Project name: d8173ea557277eb

Chain sequence(s)	A: SIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPAFVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGPAAPTADATLINGLGRSINTLNADLAVITVTKGKRYRFRLVSLSCDPNYTFSIDGHSLTVIEADGVNLKPQTVDSIQIFPAQRYSFVLNADQDVDNYWIRALPNSGTRNFDGGVNSAILRYEGAAPVEPTTSQTPSTQPLVESALTTLEGTAAPGNPTPGGVDLALNMAFGFAGGRFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATSAAPGFPHPFHLHGHTFAVVRSAGSSTYNYANPVYRDVVNTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLDAGFAVVMAEDTPDVAATNPVPQAWSDLCPTYDALSPDDQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.501
• Maximal score value: 1.3971
• Average score: -0.4812
• Total score value: -238.6622

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	S	A	-0.4384
2	I	A	0.3731
3	G	A	0.0497
4	P	A	-0.2454
5	V	A	0.8897
6	A	A	0.0496
7	D	A	-1.2437
8	L	A	0.0000
9	T	A	-0.9649
10	I	A	0.0000
11	S	A	-0.9890
12	N	A	-1.0514
13	G	A	-0.7660
14	A	A	-0.3081
15	V	A	0.0133
16	S	A	0.0585
17	P	A	0.0000
18	D	A	0.0000
19	G	A	-0.5512
20	F	A	0.5671
21	S	A	-0.0310
22	R	A	0.0000
23	Q	A	-1.1842
24	A	A	0.0000
25	I	A	0.0000
26	L	A	-0.5944
27	V	A	0.0000
28	N	A	-1.2761
29	D	A	-1.6096
30	V	A	-0.0166
31	F	A	0.2007
32	P	A	0.1874
33	S	A	0.0000
34	P	A	-0.0021
35	L	A	-0.1713
36	I	A	0.0000
37	T	A	-0.4026
38	G	A	-0.8456
39	N	A	-1.9244
40	K	A	-2.7140
41	G	A	-2.5581
42	D	A	-2.5411
43	R	A	-2.6651
44	F	A	0.0000
45	Q	A	-0.5532
46	L	A	0.0000
47	N	A	-0.2733
48	V	A	0.0000
49	I	A	-0.3130
50	D	A	0.0000
51	N	A	-1.5250
52	M	A	0.0000
53	T	A	-1.2486
54	N	A	-1.4308
55	H	A	-1.4575
56	T	A	-0.7114
57	M	A	0.0000
58	L	A	-0.9124
59	K	A	-1.3197
60	S	A	0.0000
61	T	A	0.0000
62	S	A	0.0000
63	I	A	0.0000
64	H	A	0.0000
65	W	A	0.0000
66	H	A	0.0000
67	G	A	0.0541
68	F	A	0.0000
69	F	A	-0.3845
70	Q	A	0.0000
71	H	A	-1.3215
72	G	A	-0.5883
73	T	A	-0.4442
74	N	A	0.0000
75	W	A	0.0000
76	A	A	0.0000
77	D	A	0.0000
78	G	A	0.0000
79	P	A	0.0000
80	A	A	0.0000
81	F	A	0.3222
82	V	A	0.0000
83	N	A	0.0000
84	Q	A	0.0000
85	C	A	0.0000
86	P	A	0.0000
87	I	A	0.0000
88	S	A	0.0000
89	T	A	-0.9544
90	G	A	-1.1016
91	H	A	-0.9328
92	A	A	-0.3502
93	F	A	0.0000
94	L	A	0.3500
95	Y	A	0.0000
96	D	A	-0.6328
97	F	A	0.0000
98	Q	A	-2.8332
99	V	A	0.0000
100	P	A	-2.4482
101	D	A	-2.3902
102	Q	A	-1.5766
103	A	A	-1.0408
104	G	A	0.0000
105	T	A	0.0000
106	F	A	0.0000
107	W	A	0.0000
108	Y	A	0.0000
109	H	A	0.0000
110	S	A	0.0000
111	H	A	0.0000
112	L	A	0.0000
113	S	A	-0.5496
114	T	A	0.0000
115	Q	A	0.0000
116	Y	A	0.0000
117	C	A	0.0000
118	D	A	0.0000
119	G	A	0.0000
120	L	A	0.0000
121	R	A	0.0000
122	G	A	0.0000
123	P	A	0.0000
124	I	A	0.0000
125	V	A	0.0000
126	V	A	0.0000
127	Y	A	-0.9100
128	D	A	-1.5314
129	P	A	-1.4949
130	Q	A	-1.9020
131	D	A	-1.6166
132	P	A	-1.1248
133	H	A	0.0000
134	K	A	-2.1449
135	S	A	-1.0958
136	L	A	-0.6178
137	Y	A	-1.3547
138	D	A	-2.0865
139	V	A	-1.4632
