Project name: d73e32b5fd9d3e7

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSNSEEDMMETTTEFEYEAGACPFQVLKISNNKSLIINCTNECGYGLSDGEPCVNATNPPLNFTVRGDYNCTVGSCRNGTCPSNGTVEFCWANKTNSEKRPSARSYSVQLYGGGGSLDLHTLIQNPSLSLYQDPSRFVTNKSDIYLLRASIPADTARLLPPKTPCVRSRYWTNDTEKVERSLDVYNKINHSGSESYNITLTIQKDDWTTILYINPKGKNITILNVSDVYIGISSRAGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0653
• Maximal score value: 1.9346
• Average score: -0.8552
• Total score value: -454.9855

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.1716
2	H	A	0.0000
3	H	A	-2.9059
4	E	A	-3.7092
5	G	A	-2.3949
6	Q	A	-2.5986
7	P	A	-2.0837
8	R	A	-0.9718
9	S	A	-0.3351
10	V	A	0.0019
11	C	A	0.0637
12	A	A	-0.1774
13	L	A	0.0000
14	E	A	0.0000
15	E	A	0.0000
16	N	A	-1.0835
17	A	A	0.0000
18	K	A	-1.1394
19	R	A	-1.5529
20	A	A	-0.9013
21	L	A	0.0000
22	I	A	-0.3273
23	S	A	-0.6278
24	C	A	-0.6201
25	V	A	0.0000
26	Q	A	-1.0395
27	T	A	-0.7569
28	H	A	-1.3257
29	L	A	0.0000
30	T	A	-1.3331
31	A	A	-1.3347
32	D	A	-2.3201
33	T	A	0.0000
34	T	A	-1.6133
35	Q	A	-2.0942
36	K	A	-1.1900
37	L	A	0.0000
38	S	A	-1.4958
39	A	A	-1.3417
40	V	A	0.0000
41	K	A	-2.3338
42	D	A	-3.1617
43	Q	A	-2.2863
44	L	A	-1.6620
45	H	A	-2.4124
46	C	A	-1.9847
47	D	A	-2.4540
48	D	A	-1.7050
49	V	A	0.0000
50	Y	A	-0.6234
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	-0.9374
56	I	A	-0.7470
57	C	A	0.0000
58	D	A	0.0000
59	R	A	-1.6161
60	N	A	-1.5067
61	N	A	-1.8228
62	G	A	-1.2802
63	T	A	-0.5876
64	L	A	0.0763
65	E	A	0.0000
66	H	A	-1.3064
67	P	A	-1.1764
68	S	A	-1.0128
69	N	A	-1.2492
70	E	A	-1.7961
71	F	A	-0.0461
72	F	A	0.0000
73	S	A	-1.1697
74	N	A	-1.8953
75	A	A	-1.2315
76	E	A	-1.5365
77	K	A	-1.1823
78	T	A	-1.3724
79	D	A	-2.0887
80	I	A	0.0000
81	R	A	-1.1168
82	S	A	-0.9674
83	A	A	0.0000
84	V	A	0.0000
85	V	A	-0.2651
86	T	A	-0.8605
87	C	A	0.0000
88	R	A	-1.7773
89	E	A	-2.8042
90	N	A	-2.2814
91	L	A	-2.1537
92	Q	A	-2.9655
93	R	A	-3.3660
94	Q	A	-2.5247
95	A	A	-1.8724
96	E	A	-2.6235
97	A	A	-1.7594
98	A	A	-0.9766
99	K	A	0.0000
100	T	A	0.0000
101	S	A	-0.1901
102	G	A	0.0000
103	G	A	0.0000
104	G	A	-0.5389
105	G	A	0.0000
106	S	A	0.0000
107	N	A	0.0000
108	S	A	-1.7293
109	E	A	0.0000
110	E	A	-3.2836
111	D	A	0.0000
112	M	A	0.0000
113	M	A	0.0000
114	E	A	-2.9632
115	T	A	0.0000
116	T	A	0.0000
117	T	A	-1.0207
118	E	A	-1.4622
119	F	A	-0.6501
120	E	A	-1.6205
121	Y	A	-1.1320
122	E	A	-1.9093
123	A	A	-1.0254
124	G	A	0.1545
125	A	A	0.1545
126	C	A	0.0000
127	P	A	0.4208
128	F	A	1.2011
129	Q	A	0.4034
130	V	A	0.4494
131	L	A	0.0000
132	K	A	-3.1300
133	I	A	-2.4106
134	S	A	-2.2863
135	N	A	-3.2035
136	N	A	-3.3948
137	K	A	-3.5045
138	S	A	-1.9552
139	L	A	0.0000
140	I	A	0.2892
141	I	A	0.0000
142	N	A	0.2175
143	C	A	0.0000
144	T	A	-0.6964
145	N	A	-1.4630
146	E	A	-1.6434
147	C	A	0.0000
148	G	A	-0.6938
149	Y	A	-0.4953
150	G	A	-1.1562
151	L	A	-1.2082
152	S	A	-1.4459
153	D	A	-2.5666
154	G	A	-2.0977
155	E	A	-2.3112
156	P	A	-1.2262
157	C	A	0.0000
158	V	A	-0.0043
159	N	A	0.0431
160	A	A	0.0000
161	T	A	-0.6456
162	N	A	-0.5634
163	P	A	-0.7165
164	P	A	-0.1876
165	L	A	0.8924
166	N	A	-0.3094
167	F	A	0.1651
168	T	A	-1.3142
169	V	A	-2.4370
170	R	A	-4.0653
171	G	A	-2.9619
172	D	A	-2.4962
173	Y	A	-0.9886
174	N	A	0.0000
175	C	A	0.0000
176	T	A	0.7919
177	V	A	1.0297
178	G	A	0.0000
179	S	A	0.0000
180	C	A	0.0000
181	R	A	-2.0948
182	N	A	-2.0775
183	G	A	-1.5558
184	T	A	-1.1061
185	C	A	0.0000
186	P	A	-0.8393
187	S	A	-1.0890
188	N	A	-1.7149
189	G	A	-1.4085
190	T	A	-0.5352
191	V	A	-0.3936
192	E	A	-0.9737
193	F	A	1.3848
194	C	A	1.0275
195	W	A	0.7551
196	A	A	0.0000
197	N	A	-1.6234
198	K	A	-2.0069
199	T	A	-2.2133
200	N	A	-2.6434
201	S	A	-2.1369
202	E	A	-2.9949
203	K	A	-3.3269
204	R	A	-2.9169
205	P	A	-1.7730
206	S	A	-1.7334
207	A	A	-1.4053
208	R	A	-2.1372
209	S	A	-1.2405
210	Y	A	-1.1161
211	S	A	0.0000
212	V	A	0.0000
213	Q	A	0.0000
214	L	A	0.0000
215	Y	A	0.0000
216	G	A	-0.2164
217	G	A	-0.2037
218	G	A	0.0000
219	G	A	0.0000
220	S	A	0.0000
221	L	A	0.2831
222	D	A	0.0000
223	L	A	0.0000
224	H	A	0.0000
225	T	A	-0.0307
226	L	A	0.0000
227	I	A	0.0000
228	Q	A	0.0000
229	N	A	-0.1986
230	P	A	0.3137
231	S	A	0.5599
232	L	A	0.8337
233	S	A	0.8170
234	L	A	1.9346
235	Y	A	1.5556
236	Q	A	0.0209
237	D	A	-1.3876
238	P	A	-1.3294
239	S	A	-2.0226
240	R	A	-2.3168
241	F	A	-1.4386
242	V	A	-1.8134
243	T	A	-1.7998
244	N	A	-2.3751
245	K	A	-2.3428
246	S	A	-1.8025
247	D	A	-1.3440
248	I	A	0.0000
249	Y	A	-0.0759
250	L	A	0.0000
251	L	A	0.0539
252	R	A	0.0000
253	A	A	0.0000
