| Chain sequence(s) |
A: PRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
| Mutated residues | RA137Q |
| Energy difference between WT (input) and mutated protein (by FoldX) | 2.30977 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 3 | P | A | -0.5910 | |
| 4 | R | A | -1.8510 | |
| 5 | L | A | 0.2494 | |
| 6 | I | A | 2.0761 | |
| 7 | C | A | 0.4992 | |
| 8 | I | A | 0.0000 | |
| 9 | N | A | -1.3745 | |
| 10 | D | A | -0.7908 | |
| 11 | Y | A | 0.0000 | |
| 12 | E | A | -0.7374 | |
| 13 | Q | A | -1.3183 | |
| 14 | H | A | -0.3552 | |
| 15 | A | A | 0.0000 | |
| 16 | K | A | -1.7393 | |
| 17 | S | A | -0.2627 | |
| 18 | V | A | 1.4506 | |
| 19 | L | A | 0.3672 | |
| 20 | P | A | -0.5350 | |
| 21 | K | A | -1.7601 | |
| 22 | S | A | -0.3882 | |
| 23 | I | A | 0.0000 | |
| 24 | Y | A | 0.0000 | |
| 25 | D | A | -0.1752 | |
| 26 | Y | A | 0.0000 | |
| 27 | Y | A | 0.0000 | |
| 28 | R | A | -0.3573 | |
| 29 | S | A | 0.0000 | |
| 30 | G | A | 0.0000 | |
| 31 | A | A | 0.0000 | |
| 32 | N | A | -1.4579 | |
| 33 | D | A | -2.0544 | |
| 34 | E | A | -0.9641 | |
| 35 | E | A | -1.8792 | |
| 36 | T | A | 0.0000 | |
| 37 | L | A | 0.1450 | |
| 38 | A | A | -0.0031 | |
| 39 | D | A | -0.4911 | |
| 40 | N | A | 0.0000 | |
| 41 | I | A | 1.1628 | |
| 42 | A | A | 0.1741 | |
| 43 | A | A | 0.0000 | |
| 44 | F | A | 0.0000 | |
| 45 | S | A | -0.3665 | |
| 46 | R | A | -0.8913 | |
| 47 | W | A | 0.0000 | |
| 48 | K | A | -1.6459 | |
| 49 | L | A | 0.2248 | |
| 50 | Y | A | 1.3359 | |
| 51 | P | A | -0.0868 | |
| 52 | R | A | -0.6457 | |
| 53 | M | A | 1.1861 | |
| 54 | L | A | 1.5728 | |
| 55 | R | A | -0.8646 | |
| 56 | N | A | -1.3401 | |
| 57 | V | A | 0.3199 | |
| 58 | A | A | -0.1763 | |
| 59 | E | A | -1.8117 | |
| 60 | T | A | -0.6346 | |
| 61 | D | A | -1.2281 | |
| 62 | L | A | 0.0000 | |
| 63 | S | A | -0.0412 | |
| 64 | T | A | 0.0000 | |
| 65 | S | A | -0.3446 | |
| 66 | V | A | 0.0000 | |
| 67 | L | A | 0.1789 | |
| 68 | G | A | -0.5273 | |
| 69 | Q | A | -1.0281 | |
| 70 | R | A | -1.9638 | |
| 71 | V | A | 0.0000 | |
| 72 | S | A | -0.0763 | |
| 73 | M | A | 0.0000 | |
| 74 | P | A | 0.0000 | |
| 75 | I | A | 0.0000 | |
| 76 | C | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | G | A | 0.0000 | |
| 79 | A | A | 0.0105 | |
| 80 | T | A | -0.0070 | |
| 81 | A | A | 0.0000 | |
| 82 | M | A | 0.0000 | |
| 83 | Q | A | 0.0000 | |
| 84 | R | A | -0.2826 | |
| 85 | M | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | H | A | 0.0696 | |
| 88 | V | A | 1.5161 | |
