Project name: ee233a062e6f075

Chain sequence(s)	H: VQLVQSGGGVVQPGRSLKLSCLASGYIFTSSWINWVKQRPGRGLEWIGRIDPSDGEVHYNQDFKDRFTISRDKSKNTLYLQMNSLRPEDTAVYYCARGFLPWFADWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC; L: DIQMTQSPSTLSASVGDRVTITCKASENVDTYVSWYQQKPGKAPKLLIYGASNRYTGVPSRFSGSGSGTDFTLTISSLQPDDFATYYCGQSYNYPFTFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8277
• Maximal score value: 1.9437
• Average score: -0.721
• Total score value: -312.1792

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.3133
2	I	L	0.0000
3	Q	L	-2.2814
4	M	L	0.0000
5	T	L	-1.1705
6	Q	L	0.0000
7	S	L	-0.5229
8	P	L	-0.3034
9	S	L	-0.5323
10	T	L	-0.2675
11	L	L	-0.1628
12	S	L	-0.5730
13	A	L	0.0000
14	S	L	-0.2624
15	V	L	0.5337
16	G	L	-0.5712
17	D	L	-1.4811
18	R	L	-2.2243
19	V	L	0.0000
20	T	L	-0.5782
21	I	L	0.0000
22	T	L	-0.6863
23	C	L	0.0000
24	K	L	-2.1738
25	A	L	0.0000
26	S	L	-2.2032
27	E	L	-2.8868
28	N	L	-2.6926
29	V	L	0.0000
30	D	L	-2.0539
31	T	L	-0.9837
32	Y	L	0.1135
33	V	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	-1.0752
38	Q	L	-1.5008
39	K	L	-1.7214
40	P	L	-1.4075
41	G	L	-1.5743
42	K	L	-2.6435
43	A	L	-1.9548
44	P	L	0.0000
45	K	L	-1.9153
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.1722
50	G	L	-0.4329
51	A	L	-0.8750
52	S	L	-1.0674
53	N	L	-1.5893
54	R	L	-1.5346
55	Y	L	-0.7909
56	T	L	-0.3322
57	G	L	-0.6238
58	V	L	0.0000
59	P	L	-0.5325
60	S	L	-0.6650
61	R	L	-0.9266
62	F	L	0.0000
63	S	L	-0.7364
64	G	L	-0.7944
65	S	L	-0.9022
66	G	L	-1.4100
67	S	L	-1.6905
68	G	L	-2.1344
69	T	L	-2.3972
70	D	L	-2.5028
71	F	L	0.0000
72	T	L	-0.7762
73	L	L	0.0000
74	T	L	-0.6089
75	I	L	0.0000
76	S	L	-1.3641
77	S	L	-1.1332
78	L	L	0.0000
79	Q	L	-0.7691
80	P	L	-0.8252
81	D	L	-1.8268
82	D	L	0.0000
83	F	L	-0.2954
84	A	L	0.0000
85	T	L	-0.3683
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	G	L	0.0000
90	Q	L	0.0000
91	S	L	0.0000
92	Y	L	0.3521
93	N	L	-0.2724
94	Y	L	0.4494
95	P	L	-0.1638
96	F	L	0.0000
97	T	L	-0.7170
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.3363
101	G	L	-0.8548
102	T	L	0.0000
103	K	L	-0.4502
104	V	L	0.0000
105	E	L	0.0000
106	V	L	-0.2672
107	K	L	-1.1377
108	R	L	-0.9988
109	T	L	0.1080
110	V	L	1.0671
111	A	L	0.4507
112	A	L	0.1088
113	P	L	0.0000
114	S	L	0.0412
115	V	L	0.1804
116	F	L	0.3005
117	I	L	0.1091
118	F	L	0.0000
119	P	L	-0.3421
120	P	L	-0.7957
121	S	L	-1.3648