254	S	A	0.0000
255	I	A	0.0000
256	P	A	-1.4422
257	A	A	-1.7327
258	D	A	-2.0128
259	T	A	-0.8859
260	A	A	-1.1269
261	R	A	-1.4430
262	L	A	0.5165
263	L	A	0.2910
264	P	A	-0.1021
265	P	A	-0.1501
266	K	A	-0.7402
267	T	A	0.0000
268	P	A	-0.0614
269	C	A	-0.3059
270	V	A	0.0000
271	R	A	-2.4701
272	S	A	0.0000
273	R	A	-2.2626
274	Y	A	-1.0925
275	W	A	-0.5676
276	T	A	-1.5611
277	N	A	-2.5452
278	D	A	-2.8479
279	T	A	-2.4212
280	E	A	-2.8172
281	K	A	-2.8866
282	V	A	0.0000
283	E	A	-1.2416
284	R	A	0.0000
285	S	A	-1.3976
286	L	A	0.0000
287	D	A	-1.6784
288	V	A	0.0000
289	Y	A	-0.6013
290	N	A	0.0000
291	K	A	-1.3118
292	I	A	0.0000
293	N	A	-2.0466
294	H	A	-1.8117
295	S	A	-1.4999
296	G	A	-1.8026
297	S	A	0.0000
298	E	A	-1.9532
299	S	A	-1.1545
300	Y	A	-1.3677
301	N	A	-1.9484
302	I	A	0.0000
303	T	A	-0.9245
304	L	A	0.0000
305	T	A	0.0000
306	I	A	0.0000
307	Q	A	-2.5797
308	K	A	-3.2066
309	D	A	-3.4324
310	D	A	-3.1825
311	W	A	-1.8023
312	T	A	-1.7241
313	T	A	0.0000
314	I	A	0.0000
315	L	A	0.0000
316	Y	A	0.0000
317	I	A	0.0000
318	N	A	0.0000
319	P	A	-1.4300
320	K	A	-2.3132
321	G	A	-1.8699
322	K	A	-1.7873
323	N	A	-1.0343
324	I	A	0.0000
325	T	A	0.0000
326	I	A	0.0000
327	L	A	0.0000
328	N	A	-1.1824
329	V	A	0.0000
330	S	A	-1.6271
331	D	A	-2.1472
332	V	A	-1.0196
333	Y	A	0.9348
334	I	A	0.8830
335	G	A	0.0000
336	I	A	0.0000
337	S	A	0.0000
338	S	A	0.0000
339	R	A	0.0000
340	A	A	-0.6658
341	G	A	-1.5179
342	G	A	-1.3927
343	G	A	-1.5271
344	G	A	-1.1276
345	S	A	0.0000
346	S	A	0.0000
347	E	A	0.0000
348	I	A	0.0000
349	K	A	0.1086
350	Y	A	0.0424
351	H	A	0.0000
352	N	A	0.0000
353	Y	A	-0.4487
354	N	A	-1.0627
355	S	A	-0.5169
356	N	A	0.0000
357	G	A	-0.7822
358	F	A	-0.8442
359	N	A	-1.8956
360	P	A	0.0000
361	K	A	-2.7580
362	G	A	-2.2233
363	P	A	-1.7391
364	G	A	-1.5527
365	P	A	-1.5892
366	G	A	0.0000
367	I	A	0.0000
368	L	A	0.0019
369	F	A	0.0000
370	G	A	-0.6837
371	D	A	-1.3144
372	A	A	0.0000
373	F	A	0.7573
374	I	A	0.8770
375	P	A	0.0000
376	A	A	0.9139
377	I	A	0.0000
378	V	A	1.1581
379	Q	A	0.6245
380	P	A	0.0000
381	V	A	0.0000
382	S	A	0.0000
383	Q	A	0.1758
384	I	A	1.3239
385	F	A	0.8327
386	P	A	-0.0289
387	G	A	-0.4760
388	P	A	-0.4893
389	G	A	0.0000
390	P	A	0.2972
391	G	A	0.0966
392	I	A	0.7904
393	L	A	1.1774
