Project name: 4hkz:B

Chain sequence(s)	B: EVQLVESGGGLVQPGGSLRLSSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCCSRWGGDGFYAMDYWGQGTLVTVSSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8766
• Maximal score value: 2.4909
• Average score: -0.5841
• Total score value: -129.0953

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	B	-2.1093
2	V	B	-1.3606
3	Q	B	-1.1180
4	L	B	0.0000
5	V	B	0.6753
6	E	B	0.0000
7	S	B	-0.4430
8	G	B	-0.8214
9	G	B	-0.4305
10	G	B	-0.4685
11	L	B	-0.1246
12	V	B	0.0000
13	Q	B	-1.6558
14	P	B	-1.7216
15	G	B	-1.4336
16	G	B	-1.1409
17	S	B	-1.2367
18	L	B	-1.0139
19	R	B	-1.8008
20	L	B	0.0000
21	S	B	-0.3639
22	C	B	0.0000
23	A	B	-0.1812
24	A	B	0.0000
25	S	B	-1.1610
26	G	B	-1.3930
27	F	B	-1.5333
28	N	B	-2.0512
29	I	B	0.0000
30	K	B	-2.3869
31	D	B	-2.7049
32	T	B	0.0000
33	Y	B	-0.0109
34	I	B	0.0000
35	H	B	0.0000
36	W	B	0.0000
37	V	B	0.0000
38	R	B	0.0000
39	Q	B	-0.5163
40	A	B	-1.1309
41	P	B	-1.0678
42	G	B	-1.4221
43	K	B	-2.1146
44	G	B	-1.0080
45	L	B	0.4765
46	E	B	-0.4154
47	W	B	0.1474
48	V	B	0.0000
49	A	B	0.0000
50	R	B	-0.9651
51	I	B	0.0000
52	Y	B	-0.4080
53	P	B	-1.0186
54	T	B	-1.0967
55	N	B	-0.9452
56	G	B	-0.4049
57	Y	B	0.4087
58	T	B	-0.6330
59	R	B	-2.1457
60	Y	B	-1.8803
61	A	B	-1.7714
62	D	B	-2.6513
63	S	B	-1.6099
64	V	B	0.0000
65	K	B	-2.8766
66	G	B	-1.8073
67	R	B	-1.4501
68	F	B	0.0000
69	T	B	-1.1395
70	I	B	0.0000
71	S	B	-0.2098
72	A	B	-0.7665
73	D	B	-1.4342
74	T	B	-1.5044
75	S	B	-1.5228
76	K	B	-2.2204
77	N	B	-1.6808
78	T	B	-0.8953
79	A	B	0.0000
80	Y	B	-0.4481
81	L	B	0.0000
82	Q	B	-1.0555
83	M	B	0.0000
84	N	B	-1.4018
85	S	B	-1.2643
86	L	B	0.0000
87	R	B	-2.3673
88	A	B	-1.7550
89	E	B	-2.2356
90	D	B	0.0000
91	T	B	-0.7936
92	A	B	0.0000
93	V	B	0.4312
94	Y	B	0.0000
95	Y	B	0.3862
96	C	B	0.0000
97	S	B	0.0000
98	R	B	0.0000
99	W	B	0.6266
100	G	B	0.3772
101	G	B	0.0000
102	D	B	-1.5444
103	G	B	-0.2402
104	F	B	1.7592
105	Y	B	1.9091
106	A	B	1.2384
107	M	B	0.8830
108	D	B	0.1873
109	Y	B	0.0899
110	W	B	0.2824
111	G	B	-0.1059
112	Q	B	-0.8586
113	G	B	-0.2042
114	T	B	-0.0229
115	L	B	0.1798
116	V	B	0.0000
117	T	B	-0.4650
118	V	B	0.0000
119	S	B	-0.8116
120	S	B	-0.7211
121	A	B	-0.4675
122	S	B	-0.5751
123	T	B	-0.7540
124	K	B	-1.2648
125	G	B	-1.5403
126	P	B	-0.6943
127	S	B	-0.1457
128	V	B	0.0000
129	F	B	1.1494
130	P	B	0.0623
131	L	B	0.3704
132	A	B	-1.0757
133	P	B	0.0000
134	S	B	-1.3901
135	S	B	-1.2016
136	K	B	-1.9221
137	S	B	-1.0234
138	T	B	-1.0087
139	S	B	-0.9448
140	G	B	-0.8560
141	G	B	-0.9184
142	T	B	-0.6329
143	A	B	0.0000
144	A	B	-0.2121
145	L	B	0.0000
146	G	B	0.0000
147	C	B	0.0000
148	L	B	0.7184
149	V	B	0.0000
150	K	B	-0.3171
151	D	B	-0.6040
152	Y	B	0.0000
153	F	B	0.0000
154	P	B	0.0000
155	E	B	-0.4491
156	P	B	-0.7726
157	V	B	-0.7315
158	T	B	-0.6479
159	V	B	-0.4949
160	S	B	-0.4286
161	W	B	0.0000
162	N	B	-0.8198
163	S	B	-0.6975
164	G	B	-0.6180
165	A	B	-0.2897
166	L	B	-0.0827
167	T	B	-0.3124
168	S	B	-0.3577
169	G	B	-0.4388
170	V	B	0.0640
171	H	B	-0.3311
172	T	B	0.2838
173	F	B	1.0116
174	P	B	0.7481
175	A	B	1.2925
176	V	B	2.4909
177	L	B	2.1787
178	Q	B	0.7513
179	S	B	0.1272
180	S	B	-0.2175
181	G	B	0.2201
182	L	B	0.2557
183	Y	B	0.8125
184	S	B	0.0000
185	L	B	0.0000
186	S	B	0.6706
187	S	B	0.0000
188	V	B	0.4680
189	V	B	0.0000
190	T	B	-0.2181
191	V	B	0.0000
192	P	B	-0.6280
193	S	B	-0.5713
194	S	B	-0.5319
195	S	B	-0.5376
196	L	B	-0.6788
197	G	B	-1.0559
198	T	B	-0.7366
199	Q	B	-1.3117
200	T	B	-1.1671
201	Y	B	0.0000
202	I	B	-1.3240
203	C	B	0.0000
204	N	B	-1.5481
205	V	B	0.0000
206	N	B	-2.1288
207	H	B	0.0000
208	K	B	-2.8333
209	P	B	-1.6338
210	S	B	-1.8922
211	N	B	-2.6079
212	T	B	-2.1575
213	K	B	-2.7505
214	V	B	-1.7013
215	D	B	-2.4180
216	K	B	-2.0186
217	K	B	-2.4258
218	V	B	0.0000
219	E	B	-2.8621
220	P	B	-1.9221
221	K	B	-2.2561