122	D	L	-2.5987
123	E	L	-2.5359
124	Q	L	0.0000
125	L	L	-2.1233
126	K	L	-2.5966
127	S	L	-1.5991
128	G	L	-1.0479
129	T	L	-0.8872
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.8036
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.7031
142	R	L	-3.2577
143	E	L	-3.3404
144	A	L	-2.4416
145	K	L	-2.5748
146	V	L	-1.3075
147	Q	L	-1.0760
148	W	L	0.0000
149	K	L	-0.9353
150	V	L	0.0000
151	D	L	-1.9210
152	N	L	-1.6446
153	A	L	-0.5737
154	L	L	0.0581
155	Q	L	-0.6698
156	S	L	-0.6742
157	G	L	-0.9415
158	N	L	-0.9070
159	S	L	-1.1259
160	Q	L	-1.1625
161	E	L	-1.8385
162	S	L	-0.9346
163	V	L	-0.8186
164	T	L	-1.0078
165	E	L	-1.8827
166	Q	L	-1.9297
167	D	L	-2.0426
168	S	L	-1.7399
169	K	L	-2.4203
170	D	L	-1.9797
171	S	L	-1.8572
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.5861
179	L	L	0.0000
180	T	L	-0.2121
181	L	L	-0.4674
182	S	L	-1.2441
183	K	L	-2.2057
184	A	L	-2.0747
185	D	L	-3.1468
186	Y	L	0.0000
187	E	L	-3.7882
188	K	L	-3.8127
189	H	L	-2.9349
190	K	L	-3.0523
191	V	L	-1.5570
192	Y	L	0.0000
193	A	L	-0.9876
194	C	L	0.0000
195	E	L	-0.9014
196	V	L	0.0000
197	T	L	-1.2624
198	H	L	0.0000
199	Q	L	-1.7761
200	G	L	-0.4820
201	L	L	-0.1644
202	S	L	-0.4328
203	S	L	-0.4444
204	P	L	-0.6667
205	V	L	0.0213
206	T	L	-0.5164
207	K	L	-0.7262
208	S	L	-0.6833
209	F	L	0.0000
210	N	L	-1.8074
211	R	L	-2.5889
212	G	L	-2.0278
213	E	L	-2.1116
214	C	L	-0.5052
2	V	H	0.9392
3	Q	H	-0.6150
4	L	H	0.0000
5	V	H	0.6180
6	Q	H	0.0000
7	S	H	-0.1554
8	G	H	-0.3867
9	G	H	0.0169
10	G	H	0.6941
11	V	H	1.5805
12	V	H	0.0000
13	Q	H	-1.3105
14	P	H	-1.8300
15	G	H	-2.1090
16	R	H	-2.6532
17	S	H	-2.0381
18	L	H	-1.3629
19	K	H	-1.9469
20	L	H	0.0000
21	S	H	-0.2030
22	C	H	0.0000
23	L	H	0.5784
24	A	H	0.0000
25	S	H	-0.0224
26	G	H	-0.4354
27	Y	H	0.9217
28	I	H	0.0000
29	F	H	0.0000
30	T	H	-0.4321
31	S	H	0.0708
32	S	H	0.3919
33	W	H	0.2068
34	I	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	0.0000
40	R	H	-1.4810
41	P	H	-1.1401
42	G	H	-1.2256
43	R	H	-1.7327
44	G	H	-1.2837
45	L	H	0.0000
46	E	H	-1.0656
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	R	H	0.0000
51	I	H	0.0000
52	D	H	-1.5191
53	P	H	0.0000
54	S	H	-1.5418
55	D	H	-2.5819
56	G	H	-2.1153
57	E	H	-2.3997
58	V	H	-0.9161
59	H	H	-0.7799
60	Y	H	-1.3322
61	N	H	-2.0690
62	Q	H	-3.3033
63	D	H	-3.5150
64	F	H	0.0000
65	K	H	-3.8277
66	D	H	-3.6132
67	R	H	-2.4304
68	F	H	0.0000
69	T	H	-1.0761
