| Chain sequence(s) |
A: GSMDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWT P: KSATTV B: GSMDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLESYKDSTLIMQLLRDNLTLW |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| -1 | G | A | -0.7568 | |
| 0 | S | A | -0.4103 | |
| 1 | M | A | -0.6645 | |
| 2 | D | A | -2.5726 | |
| 3 | K | A | -3.0706 | |
| 4 | N | A | -2.7643 | |
| 5 | E | A | -2.9194 | |
| 6 | L | A | -1.6867 | |
| 7 | V | A | -1.6251 | |
| 8 | Q | A | -1.6806 | |
| 9 | K | A | -1.5202 | |
| 10 | A | A | 0.0000 | |
| 11 | K | A | -1.9881 | |
| 12 | L | A | 0.0000 | |
| 13 | A | A | 0.0000 | |
| 14 | E | A | -2.3739 | |
| 15 | Q | A | -2.1044 | |
| 16 | A | A | 0.0000 | |
| 17 | E | A | -2.8719 | |
| 18 | R | A | -2.2509 | |
| 19 | Y | A | -1.9530 | |
| 20 | D | A | -2.3214 | |
| 21 | D | A | -1.7493 | |
| 22 | M | A | 0.0000 | |
| 23 | A | A | 0.0000 | |
| 24 | A | A | -0.8286 | |
| 25 | C | A | -0.8440 | |
| 26 | M | A | 0.0000 | |
| 27 | K | A | -1.2521 | |
| 28 | S | A | -1.2803 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | 0.0000 | |
| 31 | E | A | -2.7370 | |
| 32 | Q | A | -2.1290 | |
| 33 | G | A | -1.8142 | |
| 34 | A | A | -1.3028 | |
| 35 | E | A | -1.7276 | |
| 36 | L | A | 0.0000 | |
| 37 | S | A | -1.7154 | |
| 38 | N | A | -2.4859 | |
| 39 | E | A | -2.5884 | |
| 40 | E | A | -1.9486 | |
| 41 | R | A | -1.7452 | |
| 42 | N | A | -1.3860 | |
| 43 | L | A | 0.0000 | |
| 44 | L | A | 0.0000 | |
| 45 | S | A | -0.1436 | |
| 46 | V | A | 0.1151 | |
| 47 | A | A | 0.0000 | |
| 48 | Y | A | 0.0000 | |
| 49 | K | A | -0.3280 | |
| 50 | N | A | -1.0411 | |
| 51 | V | A | 0.0000 | |
| 52 | V | A | 0.0000 | |
| 53 | G | A | -0.5873 | |
| 54 | A | A | -0.7349 | |
| 55 | R | A | -0.9408 | |
| 56 | R | A | -0.7613 | |
| 57 | S | A | -0.7869 | |
| 58 | S | A | 0.0000 | |
| 59 | W | A | -0.9150 | |
| 60 | R | A | -0.8078 | |
| 61 | V | A | -0.1618 | |
| 62 | V | A | 0.0000 | |
| 63 | S | A | -1.2507 | |
| 64 | S | A | -0.7206 | |
| 65 | I | A | -0.5745 | |
| 66 | E | A | 0.0000 | |
| 67 | Q | A | -2.1403 | |
| 68 | K | A | -2.0661 | |
| 72 | A | A | -2.5024 | |
| 73 | E | A | -3.9536 | |
| 74 | K | A | -4.2408 | |
| 75 | K | A | -4.2704 | |
| 76 | Q | A | -4.2154 | |
| 77 | Q | A | -4.2384 | |
| 78 | M | A | -3.3922 | |
| 79 | A | A | 0.0000 | |
| 80 | R | A | -4.5658 | |
| 81 | E | A | -3.9850 | |
| 82 | Y | A | -2.7226 | |
| 83 | R | A | -2.6672 | |
| 84 | E | A | -3.4103 | |
| 85 | K | A | -2.9471 | |
| 86 | I | A | 0.0000 | |
| 87 | E | A | 0.0000 | |
| 88 | T | A | -1.7829 | |
