Project name: d9111de97278526

Chain sequence(s)	A: ASAKESIPGFKNITLSPCDKDPCVINKGEKYKKMVSDSEQQQTDTINIQSARSISKKYIDVPCNVTKGEVFRGSVTLRILKKVSNLIVEKKVCEDVPDDKKTMWTTKCPVKPGTYWKKKLLKHIGSGKKSKGKKLKKLIKCSQNYSAEKKERLAKTGQFRHRSRSPYKKHYRRLHGVPDLKESEEKKIKYHNYNSNGFNPKTKKSDPNFKLKGKKNRKGQSKKFGRGCARENVKKGNIHKRHGKKKPHAKYNEKSFSKKTATDSCQGDSGKKREGGPDTNKKQHDSRSMRFSKKFVPGHQFRAADHYWDFLFVDGTVCLNELRKKWSREASCLHVNDSMKYPLNWLIKYKLPGDFLSLNRQCEIAKKYTNDRMSALEGKKGTSAPGIVKAFVPNSLHCPWKKYTNDRMSALEGKKGTSAPGIVKAFVPNSLHCPWGPGPGSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.4202
• Maximal score value: 2.4492
• Average score: -0.8447
• Total score value: -529.6091

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	-0.6930
2	S	A	-1.1603
3	A	A	0.0000
4	K	A	-2.1832
5	E	A	-1.8227
6	S	A	-1.3209
7	I	A	-1.0016
8	P	A	-0.7285
9	G	A	-1.1128
10	F	A	0.0000
11	K	A	-1.1050
12	N	A	-1.2997
13	I	A	0.0000
14	T	A	0.0000
15	L	A	0.0000
16	S	A	0.0000
17	P	A	0.2188
18	C	A	-1.4569
19	D	A	-2.8007
20	K	A	-3.4737
21	D	A	-3.0830
22	P	A	-1.7825
23	C	A	-0.9853
24	V	A	0.0000
25	I	A	0.0000
26	N	A	0.0000
27	K	A	0.0000
28	G	A	0.0000
29	E	A	0.0000
30	K	A	-0.7931
31	Y	A	0.0000
32	K	A	-1.4314
33	K	A	-1.7560
34	M	A	-0.6402
35	V	A	0.0000
36	S	A	-1.7410
37	D	A	-2.7653
38	S	A	-2.3476
39	E	A	-3.0624
40	Q	A	-2.2755
41	Q	A	-2.3740
42	Q	A	-2.9374
43	T	A	0.0000
44	D	A	0.0000
45	T	A	0.0000
46	I	A	0.4323
47	N	A	0.0000
48	I	A	0.0000
49	Q	A	0.2420
50	S	A	0.3038
51	A	A	0.2770
52	R	A	-0.1370
53	S	A	0.0000
54	I	A	1.0123
55	S	A	-0.5251
56	K	A	-1.7366
57	K	A	-1.8722
58	Y	A	-0.7227
59	I	A	-0.0114
60	D	A	0.0000
61	V	A	0.7266
62	P	A	0.4500
63	C	A	-0.1130
64	N	A	-1.6552
65	V	A	0.0000
66	T	A	-1.6655
67	K	A	-2.0658
68	G	A	0.0000
69	E	A	0.0000
70	V	A	0.0000
71	F	A	0.0000
72	R	A	0.0000
73	G	A	0.0000
74	S	A	0.0000
75	V	A	0.0000
76	T	A	0.0000
77	L	A	0.0000
78	R	A	0.0000
79	I	A	0.0000
80	L	A	0.0000
81	K	A	-0.9334
82	K	A	-0.9607
83	V	A	0.0000
84	S	A	-0.3878
85	N	A	-0.4060
86	L	A	0.0000
87	I	A	0.0000
88	V	A	0.0000
89	E	A	0.0000
90	K	A	-0.7678
91	K	A	-0.6239
92	V	A	0.0000
93	C	A	0.0000
94	E	A	-0.6063
95	D	A	-0.7868
96	V	A	0.0000
