Project name: model 4 TAU

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2764
• Maximal score value: 1.4687
• Average score: -1.4002
• Total score value: -617.4704

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.1337
2	A	A	-0.8130
3	E	A	-1.8514
4	P	A	-1.5277
5	R	A	-1.7667
6	Q	A	-2.1729
7	E	A	-2.0964
8	F	A	-0.4968
9	E	A	-1.9021
10	V	A	0.0000
11	M	A	-1.3591
12	E	A	-2.8326
13	D	A	-3.3285
14	H	A	-2.5989
15	A	A	-1.5089
16	G	A	-1.1332
17	T	A	-0.2578
18	Y	A	0.6911
19	G	A	-0.1893
20	L	A	-0.8581
21	G	A	-1.7887
22	D	A	-3.6375
23	R	A	-4.1734
24	K	A	-4.2764
25	D	A	-3.8902
26	Q	A	-3.3146
27	G	A	-2.3079
28	G	A	-1.4879
29	Y	A	-1.0916
30	T	A	-0.2491
31	M	A	-0.1904
32	H	A	-1.2820
33	Q	A	-2.0853
34	D	A	-3.4825
35	Q	A	-3.8110
36	E	A	-3.7812
37	G	A	-3.5267
38	D	A	-3.6874
39	T	A	-3.2615
40	D	A	-3.3770
41	A	A	-2.0959
42	G	A	-1.2013
43	L	A	-0.8870
44	K	A	-1.7990
45	E	A	-2.0496
46	S	A	-1.1777
47	P	A	-0.5182
48	L	A	0.4933
49	Q	A	-0.9311
50	T	A	-1.1429
51	P	A	-2.0099
52	T	A	-2.1580
53	E	A	-3.8426
54	D	A	-3.7046
55	G	A	-2.8472
56	S	A	-3.0033
57	E	A	-3.1882
58	E	A	-3.3477
59	P	A	-2.2155
60	G	A	-2.1718
61	S	A	-1.7410
62	E	A	-2.3589
63	T	A	-1.9193
64	S	A	-2.1425
65	D	A	-2.9016
66	A	A	-1.8084
67	K	A	-2.4907
68	S	A	-1.9638
69	T	A	-1.3003
70	P	A	-1.6417
71	T	A	-1.7783
72	A	A	-1.8465
73	E	A	-2.6425
74	D	A	-2.5141
75	V	A	-1.1652
76	T	A	-0.8810
77	A	A	-0.4707
78	P	A	-0.7661
79	L	A	0.0000
80	V	A	-0.6246
81	D	A	-1.8599
82	E	A	-2.2506
83	G	A	-1.6487
84	A	A	-1.3775
85	P	A	-1.3800
86	G	A	-1.9552
87	K	A	-3.0440
88	Q	A	-2.2529
89	A	A	-1.7418
90	A	A	-1.2986
91	A	A	-1.6874
92	Q	A	-1.6852
93	P	A	-1.4432
94	H	A	-1.9105
95	T	A	-1.7113
96	E	A	-2.3348
97	I	A	-1.4280
98	P	A	-1.9306
99	E	A	-2.5532
100	G	A	-2.3859
101	T	A	-1.9008
102	T	A	-1.9789
103	A	A	-2.0532
104	E	A	-2.6857
105	E	A	-2.7621
106	A	A	-2.3200
107	G	A	-1.5381
108	I	A	0.0000
109	G	A	-1.4704
110	D	A	-2.1929
111	T	A	-1.4549
112	P	A	-1.2460
113	S	A	-1.5045
114	L	A	-2.3427
115	E	A	-3.4140
116	D	A	-3.8608
117	E	A	-3.4135
118	A	A	-2.3814
119	A	A	0.0000
120	G	A	-2.4037
121	H	A	-2.0993
122	V	A	-1.3746
123	T	A	-1.0072
124	Q	A	-1.6852
125	A	A	-1.4857
126	R	A	-2.7195
127	M	A	-1.7145
128	V	A	-2.0539
129	S	A	-2.2714
130	K	A	-3.0117
131	S	A	-2.4268
132	K	A	-3.0946
133	D	A	-2.8777
134	G	A	-1.9373
135	T	A	-1.7912
136	G	A	-1.6430
137	S	A	-2.0215
138	D	A	-3.4090
139	D	A	-3.5261
140	K	A	-3.6657
141	K	A	-3.5252
142	A	A	-2.3643