394	F	A	0.6091
395	N	A	0.1499
396	S	A	0.0000
397	L	A	0.0000
398	Q	A	0.0000
399	Y	A	0.2458
400	T	A	0.0089
401	N	A	-0.9589
402	V	A	0.0000
403	V	A	-0.0502
404	K	A	-0.6314
405	D	A	-1.4427
406	Y	A	-0.0316
407	W	A	-0.3664
408	G	A	-0.6225
409	N	A	0.0000
410	D	A	-0.5573
411	L	A	-0.2804
412	G	A	0.0000
413	P	A	-1.0515
414	G	A	0.0000
415	P	A	-1.3004
416	G	A	-1.7322
417	K	A	-2.8182
418	E	A	-2.6643
419	T	A	-1.3075
420	V	A	-0.4011
421	L	A	-0.1075
422	R	A	-0.3716
423	V	A	0.0000
424	A	A	0.0000
425	V	A	0.0000
426	T	A	-0.4688
427	A	A	-1.0124
428	Q	A	-2.0556
429	H	A	-2.0098
430	P	A	-2.0272
431	K	A	-2.5077
432	P	A	-1.7806
433	A	A	-0.9503
434	S	A	-0.3338
435	L	A	0.3195
436	M	A	0.0000
437	G	A	0.0000
438	P	A	0.0000
439	G	A	-0.4443
440	P	A	-0.3730
441	G	A	0.0000
442	Y	A	0.0000
443	D	A	0.0000
444	A	A	-0.3945
445	G	A	0.0000
446	I	A	0.0000
447	E	A	0.0000
448	L	A	0.0000
449	A	A	-0.2370
450	H	A	0.0000
451	L	A	0.0000
452	L	A	0.0000
453	A	A	0.0000
454	F	A	-0.6868
455	N	A	-1.8382
456	K	A	0.0000
457	Y	A	-1.6063
458	G	A	0.0000
459	P	A	-1.8350
460	G	A	-1.6249
461	P	A	-1.3184
462	G	A	-1.7024
463	H	A	-2.3436
464	D	A	-2.6770
465	K	A	-3.3669
466	K	A	-3.3704
467	Q	A	-2.9089
468	F	A	0.0000
469	A	A	-1.0909
470	A	A	0.0000
471	L	A	0.0000
472	M	A	0.0000
473	L	A	0.0000
474	Y	A	-0.5821
475	E	A	-1.3944
476	E	A	-2.5254
477	D	A	-2.7649
478	G	A	-1.9932
479	T	A	-1.9802
480	L	A	0.0000
481	R	A	-2.4892
482	V	A	0.0000
483	E	A	-2.5062
484	G	A	0.0000
485	V	A	0.0000
486	G	A	-1.5334
487	P	A	-1.6554
488	G	A	-1.1801
489	P	A	-1.1089
490	G	A	-1.8638
491	K	A	-3.0924
492	R	A	-3.6127
493	H	A	-3.3426
494	G	A	-2.5974
495	K	A	-3.3478
496	R	A	-3.3821
497	L	A	-1.8076
498	R	A	-1.9762
499	V	A	-0.5849
500	T	A	-0.8901
501	K	A	-1.1105
502	V	A	0.0000
503	I	A	0.0000
504	P	A	-0.1525
505	H	A	-0.0226
506	A	A	0.2730
507	K	A	-0.0986
508	Y	A	-0.3536
509	N	A	-1.5813
510	E	A	-1.7075
511	K	A	-2.4867
512	S	A	-2.1298
513	E	A	-2.5207
514	A	A	-1.5472
515	A	A	0.0000
516	A	A	-1.6997
517	K	A	-1.7679
518	F	A	-0.3788
519	Y	A	-0.3718
520	P	A	-0.4898
521	S	A	-0.4922
522	Y	A	-0.1985
523	H	A	-0.9236
524	S	A	-0.7183
525	T	A	-0.3333
526	P	A	-0.1367
527	Q	A	-0.7305
528	R	A	-0.4301
529	P	A	-0.3830
530	G	A	-0.5550
531	T	A	-0.6055
532	P	A	-0.4993