Project name: e7d08cf67e75032

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSDHHEGTEEHHHGGHEHHHGHGHGHHASVCSFPPDALVTVVECVERNVTDQVRGKLAEVSQRLQCDTILCGIQKFCQMHGTLEGNRTDVFTREENIQLRNAFIGCKPQTLATTGDAAKGGGGSYQMKRKGHHGGGNEPTDFHGEFTNYMRKVQHQARMRHNHYRRLHGVPDLKESEELNRYAQAWAERLAKTGQFRHRSRSPYGENIYMSYNSDPNFKLKGRAPVDSWYSEIKYHNYNSNGFNPKTGHFTQVIWKGSRWLGTGVAKSRDGKIFVVSNYKPRGNMMGRFRENVPRPNSDGEMQQQNLVKLISNKNVNTDKLLIRSPCSLALTINSSAVCVITHGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9931
• Maximal score value: 2.1075
• Average score: -1.0538
• Total score value: -673.3492

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.4632
2	H	A	-2.6048
3	H	A	-3.0878
4	E	A	-3.5950
5	G	A	-2.8106
6	Q	A	-3.1489
7	P	A	-2.3900
8	R	A	-1.8367
9	S	A	-0.2794
10	V	A	-0.1285
11	C	A	-0.1750
12	A	A	-1.2024
13	L	A	0.0000
14	E	A	-2.6609
15	E	A	-3.4685
16	N	A	-3.2473
17	A	A	0.0000
18	K	A	-2.5559
19	R	A	-3.0726
20	A	A	-1.9876
21	L	A	0.0000
22	I	A	-0.7856
23	S	A	-0.8280
24	C	A	0.0000
25	V	A	0.0000
26	Q	A	-0.7885
27	T	A	-0.4156
28	H	A	-0.9057
29	L	A	-0.8262
30	T	A	-1.0548
31	A	A	-1.2564
32	D	A	-2.5347
33	T	A	0.0000
34	T	A	-1.8539
35	Q	A	-2.5077
36	K	A	-2.4740
37	L	A	0.0000
38	S	A	-1.9602
39	A	A	-1.7571
40	V	A	0.0000
41	K	A	-2.4539
42	D	A	-2.8323
43	Q	A	-2.4120
44	L	A	-2.3432
45	H	A	-2.9676
46	C	A	0.0000
47	D	A	-3.1293
48	D	A	-2.9651
49	V	A	0.0000
50	Y	A	-0.7638
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	-0.1411
55	R	A	0.0000
56	I	A	-0.6187
57	C	A	0.0000
58	D	A	-2.4745
59	R	A	-3.4245
60	N	A	-3.1573
61	N	A	-2.8724
62	G	A	-2.2128
63	T	A	-1.7165
64	L	A	-1.2667
65	E	A	-1.7856
66	H	A	-1.0691
67	P	A	-0.2846
68	S	A	-0.2494
69	N	A	-0.6547
70	E	A	0.0000
71	F	A	0.0792
72	F	A	-0.5847
73	S	A	-1.4460
74	N	A	-1.8232
75	A	A	-0.9041
76	E	A	0.0000
77	K	A	-0.8181
78	T	A	-0.8787
79	D	A	0.0000
80	I	A	0.0000
81	R	A	-1.0541
82	S	A	0.0000
83	A	A	0.0000
84	V	A	0.0000
85	V	A	0.0000
86	T	A	0.0000
87	C	A	0.0000
88	R	A	-2.0800
89	E	A	-2.6749
90	N	A	-2.3303
91	L	A	-2.1102
92	Q	A	-3.1281
93	R	A	-3.4826
94	Q	A	-2.7055
95	A	A	-2.7427
96	E	A	-3.4917
97	A	A	-2.4706
98	A	A	0.0000
99	K	A	-2.9365
100	T	A	-1.8616
101	S	A	-1.7963
