Project name: TS14-8

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGFSPTNFGVHWIRQPPGKGLEWIGVIWAGGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGYNGYYYTMAYWGQGTSVTVSSDIQMTQSPSSLSASVGDRVTITCSASSTVSFMNWYQQKPGKAPKLLIYSTSILASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQRSSLPLITFGAGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.0081
• Maximal score value: 1.628
• Average score: -0.1871
• Total score value: -42.2924

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2588
2	V	H	0.0000
3	Q	H	-1.0515
4	L	H	0.0000
5	Q	H	-0.7616
6	E	H	0.0000
7	S	H	-0.2826
8	G	H	-0.5209
9	P	H	-0.3722
10	G	H	-0.1253
11	L	H	1.4806
12	V	H	0.0000
13	K	H	-1.4092
14	P	H	-0.4114
15	S	H	-0.5364
16	E	H	-1.5127
17	T	H	-0.3406
18	L	H	0.0000
19	S	H	-0.2965
20	L	H	0.0000
21	T	H	-0.0233
22	C	H	0.0000
23	T	H	-0.0486
24	V	H	0.0000
25	S	H	-0.4196
26	G	H	-0.3274
27	F	H	1.6280
28	S	H	0.2366
29	P	H	0.0000
30	T	H	-0.1401
31	N	H	-0.4199
32	F	H	0.0000
33	G	H	0.0000
34	V	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1496
40	P	H	-0.1047
41	P	H	-0.3469
42	G	H	-0.8280
43	K	H	-1.8080
44	G	H	-0.4331
45	L	H	0.0000
46	E	H	-0.5784
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	W	H	0.1959
53	A	H	-0.0688
54	G	H	-0.5385
55	G	H	-0.5535
56	S	H	-0.2972
57	T	H	-0.1569
58	N	H	-0.4434
59	Y	H	0.1594
60	N	H	-0.1782
61	P	H	-0.3274
62	S	H	-0.2594
63	L	H	0.0000
64	K	H	-1.7392
65	S	H	-0.5952
66	R	H	-0.4252
67	V	H	0.0000
68	T	H	-0.0257
69	I	H	0.0000
70	S	H	-0.0669
71	V	H	0.0651
72	D	H	-1.7252
73	T	H	-0.5371
75	K	H	-1.9132
76	N	H	-1.5158
77	Q	H	-0.3883
78	F	H	0.0000
79	S	H	-0.0583
80	L	H	0.0000
81	K	H	-0.9094
82	L	H	0.0000
83	S	H	-0.1453
84	S	H	-0.2585
85	V	H	0.0000
86	T	H	-0.0424
87	A	H	0.0593
88	A	H	0.0691
89	D	H	0.0000
90	T	H	-0.0209
91	A	H	0.0000
92	V	H	0.4751
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	0.0000
98	D	H	0.0000
99	G	H	0.0000
100	Y	H	0.6513
101	N	H	-0.8751
102	G	H	-0.5082
103	Y	H	0.8794
104	Y	H	0.8942
105	Y	H	0.5442
106	T	H	0.0000
107	M	H	0.0000
108	A	H	0.1088
109	Y	H	0.5560
110	W	H	0.2344
111	G	H	0.0000
112	Q	H	-1.1983
113	G	H	0.0000
114	T	H	-0.0513
115	S	H	-0.1440
116	V	H	0.0000
117	T	H	-0.0375
118	V	H	0.0000
119	S	H	-0.1500
120	S	H	-0.2334
121	D	H	-1.7458
122	I	H	-0.3106
123	Q	H	-1.1546
124	M	H	0.0000
125	T	H	-0.0709
126	Q	H	0.0000
127	S	H	-0.1496
128	P	H	-0.1688
129	S	H	-0.2691
130	S	H	-0.3149
131	L	H	0.4450
132	S	H	-0.0910
133	A	H	0.0000
134	S	H	-0.0172
135	V	H	1.3825
136	G	H	-0.2435
137	D	H	-1.2493
138	R	H	-2.0081
139	V	H	0.0000
140	T	H	-0.0727
141	I	H	0.0000
142	T	H	-0.0340
143	C	H	0.0000
144	S	H	-0.2896
145	A	H	-0.0506
146	S	H	-0.2488
147	S	H	-0.2567
148	T	H	-0.1263
149	V	H	0.0000
150	S	H	-0.0862
151	F	H	0.4073
152	M	H	0.0000
153	N	H	0.0000
154	W	H	0.0000
155	Y	H	0.0000
156	Q	H	-0.1302
157	Q	H	0.0000
158	K	H	-0.4741
159	P	H	-0.4197
160	G	H	-0.8248
161	K	H	-1.7834
162	A	H	-0.3087
163	P	H	0.0000
164	K	H	-1.4769
165	L	H	0.0000
166	L	H	0.0000
167	I	H	0.0000
168	Y	H	0.1973
169	S	H	0.0116
170	T	H	-0.0536
171	S	H	-0.0064
172	I	H	1.1961
173	L	H	0.6292
174	A	H	0.0490
175	S	H	-0.2990
176	G	H	-0.5066
177	V	H	0.0000
178	P	H	-0.1504
179	S	H	-0.2922
180	R	H	-0.3656
181	F	H	0.0000
182	S	H	-0.1712
183	G	H	-0.1576
184	S	H	-0.2631
185	G	H	-0.2864
186	S	H	-0.2741
187	G	H	-0.1730
188	T	H	-0.3731
189	D	H	-1.8026
190	F	H	0.0000
191	T	H	-0.0266
192	L	H	0.0000
193	T	H	-0.0233
194	I	H	0.0000
195	S	H	-0.3476
196	S	H	-0.1465
197	L	H	0.0000
198	Q	H	-0.3791
199	P	H	-0.6483
200	E	H	-1.8665
201	D	H	0.0000
202	F	H	0.7881
203	A	H	0.0000
204	T	H	-0.2137
205	Y	H	0.0000
206	Y	H	0.0000
207	C	H	0.0000
208	Q	H	0.0000
209	Q	H	0.0000
210	R	H	0.0000
211	S	H	0.0000
212	S	H	0.0707
213	L	H	1.4841
214	P	H	0.1763
215	L	H	0.1588
216	I	H	0.0000
217	T	H	0.0284
218	F	H	0.2048
219	G	H	0.0000
220	A	H	0.0585
221	G	H	0.0000
222	T	H	0.0000
223	K	H	-1.3365
224	L	H	0.0000
225	E	H	-0.8699
226	I	H	0.0901
227	K	H	-1.6036