Project name: d8f7b899a848b57

Chain sequence(s)	A: MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7791
• Maximal score value: 3.3378
• Average score: -0.4827
• Total score value: -186.7963

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.5108
2	P	A	-0.5898
3	R	A	-2.1897
4	P	A	-1.6940
5	R	A	-1.2768
6	L	A	1.1695
7	L	A	2.0084
8	A	A	1.4659
9	A	A	1.5393
10	L	A	2.0025
11	C	A	1.5021
12	G	A	0.8336
13	A	A	1.4567
14	L	A	2.4878
15	L	A	2.6032
16	C	A	1.7953
17	A	A	1.1175
18	P	A	0.7961
19	S	A	1.1855
20	L	A	2.7338
21	L	A	3.3378
22	V	A	3.1954
23	A	A	2.0127
24	L	A	1.3237
25	D	A	-1.4514
26	I	A	0.0000
27	C	A	-1.6543
28	S	A	-1.6822
29	K	A	-2.2193
30	N	A	-1.8884
31	P	A	-0.9828
32	C	A	0.0000
33	H	A	-2.0027
34	N	A	-1.3954
35	G	A	-0.6438
36	G	A	0.0000
37	L	A	0.7089
38	C	A	-0.7955
39	E	A	-1.9054
40	E	A	-2.1813
41	I	A	-0.9179
42	S	A	-0.9585
43	Q	A	-1.5208
44	E	A	-2.2367
45	V	A	-1.4548
46	R	A	-2.4295
47	G	A	-1.7529
48	D	A	-1.2723
49	V	A	0.4953
50	F	A	1.9754
51	P	A	0.3068
52	S	A	0.1633
53	Y	A	-0.9713
54	T	A	-0.6692
55	C	A	-0.6112
56	T	A	0.0115
57	C	A	-0.3282
58	L	A	-0.1372
59	K	A	-1.7632
60	G	A	-1.6039
61	Y	A	-1.5070
62	A	A	-1.3292
63	G	A	-1.5941
64	N	A	-1.8333
65	H	A	-1.6571
66	C	A	0.0000
67	E	A	-2.5027
68	T	A	-1.8757
69	K	A	-2.3938
70	C	A	0.0000
71	V	A	-1.2429
72	E	A	-2.2930
73	P	A	-1.3339
74	L	A	-0.6914
75	G	A	0.0000
76	L	A	0.0000
77	E	A	-2.2571
78	N	A	-2.0390
79	G	A	-1.3557
80	N	A	-1.0081
81	I	A	0.0000
82	A	A	-1.0189
83	N	A	-1.5471
84	S	A	-0.9327
85	Q	A	0.0000
86	I	A	0.0000
87	A	A	-0.3067
88	A	A	0.0440
89	S	A	-0.4166
90	S	A	-0.2705
91	V	A	0.1651
92	R	A	-0.5329
93	V	A	1.2132
94	T	A	0.0000
95	F	A	3.1189
96	L	A	2.9094
97	G	A	1.7765
98	L	A	2.4040
99	Q	A	1.4342
100	H	A	0.2831
101	W	A	0.0000
102	V	A	0.2102
103	P	A	-0.2667
104	E	A	-0.8128
105	L	A	-0.6528
106	A	A	0.0000
107	R	A	-1.5726
108	L	A	0.0000
109	N	A	-2.5272
110	R	A	-2.4544
111	A	A	-1.0095
112	G	A	-0.3197
113	M	A	0.8738
114	V	A	0.2313
115	N	A	-0.6028
116	A	A	0.0000
117	W	A	0.0000
118	T	A	0.0000
119	P	A	0.0000
120	S	A	-0.9441
121	S	A	-1.2670
122	N	A	-2.3175
123	D	A	-2.3783
124	D	A	-2.9767
125	N	A	-2.3801
126	P	A	-1.2846
127	W	A	-0.4651
128	I	A	0.0000
129	Q	A	-0.1750
130	V	A	0.0000
131	N	A	-0.3501
132	L	A	0.0000
133	L	A	-0.1277
134	R	A	-0.5245
135	R	A	-1.1504
136	M	A	-0.4635
137	W	A	-0.1873
138	V	A	0.0000
139	T	A	0.0000
140	G	A	0.0000
141	V	A	0.0000
142	V	A	0.0000
143	T	A	0.0000
144	Q	A	0.0000
145	G	A	0.0000
146	A	A	0.0000
147	S	A	-0.5542
148	R	A	0.1753
149	L	A	1.3210
150	A	A	0.3005
151	S	A	-0.3238
152	H	A	-1.1906
153	E	A	0.0000
154	Y	A	-0.5653
155	L	A	0.0000
156	K	A	-0.1489
157	A	A	0.0000
158	F	A	0.0000
159	K	A	-1.3130
160	V	A	0.0000
161	A	A	0.0000
162	Y	A	-0.6734
163	S	A	0.0000
164	L	A	-0.7164
165	N	A	-1.5853
166	G	A	-1.3121
167	H	A	-2.0084
168	E	A	-2.6274
169	F	A	-1.5425
170	D	A	-1.8826
171	F	A	-1.6077
172	I	A	0.0000
173	H	A	-3.1956
174	D	A	-2.3917
175	V	A	-0.4317
176	N	A	-2.2179
177	K	A	-3.2237
178	K	A	-3.7791
179	H	A	-3.5247
180	K	A	-3.0332
181	E	A	-2.6710
182	F	A	0.0000
183	V	A	0.5605
184	G	A	0.0000
185	N	A	0.0000
186	W	A	0.5444
187	N	A	-0.9040
188	K	A	-1.6005
189	N	A	-1.7240
