Project name: e0e468cd4611085

Chain sequence(s)	A: GTEEHHHGGHEHHHGHGHGHHASVCKKRNVTDQVRGKLAEVSQRLKKQMHGTLEGNRTDVFTREENIQLRNAFKKIGCKPQTLATTKKPPPDDYDYEAYYDPTRWPDKKHHEGQPRSVCALEENAKRKKLTADTTQKKDRNNGTLEHPSNEFFSNAEKTDIRSAVVTKKMPFCSTLGGTCQAKKVCGGNIQRNVTCSKKGKKCVPKADCPTEKKGYGLSDGEPCVNATNPPLKKRGDYNCTVGSCRNGTCPKKKTNSEKRPSARSYSGPGPGSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2494
• Maximal score value: 1.4058
• Average score: -1.3731
• Total score value: -630.2405

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	G	A	-1.2053
2	T	A	-1.6275
3	E	A	-2.3149
4	E	A	-2.0931
5	H	A	0.0000
6	H	A	0.0000
7	H	A	0.0000
8	G	A	-1.4874
9	G	A	-1.7372
10	H	A	-1.8687
11	E	A	-2.2171
12	H	A	-1.9921
13	H	A	-2.1751
14	H	A	-2.1690
15	G	A	-1.6754
16	H	A	-1.7725
17	G	A	-1.3575
18	H	A	-1.5587
19	G	A	0.0000
20	H	A	-0.8326
21	H	A	-0.8949
22	A	A	-0.4542
23	S	A	-0.4215
24	V	A	0.3448
25	C	A	-1.2273
26	K	A	-2.8672
27	K	A	-3.4239
28	R	A	-3.9298
29	N	A	-3.2494
30	V	A	-2.5885
31	T	A	-3.3035
32	D	A	-3.9874
33	Q	A	-3.2984
34	V	A	0.0000
35	R	A	-2.9542
36	G	A	-2.4642
37	K	A	-2.2463
38	L	A	0.0000
39	A	A	-1.7242
40	E	A	-2.0297
41	V	A	0.0000
42	S	A	-2.0472
43	Q	A	-3.1300
44	R	A	-3.6391
45	L	A	0.0000
46	K	A	-3.3784
47	K	A	-3.8073
48	Q	A	-2.8934
49	M	A	-2.3928
50	H	A	-2.5611
51	G	A	-2.2968
52	T	A	-1.6403
53	L	A	-1.6251
54	E	A	-2.3508
55	G	A	-1.6125
56	N	A	-1.7799
57	R	A	-1.4337
58	T	A	-1.1287
59	D	A	-1.3776
60	V	A	0.0000
61	F	A	0.0000
62	T	A	-1.8270
63	R	A	-2.7974
64	E	A	-2.7918
65	E	A	-2.2730
66	N	A	-1.5183
67	I	A	-0.9087
68	Q	A	-1.9525
69	L	A	0.0000
70	R	A	-1.8649
71	N	A	-2.1220
72	A	A	0.0000
73	F	A	0.0000
74	K	A	-3.5465
75	K	A	-3.1954
76	I	A	0.0000
77	G	A	-1.8267
78	C	A	0.0000
79	K	A	-2.5921
80	P	A	-1.7613
81	Q	A	-1.6380
82	T	A	-0.6557
83	L	A	0.0294
84	A	A	-0.5606
85	T	A	-0.8656
86	T	A	-1.6175
87	K	A	-2.7917
88	K	A	-2.7738
89	P	A	-1.9939
90	P	A	-1.6097
91	P	A	-1.8301
92	D	A	-2.8961
93	D	A	-2.6319
94	Y	A	-0.9999
95	D	A	-1.1252
96	Y	A	0.4000
97	E	A	-0.5239
98	A	A	-0.5202
99	Y	A	0.1513
100	Y	A	-0.5394
101	D	A	-1.1077
102	P	A	-1.3156
103	T	A	-1.0986
104	R	A	-1.6115
105	W	A	-1.2463
106	P	A	-1.2855
107	D	A	-2.1026
108	K	A	-2.5523
109	K	A	-3.0971
110	H	A	-2.9798
111	H	A	-2.8876
112	E	A	-3.1612
113	G	A	-2.1341
114	Q	A	-2.2658
115	P	A	-1.5511
116	R	A	-1.7816
117	S	A	-0.8655
118	V	A	-0.6207
119	C	A	-0.6437
120	A	A	-1.5535
121	L	A	-1.5812
122	E	A	-2.9890
123	E	A	-3.5680
124	N	A	-3.6229
125	A	A	-3.1697
126	K	A	-3.7254
127	R	A	-4.1603
128	K	A	-4.1377
129	K	A	-3.0351
130	L	A	-1.9544
131	T	A	-1.9337
132	A	A	-1.6006
133	D	A	-3.0438
134	T	A	-3.0991
135	T	A	0.0000
