Project name: 4g3y:H

Chain sequence(s)	H: EVKLEESGGGLVQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.7425
• Maximal score value: 2.4567
• Average score: -0.5969
• Total score value: -131.3179

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.2996
2	V	H	-1.5989
3	K	H	-2.6139
4	L	H	0.0000
5	E	H	-2.2697
6	E	H	0.0000
7	S	H	-1.0662
8	G	H	-0.8373
9	G	H	-0.6127
10	G	H	-0.3967
11	L	H	-0.2278
12	V	H	-0.6144
13	Q	H	-1.6814
14	P	H	-1.7407
15	G	H	-1.7331
16	G	H	-1.2509
17	S	H	-1.2710
18	M	H	-1.0983
19	K	H	-1.9618
20	L	H	0.0000
21	S	H	-0.8313
22	C	H	0.0000
23	V	H	-0.7473
24	A	H	0.0000
25	S	H	-0.9892
26	G	H	-0.8133
27	F	H	0.4358
28	I	H	1.7086
29	F	H	0.0000
30	S	H	-0.8275
31	N	H	-0.6212
32	H	H	0.0000
33	W	H	-0.1638
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.4081
40	S	H	-1.2318
41	P	H	-1.3629
42	E	H	-2.6027
43	K	H	-2.1079
44	G	H	-0.7934
45	L	H	0.7103
46	E	H	0.1755
47	W	H	0.4809
48	V	H	0.0000
49	A	H	0.0000
50	E	H	0.0000
51	I	H	0.0000
52	R	H	-0.9052
53	S	H	0.0000
54	K	H	-2.1311
55	S	H	-0.9155
56	I	H	0.1560
57	N	H	-1.3171
58	S	H	-1.1406
59	A	H	-0.5985
60	T	H	-0.4280
61	H	H	-1.0382
62	Y	H	-1.1560
63	A	H	-1.4409
64	E	H	-2.5579
65	S	H	-1.7967
66	V	H	0.0000
67	K	H	-2.6883
68	G	H	-1.7908
69	R	H	-1.6236
70	F	H	0.0000
71	T	H	-0.9841
72	I	H	0.0000
73	S	H	-0.6828
74	R	H	-1.3490
75	D	H	-1.9276
76	D	H	-1.7955
77	S	H	-1.6387
78	K	H	-2.1976
79	S	H	-0.9201
80	A	H	0.0000
81	V	H	0.0000
82	Y	H	-0.6803
83	L	H	0.0000
84	Q	H	-1.5758
85	M	H	0.0000
86	T	H	-1.4817
87	D	H	-1.9499
88	L	H	0.0000
89	R	H	-2.2313
90	T	H	-1.7058
91	E	H	-2.5627
92	D	H	0.0000
93	T	H	-0.8321
94	G	H	-0.5379
95	V	H	0.2558
96	Y	H	0.0000
97	Y	H	-0.0771
98	C	H	0.0000
99	S	H	0.0000
100	R	H	0.0000
101	N	H	0.0000
102	Y	H	0.8674
103	Y	H	0.6594
104	G	H	0.0523
105	S	H	0.0012
106	T	H	0.2185
107	Y	H	0.5901
108	D	H	0.2592
109	Y	H	0.0638
110	W	H	-0.1319
111	G	H	0.0000
112	Q	H	-1.6033
113	G	H	-0.8260
114	T	H	-0.5181
115	T	H	-0.0877
116	L	H	0.0000
117	T	H	-0.5120
118	V	H	0.0000
119	S	H	-0.9512
120	S	H	-0.7159
121	A	H	-0.4289
122	S	H	-0.5749
123	T	H	-0.8830
124	K	H	-1.1983
125	G	H	-1.4116
126	P	H	0.0000
127	S	H	-0.4187
128	V	H	0.0000
129	F	H	0.6581
130	P	H	0.0132
131	L	H	0.5193
132	A	H	-0.4620
133	P	H	0.0000
134	S	H	-1.0078
135	S	H	-1.3461
136	K	H	-2.0766
137	S	H	-1.3199
138	T	H	-1.1726
139	S	H	-0.9780
140	G	H	-1.3047
141	G	H	-0.9976
142	T	H	-0.7151
143	A	H	0.0000
144	A	H	0.0306
145	L	H	0.0000
146	G	H	0.0000
147	C	H	0.0000
148	L	H	0.6120
149	V	H	0.0000
150	K	H	-0.2385
151	D	H	-0.4250
152	Y	H	0.0000
153	F	H	-0.2587
154	P	H	0.0000
155	E	H	-0.3144
156	P	H	-0.7075
157	V	H	-0.6310
158	T	H	-0.5966
159	V	H	-0.4448
160	S	H	-0.4719
161	W	H	0.0000
162	N	H	-0.8049
163	S	H	-0.7555
164	G	H	-0.5758
165	A	H	-0.2505
166	L	H	-0.0304
167	T	H	-0.2445
168	S	H	-0.3013
169	G	H	-0.3200
170	V	H	0.1751
171	H	H	-0.2136
172	T	H	0.3525
173	F	H	1.1539
174	P	H	0.8024
175	A	H	1.3017
176	V	H	2.4567
177	L	H	2.1662
178	Q	H	0.7103
179	S	H	0.0849
180	S	H	-0.2569
181	G	H	0.1490
182	L	H	0.3680
183	Y	H	0.8579
184	S	H	0.7718
185	L	H	0.0000
186	S	H	0.7151
187	S	H	0.0000
188	V	H	0.5337
189	V	H	0.0000
190	T	H	-0.1694
191	V	H	0.0000
192	P	H	-0.7019
193	S	H	-0.7742
194	S	H	-0.6753
195	S	H	-0.6138
196	L	H	-0.8059
197	G	H	-0.9907
198	T	H	-0.7025
199	Q	H	-1.1842
200	T	H	-1.0766
201	Y	H	0.0000
202	I	H	-1.6312
203	C	H	0.0000
204	N	H	-1.7359
205	V	H	0.0000
206	N	H	-1.8855
207	H	H	0.0000
208	K	H	-2.6760
209	P	H	-1.5174
210	S	H	-1.8143
211	N	H	-2.5453
212	T	H	-2.0526
213	K	H	-2.7425
214	V	H	-1.7608
215	D	H	-2.7247
216	K	H	-2.3399
217	K	H	-2.7242
218	V	H	0.0000
219	E	H	-2.4537
220	P	H	-1.1697