| Chain sequence(s) |
A: GEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALK H: RIPNYQLSPTKL B: AGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKAL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 44 | G | A | -1.7622 | |
| 45 | E | A | -2.7858 | |
| 46 | A | A | -1.9751 | |
| 47 | R | A | -2.5854 | |
| 48 | L | A | -1.6429 | |
| 49 | E | A | -1.5775 | |
| 50 | E | A | -1.6423 | |
| 51 | A | A | 0.0000 | |
| 52 | V | A | 0.0000 | |
| 53 | N | A | 0.0000 | |
| 54 | R | A | -0.8657 | |
| 55 | W | A | -0.1498 | |
| 56 | V | A | 0.0000 | |
| 57 | L | A | 0.0000 | |
| 58 | K | A | -0.7582 | |
| 59 | F | A | 0.0000 | |
| 60 | Y | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | H | A | -1.4102 | |
| 63 | E | A | -1.5339 | |
| 64 | A | A | 0.0000 | |
| 65 | L | A | 0.0000 | |
| 66 | R | A | -3.0474 | |
| 67 | A | A | -2.7350 | |
| 68 | F | A | 0.0000 | |
| 69 | R | A | -3.2864 | |
| 70 | G | A | -2.2587 | |
| 71 | S | A | -2.2582 | |
| 72 | R | A | -3.0609 | |
| 73 | Y | A | -2.0203 | |
| 74 | G | A | -1.9137 | |
| 75 | D | A | -2.1414 | |
| 76 | F | A | 0.0000 | |
| 77 | R | A | -2.2844 | |
| 78 | Q | A | -1.0808 | |
| 79 | I | A | 0.0000 | |
| 80 | R | A | 0.0000 | |
| 81 | D | A | -1.4636 | |
| 82 | I | A | 0.0000 | |
| 83 | M | A | 0.0000 | |
| 84 | Q | A | -0.5087 | |
| 85 | A | A | -0.6425 | |
| 86 | L | A | 0.0000 | |
| 87 | L | A | 0.0000 | |
| 88 | V | A | 0.2326 | |
| 89 | R | A | 0.0000 | |
| 90 | P | A | -0.8481 | |
| 91 | L | A | -1.1541 | |
| 92 | G | A | -1.8032 | |
| 93 | K | A | -2.5120 | |
| 94 | E | A | -2.4290 | |
| 95 | H | A | -2.1646 | |
| 96 | T | A | -1.2909 | |
| 97 | V | A | 0.0000 | |
| 98 | S | A | -1.2760 | |
| 99 | R | A | -1.1090 | |
| 100 | L | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | R | A | -0.5525 | |
| 103 | V | A | 0.0000 | |
| 104 | M | A | 0.0000 | |
| 105 | Q | A | 0.0000 | |
| 106 | C | A | 0.0000 | |
| 107 | L | A | 0.0000 | |
| 108 | S | A | 0.0000 | |
| 109 | R | A | 0.0000 | |
| 110 | I | A | 0.0000 | |
| 111 | E | A | -1.0456 | |
| 112 | E | A | -1.3023 | |
| 113 | G | A | 0.0000 | |
| 114 | E | A | -1.8608 | |
| 115 | N | A | -1.8237 | |
| 116 | L | A | -1.5426 | |
| 117 | D | A | -2.1462 | |
| 118 | C | A | 0.0000 | |
| 119 | S | A | 0.0000 | |
| 120 | F | A | 0.0000 | |
| 121 | D | A | -1.2448 | |
| 122 | M | A | -0.9962 | |
| 123 | E | A | -1.9965 | |
| 124 | A | A | -1.3577 | |
| 125 | E | A | -1.4510 | |
| 126 | L | A | -0.5813 | |
| 127 | T | A | 0.0000 | |
| 128 | P | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | E | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | I | A | 0.0000 | |
| 134 | N | A | -1.5734 | |
| 135 | V | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | E | A | -2.3045 | |
| 138 | M | A | -1.2105 | |
| 139 | I | A | 0.0000 | |
| 140 | K | A | -1.9512 | |
| 141 | T | A | -1.4005 | |
| 142 | E | A | -1.8290 | |
| 143 | F | A | 0.0000 | |
| 144 | T | A | -0.7719 | |
| 145 | L | A | -0.6338 | |
| 146 | T | A | -1.0031 | |
| 147 | E | A | -2.2864 | |
| 148 | A | A | -1.0293 | |
| 149 | V | A | -0.4195 | |
| 150 | V | A | 0.0000 | |
| 151 | E | A | -2.6811 | |
| 152 | S | A | -1.3023 | |
| 153 | S | A | 0.0000 | |
| 154 | R | A | -1.5831 | |
| 155 | K | A | -1.0760 | |
| 156 | L | A | -0.6283 | |
| 157 | V | A | 0.0000 | |
| 158 | K | A | 0.0000 | |
| 159 | E | A | -0.3751 | |
| 160 | A | A | 0.0000 | |
| 161 | A | A | 0.0000 | |
| 162 | V | A | 0.0000 | |
| 163 | I | A | 0.0000 | |
| 164 | I | A | 0.0000 | |
| 165 | C | A | 0.0000 | |
| 166 | I | A | 0.0000 | |
| 167 | K | A | -2.5854 | |
| 168 | N | A | -2.5097 | |
| 169 | K | A | -3.4721 | |
| 170 | E | A | -3.1145 | |
| 171 | F | A | -3.0859 | |
| 172 | E | A | -3.0216 | |
| 173 | K | A | -2.2946 | |
| 174 | A | A | 0.0000 | |
| 175 | S | A | -2.2398 | |
| 176 | K | A | -2.8882 | |
| 177 | I | A | 0.0000 | |
| 178 | L | A | 0.0000 | |
| 179 | K | A | -2.7713 | |
| 180 | K | A | -2.8266 | |
| 181 | H | A | -1.8965 | |
| 182 | M | A | 0.0000 | |
| 183 | S | A | -1.7857 | |
| 184 | K | A | -2.2386 | |
| 185 | D | A | -1.7517 | |
| 186 | P | A | -1.6149 | |
| 187 | T | A | -1.3192 | |
| 188 | T | A | 0.0000 | |
| 189 | Q | A | -3.1163 | |
| 190 | K | A | -3.0333 | |
| 191 | L | A | -1.8345 | |
| 192 | R | A | -2.7134 | |
| 193 | N | A | -2.6945 | |
| 194 | D | A | -1.7470 | |
| 195 | L | A | 0.0000 | |
| 196 | L | A | -1.7535 | |
| 197 | N | A | -2.6578 | |
| 198 | I | A | 0.0000 | |
| 199 | I | A | 0.0000 | |
| 200 | R | A | -3.7481 | |
| 201 | E | A | -3.8823 | |
| 202 | K | A | -3.9977 | |
| 203 | N | A | -2.7831 | |
| 204 | L | A | -1.6024 | |
| 205 | A | A | -0.9397 | |
| 206 | H | A | -1.0557 | |
| 207 | P | A | -1.0203 | |
| 208 | V | A | -0.4290 | |
| 209 | I | A | 0.0000 | |
| 210 | Q | A | -1.8345 | |
| 211 | N | A | -1.6972 | |
| 212 | F | A | -0.7865 | |
| 213 | S | A | -0.7255 | |
| 214 | Y | A | -0.7826 | |
| 215 | E | A | -1.0670 | |
| 216 | T | A | -0.9184 | |
| 217 | F | A | 0.0000 | |
| 218 | Q | A | 0.0000 | |
| 219 | Q | A | -2.0668 | |
| 220 | K | A | -2.4495 | |
| 221 | M | A | 0.0000 | |
| 222 | L | A | 0.0000 | |
| 223 | R | A | -2.9289 | |
| 224 | F | A | -1.4302 | |
| 225 | L | A | 0.0000 | |
| 226 | E | A | -2.2903 | |
| 227 | S | A | -1.7472 | |
| 228 | H | A | -1.3577 | |
| 229 | L | A | -1.7666 | |
| 230 | D | A | -3.0019 | |
| 231 | D | A | -3.2574 | |
| 232 | A | A | -2.1907 | |
| 233 | E | A | -2.4533 | |
| 234 | P | A | 0.0000 | |
| 235 | Y | A | -0.1097 | |
| 236 | L | A | 0.0000 | |
| 237 | L | A | -0.7484 | |
| 238 | T | A | -0.8009 | |
| 239 | M | A | -0.4281 | |
| 240 | A | A | 0.0000 | |
| 241 | K | A | -2.1353 | |
| 242 | K | A | -2.4294 | |
| 243 | A | A | -1.3212 | |
| 244 | L | A | -1.4280 | |
| 245 | K | A | -2.2557 | |
| 43 | A | B | -1.1490 | |
| 44 | G | B | -1.8439 | |
| 45 | E | B | -2.7062 | |
| 46 | A | B | -1.9326 | |
| 47 | R | B | -2.6518 | |
| 48 | L | B | -1.6321 | |
| 49 | E | B | 0.0000 | |
| 50 | E | B | -1.5112 | |
| 51 | A | B | 0.0000 | |
| 52 | V | B | 0.0000 | |
| 53 | N | B | 0.0000 | |
| 54 | R | B | -0.5707 | |
| 55 | W | B | -0.0586 | |
| 56 | V | B | 0.0000 | |
| 57 | L | B | 0.0000 | |
| 58 | K | B | -0.7279 | |
| 59 | F | B | 0.0000 | |
| 60 | Y | B | 0.0000 | |
| 61 | F | B | 0.0000 | |
| 62 | H | B | -1.4116 | |
| 63 | E | B | -1.2185 | |
| 64 | A | B | 0.0000 | |
| 65 | L | B | 0.0000 | |
| 66 | R | B | -2.6725 | |
| 67 | A | B | 0.0000 | |
| 68 | F | B | 0.0000 | |
| 69 | R | B | -2.6617 | |
| 70 | G | B | -2.0956 | |
| 71 | S | B | -2.2551 | |
| 72 | R | B | -2.8771 | |
| 73 | Y | B | -1.7759 | |
| 74 | G | B | -1.7071 | |
| 75 | D | B | -2.0941 | |
| 76 | F | B | 0.0000 | |
| 77 | R | B | -2.6188 | |
| 78 | Q | B | -1.8063 | |
| 79 | I | B | 0.0000 | |
| 80 | R | B | -2.1518 | |
| 81 | D | B | -2.8942 | |
| 82 | I | B | 0.0000 | |
| 83 | M | B | 0.0000 | |
| 84 | Q | B | -1.5336 | |
| 85 | A | B | -0.7263 | |
| 86 | L | B | 0.0000 | |
| 87 | L | B | 0.7369 | |
| 88 | V | B | 1.5220 | |
| 89 | R | B | 0.0000 | |
| 90 | P | B | -0.2024 | |
| 91 | L | B | -0.6306 | |
| 92 | G | B | -1.8569 | |
| 93 | K | B | -2.4782 | |
| 94 | E | B | -2.3855 | |
| 95 | H | B | -2.2106 | |
| 96 | T | B | -1.5153 | |
| 97 | V | B | 0.0000 | |
| 98 | S | B | -1.5058 | |
| 99 | R | B | -1.5867 | |
| 100 | L | B | 0.0000 | |
| 101 | L | B | -0.7313 | |
| 102 | R | B | -1.2105 | |
| 103 | V | B | 0.0000 | |
| 104 | M | B | 0.0000 | |
| 105 | Q | B | -0.6189 | |
| 106 | C | B | 0.0000 | |
| 107 | L | B | 0.0000 | |
| 108 | S | B | 0.0000 | |
| 109 | R | B | 0.0000 | |
| 110 | I | B | 0.0000 | |
| 111 | E | B | 0.0000 | |
| 112 | E | B | -1.3368 | |
| 113 | G | B | 0.0000 | |
| 114 | E | B | -2.6933 | |
| 115 | N | B | -2.4382 | |
| 116 | L | B | -1.7675 | |
| 117 | D | B | -2.1036 | |
| 118 | C | B | -1.0269 | |
| 119 | S | B | -0.5882 | |
| 120 | F | B | 0.0738 | |
| 121 | D | B | -0.6323 | |
| 122 | M | B | -0.4181 | |
| 123 | E | B | -1.7905 | |
| 124 | A | B | -1.2841 | |
| 125 | E | B | -1.6931 | |
| 126 | L | B | -0.4549 | |
| 127 | T | B | 0.0000 | |
| 128 | P | B | 0.0000 | |
| 129 | L | B | 0.0000 | |
| 130 | E | B | 0.0000 | |
| 131 | S | B | 0.0000 | |
| 132 | A | B | 0.0000 | |
| 133 | I | B | 0.0000 | |
| 134 | N | B | -1.7029 | |
| 135 | V | B | 0.0000 | |
| 136 | L | B | 0.0000 | |
| 137 | E | B | -2.1709 | |
| 138 | M | B | -1.3318 | |
| 139 | I | B | 0.0000 | |
| 140 | K | B | -1.5821 | |
| 141 | T | B | -1.2366 | |
| 142 | E | B | -1.7120 | |
| 143 | F | B | -0.9040 | |
| 144 | T | B | -0.6331 | |
| 145 | L | B | -0.6102 | |
| 146 | T | B | -0.8676 | |
| 147 | E | B | -2.2157 | |
| 148 | A | B | -0.8956 | |
| 149 | V | B | -0.0532 | |
| 150 | V | B | 0.0000 | |
| 151 | E | B | -2.4058 | |
| 152 | S | B | -1.3057 | |
| 153 | S | B | 0.0000 | |
| 154 | R | B | -1.5309 | |
| 155 | K | B | -1.5981 | |
| 156 | L | B | -0.9593 | |
| 157 | V | B | 0.0000 | |
| 158 | K | B | -0.9294 | |
| 159 | E | B | -0.6521 | |
| 160 | A | B | 0.0000 | |
| 161 | A | B | 0.0000 | |
| 162 | V | B | 0.0000 | |
| 163 | I | B | 0.0000 | |
| 164 | I | B | 0.0000 | |
| 165 | C | B | 0.0000 | |
| 166 | I | B | 0.0000 | |
| 167 | K | B | -2.2680 | |
| 168 | N | B | -2.4069 | |
| 169 | K | B | -3.2171 | |
| 170 | E | B | -2.6030 | |
| 171 | F | B | -2.8810 | |
| 172 | E | B | -2.9433 | |
| 173 | K | B | -2.1201 | |
| 174 | A | B | 0.0000 | |
| 175 | S | B | -2.4412 | |
| 176 | K | B | -3.2780 | |
| 177 | I | B | 0.0000 | |
| 178 | L | B | 0.0000 | |
| 179 | K | B | -3.3986 | |
| 180 | K | B | -3.1041 | |
| 181 | H | B | -2.1797 | |
| 182 | M | B | 0.0000 | |
| 183 | S | B | -2.1874 | |
| 184 | K | B | -2.8374 | |
| 185 | D | B | -2.2205 | |
| 186 | P | B | -1.7951 | |
| 187 | T | B | -1.3238 | |
| 188 | T | B | -2.0121 | |
| 189 | Q | B | -3.0641 | |
| 190 | K | B | -2.7718 | |
| 191 | L | B | -1.6644 | |
| 192 | R | B | -2.5235 | |
| 193 | N | B | -2.1939 | |
| 194 | D | B | -1.9537 | |
| 195 | L | B | 0.0000 | |
| 196 | L | B | -1.8516 | |
| 197 | N | B | -2.5434 | |
| 198 | I | B | 0.0000 | |
| 199 | I | B | 0.0000 | |
| 200 | R | B | -3.7533 | |
| 201 | E | B | -3.9153 | |
| 202 | K | B | -3.9854 | |
| 203 | N | B | -2.8924 | |
| 204 | L | B | -1.6662 | |
| 205 | A | B | -0.9515 | |
| 206 | H | B | -1.1882 | |
| 207 | P | B | -1.0118 | |
| 208 | V | B | -0.5741 | |
| 209 | I | B | 0.0000 | |
| 210 | Q | B | -1.7971 | |
| 211 | N | B | -1.7383 | |
| 212 | F | B | -1.0286 | |
| 213 | S | B | -1.1544 | |
| 214 | Y | B | 0.0000 | |
| 215 | E | B | -2.1689 | |
| 216 | T | B | -1.5111 | |
| 217 | F | B | 0.0000 | |
| 218 | Q | B | 0.0000 | |
| 219 | Q | B | -2.2011 | |
| 220 | K | B | -2.7282 | |
| 221 | M | B | 0.0000 | |
| 222 | L | B | 0.0000 | |
| 223 | R | B | -2.7360 | |
| 224 | F | B | -1.2498 | |
| 225 | L | B | 0.0000 | |
| 226 | E | B | -1.9132 | |
| 227 | S | B | -1.4484 | |
| 228 | H | B | -1.2508 | |
| 229 | L | B | -1.5432 | |
| 230 | D | B | -2.9661 | |
| 231 | D | B | -3.2102 | |
| 232 | A | B | -2.2349 | |
| 233 | E | B | -2.4324 | |
| 234 | P | B | 0.0000 | |
| 235 | Y | B | 0.0627 | |
| 236 | L | B | 0.0000 | |
| 237 | L | B | -0.6278 | |
| 238 | T | B | -0.9851 | |
| 239 | M | B | -0.4584 | |
| 240 | A | B | 0.0000 | |
| 241 | K | B | -2.0873 | |
| 242 | K | B | -1.8104 | |
| 243 | A | B | -0.3956 | |
| 244 | L | B | 0.4386 | |
| 425 | R | H | -1.3624 | |
| 426 | I | H | 0.5030 | |
| 427 | P | H | -0.5293 | |
| 428 | N | H | -1.2947 | |
| 429 | Y | H | 0.0000 | |
| 430 | Q | H | -0.6148 | |
| 431 | L | H | 0.0000 | |
| 432 | S | H | -0.7210 | |
| 433 | P | H | -0.5939 | |
| 434 | T | H | -0.7140 | |
| 435 | K | H | -1.4136 | |
| 436 | L | H | 0.1126 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine