| Chain sequence(s) |
A: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT B: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | VA11A |
| Energy difference between WT (input) and mutated protein (by FoldX) | 0.499211 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | A | A | -1.1167 | |
| 2 | S | A | -1.5521 | |
| 3 | K | A | -2.0936 | |
| 4 | G | A | 0.0000 | |
| 5 | E | A | -1.5045 | |
| 6 | E | A | -1.9886 | |
| 7 | L | A | -0.8904 | |
| 8 | F | A | 0.0000 | |
| 9 | T | A | -0.7432 | |
| 10 | G | A | -0.6781 | |
| 11 | A | A | -0.8129 | mutated: VA11A |
| 12 | V | A | 0.0000 | |
| 13 | P | A | -1.5653 | |
| 14 | I | A | 0.0000 | |
| 15 | L | A | -1.1757 | |
| 16 | V | A | 0.0000 | |
| 17 | E | A | -1.9661 | |
| 18 | L | A | 0.0000 | |
| 19 | D | A | -3.2271 | |
| 20 | G | A | -2.6697 | |
| 21 | D | A | -2.2440 | |
| 22 | V | A | 0.0000 | |
| 23 | N | A | -1.7255 | |
| 24 | G | A | -1.2809 | |
| 25 | H | A | -1.7405 | |
| 26 | K | A | -2.6530 | |
| 27 | F | A | 0.0000 | |
| 28 | S | A | -1.7842 | |
| 29 | V | A | 0.0000 | |
| 30 | S | A | -1.1026 | |
| 31 | G | A | 0.0000 | |
| 32 | E | A | -2.4637 | |
| 33 | G | A | -2.0155 | |
| 34 | E | A | -2.4943 | |
| 35 | G | A | 0.0000 | |
| 36 | D | A | -1.1583 | |
| 37 | A | A | 0.0000 | |
| 38 | T | A | -0.4225 | |
| 39 | Y | A | -0.5653 | |
| 40 | G | A | 0.0000 | |
| 41 | K | A | -0.9194 | |
| 42 | L | A | 0.0000 | |
| 43 | T | A | -1.1753 | |
| 44 | L | A | 0.0000 | |
| 45 | K | A | -1.5565 | |
| 46 | F | A | 0.0000 | |
| 47 | I | A | -1.2200 | |
| 48 | C | A | 0.0000 | |
| 49 | T | A | -0.7474 | |
| 50 | T | A | -1.1623 | |
| 51 | G | A | -1.6608 | |
| 52 | K | A | -2.2842 | |
| 53 | L | A | 0.0000 | |
| 54 | P | A | -1.1293 | |
| 55 | V | A | 0.0000 | |
| 56 | P | A | 0.0000 | |
| 57 | W | A | 0.0000 | |
| 58 | P | A | 0.0000 | |
| 59 | T | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | V | A | 0.0000 | |
| 62 | T | A | 0.0000 | |
| 63 | T | A | 0.0000 | |
| 64 | F | A | 0.0000 | |
| 66 | Y | A | 0.0000 | |
| 67 | G | A | 0.0000 | |
| 68 | V | A | 0.0000 | |
| 69 | Q | A | 0.0000 | |
| 70 | C | A | 0.0000 | |
| 71 | F | A | 0.0000 | |
| 72 | S | A | 0.0000 | |
| 73 | R | A | -0.6918 | |
| 74 | Y | A | 0.0000 | |
| 75 | P | A | -1.6439 | |
| 76 | D | A | -2.7584 | |
| 77 | H | A | -2.3593 | |
| 78 | M | A | 0.0000 | |
| 79 | K | A | -2.3336 | |
| 80 | R | A | -2.7276 | |
| 81 | H | A | -1.6827 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | 0.0000 | |
| 84 | F | A | 0.0000 | |
| 85 | K | A | 0.0000 | |
| 86 | S | A | -0.9615 | |