| 89 | E | A | -1.8260 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -1.9629 | |
| 92 | D | A | -2.6626 | |
| 93 | I | A | -1.7679 | |
| 94 | C | A | 0.0000 | |
| 95 | N | A | -2.2760 | |
| 96 | D | A | -1.9470 | |
| 97 | V | A | 0.0000 | |
| 98 | L | A | 0.0000 | |
| 99 | S | A | -1.4014 | |
| 100 | L | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | E | A | -1.6723 | |
| 103 | K | A | -2.3351 | |
| 104 | F | A | -1.6443 | |
| 105 | L | A | 0.0000 | |
| 106 | I | A | -0.9702 | |
| 107 | P | A | -1.2379 | |
| 108 | N | A | -1.7215 | |
| 109 | A | A | 0.0000 | |
| 110 | S | A | -1.3800 | |
| 111 | Q | A | -1.8110 | |
| 112 | A | A | -1.6689 | |
| 113 | E | A | -1.6536 | |
| 114 | S | A | 0.0000 | |
| 115 | K | A | -1.2925 | |
| 116 | V | A | 0.0000 | |
| 117 | F | A | -0.3414 | |
| 118 | Y | A | 0.0000 | |
| 119 | L | A | 0.0000 | |
| 120 | K | A | 0.0000 | |
| 121 | M | A | 0.0000 | |
| 122 | K | A | -0.5817 | |
| 123 | G | A | 0.0000 | |
| 124 | D | A | 0.0000 | |
| 125 | Y | A | 0.0000 | |
| 126 | Y | A | -0.5480 | |
| 127 | R | A | 0.0000 | |
| 128 | Y | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | A | A | 0.0000 | |
| 131 | E | A | -0.3486 | |
| 132 | V | A | 0.0000 | |
| 133 | A | A | 0.0000 | |
| 134 | A | A | -1.3077 | |
| 135 | G | A | -2.2136 | |
| 136 | D | A | -3.4806 | |
| 137 | D | A | -3.5100 | |
| 138 | K | A | -3.1854 | |
| 139 | K | A | -3.4406 | |
| 140 | G | A | -2.7916 | |
| 141 | I | A | -2.0347 | |
| 142 | V | A | 0.0000 | |
| 143 | D | A | -2.9668 | |
| 144 | Q | A | -2.2800 | |
| 145 | S | A | 0.0000 | |
| 146 | Q | A | -1.8954 | |
| 147 | Q | A | -2.6627 | |
| 148 | A | A | 0.0000 | |
| 149 | Y | A | 0.0000 | |
| 150 | Q | A | -2.0854 | |
| 151 | E | A | -2.7429 | |
| 152 | A | A | 0.0000 | |
| 153 | F | A | -2.0183 | |
| 154 | E | A | -3.0742 | |
| 155 | I | A | -2.3914 | |
| 156 | S | A | 0.0000 | |
| 157 | K | A | -3.7658 | |
| 158 | K | A | -3.7553 | |
| 159 | E | A | -3.5710 | |
| 160 | M | A | 0.0000 | |
| 161 | Q | A | -2.5335 | |
| 162 | P | A | -1.8936 | |
| 163 | T | A | 0.0000 | |
| 164 | H | A | -0.7788 | |
| 165 | P | A | -0.4746 | |
| 166 | I | A | -0.2017 | |
| 167 | R | A | 0.0000 | |
| 168 | L | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | L | A | 0.0000 | |
| 171 | A | A | 0.0000 | |
| 172 | L | A | 0.0000 | |
| 173 | N | A | 0.0000 | |
| 174 | F | A | 0.0000 | |
| 175 | S | A | 0.0000 | |
| 176 | V | A | 0.0000 | |
| 177 | F | A | 0.0000 | |
| 178 | Y | A | 0.0000 | |
| 179 | Y | A | -0.5454 | |
| 180 | E | A | -0.6493 | |
| 181 | I | A | -0.1932 | |