97	P	A	-1.5615
98	D	A	-3.0139
99	D	A	-3.0735
100	K	A	-2.1084
101	K	A	0.0000
102	T	A	0.7779
103	M	A	0.0000
104	W	A	1.1162
105	T	A	0.1642
106	T	A	-0.5088
107	K	A	-1.5886
108	C	A	-0.7540
109	P	A	-0.5451
110	V	A	-0.5000
111	K	A	-1.6319
112	P	A	-1.1178
113	G	A	-0.8884
114	T	A	-0.9234
115	Y	A	0.0000
116	W	A	-0.0984
117	K	A	-1.1466
118	K	A	-1.3537
119	K	A	-0.8802
120	L	A	-0.1163
121	L	A	-0.4066
122	K	A	-1.9041
123	H	A	-1.1291
124	I	A	-1.8473
125	G	A	-2.3435
126	S	A	-1.6960
127	G	A	-1.9926
128	K	A	-3.4205
129	K	A	-3.3314
130	S	A	-2.6006
131	K	A	-3.2487
132	G	A	-2.5963
133	K	A	-3.0671
134	K	A	-2.1809
135	L	A	-0.4447
136	K	A	-1.5275
137	K	A	-1.2329
138	L	A	0.1239
139	I	A	1.2191
140	K	A	-0.1056
141	C	A	-0.1682
142	S	A	-0.6785
143	Q	A	-1.3752
144	N	A	-1.5236
145	Y	A	-1.2650
146	S	A	-1.1980
147	A	A	-1.3721
148	E	A	-2.8325
149	K	A	-2.5471
150	K	A	-1.9025
151	E	A	0.0000
152	R	A	-2.8722
153	L	A	0.0000
154	A	A	0.0000
155	K	A	-1.8060
156	T	A	-1.3447
157	G	A	-1.3556
158	Q	A	-1.6741
159	F	A	-1.2825
160	R	A	-2.0396
161	H	A	-2.1404
162	R	A	-2.8720
163	S	A	-2.1011
164	R	A	-2.4817
165	S	A	0.0000
166	P	A	0.0000
167	Y	A	0.0000
168	K	A	-1.2748
169	K	A	0.0000
170	H	A	-0.5188
171	Y	A	-0.0940
172	R	A	-0.8066
173	R	A	-0.9817
174	L	A	0.5965
175	H	A	-0.5383
176	G	A	-0.8009
177	V	A	-0.0536
178	P	A	-1.0540
179	D	A	-2.6718
180	L	A	-2.5590
181	K	A	-3.5529
182	E	A	0.0000
183	S	A	0.0000
184	E	A	-4.4202
185	E	A	-4.0602
186	K	A	-3.3500
187	K	A	-2.6693
188	I	A	0.2561
189	K	A	-0.7132
190	Y	A	0.8740
191	H	A	-0.3025
192	N	A	-1.0375
193	Y	A	-0.7749
194	N	A	-2.1250
195	S	A	-1.2480
196	N	A	-1.6089
197	G	A	-1.3252
198	F	A	-1.4029
199	N	A	-2.1993
200	P	A	-2.4197
201	K	A	-2.6523
202	T	A	-2.2762
203	K	A	-3.5296
204	K	A	-3.2059
205	S	A	-1.6042
206	D	A	-1.3617
207	P	A	0.0000
208	N	A	0.3263
209	F	A	1.6259
210	K	A	0.0000
211	L	A	-0.5143
212	K	A	-2.7381
213	G	A	-2.6922
214	K	A	-3.4977
215	K	A	-3.3937
216	N	A	0.0000
217	R	A	-3.4941
218	K	A	0.0000
219	G	A	0.0000
220	Q	A	-1.7312
221	S	A	-0.5744
222	K	A	0.0000
223	K	A	-1.0616
224	F	A	0.1941
225	G	A	0.0000
226	R	A	-2.1962
227	G	A	-1.4556
228	C	A	-1.8789
