Project name: TS14-5

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGQSLTNFGVHWIRQPPGKGLEWIGVIWAGGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGYNGYYYTMDYWGQGTSVTVSS; L: DIQMTQSPSSLSASVGDRVTITCSASSTVSFMNWYQQKPGKAPKLLIYSTSILASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQRSSLPLITFGAGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.0073
• Maximal score value: 1.4862
• Average score: -0.1917
• Total score value: -43.5193

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2570
2	V	H	0.0000
3	Q	H	-1.2224
4	L	H	0.0000
5	Q	H	-0.7616
6	E	H	0.0000
7	S	H	-0.2837
8	G	H	-0.5209
9	P	H	-0.3714
10	G	H	-0.1270
11	L	H	1.4802
12	V	H	0.0000
13	K	H	-1.2647
14	P	H	-0.3814
15	S	H	-0.5471
16	E	H	-1.5749
17	T	H	-0.3520
18	L	H	0.0000
19	S	H	-0.2965
20	L	H	0.0000
21	T	H	-0.0231
22	C	H	0.0000
23	T	H	-0.0552
24	V	H	0.0000
25	S	H	-0.4192
26	G	H	-0.7918
27	Q	H	-1.0107
28	S	H	-0.2257
29	L	H	0.0000
30	T	H	-0.2051
31	N	H	-0.7851
32	F	H	0.0000
33	G	H	0.0000
34	V	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1497
40	P	H	-0.1049
41	P	H	-0.3469
42	G	H	-0.8280
43	K	H	-1.8080
44	G	H	-0.4331
45	L	H	0.0000
46	E	H	-0.5784
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	W	H	0.2006
53	A	H	-0.1090
54	G	H	-0.5026
55	G	H	-0.3553
56	S	H	-0.2598
57	T	H	-0.1414
58	N	H	-0.3794
59	Y	H	0.1774
60	N	H	-0.1742
61	P	H	-0.3269
62	S	H	-0.2594
63	L	H	0.0000
64	K	H	-1.7392
65	S	H	-0.5959
66	R	H	-0.4292
67	V	H	0.0000
68	T	H	-0.0254
69	I	H	0.0000
70	S	H	-0.0501
71	V	H	0.3823
72	D	H	-0.4569
73	T	H	-0.2517
74	S	H	-0.5383
75	K	H	-1.8066
76	N	H	-0.7304
77	Q	H	-0.3041
78	F	H	0.0000
79	S	H	-0.0580
80	L	H	0.0000
81	K	H	-0.9094
82	L	H	0.0000
83	S	H	-0.1458
84	S	H	-0.2585
85	V	H	0.0000
86	T	H	-0.0416
87	A	H	0.0594
88	A	H	0.0691
89	D	H	0.0000
90	T	H	-0.0222
91	A	H	0.0000
92	V	H	0.4751
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	-0.1973
98	D	H	0.0000
99	G	H	0.0000
100	Y	H	1.0417
101	N	H	-0.9431
102	G	H	-0.5234
103	Y	H	0.8978
104	Y	H	0.7508
105	Y	H	0.5773
106	T	H	0.0000
107	M	H	0.0000
108	D	H	-0.1666
109	Y	H	0.5381
110	W	H	0.2393
111	G	H	0.0000
112	Q	H	-1.1983
113	G	H	0.0000
114	T	H	-0.0512
115	S	H	-0.1440
116	V	H	0.0000
117	T	H	-0.0462
118	V	H	0.0000
119	S	H	-0.1361
120	S	H	-0.2308
121	D	L	-1.7471
122	I	L	-0.3179
123	Q	L	-1.1560
124	M	L	0.0000
125	T	L	-0.0709
126	Q	L	0.0000
127	S	L	-0.1794
128	P	L	-0.1769
129	S	L	-0.2690
130	S	L	-0.2790
131	L	L	0.4293
132	S	L	-0.0915
133	A	L	0.0000
134	S	L	-0.0205
135	V	L	1.3642
136	G	L	-0.2617
137	D	L	-1.2524
138	R	L	-2.0073
139	V	L	0.0000
140	T	L	-0.0503
141	I	L	0.0000
142	T	L	-0.0334
143	C	L	0.0000
144	S	L	-0.3170
145	A	L	-0.0557
146	S	L	-0.2502
147	S	L	-0.2643
148	T	L	-0.1276
149	V	L	0.0000
150	S	L	-0.0091
151	F	L	0.4653
152	M	L	0.0000
153	N	L	0.0000
154	W	L	0.0000
155	Y	L	0.0000
156	Q	L	0.0000
157	Q	L	0.0000
158	K	L	-0.5704
159	P	L	-0.4373
160	G	L	-0.8248
161	K	L	-1.7834
162	A	L	-0.3087
163	P	L	0.0000
164	K	L	-1.7000
165	L	L	0.0000
166	L	L	0.0000
167	I	L	0.0000
168	Y	L	0.1964
169	S	L	0.0121
170	T	L	-0.0539
171	S	L	-0.0152
172	I	L	1.1613
173	L	L	0.6291
174	A	L	0.0502
175	S	L	-0.2991
176	G	L	-0.5066
177	V	L	0.0000
178	P	L	-0.1516
179	S	L	-0.2918
180	R	L	-0.3617
181	F	L	0.0000
182	S	L	-0.1720
183	G	L	-0.1580
184	S	L	-0.2629
185	G	L	-0.2853
186	S	L	-0.2737
187	G	L	-0.1724
188	T	L	-0.3731
189	D	L	-1.8057
190	F	L	0.0000
191	T	L	-0.0258
192	L	L	0.0000
193	T	L	-0.0244
194	I	L	0.0000
195	S	L	-0.3395
196	S	L	-0.1398
197	L	L	0.0000
198	Q	L	-0.3843
199	P	L	-0.6493
200	E	L	-1.8665
201	D	L	0.0000
202	F	L	0.8885
203	A	L	0.0000
204	T	L	-0.1627
205	Y	L	0.0000
206	Y	L	0.0000
207	C	L	0.0000
208	Q	L	0.0000
209	Q	L	0.0000
210	R	L	0.0000
211	S	L	0.0000
212	S	L	0.0707
213	L	L	1.4862
214	P	L	0.2063
215	L	L	0.2618
216	I	L	0.0000
217	T	L	0.0305
218	F	L	0.2052
219	G	L	0.0000
220	A	L	0.0585
221	G	L	0.0000
222	T	L	0.0000
223	K	L	-1.0102
224	L	L	0.0000
225	E	L	-0.8356
226	I	L	0.0964
227	K	L	-1.6037