190	A	A	-0.2838
191	V	A	0.6902
192	H	A	1.0514
193	V	A	1.9029
194	N	A	0.8302
195	L	A	0.4243
196	F	A	0.0000
197	E	A	-1.6535
198	T	A	-1.0633
199	P	A	-0.5162
200	V	A	0.0000
201	E	A	-0.6715
202	A	A	0.0000
203	Q	A	-0.4867
204	Y	A	-0.4984
205	V	A	0.0000
206	R	A	-0.3234
207	L	A	0.0000
208	Y	A	-0.4409
209	P	A	-0.7072
210	T	A	-0.8307
211	S	A	-0.1502
212	C	A	-0.1521
213	H	A	-0.5984
214	T	A	-0.4043
215	A	A	-0.4183
216	C	A	-0.1056
217	T	A	0.0000
218	L	A	0.0000
219	R	A	0.0000
220	F	A	0.0000
221	E	A	0.0000
222	L	A	0.0000
223	L	A	0.0000
224	G	A	0.0000
225	C	A	-0.8693
226	E	A	-0.9366
227	L	A	-0.6580
228	N	A	-1.2671
229	G	A	-1.0398
230	C	A	0.0000
231	A	A	-0.8542
232	N	A	-1.2766
233	P	A	-1.1536
234	L	A	-0.8657
235	G	A	0.0000
236	L	A	0.0000
237	K	A	-2.9331
238	N	A	-2.9024
239	N	A	-2.7613
240	S	A	-1.7016
241	I	A	0.0000
242	P	A	-2.0309
243	D	A	-2.7560
244	K	A	-2.6153
245	Q	A	-1.6998
246	I	A	0.0000
247	T	A	-0.8440
248	A	A	-0.2118
249	S	A	-0.4632
250	S	A	-0.5779
251	S	A	-0.5224
252	Y	A	-0.4969
253	K	A	-0.3710
254	T	A	0.0000
255	W	A	1.0831
256	G	A	0.1534
257	L	A	0.6311
258	H	A	-0.0147
259	L	A	1.4516
260	F	A	0.8576
261	S	A	0.0000
262	W	A	0.0000
263	N	A	-0.7090
264	P	A	-0.6631
265	S	A	-1.0940
266	Y	A	-0.5486
267	A	A	0.0000
268	R	A	0.0000
269	L	A	0.0000
270	D	A	-1.8346
271	K	A	-2.2129
272	Q	A	-2.1162
273	G	A	-1.7851
274	N	A	-1.6707
275	F	A	-0.8418
276	N	A	-1.4014
277	A	A	0.0000
278	W	A	0.0000
279	V	A	0.0000
280	A	A	0.0000
281	G	A	-0.4544
282	S	A	-0.2366
283	Y	A	0.3273
284	G	A	-0.7122
285	N	A	-1.6773
286	D	A	-2.1278
287	Q	A	0.0000
288	W	A	-0.5022
289	L	A	0.0000
290	Q	A	-0.2030
291	V	A	0.0000
292	D	A	-1.1823
293	L	A	0.0000
294	G	A	-0.9128
295	S	A	-1.0540
296	S	A	-0.9667
297	K	A	-0.5785
298	E	A	-0.3684
299	V	A	0.0000
300	T	A	0.0000
301	G	A	0.0000
302	I	A	0.0000
303	I	A	-0.1030
304	T	A	0.0000
305	Q	A	0.0000
306	G	A	0.0000
307	A	A	0.0000
308	R	A	-1.7633
309	N	A	0.0000
310	F	A	1.1426
311	G	A	0.0402
312	S	A	-0.4391
313	V	A	-0.7160
314	Q	A	0.0000
315	F	A	0.0000
316	V	A	0.0000
317	A	A	0.3528
318	S	A	0.6165
319	Y	A	0.0000
320	K	A	0.0795
321	V	A	0.0000
322	A	A	0.0000
323	Y	A	-0.4201
324	S	A	0.0000
325	N	A	-2.3824
326	D	A	-2.7396
327	S	A	-1.6371
328	A	A	-1.2968
329	N	A	-1.7717
330	W	A	-0.9212
331	T	A	-0.7535
332	E	A	-1.0268
333	Y	A	0.0000
334	Q	A	-1.9858
335	D	A	-1.7901
336	P	A	-1.8952
337	R	A	-2.4380
338	T	A	-1.6517
339	G	A	-1.6880
340	S	A	-1.2387
341	S	A	-0.8777
342	K	A	-0.6426
343	I	A	1.0996
344	F	A	0.0000
345	P	A	0.2832
346	G	A	0.0000
347	N	A	0.0000
348	W	A	0.8429
349	D	A	-0.2998
350	N	A	-1.0599
351	H	A	-1.3731
352	S	A	-0.7926
353	H	A	-0.8015
354	K	A	0.0000
355	K	A	-0.6668
356	N	A	0.0000
357	L	A	0.0030
358	F	A	0.0000
359	E	A	-0.6003
360	T	A	-0.3610
361	P	A	-0.0954
362	I	A	0.0000
363	L	A	0.8330
364	A	A	0.0000
365	R	A	-1.5005
366	Y	A	-0.9004
367	V	A	0.0000
368	R	A	-0.2462
369	I	A	0.0000
370	L	A	-0.2082
371	P	A	0.0000
372	V	A	0.4030
373	A	A	0.2701
374	W	A	0.0347
375	H	A	-0.9466
376	N	A	-1.4533
377	R	A	-0.9182
378	I	A	0.0000
379	A	A	0.0000
380	L	A	0.0000
381	R	A	0.0000
382	L	A	0.0000
383	E	A	0.0000
384	L	A	0.0000
385	L	A	0.0000
386	G	A	0.0000
387	C	A	-0.0423