| Chain sequence(s) |
A: MESSSIKCVVVGDGAVGKTALLIAYSSGCFPEDYVPTVFDNYNNKNIPYGDGIVSIALYDTAGQQEDYDRLRPLSYPDTDVFLVCFSLENPNNSLENCHSKKWAEELKHYNPDTPIVLVGTKLDLKKDEEYVKKLKEKKISPVTTEQGQEMKDKIKACGYIECSAKTMENLTEAFNMAIDIAMKQRLKDAPP B: HMESIKCVVVGDGAVGKTALLIAYSSGCFPEDYVPTVFDNYNKNIPYGDGIVSIALYDTAGQEDYYDRLRPLSYPDTDVFLVCFSLENPNSLENCHSKWAEELKHYNPDTPIVLVGTKLDLKKDEEYVKKLKEKKISPVTTEQGQEMKDKIKACGYIECSAKTMMENLTEAFNMAIDIAMKQRLKD |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.4007 | |
| 2 | E | A | -0.5742 | |
| 3 | S | A | -0.8433 | |
| 4 | I | A | 0.0000 | |
| 5 | K | A | -0.9494 | |
| 6 | C | A | 0.0000 | |
| 7 | V | A | 0.0000 | |
| 8 | V | A | 0.0000 | |
| 9 | V | A | 0.0000 | |
| 10 | G | A | 0.0000 | |
| 11 | D | A | -1.1677 | |
| 12 | G | A | -0.9841 | |
| 13 | A | A | -0.3906 | |
| 14 | V | A | 0.0000 | |
| 15 | G | A | -0.4578 | |
| 16 | K | A | 0.0000 | |
| 17 | T | A | 0.2796 | |
| 18 | A | A | 0.0756 | |
| 19 | L | A | 0.0000 | |
| 20 | L | A | 0.0000 | |
| 21 | I | A | 0.1048 | |
| 22 | A | A | 0.0000 | |
| 23 | Y | A | 0.0000 | |
| 24 | S | A | -0.3640 | |
| 25 | S | A | -0.1934 | |
| 26 | G | A | -0.3580 | |
| 27 | C | A | -0.1597 | |
| 28 | F | A | -0.3195 | |
| 29 | P | A | -0.7511 | |
| 30 | E | A | -1.9605 | |
| 31 | D | A | -1.6901 | |
| 32 | Y | A | 0.5106 | |
| 33 | V | A | 1.0232 | |
| 34 | P | A | 0.6544 | |
| 35 | T | A | 0.4953 | |
| 36 | V | A | 0.4815 | |
| 37 | F | A | -0.1943 | |
| 38 | D | A | -1.9167 | |
| 39 | N | A | -1.9963 | |
| 40 | Y | A | -1.4800 | |
| 41 | N | A | -1.9462 | |
| 42 | K | A | -1.5392 | |
| 43 | N | A | -1.4650 | |
| 44 | I | A | -0.6697 | |
| 45 | P | A | -0.9907 | |
| 46 | Y | A | -1.1585 | |
| 47 | G | A | 0.0000 | |
| 48 | D | A | -3.1184 | |
| 49 | G | A | -1.1574 | |
| 50 | I | A | -0.1107 | |
| 51 | V | A | 0.0000 | |
| 52 | S | A | -0.9106 | |
| 53 | I | A | 0.0000 | |
| 54 | A | A | -1.1246 | |
| 55 | L | A | 0.0000 | |
| 56 | Y | A | -0.5289 | |
| 57 | D | A | 0.0000 | |
| 58 | T | A | 0.0000 | |
| 59 | A | A | 0.0000 | |
| 60 | G | A | 0.0000 | |
| 61 | Q | A | -2.3149 | |
| 62 | E | A | -3.5279 | |
| 63 | D | A | -3.1546 | |
| 64 | Y | A | -2.0071 | |
| 65 | D | A | -2.6049 | |
| 66 | R | A | -2.1506 | |
| 67 | L | A | -0.2156 | |
| 68 | R | A | 0.0000 | |
| 69 | P | A | 0.0000 | |
| 70 | L | A | 1.2825 | |
| 71 | S | A | 0.5316 | |
| 72 | Y | A | 0.0000 | |
| 73 | P | A | -0.7947 | |
| 74 | D | A | -2.1085 | |
| 75 | T | A | 0.0000 | |
| 76 | D | A | -1.4108 | |
| 77 | V | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | L | A | 0.0000 | |
| 80 | V | A | 0.0000 | |
| 81 | C | A | 0.0000 | |
| 82 | F | A | 0.0000 | |
