Project name: e51130c75f69cdd

Chain sequence(s)	B: SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICCFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICCGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1235
• Maximal score value: 0.9447
• Average score: -0.8341
• Total score value: -282.7593

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	B	-1.4591
3	E	B	-2.2136
4	L	B	-1.2566
5	D	B	-3.1305
6	Q	B	-3.3162
7	L	B	-1.9542
8	R	B	-3.6171
9	Q	B	-4.0930
10	E	B	-3.8886
11	A	B	-3.0075
12	E	B	-4.1235
13	Q	B	-3.5581
14	L	B	-2.1374
15	K	B	-3.4804
16	N	B	-3.4369
17	Q	B	-3.0739
18	I	B	-2.3618
19	R	B	-3.6252
20	D	B	-3.5484
21	A	B	-2.2031
22	R	B	-2.1924
23	K	B	-2.8981
24	A	B	-1.4696
25	C	B	-0.7191
26	A	B	-1.1447
27	D	B	-1.8014
28	A	B	-0.5302
29	T	B	-0.1558
30	L	B	0.3996
31	S	B	-0.3623
32	Q	B	-0.8280
33	I	B	0.9447
34	T	B	0.0000
35	N	B	-1.8765
36	N	B	-1.9268
37	I	B	-1.0108
38	D	B	-2.1046
39	P	B	-1.7029
40	V	B	-0.8625
41	G	B	-1.6963
42	R	B	-2.0957
43	I	B	-1.2100
44	Q	B	-1.9435
45	M	B	-1.9724
46	R	B	-2.9246
47	T	B	-2.2310
48	R	B	-2.6888
49	R	B	-2.1076
50	T	B	-1.3065
51	L	B	0.0000
52	R	B	-2.0406
53	G	B	-0.9590
54	H	B	0.0000
55	L	B	0.9195
56	A	B	0.3064
57	K	B	-0.2230
58	I	B	0.0000
59	Y	B	0.1811
60	A	B	0.1665
61	M	B	0.0000
62	H	B	-0.2021
63	W	B	0.0000
64	G	B	0.0000
65	T	B	-1.8487
66	D	B	-2.6550
67	S	B	0.0000
68	R	B	-1.3505
69	L	B	-0.4956
70	L	B	0.0000
71	V	B	0.0000
72	S	B	0.0000
73	A	B	0.0000
74	S	B	0.0000
75	Q	B	-0.4265
76	D	B	-0.2344
77	G	B	0.0000
78	K	B	-0.6364
79	L	B	0.0000
80	I	B	0.0000
81	I	B	0.0000
82	W	B	0.0000
83	D	B	0.0000
84	S	B	0.0000
85	Y	B	0.0051
86	T	B	-0.4896
87	T	B	-1.0800
88	N	B	-1.6585
89	K	B	-1.4629
90	V	B	0.1724
91	H	B	-0.1168
92	A	B	-0.1688
93	I	B	0.0000
94	P	B	-0.8117
95	L	B	-0.8427
96	R	B	-1.8119
97	S	B	-0.6952
98	S	B	-0.3041
99	W	B	0.7701
100	V	B	0.0000
101	M	B	0.6252
102	T	B	0.0000
103	C	B	0.0000
104	A	B	0.0000
105	Y	B	0.0000
106	A	B	0.0000
107	P	B	-0.8961
108	S	B	-0.9379
109	G	B	-1.0489
110	N	B	-1.1806
111	Y	B	-0.8271
112	V	B	0.0000
113	A	B	0.0000
114	C	B	0.0000
115	G	B	0.0000
116	G	B	0.0000
117	L	B	0.9215
118	D	B	-0.2024
119	N	B	-0.2672
120	I	B	-0.1912
121	C	B	0.0000
122	S	B	-0.7819
123	I	B	0.0000
124	Y	B	0.0000
125	N	B	-1.7168
126	L	B	0.0000
127	K	B	-3.2718
128	T	B	-3.3003
129	R	B	-3.4869
130	E	B	-3.5500
131	G	B	-3.2238
132	N	B	-3.0570
133	V	B	-1.7186
134	R	B	-2.2145
135	V	B	-1.2533
136	S	B	-1.1698
137	R	B	-1.6858
138	E	B	-1.3964
139	L	B	0.0000
140	A	B	-0.8429
141	G	B	-0.8606
142	H	B	0.0000
143	T	B	-0.3975
144	G	B	-0.3058
145	Y	B	0.2896
146	L	B	0.0000
147	S	B	0.0000
148	C	B	0.0000
149	C	B	0.0000
150	R	B	-0.4112
151	F	B	0.0000
152	L	B	-0.9980
153	D	B	-1.4909
154	D	B	-1.7689
155	N	B	-1.8470
156	Q	B	-1.5423
157	I	B	0.0000
158	V	B	0.0000
159	T	B	0.0000
160	S	B	0.0000
161	S	B	0.0000
162	G	B	-0.3424
163	D	B	-0.6256
164	T	B	-0.5577
165	T	B	-0.3871
166	C	B	0.0000
167	A	B	0.0000
168	L	B	0.0000
169	W	B	0.0000
170	D	B	-1.8646
171	I	B	0.0000
172	E	B	-2.5756
173	T	B	-1.7186
174	G	B	-1.9683
175	Q	B	-1.9668
176	Q	B	-1.2856
177	T	B	-0.9998
178	T	B	-0.9441
179	T	B	-0.1729
180	F	B	0.0000
181	T	B	-0.2214
182	G	B	-0.3775
183	H	B	0.0000
184	T	B	-0.4967
185	G	B	-0.6641
186	D	B	-0.7800
187	V	B	0.0000
188	M	B	-0.0103
189	S	B	-0.0197
190	L	B	0.0000
191	S	B	0.0605
192	L	B	-0.3514
193	A	B	0.0000
194	P	B	-1.5303
195	D	B	-2.2620
196	T	B	-1.8385
197	R	B	-2.7570
198	L	B	-1.7300
199	F	B	0.0000
200	V	B	0.0000
201	S	B	0.0000
202	G	B	0.0000
203	A	B	0.0000
204	C	B	-0.6848
205	D	B	-0.9614
206	A	B	-1.2279
207	S	B	-0.5863
208	A	B	0.0000
209	K	B	-0.5889
210	L	B	0.0000
211	W	B	0.0000
212	D	B	-2.0517
213	V	B	0.0000
214	R	B	-3.1431
215	E	B	-3.0464
216	G	B	-1.5441
217	M	B	-0.8537
218	C	B	-0.8596
219	R	B	-1.9237
220	Q	B	-1.2496
221	T	B	-0.6391
222	F	B	0.0000
223	T	B	-0.6509
224	G	B	-0.8775
225	H	B	0.0000
226	E	B	-2.4236
227	S	B	-1.8749
228	D	B	-1.5796
229	I	B	0.0000
230	N	B	-0.6232
231	A	B	0.0000
232	I	B	0.0000
233	C	B	0.1888
234	F	B	0.0000
235	F	B	-0.6592
236	P	B	-1.2372
237	N	B	-1.7690
238	G	B	-1.3169
239	N	B	-1.6368
240	A	B	0.0000
241	F	B	0.0000
242	A	B	0.0000
243	T	B	0.0000
244	G	B	0.0000
245	S	B	0.0000
246	D	B	-1.9158
247	D	B	-1.3333
248	A	B	0.0000
249	T	B	-0.4923
250	C	B	0.0000
251	R	B	-0.2873
252	L	B	0.0000
253	F	B	0.0000
254	D	B	-1.1880
255	L	B	0.0000
256	R	B	-2.2491
257	A	B	-1.3690
258	D	B	-1.2927
259	Q	B	-1.3219
260	E	B	-0.7092
261	L	B	0.0953
262	M	B	0.0000
263	T	B	-0.4185
264	Y	B	0.0000
265	S	B	-1.0869
266	H	B	-1.8292
267	D	B	-2.2426
268	N	B	-1.7466
269	I	B	0.0000
270	I	B	0.8605
271	C	B	0.3587
272	G	B	-0.7211
273	I	B	0.0000
274	T	B	-0.4476
275	S	B	0.0000
276	V	B	0.0000
277	S	B	-0.0785
278	F	B	0.0000
279	S	B	-1.2653
280	K	B	-2.5213
281	S	B	-1.3094
282	G	B	0.0000
283	R	B	-0.4794
284	L	B	-0.2362
285	L	B	0.0000
286	L	B	0.0000
287	A	B	0.0000
288	G	B	0.0000
289	Y	B	0.0000
290	D	B	-0.8317
291	D	B	-0.8439
292	F	B	-0.6347
293	N	B	-0.4241
294	C	B	0.0000
295	N	B	0.0000
296	V	B	0.0000
297	W	B	0.0000
298	D	B	0.0000
299	A	B	0.0000
300	L	B	0.0918
301	K	B	-1.1530
302	A	B	-1.1541
303	D	B	-2.2418
304	R	B	-1.7598
305	A	B	0.0000
306	G	B	0.0000
307	V	B	0.1087
308	L	B	0.0000
309	A	B	-0.2555
310	G	B	-0.6127
311	H	B	-1.1222
312	D	B	-2.0726
313	N	B	-1.6148
314	R	B	-1.2029
315	V	B	0.0000
316	S	B	-0.1433
317	C	B	0.0000
318	L	B	0.0000
319	G	B	-0.1972
320	V	B	-0.7507
321	T	B	0.0000
322	D	B	-3.2983
323	D	B	-3.0904
324	G	B	-2.0531
325	M	B	-0.9877
326	A	B	0.0000
327	V	B	0.0000
328	A	B	0.0000
329	T	B	0.0000
330	G	B	0.0000
331	S	B	0.0000
332	W	B	-0.5322
333	D	B	-0.6194
334	S	B	-0.3879
335	F	B	-0.4303
336	L	B	0.0000
337	K	B	-1.2132
338	I	B	0.0000
339	W	B	0.0000
340	N	B	-1.9949