| 87 | A | A | 0.0000 | |
| 88 | M | A | 0.0000 | |
| 89 | P | A | -1.0597 | |
| 90 | E | A | -1.6752 | |
| 91 | G | A | 0.0000 | |
| 92 | Y | A | 0.0000 | |
| 93 | V | A | -0.6413 | |
| 94 | Q | A | 0.0000 | |
| 95 | E | A | -2.2860 | |
| 96 | R | A | 0.0000 | |
| 97 | T | A | -0.4294 | |
| 98 | I | A | 0.0000 | |
| 99 | F | A | 0.2670 | |
| 100 | F | A | 0.0000 | |
| 101 | K | A | -2.2120 | |
| 102 | D | A | -2.9610 | |
| 103 | D | A | -2.5970 | |
| 104 | G | A | 0.0000 | |
| 105 | N | A | -0.6755 | |
| 106 | Y | A | 0.0000 | |
| 107 | K | A | -1.5595 | |
| 108 | T | A | 0.0000 | |
| 109 | R | A | -3.1441 | |
| 110 | A | A | 0.0000 | |
| 111 | E | A | -1.7836 | |
| 112 | V | A | 0.0000 | |
| 113 | K | A | -1.2136 | |
| 114 | F | A | -1.3449 | |
| 115 | E | A | -1.6866 | |
| 116 | G | A | -1.7584 | |
| 117 | D | A | -2.1589 | |
| 118 | T | A | -1.6655 | |
| 119 | L | A | 0.0000 | |
| 120 | V | A | 0.0000 | |
| 121 | N | A | 0.0000 | |
| 122 | R | A | -2.2421 | |
| 123 | I | A | 0.0000 | |
| 124 | E | A | -3.7845 | |
| 125 | L | A | 0.0000 | |
| 126 | K | A | -2.1386 | |
| 127 | G | A | 0.0000 | |
| 128 | I | A | -1.0648 | |
| 129 | D | A | -2.4591 | |
| 130 | F | A | 0.0000 | |
| 131 | K | A | -3.7352 | |
| 132 | E | A | -3.8467 | |
| 133 | D | A | -3.5174 | |
| 134 | G | A | -2.7671 | |
| 135 | N | A | -2.2207 | |
| 136 | I | A | 0.0000 | |
| 137 | L | A | -1.9451 | |
| 138 | G | A | -2.2737 | |
| 139 | H | A | -2.0997 | |
| 140 | K | A | -2.3559 | |
| 141 | L | A | 0.0000 | |
| 142 | E | A | -1.2774 | |
| 143 | Y | A | -0.3267 | |
| 144 | N | A | 0.0000 | |
| 145 | Y | A | 0.0000 | |
| 146 | N | A | 0.0000 | |
| 147 | S | A | 0.0000 | |
| 148 | H | A | 0.0000 | |
| 149 | N | A | -0.3686 | |
| 150 | V | A | 0.0000 | |
| 151 | Y | A | 0.2589 | |
| 152 | I | A | 0.0000 | |
| 153 | M | A | -0.8362 | |
| 154 | A | A | -1.7728 | |
| 155 | D | A | -2.3373 | |
| 156 | K | A | -3.2650 | |
| 157 | Q | A | -3.2018 | |
| 158 | K | A | -3.3979 | |
| 159 | N | A | -2.8573 | |
| 160 | G | A | 0.0000 | |
| 161 | I | A | 0.0000 | |
| 162 | K | A | -1.0975 | |
| 163 | V | A | 0.0000 | |
| 164 | N | A | -0.3124 | |
| 165 | F | A | 0.0000 | |
| 166 | K | A | -1.4604 | |
| 167 | I | A | 0.0000 | |
| 168 | R | A | -0.7844 | |
| 169 | H | A | 0.0000 | |
| 170 | N | A | -0.9325 | |
| 171 | I | A | 0.0000 | |
| 172 | E | A | -3.1605 | |
| 173 | D | A | -2.9772 | |
| 174 | G | A | -1.8731 | |
| 175 | S | A | -0.8288 | |
| 176 | V | A | -0.0463 | |
| 177 | Q | A | 0.0000 | |
| 178 | L | A | -0.7623 | |
| 179 | A | A | 0.0000 | |