70	I	H	0.0000
71	S	H	-0.5838
72	R	H	-1.3907
73	D	H	-2.0101
74	K	H	-2.7838
75	S	H	-2.1614
76	K	H	-2.6028
77	N	H	-1.7875
78	T	H	0.0000
79	L	H	0.0000
80	Y	H	-0.3611
81	L	H	0.0000
82	Q	H	-1.3279
83	M	H	0.0000
84	N	H	-1.9103
85	S	H	-1.6336
86	L	H	0.0000
87	R	H	-2.5716
88	P	H	-1.8441
89	E	H	-2.4495
90	D	H	0.0000
91	T	H	-0.5541
92	A	H	0.0000
93	V	H	0.4373
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	-0.0938
99	G	H	0.0000
100	F	H	1.3359
101	L	H	1.9437
102	P	H	1.1300
103	W	H	0.0000
104	F	H	0.0000
105	A	H	0.0000
106	D	H	0.0000
107	W	H	0.0000
108	G	H	0.0000
109	Q	H	-1.4431
110	G	H	-0.3931
111	T	H	0.0000
112	L	H	1.5159
113	V	H	0.0000
114	T	H	0.4692
115	V	H	0.0000
116	S	H	-0.5086
117	S	H	-0.4137
118	A	H	-0.2989
119	S	H	-0.6021
120	T	H	-0.8572
121	K	H	-1.2893
122	G	H	-1.3211
123	P	H	-0.5935
124	S	H	-0.2859
125	V	H	0.0000
126	F	H	0.0000
127	P	H	-1.1013
128	L	H	0.0000
129	A	H	-1.1723
130	P	H	0.0000
131	S	H	-1.0074
132	S	H	-0.9837
133	K	H	-1.1395
134	S	H	-0.8720
135	T	H	-0.7127
136	S	H	-0.8653
137	G	H	-0.8950
138	G	H	-0.9033
139	T	H	-0.5970
140	A	H	0.0000
141	A	H	0.0000
142	L	H	0.0000
143	G	H	0.0000
144	C	H	0.0000
145	L	H	0.0000
146	V	H	0.0000
147	K	H	0.0000
148	D	H	-0.3444
149	Y	H	0.0000
150	F	H	0.0000
151	P	H	-0.6072
152	E	H	-1.1415
153	P	H	-0.8990
154	V	H	-0.6650
155	T	H	-0.4973
156	V	H	-0.3085
157	S	H	-0.3372
158	W	H	0.0000
159	N	H	-0.7764
160	S	H	-0.6071
161	G	H	-0.4045
162	A	H	-0.1815
163	L	H	0.0075
164	T	H	-0.1547
165	S	H	-0.2005
166	G	H	-0.1617
167	V	H	0.2181
168	H	H	-0.2326
169	T	H	0.0246
170	F	H	0.0000
171	P	H	-0.2928
172	A	H	0.1094
173	V	H	0.5545
174	L	H	1.3256
175	Q	H	0.3848
176	S	H	-0.0192
177	S	H	-0.1554
178	G	H	0.0905
179	L	H	0.1393
180	Y	H	0.3685
181	S	H	0.0000
182	L	H	0.0000
183	S	H	0.0000
184	S	H	0.0000
185	V	H	0.0000
186	V	H	0.0000
187	T	H	-0.0973
188	V	H	0.0000
189	P	H	-0.5414
190	S	H	-0.6392
191	S	H	-0.5774
192	S	H	-0.5732
193	L	H	-0.7426
194	G	H	-1.0310
195	T	H	-0.6769
196	Q	H	-0.9166
197	T	H	-1.0758
198	Y	H	0.0000
199	I	H	-1.5425
200	C	H	0.0000
201	N	H	-1.4893
202	V	H	0.0000
203	N	H	-1.6844
204	H	H	0.0000
205	K	H	-2.3279
206	P	H	-1.5338
207	S	H	-1.7785
208	N	H	-2.4248
209	T	H	-1.9414
210	K	H	-2.6189
211	V	H	-1.7873
212	D	H	-2.7305
213	K	H	-2.4837
214	K	H	-2.7147
215	V	H	0.0000
216	E	H	-2.7702
217	P	H	-1.7334
218	K	H	-2.0625
219	S	H	-0.9540
220	C	H	-0.3756