| 83 | S | A | 0.0000 | |
| 84 | L | A | 0.0000 | |
| 85 | E | A | 0.0000 | |
| 86 | N | A | -1.2230 | |
| 87 | P | A | -1.4963 | |
| 88 | N | A | -2.2407 | |
| 89 | S | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | E | A | -2.9886 | |
| 92 | N | A | -2.4184 | |
| 93 | C | A | 0.0000 | |
| 94 | H | A | -2.3033 | |
| 95 | S | A | -1.8287 | |
| 96 | K | A | -1.9850 | |
| 97 | W | A | 0.0000 | |
| 98 | A | A | -2.4074 | |
| 99 | E | A | -3.0477 | |
| 100 | E | A | -2.1220 | |
| 101 | L | A | 0.0000 | |
| 102 | K | A | -3.0938 | |
| 103 | H | A | -2.2543 | |
| 104 | Y | A | -0.6727 | |
| 105 | N | A | -1.8083 | |
| 106 | P | A | -2.2071 | |
| 107 | D | A | -2.3281 | |
| 108 | T | A | -1.5928 | |
| 109 | P | A | -0.9891 | |
| 110 | I | A | 0.0000 | |
| 111 | V | A | 0.0000 | |
| 112 | L | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | G | A | 0.0000 | |
| 115 | T | A | 0.0000 | |
| 116 | K | A | -1.3974 | |
| 117 | L | A | 0.0000 | |
| 118 | D | A | -1.8618 | |
| 119 | L | A | -1.6157 | |
| 120 | K | A | -1.8448 | |
| 121 | K | A | -2.8488 | |
| 122 | D | A | -3.0858 | |
| 123 | E | A | -4.0117 | |
| 124 | E | A | -4.0405 | |
| 125 | Y | A | -3.0151 | |
| 126 | V | A | -3.2474 | |
| 127 | K | A | -4.7209 | |
| 128 | K | A | -4.5667 | |
| 129 | L | A | 0.0000 | |
| 130 | K | A | -4.3713 | |
| 131 | E | A | -4.6016 | |
| 132 | K | A | -4.2305 | |
| 133 | K | A | -3.7137 | |
| 134 | I | A | -2.1989 | |
| 135 | S | A | -1.5907 | |
| 136 | P | A | -0.5706 | |
| 137 | V | A | 0.0000 | |
| 138 | T | A | -1.1415 | |
| 139 | T | A | -1.3509 | |
| 140 | E | A | -2.6849 | |
| 141 | Q | A | -2.5266 | |
| 142 | G | A | 0.0000 | |
| 143 | Q | A | -2.0989 | |
| 144 | E | A | -3.1676 | |
| 145 | M | A | 0.0000 | |
| 146 | K | A | 0.0000 | |
| 147 | D | A | -2.7795 | |
| 148 | K | A | -2.7307 | |
| 149 | I | A | 0.0000 | |
| 150 | K | A | -2.4006 | |
| 151 | A | A | -1.1322 | |
| 152 | C | A | -0.3471 | |
| 153 | G | A | 0.0000 | |
| 154 | Y | A | 0.0000 | |
| 155 | I | A | 0.0000 | |
| 156 | E | A | -0.6236 | |
| 157 | C | A | 0.0000 | |
| 158 | S | A | 0.0000 | |
| 159 | A | A | -0.9288 | |
| 160 | K | A | -1.6658 | |
| 161 | T | A | -1.1093 | |
| 162 | M | A | -0.9529 | |
| 163 | E | A | -2.1550 | |
| 164 | N | A | -1.3671 | |
| 165 | L | A | 0.0000 | |
| 166 | T | A | -0.5236 | |
| 167 | E | A | -0.6598 | |
| 168 | A | A | 0.0000 | |
| 169 | F | A | 0.0000 | |
| 170 | N | A | -0.4661 | |
| 171 | M | A | -0.0708 | |
| 172 | A | A | 0.0000 | |
| 173 | I | A | 0.0000 | |
| 174 | D | A | -0.5209 | |
| 175 | I | A | -0.1826 | |
| 176 | A | A | 0.0000 | |
| 177 | M | A | 0.0000 | |
| 178 | K | A | -1.0504 | |