| 89 | D | A | -0.8472 | |
| 90 | G | A | 0.0000 | |
| 91 | E | A | 0.0000 | |
| 92 | L | A | 0.2847 | |
| 93 | A | A | 0.0000 | |
| 94 | T | A | 0.0000 | |
| 95 | V | A | 0.0000 | |
| 96 | R | A | -1.4212 | |
| 97 | A | A | 0.0000 | |
| 98 | C | A | 0.0000 | |
| 99 | Q | A | -0.4525 | |
| 100 | S | A | -0.2610 | |
| 101 | L | A | 0.0522 | |
| 102 | G | A | -0.2883 | |
| 103 | T | A | 0.0000 | |
| 104 | G | A | 0.0000 | |
| 105 | M | A | 0.0000 | |
| 106 | M | A | 0.0000 | |
| 107 | L | A | 0.0000 | |
| 108 | S | A | 0.0000 | |
| 109 | S | A | 0.0000 | |
| 110 | W | A | 0.0000 | |
| 111 | A | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | S | A | 0.0000 | |
| 114 | S | A | -0.2098 | |
| 115 | I | A | 0.0000 | |
| 116 | E | A | -1.2669 | |
| 117 | E | A | -0.7241 | |
| 118 | V | A | 0.0000 | |
| 119 | A | A | 0.0000 | |
| 120 | E | A | -1.8199 | |
| 121 | A | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | P | A | -0.5768 | |
| 124 | E | A | -1.8648 | |
| 125 | A | A | 0.0000 | |
| 126 | L | A | 0.1555 | |
| 127 | R | A | 0.0000 | |
| 128 | W | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | Q | A | 0.0000 | |
| 131 | L | A | 0.0000 | |
| 132 | Y | A | 0.0000 | |
| 133 | I | A | 0.0000 | |
| 134 | Y | A | 0.0000 | |
| 135 | K | A | -1.1627 | |
| 136 | D | A | -1.6263 | |
| 137 | Q | A | -1.6202 | mutated: RA137Q |
| 138 | E | A | -2.0411 | |
| 139 | V | A | -0.1182 | |
| 140 | T | A | 0.0000 | |
| 141 | K | A | -1.0537 | |
| 142 | K | A | -1.3787 | |
| 143 | L | A | 0.0000 | |
| 144 | V | A | 0.0000 | |
| 145 | R | A | -0.8254 | |
| 146 | Q | A | -0.5157 | |
| 147 | A | A | 0.0000 | |
| 148 | E | A | -0.8855 | |
| 149 | K | A | -1.7851 | |
| 150 | M | A | -0.1210 | |
| 151 | G | A | -0.1234 | |
| 152 | Y | A | 0.0000 | |
| 153 | K | A | -1.1805 | |
| 154 | A | A | 0.0000 | |
| 155 | I | A | 0.0000 | |
| 156 | F | A | 0.0000 | |
| 157 | V | A | 0.0000 | |
| 158 | T | A | 0.0000 | |
| 159 | V | A | 0.4451 | |
| 160 | D | A | -0.0913 | |
| 161 | T | A | 0.0000 | |
| 162 | P | A | 0.0875 | |
| 163 | Y | A | 1.3215 | |
| 164 | L | A | 0.4010 | |
| 165 | G | A | -0.2481 | |
| 166 | N | A | -1.2813 | |
| 167 | R | A | 0.0000 | |
| 168 | L | A | 0.3342 | |
| 169 | D | A | -0.5361 | |
| 170 | D | A | 0.0000 | |
| 171 | V | A | -0.1079 | |
| 172 | R | A | -1.8381 | |
| 173 | N | A | -0.8300 | |
| 174 | R | A | -1.8733 | |
| 175 | F | A | 0.0000 | |
| 176 | K | A | -1.7000 | |
| 177 | L | A | 0.0000 | |
| 178 | P | A | -0.0843 | |
| 179 | P | A | -0.4808 | |
| 180 | Q | A | -1.2449 | |