| 180 | D | A | -0.7155 | |
| 181 | H | A | 0.0000 | |
| 182 | Y | A | -0.0234 | |
| 183 | Q | A | 0.0000 | |
| 184 | Q | A | -1.1664 | |
| 185 | N | A | 0.0000 | |
| 186 | T | A | -0.7651 | |
| 187 | P | A | -0.6812 | |
| 188 | I | A | -0.0461 | |
| 189 | G | A | -1.1124 | |
| 190 | D | A | -1.9856 | |
| 191 | G | A | -1.2643 | |
| 192 | P | A | -0.7656 | |
| 193 | V | A | -0.4589 | |
| 194 | L | A | -0.4511 | |
| 195 | L | A | -0.9443 | |
| 196 | P | A | 0.0000 | |
| 197 | D | A | -2.3826 | |
| 198 | N | A | -1.6386 | |
| 199 | H | A | 0.0000 | |
| 200 | Y | A | -0.0234 | |
| 201 | L | A | 0.0000 | |
| 202 | S | A | -0.0843 | |
| 203 | T | A | 0.0000 | |
| 204 | Q | A | 0.0000 | |
| 205 | S | A | 0.0000 | |
| 206 | A | A | 0.0000 | |
| 207 | L | A | 0.0000 | |
| 208 | S | A | -0.5844 | |
| 209 | K | A | -1.5299 | |
| 210 | D | A | -1.7374 | |
| 211 | P | A | -1.5461 | |
| 212 | N | A | -2.2782 | |
| 213 | E | A | -2.5593 | |
| 214 | K | A | -3.1232 | |
| 215 | R | A | -3.1492 | |
| 216 | D | A | -2.1306 | |
| 217 | H | A | 0.0000 | |
| 218 | M | A | 0.0000 | |
| 219 | V | A | 0.0000 | |
| 220 | L | A | 0.0000 | |
| 221 | L | A | -0.0397 | |
| 222 | E | A | 0.0000 | |
| 223 | F | A | 0.0000 | |
| 224 | V | A | 0.0000 | |
| 225 | T | A | -0.1955 | |
| 226 | A | A | 0.0000 | |
| 227 | A | A | -0.2042 | |
| 228 | G | A | -0.5913 | |
| 229 | I | A | -0.6090 | |
| 230 | T | A | -0.2083 | |
| 1 | A | B | -1.1426 | |
| 2 | S | B | -1.5429 | |
| 3 | K | B | -2.0480 | |
| 4 | G | B | 0.0000 | |
| 5 | E | B | -1.6219 | |
| 6 | E | B | -2.1777 | |
| 7 | L | B | -0.7792 | |
| 8 | F | B | 0.0000 | |
| 9 | T | B | -0.3801 | |
| 10 | G | B | 0.2117 | |
| 11 | V | B | 1.0309 | |
| 12 | V | B | 0.0000 | |
| 13 | P | B | -1.0884 | |
| 14 | I | B | 0.0000 | |
| 15 | L | B | -1.1455 | |
| 16 | V | B | 0.0000 | |
| 17 | E | B | -1.9380 | |
| 18 | L | B | 0.0000 | |
| 19 | D | B | -3.1811 | |
| 20 | G | B | 0.0000 | |
| 21 | D | B | -2.1580 | |
| 22 | V | B | 0.0000 | |
| 23 | N | B | -1.7071 | |
| 24 | G | B | -1.2724 | |
| 25 | H | B | -1.7195 | |
| 26 | K | B | -2.6527 | |
| 27 | F | B | 0.0000 | |
| 28 | S | B | -1.7393 | |
| 29 | V | B | 0.0000 | |
| 30 | S | B | -1.0750 | |
| 31 | G | B | 0.0000 | |
| 32 | E | B | -2.4412 | |
| 33 | G | B | -1.7885 | |
| 34 | E | B | -1.8514 | |
| 35 | G | B | 0.0000 | |
| 36 | D | B | -0.3247 | |
| 37 | A | B | 0.0000 | |
| 38 | T | B | -0.1956 | |
| 39 | Y | B | -0.4918 | |
| 40 | G | B | 0.0000 | |
| 41 | K | B | -0.7859 | |
| 42 | L | B | 0.0000 | |
| 43 | T | B | -1.1216 | |