| 179 | Q | A | -1.6485 | |
| 180 | R | A | -1.4590 | |
| 181 | L | A | -0.5014 | |
| 182 | K | A | -2.3717 | |
| 183 | D | A | -2.5919 | |
| 184 | A | A | -1.2448 | |
| 185 | P | A | -0.8120 | |
| 186 | P | A | -0.6511 | |
| 0 | H | B | -0.8486 | |
| 1 | M | B | 0.0774 | |
| 2 | E | B | -0.4510 | |
| 3 | S | B | -0.5040 | |
| 4 | I | B | 0.0000 | |
| 5 | K | B | -0.8927 | |
| 6 | C | B | 0.0000 | |
| 7 | V | B | 0.0000 | |
| 8 | V | B | 0.0000 | |
| 9 | V | B | 0.0000 | |
| 10 | G | B | 0.0000 | |
| 11 | D | B | -1.2598 | |
| 12 | G | B | -1.0112 | |
| 13 | A | B | -0.3255 | |
| 14 | V | B | 0.0000 | |
| 15 | G | B | -0.2823 | |
| 16 | K | B | 0.0000 | |
| 17 | T | B | 0.4654 | |
| 18 | A | B | 0.0905 | |
| 19 | L | B | 0.0000 | |
| 20 | L | B | 0.0000 | |
| 21 | I | B | 0.2071 | |
| 22 | A | B | 0.0000 | |
| 23 | Y | B | 0.0000 | |
| 24 | S | B | -0.5100 | |
| 25 | S | B | -0.2660 | |
| 26 | G | B | -0.1770 | |
| 27 | C | B | 0.2649 | |
| 28 | F | B | -0.1666 | |
| 29 | P | B | -0.6158 | |
| 30 | E | B | -2.1090 | |
| 31 | D | B | -1.8121 | |
| 32 | Y | B | 0.3103 | |
| 33 | V | B | 0.9849 | |
| 34 | P | B | 1.2950 | |
| 35 | T | B | 1.2659 | |
| 36 | V | B | 1.9647 | |
| 37 | F | B | 1.3489 | |
| 38 | D | B | -0.5734 | |
| 39 | N | B | -1.0094 | |
| 40 | Y | B | -1.0334 | |
| 41 | N | B | -1.8436 | |
| 42 | K | B | -1.6857 | |
| 43 | N | B | -1.4884 | |
| 44 | I | B | -0.7338 | |
| 45 | P | B | -1.0248 | |
| 46 | Y | B | -1.1503 | |
| 47 | G | B | 0.0000 | |
| 48 | D | B | -2.9679 | |
| 49 | G | B | -1.3003 | |
| 50 | I | B | -0.2833 | |
| 51 | V | B | 0.0000 | |
| 52 | S | B | -0.8293 | |
| 53 | I | B | 0.0000 | |
| 54 | A | B | -0.9195 | |
| 55 | L | B | 0.0000 | |
| 56 | Y | B | -0.1574 | |
| 57 | D | B | 0.0000 | |
| 58 | T | B | 0.0000 | |
| 59 | A | B | -0.3024 | |
| 60 | G | B | -1.4762 | |
| 61 | Q | B | -2.7384 | |
| 62 | E | B | -3.6661 | |
| 63 | D | B | -3.2098 | |
| 64 | Y | B | -1.9908 | |
| 65 | D | B | -2.3051 | |
| 66 | R | B | -2.0767 | |
| 67 | L | B | -0.2431 | |
| 68 | R | B | 0.0000 | |
| 69 | P | B | 0.0000 | |
| 70 | L | B | 1.3974 | |
| 71 | S | B | 0.5241 | |
| 72 | Y | B | 0.0000 | |
| 73 | P | B | -0.7055 | |
| 74 | D | B | -2.0895 | |
| 75 | T | B | 0.0000 | |
| 76 | D | B | -1.3371 | |
| 77 | V | B | 0.0000 | |
| 78 | F | B | 0.0000 | |
| 79 | L | B | 0.0000 | |
| 80 | V | B | 0.0000 | |
| 81 | C | B | 0.0000 | |
| 82 | F | B | 0.0000 | |
| 83 | S | B | 0.0000 | |
| 84 | L | B | 0.0000 | |
| 85 | E | B | -0.8289 | |
| 86 | N | B | -1.3099 | |
| 87 | P | B | -1.5397 | |
| 88 | N | B | -2.2211 | |
| 89 | S | B | 0.0000 | |
| 90 | L | B | 0.0000 | |
| 91 | E | B | -2.9871 | |
| 92 | N | B | -2.4429 | |
| 93 | C | B | 0.0000 | |
| 94 | H | B | -2.5474 | |
| 95 | S | B | -1.8775 | |
| 96 | K | B | -2.1164 | |
| 97 | W | B | 0.0000 | |
| 98 | A | B | 0.0000 | |
| 99 | E | B | -2.9665 | |
| 100 | E | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | K | B | -2.8961 | |
| 103 | H | B | -1.9562 | |
| 104 | Y | B | -0.1413 | |
| 105 | N | B | -1.5588 | |
| 106 | P | B | -2.0579 | |
| 107 | D | B | -2.3151 | |
| 108 | T | B | -1.5300 | |
| 109 | P | B | 0.0000 | |
| 110 | I | B | 0.0000 | |
| 111 | V | B | 0.0000 | |
| 112 | L | B | 0.0000 | |
| 113 | V | B | 0.0000 | |
| 114 | G | B | 0.0000 | |
| 115 | T | B | 0.0000 | |
| 116 | K | B | -1.2595 | |
| 117 | L | B | 0.0000 | |
| 118 | D | B | -1.9150 | |
| 119 | L | B | -1.6505 | |
| 120 | K | B | -1.9823 | |
| 121 | K | B | -2.9820 | |
| 122 | D | B | -3.2355 | |
| 123 | E | B | -3.9860 | |
| 124 | E | B | -3.9221 | |
| 125 | Y | B | -2.6920 | |
| 126 | V | B | -3.3197 | |
| 127 | K | B | -4.3299 | |
| 128 | K | B | -4.2647 | |
| 129 | L | B | 0.0000 | |
| 130 | K | B | -4.5937 | |
| 131 | E | B | -4.6546 | |
| 132 | K | B | -4.2504 | |
| 133 | K | B | -3.7549 | |
| 134 | I | B | -2.2920 | |
| 135 | S | B | -1.6655 | |
| 136 | P | B | -0.6883 | |
| 137 | V | B | 0.0000 | |
| 138 | T | B | -1.0811 | |
| 139 | T | B | -1.2370 | |
| 140 | E | B | -2.5141 | |
| 141 | Q | B | -2.5098 | |
| 142 | G | B | 0.0000 | |
| 143 | Q | B | -2.3858 | |
| 144 | E | B | -3.8890 | |
| 145 | M | B | 0.0000 | |
| 146 | K | B | 0.0000 | |
| 147 | D | B | -3.1917 | |
| 148 | K | B | -3.3400 | |
| 149 | I | B | 0.0000 | |
| 150 | K | B | -2.6740 | |
| 151 | A | B | -1.2093 | |
| 152 | C | B | -0.3187 | |
| 153 | G | B | 0.0000 | |
| 154 | Y | B | 0.0000 | |
| 155 | I | B | 0.0000 | |
| 156 | E | B | 0.0000 | |
| 157 | C | B | 0.0000 | |
| 158 | S | B | 0.0000 | |
| 159 | A | B | -0.8844 | |
| 160 | K | B | -1.7843 | |
| 161 | T | B | -1.1059 | |
| 162 | M | B | -1.0382 | |
| 163 | E | B | -2.3957 | |
| 164 | N | B | -1.4296 | |
| 165 | L | B | 0.0000 | |
| 166 | T | B | -0.5975 | |
| 167 | E | B | -0.6995 | |
| 168 | A | B | 0.0000 | |
| 169 | F | B | 0.0000 | |
| 170 | N | B | -0.4658 | |
| 171 | M | B | -0.0601 | |
| 172 | A | B | 0.0000 | |
| 173 | I | B | 0.0000 | |
| 174 | D | B | -0.6087 | |
| 175 | I | B | -0.2847 | |
| 176 | A | B | 0.0000 | |
| 177 | M | B | 0.0000 | |
| 178 | K | B | -1.3523 | |
| 179 | Q | B | -1.9865 | |
| 180 | R | B | -1.5350 | |
| 181 | L | B | -0.5543 | |
| 182 | K | B | -2.3817 | |
| 183 | D | B | -2.5232 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine