	A	0.0000
4	E	A	-2.4211
5	E	A	-1.6740
6	S	A	-1.2783
7	G	A	-1.2630
8	G	A	-1.0017
9	R	A	-0.4719
10	L	A	1.5024
11	V	A	0.9604
12	T	A	0.4637
13	P	A	-0.7592
14	G	A	-0.7271
15	T	A	-0.2680
16	P	A	-0.5544
17	L	A	0.0000
18	T	A	-0.9937
19	L	A	0.0000
20	T	A	-0.5317
21	C	A	0.0000
22	T	A	-0.7948
23	V	A	0.0000
24	S	A	-0.8213
25	G	A	-0.7004
26	F	A	-0.4884
27	S	A	-0.7472
28	L	A	-0.7608
29	S	A	-1.0424
30	N	A	-1.1536
31	Y	A	0.0000
32	A	A	0.2863
33	M	A	0.0000
34	S	A	0.0000
35	W	A	0.0000
36	V	A	0.0000
37	R	A	0.0000
38	Q	A	-1.0055
39	A	A	-1.5543
40	P	A	-1.3482
41	G	A	-1.5022
42	K	A	-2.2743
43	G	A	-1.1860
44	L	A	0.0062
45	E	A	-0.2800
46	W	A	0.9181
47	I	A	0.0000
48	G	A	0.7804
49	I	A	1.1645
50	V	A	0.0000
51	S	A	0.2123
52	I	A	0.0000
53	S	A	-0.8013
54	A	A	-0.2302
55	G	A	-0.2502
56	T	A	0.6534
57	Y	A	1.5330
58	Y	A	1.7765
59	A	A	0.7884
60	S	A	0.3051
61	W	A	-0.1654
62	A	A	-0.8287
63	K	A	-1.5048
64	G	A	0.0000
65	R	A	-1.9831
66	F	A	0.0000
67	T	A	-0.4393
68	I	A	-0.2917
69	S	A	-0.6717
70	K	A	-1.4279
71	T	A	-0.7837
72	S	A	-0.6292
73	T	A	-0.5603
74	T	A	-0.5522
75	V	A	0.0000
76	V	A	-0.3239
77	L	A	0.0000
78	R	A	-1.8645
79	V	A	0.0000
80	T	A	-1.1175
81	S	A	-0.7475
82	P	A	0.0000
83	T	A	-1.0367
84	T	A	-1.1636
85	E	A	-2.0439
86	D	A	-1.2536
87	T	A	-0.6238
88	A	A	0.0000
89	T	A	-0.4335
90	Y	A	0.0000
91	F	A	-0.3729
92	C	A	0.0000
93	A	A	0.0000
94	T	A	0.0000
95	G	A	0.0000
96	G	A	0.9103
97	Y	A	1.3869
98	T	A	0.7033
99	G	A	0.4193
100	N	A	-0.2034
101	V	A	1.5486
102	W	A	1.4559
103	G	A	0.3205
104	P	A	0.0589
105	G	A	0.2245
106	T	A	0.8664
107	L	A	1.4033
108	V	A	2.0023
109	T	A	1.1805
110	V	A	1.1575
111	S	A	0.5031
112	S	A	-0.3506
113	G	A	-0.7870
114	Q	A	0.0000
115	P	A	-1.1106
116	K	A	-1.3265
117	A	A	0.0000
118	P	A	-0.7096
119	S	A	0.0384
120	V	A	1.1293
121	F	A	2.1469
122	P	A	1.6708
123	L	A	1.6879
124	A	A	0.4206
125	P	A	0.0000
126	C	A	0.3295
127	C	A	-0.6675
128	G	A	-0.8903
129	D	A	-1.3719
130	T	A	-0.3943
131	P	A	-0.3744
132	S	A	0.0000
133	S	A	0.2727
134	T	A	0.7181
135	V	A	1.7571
136	T	A	0.9755
137	L	A	0.0000
138	G	A	0.0000
139	C	A	0.0000
140	L	A	-0.1300
141	V	A	0.0000
142	K	A	-0.7240
143	G	A	-0.5640
144	Y	A	0.0000
145	L	A	0.6444
146	P	A	0.0000
147	E	A	-1.0958
148	P	A	-0.8834
149	V	A	-0.5170
150	T	A	-0.4594
151	V	A	0.0000
152	T	A	-0.5185
153	W	A	0.0000
154	N	A	-0.7219
155	S	A	-0.7565
156	G	A	-0.6367
157	T	A	-0.3758
158	L	A	-0.2006
159	T	A	-0.7626
160	N	A	-1.1142
161	G	A	-0.7232
162	V	A	-0.7008
163	R	A	-1.3727
164	T	A	-0.0583
165	F	A	1.0628
166	P	A	0.2557
167	S	A	-0.3323
168	V	A	-0.3598
169	R	A	-2.2868
170	Q	A	-2.0189
171	S	A	-1.3435
172	S	A	-1.2191
173	G	A	0.0000
174	L	A	0.0000
175	Y	A	0.4429
176	S	A	0.0000
177	L	A	-0.0222
178	S	A	0.0000
179	S	A	0.2201
180	V	A	1.1340
181	V	A	1.5773
182	S	A	1.1542
183	V	A	1.0327
184	T	A	0.4469
185	S	A	0.3098
186	S	A	-0.3519
187	S	A	-0.4392
188	Q	A	-0.7663
189	P	A	-0.6845
190	V	A	-0.6384
191	T	A	-1.0944
192	C	A	0.0000
193	N	A	-1.4705
194	V	A	0.0000
195	A	A	-1.1768
196	H	A	0.0000
197	P	A	-1.2209
198	A	A	-0.2103
199	T	A	-0.4304
200	N	A	-1.5442
201	T	A	-1.0703
202	K	A	-2.2279
203	V	A	-1.4353
204	D	A	-2.5792
205	K	A	-2.0745
206	T	A	-1.2827
207	V	A	0.0000
208	G	A	-0.8234
209	A	A	-0.1894
210	A	A	-0.2292
211	P	A	-0.3359
212	S	A	-0.2286
213	T	A	0.0228
214	C	A	-0.0170
215	S	A	-0.6696
216	K	A	-1.7151
217	P	A	-0.8591
218	T	A	-0.4051
219	C	A	0.2580
220	P	A	-0.4938
221	P	A	-0.6617
222	P	A	-0.9905
223	E	A	-0.9486
224	L	A	0.8289
225	L	A	0.9975
226	G	A	-0.1088
227	G	A	-0.2563
228	P	A	0.0000
229	S	A	-0.1827
230	V	A	0.0000
231	F	A	1.4789
232	I	A	1.1169
233	F	A	1.3243
234	P	A	0.0897
235	P	A	0.0000
236	K	A	-2.1926
237	P	A	-1.4285
238	K	A	-1.2604
239	D	A	0.0000
240	T	A	0.0000
241	L	A	-0.2296
242	M	A	0.5821
243	I	A	1.5060
244	S	A	0.1197
245	R	A	-1.3601
246	T	A	-0.9982
247	P	A	0.0000
248	E	A	-1.3279
249	V	A	0.0000
250	T	A	0.3554
251	C	A	0.0000
252	V	A	0.0000
253	V	A	0.0000
254	V	A	-0.9794
255	D	A	-2.3623
256	V	A	0.0000
257	S	A	-2.2803
258	Q	A	-2.8190
259	D	A	-2.8748
260	D	A	-2.3638
261	P	A	-2.5556
262	E	A	-2.7645
263	V	A	-1.6708
264	Q	A	-1.7143
265	F	A	-1.1268
266	T	A	-1.0718
267	W	A	0.0000
268	Y	A	-2.0136
269	I	A	-2.0516
270	N	A	-3.0483
271	N	A	-3.0879
272	E	A	-2.9865
273	Q	A	-2.2979
274	V	A	-1.3726
275	R	A	-2.0674
276	T	A	-1.4043
277	A	A	-1.5406
278	R	A	-2.2107
279	P	A	-1.0043
280	P	A	-0.4868
281	L	A	0.2206
282	R	A	-1.9556
283	E	A	-2.5818
284	Q	A	-2.5336
285	Q	A	-1.2119
286	F	A	0.7282
287	N	A	-0.8447
288	S	A	-1.0503
289	T	A	-2.0147
290	I	A	-2.4692
291	R	A	-2.0201
292	V	A	0.0000
293	V	A	-0.1546
294	S	A	0.0000
295	T	A	-0.6928
296	L	A	0.0000
297	P	A	-0.8349
298	I	A	0.0000
299	A	A	-0.9398
300	H	A	-0.9828
301	Q	A	-1.9241
302	D	A	-1.9797
303	W	A	0.0000
304	L	A	-1.2799
305	R	A	-2.7367
306	G	A	-2.2614
307	K	A	-2.3810
308	E	A	-2.3076
309	F	A	0.0000
310	K	A	-2.1454
311	C	A	0.0000
312	K	A	-1.6995
313	V	A	0.0000
314	H	A	-1.3408
315	N	A	0.0000
316	K	A	-1.6490
317	A	A	-0.9931
318	L	A	0.0000
319	P	A	0.1057
320	A	A	-0.5833
321	P	A	-0.8675
322	I	A	-0.9266
323	E	A	-2.1581
324	K	A	-1.3676
325	T	A	-0.9592
326	I	A	-0.0440
327	S	A	-0.9882
328	K	A	-1.3523
329	A	A	-1.2478
330	R	A	-2.5814
331	G	A	-1.9180
332	Q	A	-1.9048
333	P	A	-1.3416
334	L	A	-1.0797
335	E	A	-2.4678
336	P	A	0.0000
337	K	A	-1.8773
338	V	A	0.0000
339	Y	A	0.8116
340	T	A	0.5107
341	M	A	0.2372
342	G	A	-0.6807
343	P	A	0.0000
344	P	A	-1.6261
345	R	A	-4.1160
346	E	A	-4.2997
347	E	A	-2.0626
348	L	A	-1.4893
349	S	A	-1.9468
350	S	A	-1.4477
351	R	A	-1.9367
352	S	A	-1.1132
353	V	A	0.0000
354	S	A	-0.3604
355	L	A	0.0000
356	A	A	-0.0285
357	C	A	0.0000
358	M	A	0.4975
359	I	A	0.0000
360	N	A	-0.3468
361	G	A	-1.1076
362	F	A	0.0000
363	Y	A	-0.6176
364	P	A	0.0000
365	S	A	0.1975
366	D	A	-1.0112
367	I	A	0.0000
368	S	A	0.0000
369	V	A	0.0000
370	E	A	-1.3009
371	W	A	0.0000
372	E	A	-1.9404
373	K	A	-1.6991
374	N	A	-2.1324
375	G	A	-2.1858
376	K	A	-2.8707
377	A	A	-2.2094
378	E	A	-2.5091
379	D	A	-3.0602
380	N	A	-2.6836
381	Y	A	-2.2045
382	K	A	-2.4326
383	T	A	-1.0767
384	T	A	-0.3293
385	P	A	0.0949
386	A	A	0.8198
387	V	A	1.7318
388	L	A	1.4199
389	D	A	-0.3502
390	S	A	-1.0201
391	D	A	-1.9799
392	G	A	-0.7881
393	S	A	0.0000
394	Y	A	0.6926
395	F	A	0.7519
396	L	A	0.0000
397	Y	A	0.4490
398	S	A	0.0000
399	K	A	-1.6191
400	L	A	0.0000
401	S	A	-1.2090
402	V	A	0.0000
403	P	A	-1.0301
404	T	A	-1.3863
405	S	A	-1.7240
406	E	A	-1.5644
407	W	A	0.0000
408	Q	A	-2.5211
409	R	A	-2.7207
410	G	A	-1.6734
411	D	A	-0.9370
412	V	A	0.3697
413	F	A	0.0000
414	T	A	-0.7284
415	C	A	0.0000
416	S	A	0.0000
417	V	A	0.0000
418	M	A	-0.5305
419	H	A	0.0000
420	E	A	-1.1070
421	A	A	-1.4012
422	L	A	0.0000
423	H	A	-2.0399
424	N	A	-1.9151
425	H	A	-1.5880
426	Y	A	-0.5418
427	T	A	-0.9269
428	Q	A	-0.9137
429	K	A	-0.9352
430	S	A	-0.2668
431	I	A	0.0000
432	S	A	-0.5894
433	R	A	-1.4639
434	S	A	-1.2245
435	P	A	-1.3446
436	G	A	-1.6534
437	K	A	-1.9590
438	S	A	-0.9708
439	G	A	-0.2982
440	Y	A	0.5371
441	S	A	-0.0551
442	S	A	-0.7172
443	S	A	-0.6834
444	G	A	-1.2730
445	G	A	-1.1022
446	G	A	-1.3651
447	G	A	-1.9801
448	S	A	-1.5018
449	D	A	-2.1427
450	Y	A	-1.8095
451	K	A	-4.2349
452	D	A	-4.3119
453	D	A	-5.1456
454	D	A	-5.6951
455	D	A	-5.2521
456	K	A	-3.8174