| 181 | L | A | 0.0000 | |
| 182 | R | A | -0.4834 | |
| 183 | M | A | 0.0000 | |
| 184 | K | A | -1.2087 | |
| 185 | N | A | 0.0000 | |
| 186 | F | A | -0.1390 | |
| 187 | E | A | -1.7927 | |
| 188 | T | A | -0.4197 | |
| 189 | S | A | -0.2137 | |
| 190 | T | A | -0.0222 | |
| 191 | L | A | 0.1967 | |
| 192 | S | A | 0.0000 | |
| 193 | F | A | 0.0000 | |
| 194 | S | A | 0.0000 | |
| 195 | P | A | -0.3573 | |
| 196 | E | A | -1.9626 | |
| 197 | E | A | -1.3239 | |
| 198 | N | A | -1.4123 | |
| 199 | F | A | 0.0000 | |
| 200 | G | A | -0.7989 | |
| 201 | D | A | -2.2016 | |
| 202 | D | A | -2.0651 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | L | A | 0.0000 | |
| 206 | A | A | 0.0184 | |
| 207 | A | A | 0.0131 | |
| 208 | Y | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | A | A | -0.2143 | |
| 211 | K | A | -1.4306 | |
| 212 | A | A | 0.0000 | |
| 213 | I | A | 0.0000 | |
| 214 | D | A | -0.3671 | |
| 215 | P | A | -0.2142 | |
| 216 | S | A | -0.1602 | |
| 217 | I | A | 0.3458 | |
| 218 | S | A | -0.0077 | |
| 219 | W | A | -0.1195 | |
| 220 | E | A | -1.9211 | |
| 221 | D | A | -0.6563 | |
| 222 | I | A | 0.0000 | |
| 223 | K | A | -0.8897 | |
| 224 | W | A | 0.0784 | |
| 225 | L | A | 0.0000 | |
| 226 | R | A | -0.6498 | |
| 227 | R | A | -1.8741 | |
| 228 | L | A | -0.1870 | |
| 229 | T | A | 0.0000 | |
| 230 | S | A | -0.1743 | |
| 231 | L | A | 0.1662 | |
| 232 | P | A | -0.0172 | |
| 233 | I | A | 0.0000 | |
| 234 | V | A | 0.0000 | |
| 235 | A | A | 0.0000 | |
| 236 | K | A | 0.0000 | |
| 237 | G | A | 0.0000 | |
| 238 | I | A | 0.0000 | |
| 239 | L | A | -0.0971 | |
| 240 | R | A | -1.8100 | |
| 241 | G | A | -0.7135 | |
| 242 | D | A | -1.9204 | |
| 243 | D | A | -1.0798 | |
| 244 | A | A | 0.0000 | |
| 245 | R | A | -0.9396 | |
| 246 | E | A | -1.1414 | |
| 247 | A | A | 0.0000 | |
| 248 | V | A | 0.0000 | |
| 249 | K | A | -1.7966 | |
| 250 | H | A | -0.4868 | |
| 251 | G | A | -0.3517 | |
| 252 | L | A | 0.0000 | |
| 253 | N | A | -0.6603 | |
| 254 | G | A | 0.0000 | |
| 255 | I | A | 0.0000 | |
| 256 | L | A | 0.0000 | |
| 257 | V | A | 0.0000 | |
| 258 | S | A | 0.0000 | |
| 259 | N | A | 0.0000 | |
| 260 | H | A | -0.1668 | |
| 261 | G | A | -0.1040 | |
| 262 | A | A | 0.0000 | |
| 263 | R | A | -0.1806 | |
| 264 | Q | A | 0.0000 | |
| 265 | L | A | 1.4458 | |
| 266 | D | A | -0.3548 | |
| 267 | G | A | -0.5180 | |
| 268 | V | A | 0.1477 | |
| 269 | P | A | -0.1438 | |
| 270 | A | A | 0.0000 | |
| 271 | T | A | 0.0000 | |
| 272 | I | A | 0.0000 | |
