Project name: Hunterase

Chain sequence(s)	A: TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRRCPVPSFHVELCREGKNLLKHFRPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3234
• Maximal score value: 1.8379
• Average score: -0.5392
• Total score value: -272.8543

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
34	T	A	-0.9016
35	D	A	-1.8124
36	A	A	-0.8607
37	L	A	-0.2755
38	N	A	0.0000
39	V	A	0.0000
40	L	A	0.0000
41	L	A	0.0000
42	I	A	0.0000
43	I	A	0.0000
44	V	A	0.0000
45	D	A	0.0000
46	D	A	0.0000
47	L	A	0.0000
48	R	A	-0.2794
49	P	A	-0.2590
50	S	A	0.0000
51	L	A	0.0000
52	G	A	0.0000
53	C	A	-0.5377
54	Y	A	-0.4175
55	G	A	-0.8198
56	D	A	-1.0243
57	K	A	-1.6146
58	L	A	-0.2927
59	V	A	0.0000
60	R	A	-0.3464
61	S	A	0.0000
62	P	A	0.0000
63	N	A	0.0000
64	I	A	0.0000
65	D	A	0.0000
66	Q	A	-0.2201
67	L	A	0.0000
68	A	A	0.0000
69	S	A	-1.0689
70	H	A	-1.1033
71	S	A	0.0000
72	L	A	0.0000
73	L	A	0.0000
74	F	A	0.0000
75	Q	A	-0.5230
76	N	A	0.0000
77	A	A	0.0000
78	F	A	0.0000
79	A	A	0.0000
80	Q	A	0.0000
81	Q	A	0.0000
82	A	A	0.0000
83	V	A	0.1854
85	A	A	0.0000
86	P	A	0.0000
87	S	A	0.0000
88	R	A	0.0000
89	V	A	0.0000
90	S	A	0.0000
91	F	A	0.0000
92	L	A	0.0000
93	T	A	0.0000
94	G	A	0.0000
95	R	A	0.0000
96	R	A	-0.8090
97	P	A	0.0000
98	D	A	-1.1170
99	T	A	0.0000
100	T	A	0.0000
101	R	A	-0.7821
102	L	A	0.0000
103	Y	A	0.0000
104	D	A	-0.1127
105	F	A	0.6591
106	N	A	-0.5866
107	S	A	-0.0513
108	Y	A	0.0000
109	W	A	0.0000
110	R	A	0.0062
111	V	A	1.3184
112	H	A	0.3280
113	A	A	-0.0320
114	G	A	-0.5185
115	N	A	-1.1371
116	F	A	0.0000
117	S	A	0.0000
118	T	A	0.0000
119	I	A	0.0000
120	P	A	0.0000
121	Q	A	-0.7043
122	Y	A	0.0000
123	F	A	0.0000
124	K	A	-1.6285
125	E	A	-2.4403
126	N	A	-2.0268
127	G	A	-1.4387
128	Y	A	0.0000
129	V	A	-0.1716
130	T	A	0.0000
131	M	A	0.0000
132	S	A	0.0000
133	V	A	0.0000
134	G	A	0.0000
135	K	A	-0.4160
136	V	A	0.0000
137	F	A	0.0000
138	H	A	-0.3011
139	P	A	-0.5660
140	G	A	-0.5558
141	I	A	-0.2641
142	S	A	0.0000
143	S	A	0.0000
144	N	A	-1.0390
145	H	A	-1.3333
146	T	A	-0.9203
147	D	A	-0.7097
148	D	A	0.0000
149	S	A	-0.3274
150	P	A	-0.0047
151	Y	A	0.0688
152	S	A	0.0000
153	W	A	0.0000
154	S	A	0.1722
155	F	A	0.5214
156	P	A	-0.0501
157	P	A	-0.0509
158	Y	A	-0.0696
159	H	A	-0.7795
160	P	A	0.0000
161	S	A	-1.2685
162	S	A	0.0000
163	E	A	-2.3157
164	K	A	-2.5059
165	Y	A	-1.9498
166	E	A	0.0000
167	N	A	-2.2496
168	T	A	-1.8749
169	K	A	-2.4875
170	T	A	0.0000
171	C	A	0.0000
172	R	A	-2.8157
173	G	A	-2.0401
174	P	A	-1.8218
175	D	A	-2.7662
176	G	A	-2.4805
177	E	A	-3.0540
178	L	A	-2.1887
179	H	A	-2.0914
180	A	A	-1.8018
181	N	A	-1.5525
182	L	A	0.0000
183	L	A	-0.2305
184	C	A	0.0000
185	P	A	-1.4527
186	V	A	0.0000
187	D	A	-1.6517
188	V	A	-0.3855
189	L	A	0.4932
190	D	A	-0.9068
191	V	A	-0.9201
192	P	A	-1.2570