140	D	A	-1.6328
141	D	A	-2.0361
142	D	A	-2.4168
143	S	A	-1.3424
144	T	A	0.0000
145	V	A	0.0000
146	I	A	0.0000
147	T	A	0.0000
148	L	A	0.0000
149	A	A	0.0000
150	D	A	0.0000
151	W	A	0.0000
152	Y	A	0.0000
153	H	A	0.6670
154	L	A	1.3971
155	A	A	0.5568
156	A	A	-0.0289
157	K	A	-0.6914
158	V	A	1.1707
159	G	A	0.6316
160	P	A	-0.0018
161	A	A	-0.3642
162	A	A	-0.4208
163	P	A	-0.0698
164	T	A	-0.2728
165	A	A	-0.3185
166	D	A	-0.2052
167	A	A	0.0000
168	T	A	0.0000
169	L	A	0.0000
170	I	A	0.0000
171	N	A	-0.0797
172	G	A	0.0000
173	L	A	0.0145
174	G	A	0.0000
175	R	A	0.0000
176	S	A	0.0000
177	I	A	0.9810
178	N	A	-0.3439
179	T	A	-0.3344
180	L	A	-0.5302
181	N	A	-1.5456
182	A	A	-1.4174
183	D	A	-1.8593
184	L	A	0.0000
185	A	A	0.0000
186	V	A	0.6361
187	I	A	0.0000
188	T	A	-0.5910
189	V	A	0.0000
190	T	A	-1.9646
191	K	A	-3.2148
192	G	A	-2.8284
193	K	A	-2.6324
194	R	A	-2.3426
195	Y	A	0.0000
196	R	A	0.0000
197	F	A	0.0000
198	R	A	0.0000
199	L	A	0.0000
200	V	A	0.0000
201	S	A	0.0000
202	L	A	0.0000
203	S	A	0.0000
204	C	A	0.0000
205	D	A	-0.3459
206	P	A	0.0000
207	N	A	0.0000
208	Y	A	0.0000
209	T	A	-0.4132
210	F	A	0.0000
211	S	A	-0.4596
212	I	A	0.0000
213	D	A	0.0000
214	G	A	-1.2623
215	H	A	0.0000
216	S	A	-0.8158
217	L	A	0.0000
218	T	A	-0.5758
219	V	A	0.0000
220	I	A	0.0000
221	E	A	0.0000
222	A	A	0.0000
223	D	A	0.0000
224	G	A	-0.0896
225	V	A	-0.2367
226	N	A	-0.8057
227	L	A	0.0000
228	K	A	-1.9589
229	P	A	-0.9700
230	Q	A	-0.7792
231	T	A	-0.7272
232	V	A	0.0000
233	D	A	-0.9445
234	S	A	0.0000
235	I	A	0.0000
236	Q	A	-0.6481
237	I	A	0.0000
238	F	A	-0.1686
239	P	A	0.0000
240	A	A	0.0000
241	Q	A	0.0000
242	R	A	0.0000
243	Y	A	0.0000
244	S	A	0.0000
245	F	A	0.0000
246	V	A	0.0000
247	L	A	0.0000
248	N	A	-2.7492
249	A	A	0.0000
250	D	A	-3.5010
251	Q	A	-2.8158
252	D	A	-2.5420
253	V	A	-1.4430
254	D	A	-1.5281
255	N	A	0.0000
256	Y	A	0.0000
257	W	A	-0.2512
258	I	A	0.0000
259	R	A	0.0000
260	A	A	0.0000
261	L	A	-0.7015
262	P	A	0.0000
263	N	A	-1.3700
264	S	A	-1.1331
265	G	A	-1.3320
266	T	A	-1.4083
267	R	A	-2.6964
268	N	A	-2.2020
269	F	A	-1.3780
270	D	A	-1.8260
271	G	A	-0.8931
272	G	A	0.0000
273	V	A	0.0000
274	N	A	0.0000
275	S	A	0.0000
276	A	A	0.0000
277	I	A	0.0000
278	L	A	0.0000
279	R	A	-0.7252
280	Y	A	0.0000
281	E	A	-2.2923
282	G	A	-1.4850
283	A	A	-0.8570
284	A	A	-0.1735
285	P	A	0.2354
286	V	A	0.8405
287	E	A	-0.4499
288	P	A	0.0000
289	T	A	-0.4367
290	T	A	-0.7595
291	S	A	-0.8804
292	Q	A	-1.4289
293	T	A	-0.9714
294	P	A	-0.8208
295	S	A	-0.9190
296	T	A	-0.8193
297	Q	A	-1.1932
298	P	A	-0.5610
299	L	A	0.2084
300	V	A	1.1253
301	E	A	0.3275
302	S	A	0.1865
303	A	A	0.2885
304	L	A	0.0000
305	T	A	-1.0078
306	T	A	0.0000
307	L	A	-1.2146
308	E	A	-2.0342
309	G	A	-1.4459
310	T	A	-0.8182
311	A	A	-0.7166
312	A	A	-0.6941
313	P	A	-0.8821
314	G	A	-1.4850
315	N	A	-1.7481
316	P	A	-0.9269
317	T	A	-0.7341
318	P	A	-0.6675
319	G	A	-1.0401
320	G	A	-1.2477
321	V	A	-1.3999
322	D	A	-2.1492
323	L	A	-0.5015
324	A	A	-0.4604
325	L	A	-0.2868
326	N	A	-1.2092
327	M	A	0.0000
328	A	A	-0.6501
329	F	A	0.0000
330	G	A	-0.0589
331	F	A	0.2552
332	A	A	-0.2095
333	G	A	-0.7184
334	G	A	-0.8059
335	R	A	-0.9596
336	F	A	0.0000
337	T	A	-0.4324
338	I	A	0.0000
339	N	A	-1.3160
340	G	A	-0.8616
341	A	A	-0.6946
342	S	A	-0.4472
343	F	A	0.0000
344	T	A	-0.2562
345	P	A	-0.0979
346	P	A	0.0000
347	T	A	0.1525
348	V	A	0.8159
349	P	A	0.0000
350	V	A	0.0000
351	L	A	0.0000
352	L	A	0.5537
353	Q	A	0.0000
354	I	A	0.0000
355	L	A	0.2159
356	S	A	-0.2220
357	G	A	-0.8298
358	A	A	-1.3448
359	Q	A	-2.0142
360	S	A	-1.7396
361	A	A	-1.3045
362	Q	A	-2.1461
363	D	A	-2.4740
364	L	A	0.0000
365	L	A	0.6908
366	P	A	0.2501
367	S	A	-0.4792
368	G	A	-0.7212
369	S	A	0.0000
370	V	A	0.0000
371	Y	A	-0.0657
372	S	A	-0.3789
373	L	A	0.0000
374	P	A	-1.1448
375	A	A	-1.6221
376	N	A	-2.5330
377	A	A	0.0000
378	D	A	-2.0743
379	I	A	0.0000
380	E	A	0.0000
381	I	A	0.0000
382	S	A	-0.5245
383	L	A	0.0000
384	P	A	-0.6076
385	A	A	-0.3462
386	T	A	-0.3314
387	S	A	-0.2088
388	A	A	0.1188
389	A	A	0.0000
390	P	A	-0.0546
391	G	A	-0.2175
392	F	A	0.3465
393	P	A	0.1009
394	H	A	0.0000
395	P	A	0.0000
396	F	A	0.0000
397	H	A	0.0000
398	L	A	0.0000
399	H	A	0.0000
400	G	A	0.0000
401	H	A	0.0000
402	T	A	-0.0923
403	F	A	0.0000
404	A	A	0.0000
405	V	A	0.0000
406	V	A	0.0000
407	R	A	-0.3571
408	S	A	0.0000
409	A	A	-0.4788
410	G	A	-0.6409
411	S	A	-0.3505
412	S	A	-0.4577
413	T	A	-0.0502
414	Y	A	0.2907
415	N	A	-0.2702
416	Y	A	-0.4467
417	A	A	-0.4893
418	N	A	-1.0313
419	P	A	0.0000
420	V	A	0.0000
421	Y	A	0.0362
422	R	A	0.0000
423	D	A	0.0000
424	V	A	0.0000
425	V	A	0.0000
426	N	A	-0.1032
427	T	A	0.0000
428	G	A	0.0000
429	S	A	-0.4267
430	P	A	-0.5705
431	G	A	-0.9082
432	D	A	-0.9445
433	N	A	-0.9081
434	V	A	0.0000
435	T	A	0.0000
436	I	A	0.0000
437	R	A	0.0000
438	F	A	0.0000
439	R	A	-2.9216
440	T	A	0.0000
441	D	A	-2.7713
442	N	A	0.0000
443	P	A	-1.0998
444	G	A	0.0000
445	P	A	0.0000
446	W	A	0.0000
447	F	A	0.0000
448	L	A	0.0000
449	H	A	0.0000
450	C	A	0.0000
451	H	A	0.0000
452	I	A	0.0000
453	D	A	0.0000
454	F	A	0.0000
455	H	A	0.0000
456	L	A	-0.4735
457	D	A	-1.1800
458	A	A	-0.8048
459	G	A	0.0000
460	F	A	0.0000
461	A	A	0.0000
462	V	A	0.0000
463	V	A	0.0000
464	M	A	0.0000
465	A	A	0.0000
466	E	A	0.0000
467	D	A	-1.2524
468	T	A	-0.9024
469	P	A	-1.1279
470	D	A	-1.3611
471	V	A	0.0000
472	A	A	-0.2597
473	A	A	-0.4122
474	T	A	-0.4751
475	N	A	0.0000
476	P	A	-0.0130
477	V	A	0.2849
478	P	A	-0.5819
479	Q	A	-1.5985
480	A	A	-1.0168
481	W	A	0.0000
482	S	A	-1.2940
483	D	A	-2.2230
484	L	A	0.0000
485	C	A	0.0000
486	P	A	-1.3394
487	T	A	-1.1129
488	Y	A	-1.0903
489	D	A	-1.7290
490	A	A	-0.8084
491	L	A	-0.9665
492	S	A	-1.3033
493	P	A	-1.5306
494	D	A	-2.6524
495	D	A	-2.1348
496	Q	A	-1.6694