229	A	A	-2.2877
230	R	A	-3.2173
231	E	A	-3.5141
232	N	A	-2.4156
233	V	A	0.0000
234	K	A	0.0000
235	K	A	-2.9125
236	G	A	-2.1892
237	N	A	-1.9744
238	I	A	-0.0576
239	H	A	-0.6398
240	K	A	-1.3594
241	R	A	-0.9399
242	H	A	-0.8118
243	G	A	0.0000
244	K	A	-2.6330
245	K	A	-2.4259
246	K	A	-2.9233
247	P	A	0.0000
248	H	A	-1.9522
249	A	A	-0.9459
250	K	A	0.0000
251	Y	A	0.0000
252	N	A	-2.3650
253	E	A	-2.6937
254	K	A	-2.5746
255	S	A	-1.7717
256	F	A	-1.5372
257	S	A	-1.8189
258	K	A	-2.4894
259	K	A	-2.5146
260	T	A	-1.8202
261	A	A	0.0000
262	T	A	-1.6439
263	D	A	-2.3262
264	S	A	0.0000
265	C	A	0.0000
266	Q	A	0.0000
267	G	A	0.0000
268	D	A	0.0000
269	S	A	-1.5217
270	G	A	-1.3315
271	K	A	-2.0463
272	K	A	-2.8328
273	R	A	-2.7237
274	E	A	-2.9273
275	G	A	-2.0116
276	G	A	-1.3380
277	P	A	-0.6270
278	D	A	0.0000
279	T	A	-1.7865
280	N	A	0.0000
281	K	A	-3.6031
282	K	A	-3.3071
283	Q	A	-3.3062
284	H	A	-2.3012
285	D	A	-1.9750
286	S	A	-1.9996
287	R	A	-2.4977
288	S	A	-2.0215
289	M	A	-1.2667
290	R	A	0.0000
291	F	A	0.0000
292	S	A	0.0000
293	K	A	-2.1612
294	K	A	-2.1153
295	F	A	-1.2818
296	V	A	0.0000
297	P	A	-1.1124
298	G	A	-0.8050
299	H	A	-1.3689
300	Q	A	-1.7150
301	F	A	-0.6831
302	R	A	-1.8167
303	A	A	-0.8633
304	A	A	-0.7278
305	D	A	0.0000
306	H	A	-0.5500
307	Y	A	0.2878
308	W	A	0.7399
309	D	A	-0.6662
310	F	A	0.5586
311	L	A	0.8578
312	F	A	1.6392
313	V	A	0.7911
314	D	A	0.0000
315	G	A	0.0000
316	T	A	0.0000
317	V	A	0.0000
318	C	A	0.0000
319	L	A	0.0000
320	N	A	0.0000
321	E	A	-0.9485
322	L	A	-0.7633
323	R	A	-0.4728
324	K	A	-0.5945
325	K	A	-1.1641
326	W	A	0.1742
327	S	A	0.0000
328	R	A	0.0000
329	E	A	-0.3998
330	A	A	0.0000
331	S	A	-0.0526
332	C	A	0.6312
333	L	A	0.6605
334	H	A	-0.5751
335	V	A	0.0000
336	N	A	-2.2309
337	D	A	-2.8731
338	S	A	-1.5079
339	M	A	-0.8834
340	K	A	-2.0586
341	Y	A	0.0000
342	P	A	0.1586
343	L	A	1.1492
344	N	A	0.1664
345	W	A	0.9460
346	L	A	2.2332
347	I	A	2.3421
348	K	A	0.7171
349	Y	A	1.1311
350	K	A	-0.4493
351	L	A	0.5227
352	P	A	0.0419
353	G	A	-1.0132
354	D	A	-1.7374
355	F	A	0.0000
356	L	A	-0.6870
357	S	A	-1.2536
358	L	A	-1.1329
359	N	A	-1.8242
360	R	A	-1.7663