143	K	A	-3.4499
144	G	A	-2.6807
145	A	A	-2.1592
146	D	A	-2.9338
147	G	A	-2.5093
148	K	A	-2.5129
149	T	A	-1.4436
150	K	A	-1.6037
151	I	A	0.9052
152	A	A	0.0706
153	T	A	-0.5381
154	P	A	-0.9975
155	R	A	-2.2507
156	G	A	-1.4717
157	A	A	-0.7525
158	A	A	-0.9618
159	P	A	-1.2309
160	P	A	-1.9000
161	G	A	-1.8412
162	Q	A	-2.7716
163	K	A	-3.1855
164	G	A	-2.6985
165	Q	A	-2.6242
166	A	A	-2.0768
167	N	A	-2.2870
168	A	A	-1.4101
169	T	A	-0.6700
170	R	A	-1.2673
171	I	A	0.8315
172	P	A	0.0373
173	A	A	-0.6067
174	K	A	-1.6127
175	T	A	-1.0647
176	P	A	-0.9866
177	P	A	-0.8947
178	A	A	-1.0647
179	P	A	-1.2876
180	K	A	-2.0323
181	T	A	-1.3016
182	P	A	-1.1741
183	P	A	-0.8489
184	S	A	-0.9274
185	S	A	-1.2238
186	G	A	-2.4728
187	E	A	-2.5892
188	P	A	-2.0878
189	P	A	-2.3555
190	K	A	-2.9241
191	S	A	-2.6726
192	G	A	-2.8170
193	D	A	-3.2489
194	R	A	-3.0395
195	S	A	-1.8817
196	G	A	-1.3319
197	Y	A	-0.4970
198	S	A	-0.5482
199	S	A	-0.6065
200	P	A	-0.6070
201	G	A	-0.7008
202	S	A	-0.7817
203	P	A	-1.0705
204	G	A	-1.1309
205	T	A	-1.3462
206	P	A	-0.9414
207	G	A	-1.3178
208	S	A	-1.6962
209	R	A	-2.6854
210	S	A	-2.2993
211	R	A	-2.7041
212	T	A	-1.4844
213	P	A	-0.6583
214	S	A	-0.0888
215	L	A	0.9969
216	P	A	0.1484
217	T	A	-0.4003
218	P	A	-1.0377
219	P	A	-1.6787
220	T	A	-1.8065
221	R	A	-3.1334
222	E	A	-3.6452
223	P	A	-2.6881
224	K	A	-2.8824
225	K	A	-1.9472
226	V	A	-0.1969
227	A	A	-0.0782
228	V	A	0.7361
229	V	A	1.4687
230	R	A	-0.7779
231	T	A	-0.8642
232	P	A	-1.1784
233	P	A	-1.2049
234	K	A	-1.9868
235	S	A	-1.2237
236	P	A	-0.9524
237	S	A	-0.6675
238	S	A	-0.6518
239	A	A	-0.8175
240	K	A	-1.9996
241	S	A	-1.7008
242	R	A	-1.9814
243	L	A	-0.4762
244	Q	A	-1.5667
245	T	A	-0.9728
246	A	A	-0.0260
247	P	A	0.4022
248	V	A	1.1237
249	P	A	0.4675
250	M	A	0.4952
251	P	A	-0.4760
252	D	A	-1.4538
253	L	A	-0.1804
254	K	A	-2.1219
255	N	A	-1.8403
256	V	A	-0.5541
257	K	A	-1.8003
258	S	A	-1.2526
259	K	A	-1.2689
260	I	A	0.3871
261	G	A	-0.8684
262	S	A	-1.2596
263	T	A	-1.3828
264	E	A	-2.5123
265	N	A	-2.6996
266	L	A	-1.8498
267	K	A	-2.6675
268	H	A	-1.9837
269	Q	A	-1.5332
270	P	A	-1.1857
271	G	A	-1.1388
272	G	A	-1.5450
273	G	A	-1.8500
274	K	A	-2.2988
275	V	A	-1.2466
276	Q	A	-0.5589
277	I	A	0.6010
278	I	A	1.2985
279	N	A	-0.5740
280	K	A	-1.9722
281	K	A	-2.2165
282	L	A	-0.9832
283	D	A	-1.8258
284	L	A	-0.2973
285	S	A	-0.8010
286	N	A	-1.5613
287	V	A	-0.6935
288	Q	A	-1.7922
289	S	A	-1.6981
290	K	A	-0.8852
291	C	A	-0.9434