| 182 | L | A | -0.6152 | |
| 183 | N | A | -1.3852 | |
| 184 | S | A | -1.4318 | |
| 185 | P | A | -1.6181 | |
| 186 | E | A | -2.6647 | |
| 187 | K | A | -2.2527 | |
| 188 | A | A | 0.0000 | |
| 189 | C | A | -1.4013 | |
| 190 | S | A | -1.5383 | |
| 191 | L | A | -1.0947 | |
| 192 | A | A | 0.0000 | |
| 193 | K | A | -2.5414 | |
| 194 | T | A | -1.6197 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | -1.6431 | |
| 197 | D | A | -2.5996 | |
| 198 | E | A | -2.3087 | |
| 199 | A | A | 0.0000 | |
| 200 | I | A | -0.4626 | |
| 201 | A | A | -0.9630 | |
| 202 | E | A | -1.6845 | |
| 203 | L | A | -0.6601 | |
| 204 | D | A | -1.6068 | |
| 205 | T | A | -1.3387 | |
| 206 | L | A | 0.0000 | |
| 207 | S | A | -1.9170 | |
| 208 | E | A | -2.7864 | |
| 209 | E | A | -2.9615 | |
| 210 | S | A | -1.8074 | |
| 211 | Y | A | -1.5775 | |
| 212 | K | A | -2.2639 | |
| 213 | D | A | -1.5477 | |
| 214 | S | A | 0.0000 | |
| 215 | T | A | -0.3303 | |
| 216 | L | A | -0.3109 | |
| 217 | I | A | -0.4201 | |
| 218 | M | A | 0.0000 | |
| 219 | Q | A | -1.2586 | |
| 220 | L | A | -0.4296 | |
| 221 | L | A | 0.0000 | |
| 222 | R | A | -1.7678 | |
| 223 | D | A | -0.7194 | |
| 224 | N | A | 0.0000 | |
| 225 | L | A | 0.0000 | |
| 226 | T | A | 0.3410 | |
| 227 | L | A | 1.1406 | |
| 228 | W | A | 0.7079 | |
| 229 | T | A | 0.4602 | |
| -1 | G | B | -0.8317 | |
| 0 | S | B | -0.5148 | |
| 1 | M | B | -0.8825 | |
| 2 | D | B | -2.7414 | |
| 3 | K | B | -3.1414 | |
| 4 | N | B | -2.8319 | |
| 5 | E | B | -3.1127 | |
| 6 | L | B | 0.0000 | |
| 7 | V | B | 0.0000 | |
| 8 | Q | B | -2.5789 | |
| 9 | K | B | -2.1790 | |
| 10 | A | B | 0.0000 | |
| 11 | K | B | -2.3168 | |
| 12 | L | B | 0.0000 | |
| 13 | A | B | 0.0000 | |
| 14 | E | B | -2.3878 | |
| 15 | Q | B | -1.7158 | |
| 16 | A | B | 0.0000 | |
| 17 | E | B | -2.7579 | |
| 18 | R | B | -2.1847 | |
| 19 | Y | B | -2.0605 | |
| 20 | D | B | -2.2988 | |
| 21 | D | B | -1.7863 | |
| 22 | M | B | 0.0000 | |
| 23 | A | B | 0.0000 | |
| 24 | A | B | -0.8302 | |
| 25 | C | B | -1.0621 | |
| 26 | M | B | 0.0000 | |
| 27 | K | B | -1.0655 | |
| 28 | S | B | -1.2182 | |
| 29 | V | B | 0.0000 | |
| 30 | T | B | 0.0000 | |
| 31 | E | B | -2.3941 | |
| 32 | Q | B | -2.0902 | |
| 33 | G | B | -1.8904 | |
| 34 | A | B | -1.6188 | |
| 35 | E | B | -2.4588 | |
| 36 | L | B | -1.8294 | |
| 37 | S | B | -1.8894 | |
| 38 | N | B | -2.5887 | |
| 39 | E | B | -2.6408 | |
| 40 | E | B | -2.1805 | |
| 41 | R | B | -1.8852 | |
| 42 | N | B | -1.7788 | |
| 43 | L | B | 0.0000 | |
| 44 | L | B | 0.0000 | |
| 45 | S | B | -0.7933 | |
| 46 | V | B | -0.6939 | |
| 47 | A | B | 0.0000 | |
| 48 | Y | B | 0.0000 | |
| 49 | K | B | -1.8644 | |
| 50 | N | B | -1.7518 | |
| 51 | V | B | 0.0000 | |
| 52 | V | B | 0.0000 | |
| 53 | G | B | -1.0805 | |
| 54 | A | B | -0.9942 | |
| 55 | R | B | -1.1188 | |
| 56 | R | B | -1.3159 | |
| 57 | S | B | -1.1313 | |
| 58 | S | B | 0.0000 | |
| 59 | W | B | -1.4437 | |
| 60 | R | B | -1.6844 | |
| 61 | V | B | -0.7474 | |
| 62 | V | B | 0.0000 | |
| 63 | S | B | 0.0000 | |
| 64 | S | B | -1.3138 | |
| 65 | I | B | -1.3638 | |
| 66 | E | B | 0.0000 | |
| 67 | Q | B | -2.9226 | |
| 68 | K | B | -2.8150 | |
| 69 | T | B | -2.9174 | |
| 70 | E | B | -4.0026 | |
| 73 | E | B | -4.0603 | |
| 74 | K | B | -4.1546 | |
| 75 | K | B | -3.8788 | |
| 76 | Q | B | -4.2137 | |
| 77 | Q | B | -4.1457 | |
| 78 | M | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | R | B | -4.5325 | |
| 81 | E | B | -4.0240 | |
| 82 | Y | B | 0.0000 | |
| 83 | R | B | -2.9749 | |
| 84 | E | B | -3.7154 | |
| 85 | K | B | -3.2120 | |
| 86 | I | B | 0.0000 | |
| 87 | E | B | 0.0000 | |
| 88 | T | B | -1.8488 | |
| 89 | E | B | -1.8640 | |
| 90 | L | B | 0.0000 | |
| 91 | R | B | -1.9201 | |
| 92 | D | B | -2.5938 | |
| 93 | I | B | -1.8728 | |
| 94 | C | B | 0.0000 | |
| 95 | N | B | -2.2010 | |
| 96 | D | B | -1.7712 | |
| 97 | V | B | 0.0000 | |
| 98 | L | B | 0.0000 | |
| 99 | S | B | -1.4604 | |
| 100 | L | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | E | B | -1.9122 | |
| 103 | K | B | -2.4119 | |
| 104 | F | B | -1.7463 | |
| 105 | L | B | 0.0000 | |
| 106 | I | B | -1.0855 | |
| 107 | P | B | -1.3349 | |
| 108 | N | B | -1.8301 | |
| 109 | A | B | -1.3919 | |
| 110 | S | B | -1.4235 | |
| 111 | Q | B | -1.7376 | |
| 112 | A | B | -1.5904 | |
| 113 | E | B | -1.5196 | |
| 114 | S | B | 0.0000 | |
| 115 | K | B | -1.2029 | |
| 116 | V | B | 0.0000 | |
| 117 | F | B | -0.3554 | |
| 118 | Y | B | 0.0000 | |
| 119 | L | B | 0.0000 | |
| 120 | K | B | -0.5744 | |
| 121 | M | B | 0.0000 | |
| 122 | K | B | -0.6868 | |
| 123 | G | B | 0.0000 | |
| 124 | D | B | 0.0000 | |
| 125 | Y | B | 0.0000 | |
| 126 | Y | B | -0.5336 | |
| 127 | R | B | 0.0000 | |
| 128 | Y | B | 0.0098 | |
| 129 | L | B | 0.0000 | |
| 130 | A | B | 0.0000 | |
| 131 | E | B | -0.6998 | |
| 132 | V | B | 0.0000 | |
| 133 | A | B | 0.0000 | |
| 134 | A | B | -1.3167 | |
| 135 | G | B | -2.2023 | |
| 136 | D | B | -3.4625 | |
| 137 | D | B | -3.4857 | |
| 138 | K | B | -3.1563 | |
| 139 | K | B | -3.4122 | |
| 140 | G | B | -2.7590 | |
| 141 | I | B | -2.0226 | |
| 142 | V | B | 0.0000 | |
| 143 | D | B | -2.9868 | |
| 144 | Q | B | -2.3460 | |
| 145 | S | B | 0.0000 | |
| 146 | Q | B | -1.9820 | |
| 147 | Q | B | -2.7183 | |
| 148 | A | B | 0.0000 | |
| 149 | Y | B | 0.0000 | |
| 150 | Q | B | -2.2346 | |
| 151 | E | B | -2.8208 | |
| 152 | A | B | 0.0000 | |
| 153 | F | B | -2.0300 | |
| 154 | E | B | -3.0367 | |
| 155 | I | B | -2.2901 | |
| 156 | S | B | 0.0000 | |
| 157 | K | B | -3.2672 | |
| 158 | K | B | -3.5201 | |
| 159 | E | B | -3.4191 | |
| 160 | M | B | 0.0000 | |
| 161 | Q | B | -2.4002 | |
| 162 | P | B | -1.7864 | |
| 163 | T | B | 0.0000 | |
| 164 | H | B | -0.7842 | |
| 165 | P | B | -0.5328 | |
| 166 | I | B | -0.2491 | |
| 167 | R | B | 0.0000 | |
| 168 | L | B | 0.0000 | |
| 169 | G | B | 0.0058 | |
| 170 | L | B | 0.0000 | |
| 171 | A | B | 0.0000 | |
| 172 | L | B | -0.0982 | |
| 173 | N | B | -0.1187 | |
| 174 | F | B | 0.0000 | |
| 175 | S | B | 0.0000 | |
| 176 | V | B | -0.2622 | |
| 177 | F | B | 0.0000 | |
| 178 | Y | B | 0.0000 | |
| 179 | Y | B | -1.1271 | |
| 180 | E | B | -1.7115 | |
| 181 | I | B | -0.8268 | |
| 182 | L | B | -0.9029 | |
| 183 | N | B | -1.7394 | |
| 184 | S | B | -1.5658 | |
| 185 | P | B | -1.6580 | |
| 186 | E | B | -2.5341 | |
| 187 | K | B | -1.9987 | |
| 188 | A | B | 0.0000 | |
| 189 | C | B | -1.2998 | |
| 190 | S | B | -1.4258 | |
| 191 | L | B | 0.0000 | |
| 192 | A | B | 0.0000 | |
| 193 | K | B | -2.6495 | |
| 194 | T | B | -1.6310 | |
| 195 | A | B | 0.0000 | |
| 196 | F | B | -1.7605 | |
| 197 | D | B | -2.6724 | |
| 198 | E | B | -2.1638 | |
| 199 | A | B | 0.0000 | |
| 200 | I | B | -0.5839 | |
| 201 | A | B | -1.0558 | |
| 202 | E | B | -1.8631 | |
| 203 | L | B | -0.6606 | |
| 204 | D | B | -1.5810 | |
| 205 | T | B | -0.9066 | |
| 206 | L | B | -0.8616 | |
| 209 | E | B | -1.8837 | |
| 210 | S | B | -1.1976 | |
| 211 | Y | B | -0.6329 | |
| 212 | K | B | -2.0248 | |
| 213 | D | B | -2.2344 | |
| 214 | S | B | 0.0000 | |
| 215 | T | B | -0.4238 | |
| 216 | L | B | -0.5482 | |
| 217 | I | B | -0.5819 | |
| 218 | M | B | 0.0000 | |
| 219 | Q | B | -1.5791 | |
| 220 | L | B | -0.4696 | |
| 221 | L | B | 0.0000 | |
| 222 | R | B | -2.5079 | |
| 223 | D | B | -1.3916 | |
| 224 | N | B | -0.6551 | |
| 225 | L | B | -0.6430 | |
| 226 | T | B | 0.1185 | |
| 227 | L | B | 1.1601 | |
| 228 | W | B | 0.7442 | |
| 755 | K | P | -1.5992 | |
| 756 | S | P | 0.0000 | |
| 757 | A | P | -0.4432 | |
| 759 | T | P | 0.5288 | |
| 760 | T | P | 0.7137 | |
| 761 | V | P | 1.4563 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine