Project name: e484afa17dfb7b2

Chain sequence(s)	A: EQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHSAGCGRTGAICCAIDYTWNLLKAGKIPEEFNVFNLIQEMMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2055
• Maximal score value: 1.5999
• Average score: -0.8983
• Total score value: -268.6015

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	E	A	-2.6147
3	Q	A	-2.5567
4	V	A	-1.6463
5	E	A	-3.4947
6	I	A	0.0000
7	L	A	0.0000
8	R	A	-3.7027
9	K	A	-4.2055
10	F	A	0.0000
11	I	A	-2.6337
12	Q	A	-2.8512
13	R	A	-2.7075
14	V	A	0.0000
15	Q	A	-2.4348
16	A	A	-1.5766
17	M	A	-1.9181
18	K	A	-2.2124
19	S	A	-1.6662
20	P	A	-2.3308
21	D	A	-2.5187
22	H	A	-2.2948
23	N	A	-2.7049
24	G	A	-2.4558
25	E	A	-2.9233
26	D	A	-2.5094
27	N	A	-1.9523
28	F	A	0.0000
29	A	A	-1.8290
30	R	A	-2.2694
31	D	A	-1.9278
32	F	A	0.0000
33	M	A	-1.9621
34	R	A	-2.5980
35	L	A	0.0000
36	R	A	-3.2859
37	R	A	-3.2808
38	L	A	-2.0265
39	S	A	0.0000
40	T	A	-2.0476
41	K	A	-2.4968
42	Y	A	0.0000
43	R	A	-1.9104
44	T	A	-1.9948
45	E	A	-2.7255
46	K	A	-2.3274
47	I	A	-0.4192
48	Y	A	-0.6258
49	P	A	-1.1579
50	T	A	0.0000
51	A	A	-0.9008
52	T	A	-1.3959
53	G	A	0.0000
54	E	A	-2.8700
55	K	A	-3.3089
56	E	A	-3.5982
57	E	A	-3.3611
58	N	A	0.0000
59	V	A	-1.7702
60	K	A	-2.4718
61	K	A	0.0000
62	N	A	0.0000
63	R	A	-0.8004
64	Y	A	-1.1618
65	K	A	-2.5789
66	D	A	-2.4407
67	I	A	-1.1220
68	L	A	0.0000
69	P	A	0.0000
70	F	A	0.0000
71	D	A	-1.3761
72	H	A	-1.2141
73	S	A	-1.1612
74	R	A	-1.1004
75	V	A	0.0000
76	K	A	-1.6221
77	L	A	0.0000
78	T	A	-1.2339
79	L	A	-1.2886
80	K	A	-2.4086
81	T	A	-1.5071
82	P	A	-1.1315
83	S	A	-0.9965
84	Q	A	-1.7412
85	D	A	-2.6462
86	S	A	-1.8227
87	D	A	-1.5685
88	Y	A	0.0000
89	I	A	0.0000
90	N	A	0.0000
91	A	A	0.0000
92	N	A	0.0000
93	F	A	-0.6721
94	I	A	0.0000
95	K	A	-1.5199
96	G	A	0.0000
97	V	A	0.4762
98	Y	A	0.7788
99	G	A	0.0000
100	P	A	-1.0096
101	K	A	-1.2961
102	A	A	0.0000
103	Y	A	0.0000
104	V	A	0.0000
105	A	A	0.0000
106	T	A	0.0000
107	Q	A	0.0000
108	G	A	0.0000
109	P	A	0.0000
110	L	A	-0.7035
111	A	A	-0.5322
112	N	A	-1.3281
113	T	A	0.0000
114	V	A	0.0000
115	I	A	0.0340
116	D	A	0.0000
117	F	A	0.0000
118	W	A	0.0000
119	R	A	0.0000
120	M	A	0.0000
121	I	A	0.0000
122	W	A	-0.5293
123	E	A	-0.8792
124	Y	A	-0.7590
125	N	A	-1.4028
126	V	A	0.0000
127	V	A	-0.0584
128	I	A	0.0000
129	I	A	0.0000
130	V	A	0.0000
131	M	A	0.0000
132	A	A	0.0000
133	C	A	0.0000
134	R	A	-1.3671
135	E	A	-1.1431
136	F	A	0.1192
137	E	A	0.0000
138	M	A	0.3149
139	G	A	-0.6669
140	R	A	-1.9291
141	K	A	-1.7222
142	K	A	0.0000
143	C	A	0.0000
144	E	A	-0.9561
145	R	A	-0.8008
146	Y	A	0.0000
147	W	A	0.0000
148	P	A	0.0000
149	L	A	0.4573
150	Y	A	0.0082
151	G	A	-1.1638
152	E	A	-1.9171
153	D	A	-2.3140
154	P	A	-1.1698
155	I	A	-0.2941
156	T	A	-0.1807
157	F	A	0.2506
158	A	A	0.0315
159	P	A	-0.6261
160	F	A	0.0000
161	K	A	-1.0170
162	I	A	0.0000
163	S	A	-1.1491
164	C	A	0.0000
165	E	A	-1.9687
166	D	A	-1.9711
167	E	A	-1.3193
168	Q	A	-1.0894
169	A	A	-0.6694
170	R	A	-1.1719
171	T	A	-1.0100
172	D	A	-1.0100
173	Y	A	0.0000
174	F	A	-0.0826
175	I	A	0.0000
176	R	A	0.0000
177	T	A	-0.9658
178	L	A	0.0000
179	L	A	-1.0321
180	L	A	0.0000
181	E	A	-2.2464
182	F	A	-1.8862
183	Q	A	-2.5717
184	N	A	-2.8568
185	E	A	-3.1049
186	S	A	-2.2286
187	R	A	-1.4836
188	R	A	-1.3627
189	L	A	0.0000
190	Y	A	-0.0635
191	Q	A	0.0000
192	F	A	0.0000
193	H	A	0.0000
194	Y	A	0.0000
195	V	A	-0.6149
196	N	A	-0.9518
197	W	A	0.0000
198	P	A	-0.9594
199	D	A	-1.2990
200	H	A	-1.8485
201	D	A	-1.7335
202	V	A	-0.7662
203	P	A	0.0000
204	S	A	-0.5571
205	S	A	-0.6846
206	F	A	-1.0712
207	D	A	-2.1114
208	S	A	0.0000
209	I	A	0.0000
210	L	A	0.0000
211	D	A	-1.5848
212	M	A	0.0000
213	I	A	0.0000
214	S	A	-0.8296
215	L	A	-0.7511
216	M	A	0.0000
217	R	A	0.0000
218	K	A	-1.9085
219	Y	A	-0.5388
220	Q	A	0.0000
221	E	A	-2.5640
222	H	A	-1.6791
223	E	A	0.0000
224	D	A	-2.1463
225	V	A	-1.1414
226	P	A	0.0000
227	I	A	0.0000
228	C	A	0.0000
229	I	A	0.0000
230	H	A	0.0000
232	S	A	0.0000
233	A	A	-0.1958
234	G	A	0.0000
235	C	A	0.0000
236	G	A	0.0000
237	R	A	0.0000
238	T	A	0.0000
239	G	A	0.0000
240	A	A	0.0000
241	I	A	0.0000
242	C	A	0.0000
243	A	A	0.0000
244	I	A	0.0000
245	D	A	0.0000
246	Y	A	0.1855
247	T	A	0.0000
248	W	A	-0.4550
249	N	A	-0.9521
250	L	A	0.0000
251	L	A	0.0000
252	K	A	-2.1507
253	A	A	-1.5090
254	G	A	-1.9713
255	K	A	-2.4541
256	I	A	0.0000
257	P	A	-2.4464
258	E	A	-3.8734
259	E	A	-3.4587
260	F	A	0.0000
261	N	A	-2.2649
262	V	A	0.0000
263	F	A	-0.9846
264	N	A	-1.5950
265	L	A	-1.0621
266	I	A	0.0000
267	Q	A	-1.5429
268	E	A	-2.0219
269	M	A	0.0000
270	R	A	0.0000
271	T	A	-0.5600
272	Q	A	-0.9680
273	R	A	0.0000
274	H	A	0.0000
275	S	A	-0.4350
276	A	A	0.0000
277	V	A	0.0000
278	Q	A	-1.1466
279	T	A	-1.4240
280	K	A	-1.8760
281	E	A	-1.5566
282	Q	A	0.0000
283	Y	A	0.0000
284	E	A	-1.4787
285	L	A	0.0000
286	V	A	0.0000
287	H	A	0.0000
288	R	A	-1.5902
289	A	A	0.0000
290	I	A	0.0000
291	A	A	0.0000
292	Q	A	-1.5993
293	L	A	0.0000
294	F	A	0.0000
295	E	A	-2.3404
296	K	A	-1.9504
297	Q	A	-0.9996
298	L	A	0.0000
299	Q	A	-0.8037
300	L	A	1.1473
301	Y	A	1.5999