292	G	A	-1.5245
293	S	A	-1.7797
294	K	A	-2.3635
295	D	A	-2.6238
296	N	A	-1.7818
297	I	A	-0.0037
298	K	A	-1.4073
299	H	A	-0.6924
300	V	A	0.5332
301	P	A	-0.2261
302	G	A	-0.4443
303	G	A	-0.4718
304	G	A	-0.6749
305	S	A	-0.1182
306	V	A	1.1845
307	Q	A	-0.2127
308	I	A	0.3614
309	V	A	0.0000
310	Y	A	-1.1888
311	K	A	-1.7632
312	P	A	-0.6932
313	V	A	0.8412
314	D	A	-0.5276
315	L	A	0.7253
316	S	A	-0.3841
317	K	A	-0.9164
318	V	A	-0.0715
319	T	A	-0.5876
320	S	A	-1.0637
321	K	A	-1.7250
322	C	A	-0.2767
323	G	A	-0.3465
324	S	A	-0.0610
325	L	A	1.4090
326	G	A	-0.0258
327	N	A	-0.4703
328	I	A	1.0785
329	H	A	-1.1476
330	H	A	-1.5229
331	K	A	-2.6949
332	P	A	-1.8849
333	G	A	-1.4461
334	G	A	-1.3893
335	G	A	-0.8346
336	Q	A	-0.9400
337	V	A	0.6722
338	E	A	-1.0532
339	V	A	-0.1384
340	K	A	-1.9529
341	S	A	-1.7724
342	E	A	-2.6537
343	K	A	-2.2508
344	L	A	-0.2856
345	D	A	-0.8048
346	F	A	0.0126
347	K	A	-2.2962
348	D	A	-3.0285
349	R	A	-2.7838
350	V	A	-1.5276
351	Q	A	-1.8886
352	S	A	-0.8166
353	K	A	-1.1593
354	I	A	0.9454
355	G	A	0.2877
356	S	A	-0.1599
357	L	A	0.4567
358	D	A	-1.1833
359	N	A	-1.3170
360	I	A	0.8604
361	T	A	0.2405
362	H	A	-0.1458
363	V	A	1.1144
364	P	A	-0.2914
365	G	A	-0.5922
366	G	A	-1.4728
367	G	A	-1.4402
368	N	A	-2.5142
369	K	A	-2.7324
370	K	A	-2.0117
371	I	A	-0.1059
372	E	A	-1.7013
373	T	A	-1.4917
374	H	A	-2.2948
375	K	A	-2.6272
376	L	A	-1.0563
377	T	A	0.0939
378	F	A	0.5095
379	R	A	-0.9695
380	E	A	-1.4120
381	N	A	-2.3163
382	A	A	-2.1425
383	K	A	-2.7453
384	A	A	-1.9833
385	K	A	-2.8835
386	T	A	-2.5224
387	D	A	-3.2277
388	H	A	-2.6790
389	G	A	-1.6654
390	A	A	-1.1545
391	E	A	-1.5147
392	I	A	0.2580
393	V	A	0.1487
394	Y	A	0.0000
395	K	A	-1.3470
396	S	A	-0.6113
397	P	A	-0.2218
398	V	A	-0.3211
399	V	A	-0.6765
400	S	A	-0.7413
401	G	A	-1.2613
402	D	A	-2.3374
403	T	A	-1.7656
404	S	A	-1.3243
405	P	A	-1.6994
406	R	A	-2.6928
407	H	A	-2.1165
408	L	A	0.0000
409	S	A	-1.7530
410	N	A	-2.1075
411	V	A	0.0000
412	S	A	-0.9340
413	S	A	-0.9268
414	T	A	-0.6120
415	G	A	-0.7288
416	S	A	-0.3773
417	I	A	0.0077
418	D	A	-0.9828
419	M	A	0.0000
420	V	A	0.1047
421	D	A	-0.8129
422	S	A	-0.7561
423	P	A	-0.7679
424	Q	A	-0.5013
425	L	A	0.0000
426	A	A	0.3392
427	T	A	0.3053
428	L	A	0.9048
429	A	A	-0.6410
430	D	A	-2.2460
431	E	A	-2.5543
432	V	A	0.0000
433	S	A	-0.8440
434	A	A	-1.2861
435	S	A	0.0000
436	L	A	-0.0008
437	A	A	-0.4673
438	K	A	-1.4848
439	Q	A	-0.9633
440	G	A	-0.5524
441	L	A	-0.3751