361	Q	A	0.0000
362	C	A	-1.8543
363	E	A	-3.0058
364	I	A	0.0000
365	A	A	0.0000
366	K	A	-3.0646
367	K	A	-2.4933
368	Y	A	0.0000
369	T	A	-2.0057
370	N	A	-2.2718
371	D	A	-2.3586
372	R	A	-2.0027
373	M	A	-0.9464
374	S	A	-1.5847
375	A	A	0.0000
376	L	A	0.0000
377	E	A	-2.6884
378	G	A	-2.1907
379	K	A	-2.6484
380	K	A	-2.9224
381	G	A	-1.8858
382	T	A	-1.4835
383	S	A	0.0000
384	A	A	-0.2364
385	P	A	-0.3676
386	G	A	-0.7511
387	I	A	0.0000
388	V	A	-1.2720
389	K	A	-1.8052
390	A	A	0.0000
391	F	A	-0.1219
392	V	A	-0.8052
393	P	A	-0.6144
394	N	A	-1.3654
395	S	A	-0.6867
396	L	A	-0.3083
397	H	A	-0.3170
398	C	A	-0.2577
399	P	A	-0.1760
400	W	A	0.0223
401	K	A	-1.4273
402	K	A	-1.3924
403	Y	A	0.0128
404	T	A	-0.9079
405	N	A	-1.4652
406	D	A	-2.4568
407	R	A	-2.1047
408	M	A	0.0000
409	S	A	0.0000
410	A	A	0.0000
411	L	A	-0.8401
412	E	A	-1.9923
413	G	A	-1.5811
414	K	A	-1.9333
415	K	A	-2.8690
416	G	A	-1.8996
417	T	A	-1.0957
418	S	A	-0.8032
419	A	A	-0.7180
420	P	A	-0.9291
421	G	A	-1.3884
422	I	A	-1.3632
423	V	A	-1.2353
424	K	A	-1.3511
425	A	A	0.7185
426	F	A	2.4492
427	V	A	2.1340
428	P	A	0.3695
429	N	A	-1.0990
430	S	A	-0.3201
431	L	A	0.0000
432	H	A	-0.7655
433	C	A	0.0000
434	P	A	-0.1717
435	W	A	0.5842
436	G	A	-0.1307
437	P	A	-0.8777
438	G	A	-1.0590
439	P	A	-1.5994
440	G	A	0.0000
441	S	A	0.0000
442	E	A	0.0000
443	I	A	0.0000
444	K	A	0.0000
445	Y	A	0.0000
446	H	A	0.0000
447	N	A	-0.8407
448	Y	A	0.0000
449	N	A	-1.6937
450	S	A	-1.5025
451	N	A	-1.7457
452	G	A	0.0000
453	F	A	-0.5913
454	N	A	0.0000
455	P	A	-1.1781
456	K	A	-1.8491
457	G	A	-1.1266
458	P	A	-0.5394
459	G	A	-0.3032
460	P	A	-0.1831
461	G	A	0.0000
462	I	A	0.0000
463	L	A	0.0000
464	F	A	0.0000
465	G	A	0.0000
466	D	A	-1.2650
467	A	A	0.0000
468	F	A	-0.5111
469	I	A	0.0000
470	P	A	-0.5102
471	A	A	0.0000
472	I	A	0.0000
473	V	A	0.0000
474	Q	A	0.0000
475	P	A	0.2357
476	V	A	0.4109
477	S	A	-1.1761
478	Q	A	0.0000
479	I	A	-0.9039
480	F	A	0.3199
481	P	A	0.0000
482	G	A	0.0000
483	P	A	-1.4358
484	G	A	0.0000
485	P	A	0.0000
486	G	A	0.0000
487	I	A	0.0000
488	L	A	0.0000
489	F	A	0.0000
490	N	A	0.0000
491	S	A	0.0000
492	L	A	0.0000
493	Q	A	0.0000
494	Y	A	0.0000
495	T	A	0.0000
496	N	A	0.0000
497	V	A	0.0000
498	V	A	0.0000
499	K	A	0.0000
500	D	A	-1.0043
501	Y	A	0.0000
502	W	A	0.0000
503	G	A	0.0000
504	N	A	-1.4646
505	D	A	-0.7496
506	L	A	0.0000
507	G	A	0.0000
508	P	A	0.0000
509	G	A	0.0000
510	P	A	-0.5936
511	G	A	-0.5521
512	K	A	0.0000
513	E	A	-0.2722
514	T	A	0.0000
515	V	A	0.6354
516	L	A	0.0000
517	R	A	0.0000
518	V	A	0.0000
519	A	A	0.0000
520	V	A	0.0000
521	T	A	0.0000
522	A	A	0.0000
523	Q	A	-1.1357
524	H	A	-1.4394
525	P	A	-1.5005
526	K	A	-1.8201
527	P	A	0.0000
528	A	A	0.0000
529	S	A	0.0000
530	L	A	-0.5342
531	M	A	0.4124
532	G	A	-0.2569
533	P	A	-0.4655
534	G	A	-0.2492
535	P	A	-0.5793
536	G	A	0.0000
537	Y	A	-0.1679
538	D	A	0.0000
539	A	A	0.0000
540	G	A	0.0000
541	I	A	0.0000
542	E	A	0.0000
543	L	A	0.0000
544	A	A	-0.3445
545	H	A	0.0000
546	L	A	0.0000
547	L	A	0.0000
548	A	A	0.0000
549	F	A	0.0000
550	N	A	0.0000
551	K	A	-0.6205
552	Y	A	-0.3011
553	G	A	-0.6904
554	P	A	-0.8826
555	G	A	-0.6879
556	P	A	-1.0438
557	G	A	-1.4754
558	H	A	-1.9448
559	D	A	-2.8336
560	K	A	-2.9996
561	K	A	-3.1131
562	Q	A	-2.5217
563	F	A	-1.1331
564	A	A	-0.5068
565	A	A	0.0000
566	L	A	0.0000
567	M	A	0.0000
568	L	A	0.0000
569	Y	A	-1.1723
570	E	A	-2.6392
571	E	A	-3.3567
572	D	A	-3.1042
573	G	A	-1.6318
574	T	A	-1.2784
575	L	A	-0.3353
576	R	A	0.0064
577	V	A	0.0000
578	E	A	0.0000
579	G	A	0.0000
580	V	A	0.0000
581	G	A	0.0000
582	P	A	0.0000
583	G	A	-0.6841
584	P	A	-0.9532
585	G	A	-1.2581
586	K	A	-1.2684
587	R	A	-1.4583
588	H	A	0.0000
589	G	A	0.0000
590	K	A	0.0000
591	R	A	0.0000
592	L	A	0.0000
593	R	A	0.0000
594	V	A	0.0000
595	T	A	0.0000
596	K	A	0.0000
597	V	A	0.0000
598	I	A	0.0000
599	P	A	-0.1161
600	H	A	-0.7372
601	A	A	0.0000
602	K	A	-1.1104
603	Y	A	0.0000
604	N	A	-1.8732
605	E	A	-2.1109
606	K	A	-2.7619
607	S	A	-2.1854
608	E	A	-2.6759
609	A	A	-1.6772
610	A	A	0.0000
611	A	A	-0.9697
612	K	A	-1.4434
613	F	A	0.0000
614	Y	A	0.0000
615	P	A	-0.7150
616	S	A	-0.7941
617	Y	A	-0.7516
618	H	A	-1.2877
619	S	A	-0.9036
620	T	A	-1.0038
621	P	A	-1.2418
622	Q	A	-1.8560
623	R	A	-1.8671
624	P	A	-1.2448
625	G	A	-1.2578
626	T	A	-1.3795
627	P	A	-1.3083