Project name: PROJECT_2

Chain sequence(s)	A: PALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.7667
• Maximal score value: 3.4731
• Average score: -0.1701
• Total score value: -56.1373

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
56	P	A	0.7330
57	A	A	1.4927
58	L	A	2.1966
59	S	A	1.5354
60	I	A	0.0000
61	V	A	2.6606
62	I	A	3.4731
63	I	A	0.0000
64	I	A	2.7271
65	I	A	3.4267
66	M	A	2.5711
67	T	A	0.0000
68	I	A	1.9749
69	G	A	1.2278
70	G	A	1.2486
71	N	A	0.0000
72	I	A	1.5914
73	L	A	1.1371
74	V	A	0.0000
75	I	A	1.1929
76	M	A	1.0640
77	A	A	0.0000
78	V	A	0.0000
79	S	A	0.1229
80	M	A	0.0707
81	E	A	-1.3115
82	K	A	-2.7165
83	K	A	-2.7193
84	L	A	0.0000
85	H	A	-1.7450
86	N	A	-2.0696
87	A	A	-1.0763
88	T	A	-0.3923
89	N	A	-0.3352
90	Y	A	-0.0476
91	F	A	0.0000
92	L	A	0.0000
93	M	A	0.6497
94	S	A	0.0000
95	L	A	0.0000
96	A	A	0.0000
97	I	A	1.0628
98	A	A	0.0000
99	D	A	0.0000
100	M	A	1.3244
101	L	A	1.2717
102	V	A	0.0000
103	G	A	0.0000
104	L	A	1.9198
105	L	A	1.5422
106	V	A	0.0000
107	M	A	0.0000
108	P	A	0.7681
109	L	A	0.9388
110	S	A	0.9413
111	L	A	1.3629
112	L	A	1.4514
113	A	A	1.5717
114	I	A	1.6847
115	L	A	2.2591
116	Y	A	1.6340
117	D	A	0.0652
118	Y	A	1.7425
119	V	A	1.5587
120	W	A	0.0000
121	P	A	-0.0219
122	L	A	0.3732
123	P	A	0.1755
124	R	A	0.2002
125	Y	A	1.8199
126	L	A	1.3703
127	C	A	0.0000
128	P	A	0.0000
129	V	A	1.3926
130	W	A	0.0000
131	I	A	0.0000
132	S	A	0.0000
133	L	A	0.8281
134	D	A	0.1306
135	V	A	0.3833
136	L	A	0.0000
137	F	A	0.0000
138	S	A	0.0151
139	T	A	0.0000
140	A	A	0.0000
141	S	A	0.0000
142	I	A	0.0000
143	M	A	0.6949
144	H	A	0.0000
145	L	A	0.0000
146	C	A	0.0000
147	A	A	0.2551
148	I	A	0.0000
149	S	A	0.0000
150	L	A	0.8739
151	D	A	0.4276
152	R	A	0.0000
153	Y	A	0.5070
154	V	A	0.1734
155	A	A	0.0000
156	I	A	0.0000
157	R	A	-1.6116
158	N	A	-1.4801
159	P	A	-1.2128
160	I	A	-1.1187
161	E	A	-1.1653
162	H	A	-0.7810
163	S	A	-0.8273
164	R	A	-1.2389
165	F	A	-0.0800
166	N	A	-1.7130
167	S	A	-1.6574
168	R	A	-2.1287
169	T	A	-1.2519
170	K	A	-1.5641
171	A	A	0.0000
172	I	A	0.9454
173	M	A	0.7134
174	K	A	0.1507
175	I	A	1.0336
176	A	A	1.1461
177	I	A	1.6485
178	V	A	0.0000
179	W	A	1.1197
180	A	A	1.1659
181	I	A	1.4773
182	S	A	0.0000
183	I	A	1.7599
184	G	A	0.7888
185	V	A	1.1037
186	S	A	0.0000
187	V	A	1.6322
188	P	A	1.3689
189	I	A	1.6476
190	P	A	0.0000
191	V	A	2.2174
192	I	A	2.5783
193	G	A	1.0265
194	L	A	0.5772
195	R	A	0.0000
196	D	A	-1.3449
197	E	A	-2.1617
198	E	A	-2.7803
199	K	A	-2.5679
200	V	A	0.0000
201	F	A	-1.0180
202	V	A	-0.3657
203	N	A	-1.4916
204	N	A	-1.5003
205	T	A	-0.1734
206	T	A	0.3308
207	C	A	0.5842
208	V	A	0.9331
209	L	A	0.4271
210	N	A	-0.3084
211	D	A	0.0000
212	P	A	-0.4195
213	N	A	-0.6544
214	F	A	0.0000
215	V	A	0.0000
216	L	A	1.6435
217	I	A	2.1832
218	G	A	0.0000
219	S	A	0.0000
220	F	A	3.3648
221	V	A	2.4876
222	A	A	0.0000
223	F	A	0.0000
224	F	A	2.2581
225	I	A	2.6540
226	P	A	0.0000
227	L	A	1.8579
228	T	A	1.9891
229	I	A	2.1579
230	M	A	0.0000
231	V	A	2.2994
232	I	A	3.1549
233	T	A	0.0000
234	Y	A	2.3096
235	C	A	2.8389
236	L	A	2.1284
237	T	A	0.0000
238	I	A	2.0001
239	Y	A	1.2546
240	V	A	0.0515
241	L	A	-0.9417
242	R	A	-1.9423
243	R	A	-2.3103
244	Q	A	-1.9969
245	A	A	-0.3166
246	L	A	1.4388
247	M	A	1.6535
248	L	A	2.3603
249	L	A	1.4514
250	H	A	-0.5453
251	G	A	-0.6350
252	H	A	-0.6256
253	T	A	-1.0773
254	E	A	-2.4283
255	E	A	-2.4216
256	P	A	-1.7089
257	P	A	-1.0270
258	G	A	-0.8907
259	L	A	0.9404
260	S	A	0.5366
261	L	A	0.9314
262	D	A	-0.6469
263	F	A	0.6763
264	L	A	0.9305
265	K	A	-0.3628
266	C	A	0.2653
267	C	A	-0.0955
268	K	A	-2.2401
269	R	A	-2.9488
270	N	A	-2.8881
271	T	A	-1.9674
272	A	A	-1.9571
273	E	A	-3.2639
274	E	A	-3.5933
275	E	A	-3.6228
276	N	A	-3.0390
277	S	A	-2.8937
278	A	A	-2.9163
279	N	A	-2.6734
280	P	A	-2.9941
281	N	A	-2.6728
282	Q	A	-3.1307
283	D	A	-3.5700
284	Q	A	-3.3391
285	N	A	-2.9684
286	A	A	-2.8456
287	R	A	-3.7860
288	R	A	-4.2973
289	R	A	-4.7042
290	K	A	-4.4723
291	K	A	-4.3464
292	K	A	-5.2497
293	E	A	-5.7667
294	R	A	-5.4747
295	R	A	-4.7357
296	P	A	-3.6102
297	R	A	-4.0051
298	G	A	-3.2050
299	T	A	-1.5858
300	M	A	-0.9715
301	Q	A	-0.7911
302	A	A	-1.3441
303	I	A	-1.1550
304	N	A	-2.5777
305	N	A	-2.8056
306	E	A	-2.4442
307	R	A	-3.3639
308	K	A	-3.0133
309	A	A	-2.0258
310	S	A	0.0000
311	K	A	-2.3235
312	V	A	0.0000
313	L	A	0.0000
314	G	A	0.2834
315	I	A	0.9302
316	V	A	0.0000
317	F	A	1.6534
318	F	A	2.7056
319	V	A	0.0000
320	F	A	0.0000
321	L	A	1.9709
322	I	A	2.4311
323	M	A	1.8153
324	W	A	0.0000
325	C	A	1.3896
326	P	A	1.4462
327	F	A	1.7206
328	F	A	1.5233
329	I	A	1.5693
330	T	A	0.0000
331	N	A	0.9988
332	I	A	1.3546
333	L	A	0.9504
334	S	A	0.3528
335	V	A	0.9975
336	L	A	0.8346
337	C	A	-0.3342
338	E	A	-2.6059
339	K	A	-3.2180
340	S	A	0.0000
341	C	A	-0.9710
342	N	A	-2.7258
343	Q	A	-2.7527
344	K	A	-2.4126
345	L	A	-1.1524
346	M	A	-1.1784
347	E	A	-2.0915
348	K	A	-1.8710
349	L	A	-0.2839
350	L	A	0.1340
351	N	A	0.1570
352	V	A	1.3317
353	F	A	1.5433
354	V	A	1.8396
355	W	A	1.7126
356	I	A	1.6970
357	G	A	0.0000
358	Y	A	0.9478
359	V	A	0.8689
360	C	A	0.0000
361	S	A	0.0000
362	G	A	1.0392
363	I	A	0.9682
364	N	A	0.0000
365	P	A	0.0000
366	L	A	1.7615
367	V	A	0.0000
368	Y	A	0.0000
369	T	A	-0.1882
370	L	A	1.0879
371	F	A	0.1702
372	N	A	-1.4067
373	K	A	-2.4065
374	I	A	-1.9470
375	Y	A	0.0000
376	R	A	-2.8883
377	R	A	-3.2085
378	A	A	0.0000
379	F	A	0.0000
380	S	A	-1.2484
381	N	A	-1.2326
382	Y	A	0.2699
383	L	A	0.7867
384	R	A	-0.8970
385	C	A	0.2338