Project name: CD47-M1

Chain sequence(s)	H: QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVDTSKNQFSLRLSSVTAADTAMYYCARFTGRPYYGMDVWGQGTTVTVSS; L: ELTQPPSVSATPGQRVTISCSGSESNIGSHKVKWYQQFAGAAPRLLIHGNDQRRSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGRVFGGGTKLTVLGQP
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.0492
• Maximal score value: 1.9282
• Average score: -0.2481
• Total score value: -56.5671

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	E	L	-1.8199
5	L	L	0.0000
6	T	L	-0.0850
7	Q	L	0.0000
8	P	L	-0.1390
9	P	L	-0.3113
10	S	L	-0.4243
11	V	L	0.1318
12	S	L	-0.0998
13	A	L	0.0000
14	T	L	-0.0843
15	P	L	-0.3474
16	G	L	-0.7443
17	Q	L	-1.4975
18	R	L	-2.0492
19	V	L	0.0000
20	T	L	-0.0694
21	I	L	0.0000
22	S	L	-0.1336
23	C	L	0.0000
24	S	L	-0.2184
25	G	L	-0.3653
26	S	L	-0.5548
27	E	L	-1.9103
28	S	L	-0.3831
29	N	L	0.0000
30	I	L	0.0000
31	G	L	-0.6571
32	S	L	-0.2676
33	H	L	0.0000
34	K	L	-1.0256
35	V	L	0.0000
36	K	L	0.0000
37	W	L	0.0000
38	Y	L	0.0000
39	Q	L	-0.2704
40	Q	L	0.1955
41	F	L	1.9282
42	A	L	0.3295
43	G	L	-0.4480
44	A	L	-0.0444
45	A	L	0.0133
46	P	L	0.0000
47	R	L	-1.3561
48	L	L	0.0000
49	L	L	0.0000
50	I	L	0.0000
51	H	L	-0.4177
52	G	L	-0.4797
53	N	L	-1.3890
54	D	L	-0.8463
55	Q	L	-1.0057
56	R	L	-0.7534
57	R	L	-1.1227
58	S	L	-0.4861
59	G	L	-0.5058
60	V	L	0.0000
61	P	L	-0.4557
62	D	L	-1.8814
63	R	L	-0.7080
64	F	L	0.0000
65	S	L	-0.0701
66	G	L	-0.1131
67	S	L	-0.4076
68	K	L	-1.0682
69	S	L	-0.4851
70	G	L	-0.5059
72	S	L	-0.1343
73	A	L	0.0000
74	S	L	-0.0792
75	L	L	0.0000
76	A	L	0.0011
77	I	L	0.0000
78	S	L	-0.4149
79	G	L	-0.2985
80	L	L	0.0000
81	Q	L	-0.7953
82	S	L	-0.6348
83	E	L	-1.8495
84	D	L	0.0000
85	E	L	-0.6487
86	A	L	0.0000
87	D	L	-0.5958
88	Y	L	0.0000
89	Y	L	0.0000
90	C	L	0.0000
91	A	L	0.0000
92	A	L	0.0000
93	W	L	0.1317
94	D	L	0.0000
95	D	L	-1.6952
96	S	L	-0.2196
97	L	L	1.4014
98	N	L	-0.5214
99	G	L	0.0000
100	R	L	0.0000
101	V	L	0.2593
102	F	L	0.0000
103	G	L	0.0000
104	G	L	-0.3774
105	G	L	-0.1245
106	T	L	0.0000
107	K	L	-1.7752
108	L	L	0.0000
109	T	L	-0.0401
110	V	L	0.0000
111	L	L	1.4062
112	G	L	-0.3272
113	Q	L	-0.8707
114	P	L	-0.3893
115	Q	H	-1.1555
116	V	H	-0.2960
117	Q	H	-1.1124
118	L	H	0.0000
119	Q	H	-0.5428
120	Q	H	0.0000
121	W	H	1.0349
122	G	H	-0.1459
123	A	H	-0.0419
124	G	H	0.1105
125	L	H	1.5407
126	L	H	0.2101
127	K	H	-1.2243
128	P	H	-0.3600
129	S	H	-0.4487
130	E	H	-1.0392
131	T	H	-0.2562
132	L	H	0.0000
133	S	H	-0.3136
134	L	H	0.0000
135	T	H	0.0913
136	C	H	0.0000
137	A	H	0.0000
138	V	H	0.0000
139	Y	H	0.6828
140	G	H	-0.3423
141	G	H	-0.3676
142	S	H	-0.1832
143	F	H	0.0000
144	S	H	-0.1929
145	G	H	-0.1560
146	Y	H	0.4016
147	Y	H	0.1921
148	W	H	0.0000
149	S	H	0.0000
150	W	H	0.0000
152	R	H	0.0000
153	Q	H	0.0000
154	P	H	-0.0719
155	P	H	-0.3455
156	G	H	-0.8264
157	K	H	-1.8094
158	G	H	-0.4418
159	L	H	0.0000
160	E	H	-0.4552
161	W	H	0.0000
162	I	H	0.0000
163	G	H	0.0000
164	E	H	0.0000
165	I	H	0.0000
166	N	H	-0.2008
167	H	H	-0.4254
168	S	H	-0.3231
169	G	H	-0.3202
170	S	H	-0.2618
171	T	H	-0.1249
172	N	H	-0.3020
173	Y	H	0.0896
174	N	H	-0.1804
175	P	H	-0.4346
176	S	H	-0.2438
177	L	H	0.0000
178	K	H	-1.7583
179	S	H	-0.6029
180	R	H	-0.4634
181	V	H	0.0000
182	T	H	-0.0497
183	I	H	0.0000
184	S	H	0.0233
185	V	H	0.2902
186	D	H	-0.4351
187	T	H	-0.2258
188	S	H	-0.5357
189	K	H	-1.7902
190	N	H	-0.6424
191	Q	H	-0.2900
192	F	H	0.0000
193	S	H	-0.0353
194	L	H	0.0000
195	R	H	-0.9088
196	L	H	0.0000
197	S	H	-0.1410
198	S	H	-0.2659
199	V	H	0.0000
200	T	H	-0.0336
201	A	H	0.0612
202	A	H	0.0692
203	D	H	0.0000
204	T	H	-0.0160
205	A	H	0.0000
206	M	H	0.2997
207	Y	H	0.0000
208	Y	H	0.0000
209	C	H	0.0000
210	A	H	0.0000
211	R	H	-0.2178
212	F	H	0.0000
213	T	H	0.0000
214	G	H	-0.7304
215	R	H	-1.9380
216	P	H	-0.2994
217	Y	H	0.4335
218	Y	H	0.5454
219	G	H	0.0235
220	M	H	0.0000
221	D	H	-0.3669
222	V	H	0.2294
223	W	H	0.0000
224	G	H	0.0000
225	Q	H	-1.2265
226	G	H	-0.3780
227	T	H	-0.0484
228	T	H	-0.0290
229	V	H	0.0000
230	T	H	-0.0365
231	V	H	0.0000
232	S	H	-0.1305
233	S	H	-0.3537