193	E	A	-1.8508
194	G	A	-0.9907
195	T	A	-0.9289
196	L	A	0.0000
197	P	A	0.0000
198	D	A	0.0000
199	K	A	-1.3340
200	Q	A	-1.3389
201	S	A	0.0000
202	T	A	0.0000
203	E	A	-2.5520
204	Q	A	-1.7810
205	A	A	0.0000
206	I	A	-1.7530
207	Q	A	-2.4654
208	L	A	0.0000
209	L	A	0.0000
210	E	A	-3.3234
211	K	A	-2.8038
212	M	A	0.0000
213	K	A	-2.8025
214	T	A	-1.6016
215	S	A	-1.0058
216	A	A	-0.2713
217	S	A	-0.4924
218	P	A	-0.5816
219	F	A	0.0000
220	F	A	0.0000
221	L	A	0.0000
222	A	A	0.0000
223	V	A	0.0000
224	G	A	0.0000
225	Y	A	0.0000
226	H	A	0.0000
227	K	A	0.0000
228	P	A	0.0000
229	H	A	-0.2129
230	I	A	0.0000
231	P	A	0.0000
232	F	A	0.0000
233	R	A	0.0000
234	Y	A	0.0000
235	P	A	0.0000
236	K	A	-2.9240
237	E	A	-2.7744
238	F	A	0.0000
239	Q	A	-2.1457
240	K	A	-2.2927
241	L	A	-0.7965
242	Y	A	0.0000
243	P	A	-1.4322
244	L	A	-1.5943
245	E	A	-2.2898
246	N	A	-1.9826
247	I	A	0.0000
248	T	A	-0.6649
249	L	A	0.0985
250	A	A	0.0000
251	P	A	-0.2561
252	D	A	0.0000
253	P	A	-0.7767
254	E	A	-2.0847
255	V	A	-1.1523
256	P	A	-1.7297
257	D	A	-2.3518
258	G	A	-1.5562
259	L	A	0.0000
260	P	A	-0.4344
261	P	A	0.0853
262	V	A	0.0000
263	A	A	0.0000
264	Y	A	0.0000
265	N	A	0.0000
266	P	A	0.0000
267	W	A	0.0000
268	M	A	-0.2746
269	D	A	-0.9220
270	I	A	0.0000
271	R	A	0.0000
272	Q	A	-2.0256
273	R	A	-1.9181
274	E	A	-1.8357
275	D	A	-1.2838
276	V	A	0.0000
277	Q	A	-2.0579
278	A	A	-1.0344
279	L	A	-0.5096
280	N	A	-1.1750
281	I	A	-0.3047
282	S	A	0.2022
283	V	A	0.9760
284	P	A	1.0123
285	Y	A	0.5255
286	G	A	-0.0182
287	P	A	-0.0490
288	I	A	0.0000
289	P	A	-0.0367
290	V	A	0.5473
291	D	A	-1.2367
292	F	A	0.0000
293	Q	A	0.0000
294	R	A	-1.2922
295	K	A	-1.1468
296	I	A	0.0000
297	R	A	-0.4737
298	Q	A	0.0000
299	S	A	0.0000
300	Y	A	0.0000
301	F	A	0.0000
302	A	A	0.0000
303	S	A	0.0000
304	V	A	0.0000
305	S	A	0.0000
306	Y	A	0.0000
307	L	A	0.0000
308	D	A	0.0000
309	T	A	0.0000
310	Q	A	0.0000
311	V	A	0.0000
312	G	A	0.0000
313	R	A	-1.5513
314	L	A	0.0000
315	L	A	0.0000
316	S	A	-1.1953
317	A	A	-1.6140
318	L	A	0.0000
319	D	A	0.0000
320	D	A	-2.8680
321	L	A	0.0000
322	Q	A	-2.5843
323	L	A	-1.4054
324	A	A	0.0000
325	N	A	-1.0252
326	S	A	-0.6537
327	T	A	0.0000
328	I	A	0.0000
329	I	A	0.0000
330	A	A	0.0000
331	F	A	0.0000
332	T	A	0.0000
333	S	A	0.0000
334	D	A	0.0000
335	H	A	0.0000
336	G	A	0.0000
337	W	A	0.0000
338	A	A	0.0000
339	L	A	0.0000
340	G	A	0.0000
341	E	A	0.0000
342	H	A	0.0000
343	G	A	-0.5970
344	E	A	0.0000
345	W	A	0.0000
346	A	A	0.0000
347	K	A	0.0000
348	Y	A	0.0000
349	S	A	0.0000
350	N	A	0.0000
351	F	A	0.0000
352	D	A	-0.0175
353	V	A	0.1930
354	A	A	0.0000
355	T	A	0.0000
356	H	A	-0.2765
357	V	A	0.0000
358	P	A	0.0000
359	L	A	0.0000
360	I	A	0.0000
361	F	A	0.0000
362	Y	A	0.0000
363	V	A	0.0000
364	P	A	-0.8722
365	G	A	-1.3084
366	R	A	-2.2703
367	T	A	-1.6097
368	A	A	-1.0369
369	S	A	-0.7905
370	L	A	-0.6476
371	P	A	-1.8887
372	E	A	-2.5254
373	A	A	-1.7570
374	G	A	-2.4078
375	E	A	-3.2726
376	K	A	-3.2374
377	L	A	0.0000
378	F	A	0.0000
379	P	A	-0.9950
380	Y	A	-0.2778
381	L	A	-0.3332
382	D	A	-1.1367
383	P	A	0.0000
384	F	A	-0.6238
385	D	A	-1.7196
386	S	A	-1.2071
387	A	A	-0.8460
388	S	A	-1.0274
389	Q	A	-1.4467
390	L	A	-0.7970
391	M	A	-0.9211
392	E	A	-2.1718
393	P	A	-1.6602
394	G	A	-1.8423
395	R	A	-2.6019
396	Q	A	-1.8366
397	S	A	-0.8626
398	M	A	0.1763
399	D	A	-0.8436
400	L	A	0.0000
401	V	A	0.0000
402	E	A	0.0000
403	L	A	0.0000
404	V	A	0.0000
405	S	A	0.0000
406	L	A	0.0000
407	F	A	0.0000
408	P	A	0.0000
409	T	A	0.0000
410	L	A	0.0000
411	A	A	0.0000
412	G	A	-0.3073
413	L	A	0.0000
414	A	A	0.0000
415	G	A	-0.7502
416	L	A	-0.6057
417	Q	A	-1.1755
418	V	A	-0.6598
419	P	A	0.0000
420	P	A	-1.3606
421	R	A	-2.0335
422	C	A	0.0000
423	P	A	0.0852
424	V	A	1.3829
425	P	A	0.6885
426	S	A	0.0000
427	F	A	-0.2153
428	H	A	-1.1546
429	V	A	-0.9636
430	E	A	-1.8888
431	L	A	-0.8296
432	C	A	0.0000
433	R	A	-1.4448
434	E	A	-1.1352
435	G	A	0.0000
436	K	A	-1.4586
437	N	A	-0.8711
438	L	A	0.0000
439	L	A	-0.9907
440	K	A	-2.2518
441	H	A	-1.9328
442	F	A	0.0000
443	R	A	-2.6097
454	P	A	-0.8555
455	G	A	-1.4803
456	N	A	-1.8389
457	P	A	-1.2905
458	R	A	-2.3194
459	E	A	-2.4385
460	L	A	-0.8961
461	I	A	0.0000
462	A	A	0.0000
463	Y	A	0.3505
464	S	A	0.0000
465	Q	A	0.0000
466	Y	A	0.0000
467	P	A	0.0000
468	R	A	0.0000
469	P	A	0.0000
470	S	A	-0.7174
471	D	A	-0.4295
472	I	A	1.3109
473	P	A	0.7147
474	Q	A	0.2869
475	W	A	0.6300
476	N	A	-0.4288
477	S	A	0.0000
478	D	A	0.0000
479	K	A	-0.8963
480	P	A	0.0000
481	S	A	-1.2777
482	L	A	-1.8387
483	K	A	-2.9171
484	D	A	-2.6443
485	I	A	0.0000
486	K	A	-2.5674
487	I	A	0.0000
488	M	A	0.0000
489	G	A	0.0000
490	Y	A	0.5765
491	S	A	0.0000
492	I	A	0.4631
493	R	A	0.0000
494	T	A	0.0000
495	I	A	0.0588
496	D	A	-1.3887
497	Y	A	-0.4154
498	R	A	0.0000
499	Y	A	0.2795
500	T	A	0.0000
501	V	A	0.0000
502	W	A	0.0000
503	V	A	0.0000
504	G	A	-0.7075
505	F	A	0.0000
506	N	A	-2.2680
507	P	A	-2.4987
508	D	A	-2.9322
509	E	A	-2.4228
510	F	A	-1.0639
511	L	A	-0.1708
512	A	A	0.0089
513	N	A	0.0650
514	F	A	1.4373
515	S	A	0.0959
516	D	A	-0.6939
517	I	A	0.5890
518	H	A	-0.4163
519	A	A	-0.3942
520	G	A	-0.0623
521	E	A	0.0000
522	L	A	0.0000
523	Y	A	0.0000
524	F	A	-0.2442
525	V	A	-0.4829
526	D	A	-1.7202
527	S	A	-1.0074
528	D	A	0.0000
529	P	A	-0.3242
530	L	A	0.5694
531	Q	A	0.0000
532	D	A	-1.1032
533	H	A	-1.4025
534	N	A	-1.3856
535	M	A	-0.9226
536	Y	A	-1.2884
537	N	A	-2.2510
538	D	A	-2.5817
539	S	A	-1.9623
540	Q	A	-1.8012
541	G	A	-0.7992
542	G	A	-0.3748
543	D	A	-0.2731
544	L	A	0.9424
545	F	A	1.8205
546	Q	A	0.3672
547	L	A	0.8817
548	L	A	1.8379
549	M	A	1.4938
550	P	A	0.3315