102	G	A	-1.4020
103	G	A	-1.8132
104	G	A	-1.5652
105	G	A	0.0000
106	S	A	-2.1463
107	D	A	-2.4847
108	H	A	0.0000
109	H	A	-1.9597
110	E	A	-3.3201
111	G	A	-3.0621
112	T	A	-2.7562
113	E	A	-2.9302
114	E	A	0.0000
115	H	A	-2.5175
116	H	A	-2.6758
117	H	A	-2.4122
118	G	A	-1.6253
119	G	A	-1.7550
120	H	A	-2.0570
121	E	A	-2.4101
122	H	A	0.0000
123	H	A	-1.9332
124	H	A	-2.3987
125	G	A	-1.7926
126	H	A	0.0000
127	G	A	0.0000
128	H	A	-2.5247
129	G	A	-1.8671
130	H	A	-2.0948
131	H	A	-1.9945
132	A	A	0.0000
133	S	A	0.0000
134	V	A	0.0000
135	C	A	0.0000
136	S	A	0.0000
137	F	A	0.0000
138	P	A	-0.6974
139	P	A	-0.5013
140	D	A	-0.8696
141	A	A	0.0000
142	L	A	0.0000
143	V	A	0.7170
144	T	A	0.0264
145	V	A	-0.4708
146	V	A	-1.4230
147	E	A	-2.2497
148	C	A	-1.1627
149	V	A	0.0000
150	E	A	-3.0707
151	R	A	-2.3709
152	N	A	0.0000
153	V	A	-0.9803
154	T	A	-1.3346
155	D	A	-1.2553
156	Q	A	-1.1197
157	V	A	-0.4827
158	R	A	-1.4775
159	G	A	0.0000
160	K	A	-1.2490
161	L	A	0.2235
162	A	A	-0.2704
163	E	A	-0.7483
164	V	A	0.3193
165	S	A	0.1269
166	Q	A	-0.7801
167	R	A	-1.1202
168	L	A	0.1740
169	Q	A	-1.2057
170	C	A	-0.8789
171	D	A	-2.2820
172	T	A	-1.4154
173	I	A	-0.6853
174	L	A	0.0000
175	C	A	-0.9342
176	G	A	0.0000
177	I	A	0.0000
178	Q	A	-1.0901
179	K	A	-1.7271
180	F	A	0.0000
181	C	A	0.0000
182	Q	A	-1.5037
183	M	A	0.0142
184	H	A	-0.6331
185	G	A	-1.3778
186	T	A	0.0000
187	L	A	0.0000
188	E	A	-3.0557
189	G	A	-2.9722
190	N	A	-3.0632
191	R	A	-2.9349
192	T	A	-1.9146
193	D	A	-1.2855
194	V	A	-0.5302
195	F	A	0.0000
196	T	A	0.0000
197	R	A	-2.1397
198	E	A	-2.6681
199	E	A	-1.7751
200	N	A	0.0000
201	I	A	-1.5902
202	Q	A	-1.4782
203	L	A	0.0000
204	R	A	-1.2769
205	N	A	-1.2514
206	A	A	-0.7604
207	F	A	0.0000
208	I	A	0.0000
209	G	A	-1.5283
210	C	A	-1.6060
211	K	A	-2.6516
212	P	A	-1.7689
213	Q	A	-2.0105
214	T	A	-1.0290
215	L	A	-0.4946
216	A	A	0.0000
217	T	A	0.0000
218	T	A	0.0000
219	G	A	-1.6164
220	D	A	-1.9041
221	A	A	0.0000
222	A	A	-1.9369
223	K	A	-2.3898
224	G	A	-1.6388
225	G	A	-2.0181
226	G	A	-1.6071
227	G	A	-1.2174
228	S	A	-0.4432
229	Y	A	-0.5868
230	Q	A	0.0000
231	M	A	0.0000
232	K	A	-2.0546
233	R	A	-2.5787
234	K	A	-2.7490
235	G	A	-2.0941
236	H	A	-2.9029
237	H	A	-2.6379
238	G	A	-2.1693
239	G	A	-2.2863
240	G	A	-2.1834
241	N	A	-2.4973
242	E	A	-2.8811
243	P	A	-2.1251
244	T	A	0.0000
245	D	A	-1.7995
246	F	A	-0.2982
247	H	A	0.0000
248	G	A	-1.5912
249	E	A	-2.0536
250	F	A	-1.1339
251	T	A	-1.4087
252	N	A	-2.4136
253	Y	A	-1.8981
254	M	A	0.0000
255	R	A	-3.3672
256	K	A	-3.3675
257	V	A	0.0000
258	Q	A	-2.1507
259	H	A	-2.3162
260	Q	A	-2.2144
261	A	A	0.0000
262	R	A	-1.7888
263	M	A	-1.2710
264	R	A	-1.7070
265	H	A	0.0000
266	N	A	-1.2641
267	H	A	-1.2793
268	Y	A	-0.5391
269	R	A	0.0000
270	R	A	-1.1168
271	L	A	0.2750
272	H	A	-0.5089
273	G	A	0.0000
274	V	A	0.0000
275	P	A	0.0000
276	D	A	-1.3184
277	L	A	0.0000
278	K	A	-1.5468
279	E	A	-1.7133
280	S	A	-2.2356
281	E	A	-3.2471
282	E	A	-3.2955
283	L	A	0.0000
284	N	A	-2.2061
285	R	A	-2.8422
286	Y	A	-1.2078
287	A	A	0.0000
288	Q	A	-1.0829
289	A	A	-0.9022
290	W	A	-1.2397
291	A	A	0.0000
292	E	A	-1.9938
293	R	A	-2.9264
294	L	A	0.0000
295	A	A	-3.1146
296	K	A	-3.6581
297	T	A	-2.1141
298	G	A	-2.6632
299	Q	A	-2.1514
300	F	A	-1.7075
301	R	A	-2.8181
302	H	A	-2.4352
303	R	A	-3.1316
304	S	A	-2.4252
305	R	A	-2.5889
306	S	A	-1.6103
307	P	A	-1.0635
308	Y	A	0.0000
309	G	A	0.0000
310	E	A	-0.9860
311	N	A	0.0000
312	I	A	0.3953
313	Y	A	0.9311
314	M	A	1.0503
315	S	A	0.4227
316	Y	A	0.4145
317	N	A	-0.9792
318	S	A	-0.5888
319	D	A	-0.8767
320	P	A	-1.1525
321	N	A	-1.6819
322	F	A	-0.7595
323	K	A	-1.8159
324	L	A	0.0000
325	K	A	-2.3473
326	G	A	-2.2171
327	R	A	-2.2695
328	A	A	-1.3385
329	P	A	0.0000
330	V	A	0.0000
331	D	A	-1.1279
332	S	A	-0.6106
333	W	A	0.0000
334	Y	A	-0.5887
335	S	A	-0.7024
336	E	A	-1.0298
337	I	A	-0.7382
338	K	A	-1.3226
339	Y	A	-0.3084
340	H	A	-1.0225
341	N	A	-1.4295
342	Y	A	-0.3283
343	N	A	-1.5903
344	S	A	-1.7241
345	N	A	-2.1035
346	G	A	-1.5393
347	F	A	-1.4469
348	N	A	-2.1063
349	P	A	-1.6862
350	K	A	-2.0423
351	T	A	0.0000
352	G	A	-0.7945
353	H	A	-0.7435
354	F	A	0.0000
355	T	A	-0.4091
356	Q	A	0.0000
357	V	A	0.0000
358	I	A	0.0000
359	W	A	-0.6283
360	K	A	-1.2421
361	G	A	-1.2601
362	S	A	0.0000
363	R	A	-1.2847
364	W	A	-1.2668
365	L	A	0.0000
366	G	A	0.0000
367	T	A	0.0000
368	G	A	0.0000
369	V	A	-0.1735
370	A	A	0.0000
371	K	A	-2.8862
372	S	A	0.0000
373	R	A	-3.9931
374	D	A	-3.3334
375	G	A	-2.2672
376	K	A	-1.6669
377	I	A	-0.9380
378	F	A	0.0000
379	V	A	0.0000
380	V	A	0.0000
381	S	A	0.0000
382	N	A	0.0000
383	Y	A	0.0000
384	K	A	-1.0922
385	P	A	-1.1029
386	R	A	-1.1093
387	G	A	0.0000
388	N	A	-0.7142
389	M	A	-0.0628
390	M	A	0.2814
391	G	A	-1.2024
392	R	A	-1.6785
393	F	A	-0.6294
394	R	A	0.0000
395	E	A	-1.1481
396	N	A	-1.3022
397	V	A	-1.2419
398	P	A	-1.5267
399	R	A	-2.1143
400	P	A	-1.7163
401	N	A	-1.9604
402	S	A	-2.0336
403	D	A	-2.5894
404	G	A	-1.9313
405	E	A	-2.5782
406	M	A	-1.5679
407	Q	A	-1.1181
408	Q	A	-1.5724
409	Q	A	-1.6563
410	N	A	0.0000
411	L	A	-0.3686
412	V	A	0.0000
413	K	A	-0.4441
414	L	A	0.0000
415	I	A	0.0000
416	S	A	-0.8242
417	N	A	-1.1730
418	K	A	-1.4189
419	N	A	-1.7827
420	V	A	-0.9616
421	N	A	-1.6137
422	T	A	-1.0611
423	D	A	-1.8267
424	K	A	-2.3461
425	L	A	0.0000
426	L	A	0.1024
427	I	A	0.0000
428	R	A	0.0000
429	S	A	-0.1751
430	P	A	-0.0070
431	C	A	0.3353
432	S	A	0.7544
433	L	A	1.5167
434	A	A	0.9216
435	L	A	0.0000
436	T	A	0.0000
437	I	A	-0.1932
438	N	A	-0.8676
439	S	A	-0.4709
440	S	A	-0.1579
441	A	A	0.0000
442	V	A	0.0000
443	C	A	0.0000
444	V	A	0.0000
445	I	A	0.0000
446	T	A	-1.1182
447	H	A	-1.7769
448	G	A	-1.9213
449	G	A	-1.4047
450	G	A	-1.3677
451	G	A	-1.1798
452	S	A	-0.9254
453	S	A	-0.4982
454	E	A	-0.6159
455	I	A	0.0000
456	K	A	-1.3990
457	Y	A	0.0000
458	H	A	0.0000
459	N	A	0.0000
460	Y	A	0.1547
461	N	A	0.0000
462	S	A	0.0000
463	N	A	-0.5300
464	G	A	-0.6142
465	F	A	0.0754
466	N	A	-1.0912
467	P	A	-1.2576
468	K	A	-2.0001
469	G	A	-1.3228
470	P	A	-1.1227
471	G	A	-1.0200
472	P	A	-0.5291
473	G	A	-0.0499
474	I	A	0.8070
475	L	A	1.0381
476	F	A	1.1191
477	G	A	0.2334
478	D	A	-0.1192
479	A	A	0.0000
480	F	A	2.1075
481	I	A	0.0000
482	P	A	0.5362
483	A	A	0.0000
484	I	A	0.0000
485	V	A	0.6515
486	Q	A	0.0000
487	P	A	0.0000
488	V	A	0.0000
489	S	A	-0.8708
490	Q	A	-1.1514
491	I	A	-0.8324
492	F	A	0.0000
493	P	A	-1.2987
494	G	A	-1.1003
495	P	A	-0.9981
496	G	A	-0.9338
497	P	A	-0.6097
498	G	A	-0.2633
499	I	A	0.9908
500	L	A	0.8522
501	F	A	1.1005
502	N	A	0.0000
503	S	A	-0.3172
504	L	A	0.0000
505	Q	A	0.0000
506	Y	A	0.0000
507	T	A	0.0000
508	N	A	-0.8806
509	V	A	0.0000
510	V	A	0.0000
511	K	A	-1.1944
512	D	A	-1.5450
513	Y	A	0.0000
514	W	A	-0.6885
515	G	A	-1.6551
516	N	A	-2.1134
517	D	A	-2.2082
518	L	A	-0.6892
519	G	A	-0.9934
520	P	A	-1.5222
521	G	A	-1.4316
522	P	A	-1.7334
523	G	A	-2.1138
524	K	A	-3.0271
525	E	A	-2.6098
526	T	A	0.0000
527	V	A	0.6125
528	L	A	0.0000
529	R	A	-0.4067
530	V	A	0.0000
531	A	A	-0.0414
532	V	A	0.0000
533	T	A	-0.7978
534	A	A	-1.5073
535	Q	A	-1.9898
536	H	A	-1.9305
537	P	A	-1.5068
538	K	A	-0.9790
539	P	A	-0.1586
540	A	A	-0.2193
541	S	A	0.2030
542	L	A	1.0919
543	M	A	0.1073
544	G	A	-0.7770
545	P	A	-0.1981
546	G	A	-0.1750
547	P	A	-0.0987
548	G	A	-0.5143
549	Y	A	0.0000
550	D	A	0.0000
551	A	A	-0.3493
552	G	A	0.0000
553	I	A	0.0000
554	E	A	-0.7177
555	L	A	0.0000
556	A	A	0.0000
557	H	A	0.0000
558	L	A	-0.1334
559	L	A	0.0000
560	A	A	0.0000
561	F	A	0.0000
562	N	A	0.0000
563	K	A	0.0834
564	Y	A	1.0217
565	G	A	0.0000
566	P	A	-1.0148
567	G	A	-0.6741
568	P	A	-0.7934
569	G	A	-1.3354
570	H	A	-1.8306
571	D	A	-3.2794
572	K	A	-3.3214
573	K	A	-2.9811
574	Q	A	-1.6734
575	F	A	-0.8997
576	A	A	0.0000
577	A	A	0.0000
578	L	A	0.2372
579	M	A	0.0000
580	L	A	-0.2495
581	Y	A	-0.7646
582	E	A	-1.6462
583	E	A	-2.6447
584	D	A	-2.5992
585	G	A	0.0000
586	T	A	-1.3427
587	L	A	0.0000
588	R	A	-1.2577
589	V	A	0.0000
590	E	A	-1.9499
591	G	A	-2.2019
592	V	A	0.0000
593	G	A	0.0000
594	P	A	-1.1949
595	G	A	-0.8689
596	P	A	-1.1336
597	G	A	-1.3684
598	K	A	-2.1289
599	R	A	-3.1738
600	H	A	-2.9522
601	G	A	-2.4058
602	K	A	-3.0328
603	R	A	-3.4119
604	L	A	0.0000
605	R	A	-2.1619
606	V	A	0.0000
607	T	A	0.0000
608	K	A	-0.4517
609	V	A	0.0000
610	I	A	0.0000
611	P	A	0.0000
612	H	A	-1.5724
613	A	A	-1.6344
614	K	A	-2.0507
615	Y	A	-2.1708
616	N	A	-3.3185
617	E	A	-3.7974
618	K	A	-3.4181
619	S	A	0.0000
620	E	A	-3.8441
621	A	A	-2.4335
622	A	A	0.0000
623	A	A	0.0000
624	K	A	-2.0761
625	F	A	-1.1919
626	Y	A	0.0000
627	P	A	-1.2407
628	S	A	-1.3052
629	Y	A	0.0000
630	H	A	-1.1787
631	S	A	-1.0048
632	T	A	-0.8978
633	P	A	-1.3503
634	Q	A	-2.1221
635	R	A	-2.5785
636	P	A	-1.6118
637	G	A	-1.5633
638	T	A	-1.5403
639	P	A	-1.2976