136	Q	A	-3.6345
137	K	A	-4.0475
138	K	A	-4.2494
139	D	A	-3.7076
140	R	A	-3.7658
141	N	A	-3.3122
142	N	A	-2.9548
143	G	A	-2.4675
144	T	A	-2.0835
145	L	A	-2.3647
146	E	A	-3.1318
147	H	A	-3.0770
148	P	A	-1.9512
149	S	A	-1.8567
150	N	A	-1.9797
151	E	A	-2.2134
152	F	A	-1.2373
153	F	A	0.1351
154	S	A	-1.5710
155	N	A	-2.0699
156	A	A	-1.8881
157	E	A	-2.3601
158	K	A	-2.7624
159	T	A	-2.2526
160	D	A	-2.4362
161	I	A	-0.8131
162	R	A	-2.1562
163	S	A	-1.5479
164	A	A	-0.2879
165	V	A	0.6350
166	V	A	-0.2533
167	T	A	-1.0731
168	K	A	-2.5955
169	K	A	-3.0454
170	M	A	0.0000
171	P	A	-0.7599
172	F	A	-0.6546
173	C	A	0.0000
174	S	A	-1.2100
175	T	A	0.1471
176	L	A	0.8238
177	G	A	-1.1119
178	G	A	-1.1316
179	T	A	-1.1918
180	C	A	0.0000
181	Q	A	-1.7488
182	A	A	0.0000
183	K	A	-1.0933
184	K	A	-1.1735
185	V	A	0.0000
186	C	A	0.1095
187	G	A	-0.6938
188	G	A	-1.3029
189	N	A	-1.1508
190	I	A	0.0000
191	Q	A	-1.2077
192	R	A	0.0000
193	N	A	-2.1602
194	V	A	0.0000
195	T	A	-1.4809
196	C	A	0.0000
197	S	A	-2.4618
198	K	A	-3.1169
199	K	A	-3.3219
200	G	A	-2.6313
201	K	A	-3.7020
202	K	A	-3.2393
203	C	A	0.0000
204	V	A	-1.2778
205	P	A	0.0000
206	K	A	-2.4375
207	A	A	-2.1458
208	D	A	-2.7247
209	C	A	0.0000
210	P	A	-1.1401
211	T	A	-1.0459
212	E	A	-2.2991
213	K	A	-2.9282
214	K	A	-2.4585
215	G	A	-1.3692
216	Y	A	-0.2147
217	G	A	-1.0571
218	L	A	-1.7043
219	S	A	-2.1635
220	D	A	-2.9067
221	G	A	-2.2349
222	E	A	-1.9703
223	P	A	-1.6441
224	C	A	0.0000
225	V	A	-1.3005
226	N	A	-1.0819
227	A	A	-1.2012
228	T	A	-1.0550
229	N	A	-1.1315
230	P	A	-1.1689
231	P	A	-1.8402
232	L	A	0.0000
233	K	A	-3.7082
234	K	A	-3.6424
235	R	A	-3.4211
236	G	A	-2.7326
237	D	A	-2.4654
238	Y	A	-1.8742
239	N	A	-1.1867
240	C	A	0.0000
241	T	A	-0.5702
242	V	A	0.0000
243	G	A	0.0000
244	S	A	-1.4743
245	C	A	-1.3151
246	R	A	-2.5826
247	N	A	-2.7910
248	G	A	0.0000
249	T	A	-1.6825
250	C	A	-1.1324
251	P	A	-1.5607
252	K	A	-2.5283
253	K	A	-2.7373
254	K	A	-3.6569
255	T	A	-3.0343
256	N	A	-3.1768
257	S	A	-2.7005
258	E	A	-4.0292
259	K	A	-4.1037
260	R	A	-3.8991
261	P	A	-2.2725
262	S	A	-1.4970
263	A	A	-1.6734
264	R	A	-2.2208
265	S	A	-1.1538
266	Y	A	-0.0894
267	S	A	-0.7701
268	G	A	-1.0866
269	P	A	-1.0379
270	G	A	-1.2741
271	P	A	-1.1592
272	G	A	-1.2154
273	S	A	-1.3502
274	E	A	-2.0697
275	I	A	-0.5322
276	K	A	-2.0409
277	Y	A	0.0000
278	H	A	-1.9692
279	N	A	-1.4067
280	Y	A	-0.7189
281	N	A	-1.5021
282	S	A	-0.8948
283	N	A	-1.2051
284	G	A	-0.6107
285	F	A	0.0000
286	N	A	0.0000
287	P	A	-1.2988
288	K	A	-2.2955
289	G	A	-1.1980
290	P	A	-0.7432
291	G	A	-0.7045
292	P	A	-0.5115
293	G	A	-0.7871
294	I	A	-0.3612
295	L	A	-0.2915
296	F	A	-0.3590
297	G	A	-0.6753
298	D	A	-1.3589
299	A	A	-0.3634
300	F	A	-0.1007
301	I	A	-0.1104
302	P	A	-0.3553
303	A	A	-0.1487
304	I	A	0.1050
305	V	A	0.1830
306	Q	A	-0.9197
307	P	A	-0.3608
308	V	A	0.0000
309	S	A	-0.2535
310	Q	A	-0.4990
311	I	A	1.4058
312	F	A	0.6481
313	P	A	-0.4534
314	G	A	-0.9175
315	P	A	-0.8764
316	G	A	-0.9461
317	P	A	-0.5787
318	G	A	-0.5814
319	I	A	0.2057
320	L	A	0.6193
321	F	A	0.5105
322	N	A	0.0000
323	S	A	0.0000
324	L	A	0.0000
325	Q	A	0.0000
326	Y	A	0.0000
327	T	A	-1.3022
328	N	A	-1.9548
329	V	A	0.0000
330	V	A	-1.1469
331	K	A	-2.5457
332	D	A	-2.1938
333	Y	A	-1.4754
334	W	A	-1.6202
335	G	A	-1.7357
336	N	A	-2.4199
337	D	A	-2.1664
338	L	A	-0.8664
339	G	A	-1.3909
340	P	A	-1.6874
341	G	A	-1.5539
342	P	A	-1.7345
343	G	A	-2.0631
344	K	A	-2.9733
345	E	A	-2.7976
346	T	A	0.0000
347	V	A	0.0375
348	L	A	0.0000
349	R	A	-0.5142
350	V	A	0.0000
351	A	A	0.0809
352	V	A	0.0000
353	T	A	-0.0559
354	A	A	0.0000
355	Q	A	-1.2477
356	H	A	-1.3498
357	P	A	-1.2813
358	K	A	-2.1537
359	P	A	-1.4843
360	A	A	0.0000
361	S	A	-0.3358
362	L	A	0.4116
363	M	A	0.0000
364	G	A	0.0000
365	P	A	0.1146
366	G	A	0.0000
367	P	A	0.0000
368	G	A	0.1798
369	Y	A	0.0516
370	D	A	-1.4471
371	A	A	-0.8203
372	G	A	-0.7474
373	I	A	-0.6186
374	E	A	-1.6687
375	L	A	-0.3546
376	A	A	0.1050
377	H	A	0.0000
378	L	A	1.3194
379	L	A	0.0000
380	A	A	-0.4129
381	F	A	-0.9114
382	N	A	-2.0281
383	K	A	-2.1425
384	Y	A	0.0000
385	G	A	-1.2149
386	P	A	-1.3575
387	G	A	0.0000
388	P	A	0.0000
389	G	A	-0.6408
390	H	A	-1.1478
391	D	A	-1.6458
392	K	A	-2.2271
393	K	A	-2.3607
394	Q	A	-1.2542
395	F	A	0.4524
396	A	A	0.0000
397	A	A	0.0000
398	L	A	0.0000
399	M	A	0.0000
400	L	A	0.0000
401	Y	A	0.0000
402	E	A	-1.6793
403	E	A	-2.6732
404	D	A	-3.0736
405	G	A	-1.7582
406	T	A	0.0000
407	L	A	0.0000
408	R	A	-1.2592
409	V	A	0.0000
410	E	A	0.0000
411	G	A	-0.5404
412	V	A	-0.0190
413	G	A	0.0000
414	P	A	0.0870
415	G	A	-0.6079
416	P	A	-1.2801
417	G	A	-1.2403
418	K	A	-1.7330
419	R	A	-1.6071
420	H	A	0.0000
421	G	A	-1.9008
422	K	A	-2.0041
423	R	A	-2.1001
424	L	A	0.0000
425	R	A	-1.7448
426	V	A	0.6263
427	T	A	-0.0940
428	K	A	-0.9710
429	V	A	0.3747
430	I	A	0.0000
431	P	A	-1.0143
432	H	A	-2.0674
433	A	A	-1.7333
434	K	A	-2.1726
435	Y	A	-1.3333
436	N	A	-1.8452
437	E	A	-1.9456
438	K	A	-2.6861
439	S	A	-2.1859
440	E	A	-2.7185
441	A	A	-1.7025
442	A	A	-1.6667
443	A	A	-1.9466
444	K	A	-2.2504
445	F	A	-0.7832
446	Y	A	0.0000
447	P	A	-0.6120
448	S	A	-0.2319
449	Y	A	0.4061
450	H	A	-0.8037
451	S	A	-0.6398
452	T	A	-0.9490
453	P	A	-1.5679
454	Q	A	-2.5315
455	R	A	-2.7621
456	P	A	-1.7692
457	G	A	-1.3298
458	T	A	-1.1923
459	P	A	-0.8863