Project name: 5vh5:A

Chain sequence(s)	A: PSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIISKAKKGQPRREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSSLSLS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9598
• Maximal score value: 1.6157
• Average score: -1.0342
• Total score value: -214.0732

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
241	P	A	-0.8115
242	S	A	-0.2876
243	V	A	0.0000
244	F	A	1.2144
245	L	A	0.9332
246	F	A	1.2077
247	P	A	-0.1135
248	P	A	-1.1283
249	K	A	-2.1594
250	P	A	-1.5749
251	K	A	-1.3864
252	D	A	0.0000
253	T	A	0.0000
254	L	A	0.0000
255	M	A	0.3618
256	I	A	1.3130
257	S	A	0.1209
258	R	A	-0.9296
259	T	A	-0.6791
260	P	A	0.0000
261	E	A	-0.8982
262	V	A	0.0000
263	T	A	0.3917
264	C	A	0.0000
265	V	A	0.0000
266	V	A	0.0000
267	V	A	-1.1615
268	D	A	-2.3146
269	V	A	0.0000
270	S	A	-2.2288
271	H	A	-3.0718
272	E	A	-2.6965
273	D	A	-2.5793
274	P	A	-2.8715
275	E	A	-3.1231
276	V	A	-1.9989
277	K	A	-2.1552
278	F	A	-1.1349
279	N	A	-1.1616
280	W	A	0.0000
281	Y	A	-0.7241
282	V	A	-0.9933
283	D	A	-2.1747
284	G	A	-0.9569
285	V	A	0.5216
286	E	A	-0.6986
287	V	A	-0.7025
288	H	A	-1.8728
289	N	A	-2.1577
290	A	A	-1.8526
291	K	A	-2.4115
292	T	A	-2.0584
293	K	A	-2.7038
294	P	A	-2.7073
295	R	A	-3.9549
296	E	A	-3.9598
297	E	A	-3.5954
298	Q	A	-1.9584
299	Y	A	-0.0499
300	N	A	-1.2804
301	S	A	-1.4413
302	T	A	-2.1953
303	Y	A	-3.2008
304	R	A	-2.8838
305	V	A	0.0000
306	V	A	-0.9735
307	S	A	0.0000
308	V	A	-0.7359
309	L	A	0.0000
310	T	A	-0.5371
311	V	A	0.0000
312	L	A	0.7291
313	H	A	0.0794
314	Q	A	-0.7988
315	D	A	-1.0372
316	W	A	0.0000
317	L	A	-0.9900
318	N	A	-1.9380
319	G	A	-2.0128
320	K	A	-2.1544
321	E	A	-2.2908
322	Y	A	0.0000
323	K	A	-1.8122
324	C	A	0.0000
325	K	A	-1.6499
326	V	A	0.0000
327	S	A	-1.5112
328	N	A	-1.7994
329	K	A	-2.3746
330	A	A	-1.3245
331	L	A	-0.3865
332	P	A	-0.4030
333	A	A	-0.4520
334	P	A	-0.9380
335	I	A	-0.9251
336	E	A	-2.2093
337	K	A	-1.4058
338	T	A	-1.1872
339	I	A	-0.2861
340	S	A	-1.1420
341	K	A	0.0000
342	A	A	-1.1911
343	K	A	-2.2710
344	G	A	-2.0232
345	Q	A	-2.0793
346	P	A	-2.0588
347	R	A	-2.6387
348	E	A	-2.8602
349	P	A	0.0000
350	Q	A	-1.4928
351	V	A	0.0000
352	Y	A	0.2495
353	T	A	0.2698
354	L	A	0.5180
355	P	A	-0.1229
356	P	A	-0.9095
357	S	A	-1.7076
358	R	A	-2.8656
359	D	A	-3.0729
360	E	A	-2.5445
361	L	A	-2.2464
362	T	A	-2.0877
363	K	A	-3.0965
364	N	A	-2.9603
365	Q	A	-2.7060
366	V	A	0.0000
367	S	A	-0.8599
368	L	A	0.0000
369	T	A	0.0244
370	C	A	0.0000
371	L	A	0.3778
372	V	A	0.0000
373	K	A	-0.6558
374	G	A	-1.3511
375	F	A	0.0000
376	Y	A	-1.2943
377	P	A	0.0000
378	S	A	-0.2405
379	D	A	-1.4360
380	I	A	-0.5198
381	A	A	0.0000
382	V	A	-0.8353
383	E	A	-2.6657
384	W	A	0.0000
385	E	A	-2.3486
386	S	A	0.0000
387	N	A	-1.8713
388	G	A	-1.9396
389	Q	A	-2.3539
390	P	A	-2.3354
391	E	A	0.0000
392	N	A	-2.7590
393	N	A	-2.5060
394	Y	A	-2.2771
395	K	A	-2.5456
396	T	A	-1.2032
397	T	A	-0.3508
398	P	A	-0.0029
399	P	A	0.5872
400	V	A	1.6157
401	L	A	1.4102
402	D	A	-0.2967
403	S	A	-0.9805
404	D	A	-1.9774
405	G	A	-0.8301
406	S	A	0.0000
407	F	A	0.3388
408	F	A	0.6988
409	L	A	0.0000
410	Y	A	0.3245
411	S	A	0.0000
412	K	A	-1.7000
413	L	A	0.0000
414	T	A	-1.4996
415	V	A	0.0000
416	D	A	-2.8306
417	K	A	-2.7587
418	S	A	-2.2477
419	R	A	-1.9751
420	W	A	0.0000
421	Q	A	-2.2272
422	Q	A	-2.1397
423	G	A	-0.9795
424	N	A	-0.5430
425	V	A	0.5574
426	F	A	0.0000
427	S	A	-1.2584
428	C	A	0.0000
429	S	A	-1.3323
430	V	A	0.0000
431	M	A	-0.5040
432	H	A	0.0000
433	E	A	-1.1352
434	A	A	-1.5139
435	L	A	-1.3938
436	H	A	-1.6543
437	N	A	-1.2787
438	H	A	-0.6582
439	Y	A	-0.1986
440	T	A	-0.8929
441	Q	A	-1.7611
442	K	A	-1.5901
443	S	A	-0.6232
444	L	A	0.0000
445	S	A	0.2399
446	L	A	0.2045
447	S	A	-0.0195