| 273 | D | A | -0.3457 | |
| 274 | V | A | 0.1130 | |
| 275 | L | A | 0.0000 | |
| 276 | P | A | -0.3668 | |
| 277 | E | A | -1.8271 | |
| 278 | I | A | 0.0000 | |
| 279 | V | A | 0.0703 | |
| 280 | E | A | -1.7461 | |
| 281 | A | A | -0.3180 | |
| 282 | V | A | 0.0000 | |
| 283 | E | A | -1.9044 | |
| 284 | G | A | -1.1068 | |
| 285 | K | A | -1.7473 | |
| 286 | V | A | -0.1710 | |
| 287 | E | A | -0.2830 | |
| 288 | V | A | 0.0000 | |
| 289 | F | A | 0.0000 | |
| 290 | L | A | 0.0000 | |
| 291 | D | A | 0.0000 | |
| 292 | G | A | -0.0589 | |
| 293 | G | A | 0.0000 | |
| 294 | V | A | 0.0000 | |
| 295 | R | A | -0.2772 | |
| 296 | K | A | -0.4488 | |
| 297 | G | A | 0.0000 | |
| 298 | T | A | -0.0225 | |
| 299 | D | A | 0.0000 | |
| 300 | V | A | 0.0000 | |
| 301 | L | A | 0.0000 | |
| 302 | K | A | 0.0000 | |
| 303 | A | A | 0.0000 | |
| 304 | L | A | 0.0000 | |
| 305 | A | A | 0.0000 | |
| 306 | L | A | 0.0000 | |
| 307 | G | A | -0.3010 | |
| 308 | A | A | 0.0000 | |
| 309 | K | A | -0.7122 | |
| 310 | A | A | 0.0000 | |
| 311 | V | A | 0.0000 | |
| 312 | F | A | 0.0000 | |
| 313 | V | A | 0.0000 | |
| 314 | G | A | -0.1785 | |
| 315 | R | A | -0.2066 | |
| 316 | P | A | 0.0000 | |
| 317 | I | A | 0.0000 | |
| 318 | V | A | 0.0000 | |
| 319 | W | A | 0.0000 | |
| 320 | G | A | 0.0000 | |
| 321 | L | A | 0.0000 | |
| 322 | A | A | 0.0577 | |
| 323 | F | A | 0.0661 | |
| 324 | Q | A | -1.1471 | |
| 325 | G | A | 0.0000 | |
| 326 | E | A | -1.2514 | |
| 327 | K | A | -1.6490 | |
| 328 | G | A | 0.0000 | |
| 329 | V | A | 0.0000 | |
| 330 | Q | A | -0.5573 | |
| 331 | D | A | -0.3525 | |
| 332 | V | A | 0.0000 | |
| 333 | L | A | 0.0000 | |
| 334 | E | A | -1.5138 | |
| 335 | I | A | 0.0024 | |
| 336 | L | A | 0.0000 | |
| 337 | K | A | -0.9768 | |
| 338 | E | A | -1.5047 | |
| 339 | E | A | -0.6529 | |
| 340 | F | A | 0.0000 | |
| 341 | R | A | -0.6501 | |
| 342 | L | A | 1.0378 | |
| 343 | A | A | 0.0000 | |
| 344 | M | A | 0.0000 | |
| 345 | A | A | 0.3289 | |
| 346 | L | A | 1.1102 | |
| 347 | S | A | 0.0000 | |
| 348 | G | A | 0.0000 | |
| 349 | C | A | 0.0000 | |
| 350 | Q | A | -0.6172 | |
| 351 | N | A | -0.4939 | |
| 352 | V | A | -0.1550 | |
| 353 | K | A | -1.5615 | |
| 354 | V | A | 0.2387 | |
| 355 | I | A | 0.0000 | |
| 356 | D | A | -1.0073 | |
| 357 | K | A | -1.8370 | |
| 358 | T | A | -0.3522 | |
| 359 | L | A | 0.0000 | |
| 360 | V | A | 0.0000 | |
| 361 | R | A | -1.8406 | |
| 362 | K | A | -1.9805 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine