Project name: cfbc4c138369cde

Chain sequence(s)	A: FRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRRFHIGNEKQNYRLYYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLD
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.1555
• Maximal score value: 1.8036
• Average score: -0.3109
• Total score value: -66.8422

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
283	F	A	1.8036
284	R	A	-0.3752
285	D	A	0.0000
286	C	A	0.0000
287	A	A	0.0096
288	D	A	0.0000
289	V	A	0.0000
290	Y	A	0.4076
291	Q	A	-1.1048
292	A	A	-0.2732
293	G	A	-0.1899
294	F	A	1.2283
295	N	A	-1.1767
296	K	A	-1.9218
297	S	A	-0.4206
298	G	A	0.0116
299	I	A	0.6694
300	Y	A	0.3521
301	T	A	-0.2489
302	I	A	0.0000
303	Y	A	1.3000
304	I	A	0.0000
305	N	A	-1.5066
306	N	A	-1.4783
307	M	A	-0.1256
308	P	A	-0.5641
309	E	A	-1.8927
310	P	A	-0.3776
311	K	A	-0.6004
312	K	A	-1.7552
313	V	A	0.0000
314	F	A	0.5588
315	C	A	0.0000
316	N	A	-0.1873
317	M	A	0.0000
318	D	A	-1.7555
319	V	A	-0.3786
320	N	A	-1.3252
321	G	A	-0.7020
322	G	A	0.0000
323	G	A	0.0000
324	W	A	0.0000
325	T	A	0.0000
326	V	A	0.0000
327	I	A	0.0000
328	Q	A	0.0000
329	H	A	-0.1990
330	R	A	0.0000
331	E	A	-2.1501
332	D	A	-2.1555
333	G	A	-0.5511
334	S	A	-0.2017
335	L	A	-0.0354
336	D	A	-1.2574
337	F	A	0.0000
338	Q	A	-0.8265
339	R	A	-0.6080
340	G	A	-0.1263
341	W	A	-0.1803
342	K	A	-1.8405
343	E	A	-1.0650
344	Y	A	0.0000
345	K	A	-0.3779
346	M	A	0.3152
347	G	A	-0.0021
348	F	A	0.1222
349	G	A	-0.5276
350	N	A	-1.3398
351	P	A	-0.2982
352	S	A	-0.2577
353	G	A	-0.2515
354	E	A	0.0000
355	Y	A	0.0000
356	W	A	0.0000
357	L	A	0.0000
358	G	A	0.0000
359	N	A	0.0000
360	E	A	-0.2833
361	F	A	0.0000
362	I	A	0.0000
363	F	A	0.3515
364	A	A	0.0000
365	I	A	0.0000
366	T	A	0.0000
367	S	A	-0.2551
368	Q	A	-0.3537
369	R	A	-0.7107
370	Q	A	-1.2810
371	Y	A	0.0000
372	M	A	-0.2731
373	L	A	0.0000
374	R	A	0.0000
375	I	A	0.0000
376	E	A	0.0000
377	L	A	0.0000
378	M	A	0.0214
379	D	A	0.0000
380	W	A	-0.0880
381	E	A	-1.8609
382	G	A	-1.0087
383	N	A	-1.5440
384	R	A	-1.9483
385	A	A	0.0000
386	Y	A	0.4592
387	S	A	0.0000
388	Q	A	-0.1945
389	Y	A	0.0000
390	D	A	-2.1233
391	R	A	-2.0773
392	F	A	0.0000
393	H	A	-0.9901
394	I	A	0.0000
395	G	A	-0.2134
396	N	A	-0.4197
397	E	A	-0.9821
398	K	A	-2.0290
399	Q	A	-1.5780
400	N	A	-0.6279
401	Y	A	0.0000
402	R	A	-0.9098
403	L	A	0.0000
404	Y	A	0.9522
405	L	A	0.0000
406	K	A	-1.7384
407	G	A	-0.7380
408	H	A	-0.2290
409	T	A	-0.1548
410	G	A	-0.3118
411	T	A	-0.1241
412	A	A	0.0000
413	G	A	-0.2523
414	K	A	-1.9274
415	Q	A	-1.4849
416	S	A	-0.2379
417	S	A	0.0000
418	L	A	0.0000
419	I	A	0.3480
420	L	A	0.2017
421	H	A	-0.9407
422	G	A	-0.2584
423	A	A	0.0000
424	D	A	-0.3362
425	F	A	0.0000
426	S	A	0.0000
427	T	A	0.0000
428	K	A	-1.3652
429	D	A	-1.9784
430	A	A	-0.6545
431	D	A	-1.8361
432	N	A	-0.6350
433	D	A	-0.5181
434	N	A	-1.3443
435	C	A	0.0867
436	M	A	1.1043
437	C	A	0.1047
438	K	A	-1.3158
439	C	A	0.0000
440	A	A	0.0000
441	L	A	1.4062
442	M	A	1.0108
443	L	A	0.0000
444	T	A	-0.0080
445	G	A	0.0000
446	G	A	0.0000
447	W	A	0.0000
448	W	A	0.0000
449	F	A	0.0000
450	D	A	-0.6176
451	A	A	0.0074
452	C	A	0.0094
453	G	A	-0.1729
454	P	A	-0.0622
455	S	A	0.0000
456	N	A	0.0000
457	L	A	0.0000
458	N	A	0.0000
459	G	A	0.0000
460	M	A	0.3785
461	F	A	0.4192
462	Y	A	0.2856
463	T	A	-0.0159
464	A	A	0.0455
465	G	A	0.0000
466	Q	A	-0.6749
467	N	A	-1.5376
468	H	A	-1.2721
469	G	A	-0.9518
470	K	A	-1.4909
471	L	A	1.1808
472	N	A	0.1072
473	G	A	0.0000
474	I	A	0.0000
475	K	A	0.0000
476	W	A	0.0000
477	H	A	-0.1005
478	Y	A	0.7635
479	F	A	0.3283
480	K	A	-0.5425
481	G	A	-0.2596
482	P	A	-0.3039
483	S	A	-0.0632
484	Y	A	0.0991
485	S	A	0.0000
486	L	A	0.0000
487	R	A	-0.4708
488	S	A	-0.3499
489	T	A	0.0000
490	T	A	-0.0338
491	M	A	0.0000
492	M	A	0.0000
493	I	A	0.0000
494	R	A	-0.2711
495	P	A	0.0000
496	L	A	0.3244
497	D	A	-1.6720