| 44 | L | B | 0.0000 | |
| 45 | K | B | -1.5287 | |
| 46 | F | B | 0.0000 | |
| 47 | I | B | -1.2146 | |
| 48 | C | B | 0.0000 | |
| 49 | T | B | -0.7766 | |
| 50 | T | B | -1.1946 | |
| 51 | G | B | -1.7248 | |
| 52 | K | B | -2.3419 | |
| 53 | L | B | 0.0000 | |
| 54 | P | B | -1.1749 | |
| 55 | V | B | 0.0000 | |
| 56 | P | B | 0.0000 | |
| 57 | W | B | 0.0000 | |
| 58 | P | B | 0.0000 | |
| 59 | T | B | 0.0000 | |
| 60 | L | B | 0.0000 | |
| 61 | V | B | 0.0000 | |
| 62 | T | B | 0.0000 | |
| 63 | T | B | 0.0000 | |
| 64 | F | B | 0.0000 | |
| 66 | Y | B | 0.0000 | |
| 67 | G | B | 0.0000 | |
| 68 | V | B | 0.0000 | |
| 69 | Q | B | 0.0000 | |
| 70 | C | B | 0.0000 | |
| 71 | F | B | 0.0000 | |
| 72 | S | B | 0.0000 | |
| 73 | R | B | -1.0415 | |
| 74 | Y | B | 0.0000 | |
| 75 | P | B | -1.7279 | |
| 76 | D | B | -2.8325 | |
| 77 | H | B | -2.3898 | |
| 78 | M | B | 0.0000 | |
| 79 | K | B | -2.5048 | |
| 80 | R | B | -2.7843 | |
| 81 | H | B | -1.6864 | |
| 82 | D | B | 0.0000 | |
| 83 | F | B | 0.0000 | |
| 84 | F | B | 0.0000 | |
| 85 | K | B | 0.0000 | |
| 86 | S | B | 0.0000 | |
| 87 | A | B | 0.0000 | |
| 88 | M | B | 0.0000 | |
| 89 | P | B | -1.0638 | |
| 90 | E | B | -1.4462 | |
| 91 | G | B | 0.0000 | |
| 92 | Y | B | 0.0000 | |
| 93 | V | B | -0.6478 | |
| 94 | Q | B | 0.0000 | |
| 95 | E | B | -2.1221 | |
| 96 | R | B | 0.0000 | |
| 97 | T | B | -0.3549 | |
| 98 | I | B | 0.0000 | |
| 99 | F | B | 0.2981 | |
| 100 | F | B | 0.0000 | |
| 101 | K | B | -1.5652 | |
| 102 | D | B | -2.7236 | |
| 103 | D | B | -2.4946 | |
| 104 | G | B | 0.0000 | |
| 105 | N | B | -0.6147 | |
| 106 | Y | B | 0.0000 | |
| 107 | K | B | -1.4027 | |
| 108 | T | B | 0.0000 | |
| 109 | R | B | -2.9938 | |
| 110 | A | B | 0.0000 | |
| 111 | E | B | -1.7926 | |
| 112 | V | B | 0.0000 | |
| 113 | K | B | -1.1195 | |
| 114 | F | B | -1.2500 | |
| 115 | E | B | -1.5733 | |
| 116 | G | B | -1.7145 | |
| 117 | D | B | -2.1387 | |
| 118 | T | B | -1.4381 | |
| 119 | L | B | 0.0000 | |
| 120 | V | B | 0.0000 | |
| 121 | N | B | 0.0000 | |
| 122 | R | B | -2.2127 | |
| 123 | I | B | 0.0000 | |
| 124 | E | B | -3.6852 | |
| 125 | L | B | 0.0000 | |
| 126 | K | B | -1.9622 | |
| 127 | G | B | 0.0000 | |
| 128 | I | B | -0.9432 | |
| 129 | D | B | -2.4347 | |
| 130 | F | B | 0.0000 | |
| 131 | K | B | -3.9155 | |
| 132 | E | B | -3.9461 | |
| 133 | D | B | -3.5734 | |
| 134 | G | B | 0.0000 | |
| 135 | N | B | -2.1148 | |
| 136 | I | B | 0.0000 | |
| 137 | L | B | -1.9892 | |
| 138 | G | B | -2.2810 | |
| 139 | H | B | -2.0691 | |
| 140 | K | B | -2.2898 | |
| 141 | L | B | 0.0000 | |
| 142 | E | B | -1.2233 | |
| 143 | Y | B | -0.2814 | |
| 144 | N | B | 0.0000 | |
| 145 | Y | B | 0.0000 | |
| 146 | N | B | 0.0000 | |
| 147 | S | B | 0.0000 | |
| 148 | H | B | 0.0000 | |
| 149 | N | B | -0.6957 | |
| 150 | V | B | 0.0000 | |
| 151 | Y | B | 0.0711 | |
| 152 | I | B | 0.0000 | |
| 153 | M | B | -0.6486 | |
| 154 | A | B | -1.5843 | |
| 155 | D | B | 0.0000 | |
| 156 | K | B | -3.1480 | |
| 157 | Q | B | -3.1847 | |
| 158 | K | B | -3.4898 | |
| 159 | N | B | -2.8086 | |
| 160 | G | B | 0.0000 | |
| 161 | I | B | 0.0000 | |
| 162 | K | B | -1.0802 | |
| 163 | V | B | 0.0000 | |
| 164 | N | B | -0.5630 | |
| 165 | F | B | 0.0000 | |
| 166 | K | B | -1.2837 | |
| 167 | I | B | 0.0000 | |
| 168 | R | B | -0.6253 | |
| 169 | H | B | 0.0000 | |
| 170 | N | B | -0.8395 | |
| 171 | I | B | 0.0000 | |
| 172 | E | B | -3.1353 | |
| 173 | D | B | -2.9623 | |
| 174 | G | B | -1.8386 | |
| 175 | S | B | -0.8242 | |
| 176 | V | B | 0.0511 | |
| 177 | Q | B | 0.0000 | |
| 178 | L | B | -0.3616 | |
| 179 | A | B | 0.0000 | |
| 180 | D | B | 0.0000 | |
| 181 | H | B | 0.0000 | |
| 182 | Y | B | 0.0618 | |
| 183 | Q | B | 0.0000 | |
| 184 | Q | B | -1.4362 | |
| 185 | N | B | 0.0000 | |
| 186 | T | B | -0.8029 | |
| 187 | P | B | -0.6476 | |
| 188 | I | B | 0.0115 | |
| 189 | G | B | -1.0153 | |
| 190 | D | B | -1.9396 | |
| 191 | G | B | -1.2096 | |
| 192 | P | B | -0.7271 | |
| 193 | V | B | -0.3813 | |
| 194 | L | B | -0.4250 | |
| 195 | L | B | -0.7870 | |
| 196 | P | B | 0.0000 | |
| 197 | D | B | -2.2209 | |
| 198 | N | B | -1.3658 | |
| 199 | H | B | 0.0000 | |
| 200 | Y | B | 0.0095 | |
| 201 | L | B | 0.0000 | |
| 202 | S | B | -0.2162 | |
| 203 | T | B | 0.0000 | |
| 204 | Q | B | 0.0000 | |
| 205 | S | B | 0.0000 | |
| 206 | A | B | 0.0000 | |
| 207 | L | B | 0.0000 | |
| 208 | S | B | 0.0000 | |
| 209 | K | B | -1.1371 | |
| 210 | D | B | -1.6859 | |
| 211 | P | B | -1.5082 | |
| 212 | N | B | -2.2954 | |
| 213 | E | B | -2.5610 | |
| 214 | K | B | -3.1464 | |
| 215 | R | B | -3.3848 | |
| 216 | D | B | -2.2705 | |
| 217 | H | B | 0.0000 | |
| 218 | M | B | 0.0000 | |
| 219 | V | B | 0.0000 | |
| 220 | L | B | 0.0000 | |
| 221 | L | B | -0.0459 | |
| 222 | E | B | 0.0000 | |
| 223 | F | B | 0.0000 | |
| 224 | V | B | 0.0000 | |
| 225 | T | B | -0.4467 | |
| 226 | A | B | 0.0000 | |
| 227 | A | B | -0.1778 | |
| 228 | G | B | -0.4375 | |
| 229 | I | B | -0.4889 | |
| 230 | T | B | -0.1832 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine