| Chain sequence(s) |
A: QVQLQESGPGLVKPSVTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTFGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHYVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1233 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7746 | |
| 8 | G | A | -0.6221 | |
| 9 | P | A | -0.6345 | |
| 10 | G | A | -0.5211 | |
| 11 | L | A | -0.3029 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.5787 | |
| 14 | P | A | -0.8768 | |
| 15 | S | A | -0.4500 | |
| 16 | V | A | 0.0300 | |
| 17 | T | A | -0.4704 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7981 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7033 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1457 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2074 | |
| 31 | S | A | 0.0149 | |
| 32 | G | A | 0.1264 | |
| 33 | Y | A | 0.1759 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8411 | |
| 40 | P | A | -1.0258 | |
| 41 | P | A | -1.1354 | |
| 42 | G | A | -1.5002 | |
| 43 | K | A | -2.3712 | |
| 44 | G | A | -1.5289 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6535 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0425 | |
| 53 | Y | A | 0.5855 | |
| 54 | S | A | -0.4379 | |
| 55 | G | A | -0.9418 | |
| 56 | D | A | -1.5441 | |
| 57 | T | A | -0.3348 | |
| 58 | Y | A | 0.8015 | |
| 59 | Y | A | 0.5189 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8721 | |
| 62 | S | A | -1.1291 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0177 | |
| 65 | S | A | -1.2794 | |
| 66 | R | A | -1.3925 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.6197 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6379 | |
| 71 | V | A | -0.2949 | |
| 72 | D | A | -1.1925 | |
| 73 | T | A | -1.1503 | |
| 74 | S | A | -1.3418 | |
| 75 | K | A | -2.1433 | |
| 76 | N | A | -1.4606 | |
| 77 | Q | A | -1.2652 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5407 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.7171 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.6513 | |
| 84 | S | A | -0.4246 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.3197 | |
| 87 | A | A | -0.2016 | |
| 88 | A | A | 0.0280 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0072 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | -0.0155 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6546 | |
| 98 | Y | A | -0.0581 | |
| 99 | G | A | -0.0790 | |
| 100 | S | A | -0.0774 | |
| 101 | Y | A | 0.2684 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4142 | |
| 105 | Y | A | -0.7777 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8660 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5529 | |
| 111 | T | A | -0.2713 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2967 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.6512 | |
| 116 | S | A | -0.8526 | |
| 117 | A | A | -0.2689 | |
| 118 | S | A | -0.0940 | |
| 119 | T | A | 0.2382 | |
| 120 | F | A | 0.7435 | |
| 121 | G | A | -0.5223 | |
| 122 | P | A | -0.2472 | |
| 123 | S | A | -0.3197 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3585 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.9213 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.5164 | |
| 131 | S | A | -0.6579 | |
| 132 | R | A | -1.1502 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.9577 | |
| 135 | S | A | -1.3986 | |
| 136 | E | A | -2.0789 | |
| 137 | S | A | -1.3111 | |
| 138 | T | A | -0.9401 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.3773 | |
| 147 | D | A | -0.1123 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.3101 | |
| 152 | P | A | -0.6535 | |
| 153 | V | A | -0.6186 | |
| 154 | T | A | -0.5201 | |
| 155 | V | A | -0.3165 | |
| 156 | S | A | -0.4505 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0295 | |
| 159 | S | A | -0.7657 | |
| 160 | G | A | -0.5938 | |
| 161 | A | A | -0.2852 | |
| 162 | L | A | -0.1382 | |
| 163 | T | A | -0.2477 | |
| 164 | S | A | -0.2741 | |
| 165 | G | A | -0.3925 | |
| 166 | V | A | 0.0712 | |
| 167 | H | A | -0.2423 | |
| 168 | T | A | 0.0053 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.2932 | |
| 171 | A | A | 0.2941 | |
| 172 | V | A | 0.6410 | |
| 173 | L | A | 1.3243 | |
| 174 | Q | A | 0.2846 | |
| 175 | S | A | -0.0307 | |
| 176 | S | A | -0.1989 | |
| 177 | G | A | 0.0767 | |
| 178 | L | A | 0.4512 | |
| 179 | Y | A | 0.6801 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1885 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6401 | |
| 189 | S | A | -0.6832 | |
| 190 | S | A | -0.5600 | |
| 191 | S | A | -0.6891 | |
| 192 | L | A | -0.8433 | |
| 193 | G | A | -1.2014 | |
| 194 | T | A | -0.9436 | |
| 195 | K | A | -1.7217 | |
| 196 | T | A | -1.5428 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7353 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8150 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7105 | |
| 205 | P | A | -1.3500 | |
| 206 | S | A | -1.3415 | |
| 207 | N | A | -2.3251 | |
| 208 | T | A | -1.8419 | |
| 209 | K | A | -2.6598 | |
| 210 | V | A | -2.0033 | |
| 211 | D | A | -2.9562 | |
| 212 | K | A | -2.7681 | |
| 213 | R | A | -3.1485 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6379 | |
| 216 | S | A | -1.0910 | |
| 217 | D | B | -1.2343 | |
| 218 | I | B | -0.1872 | |
| 219 | V | B | 0.7728 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4501 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3840 | |
| 224 | P | B | -0.2899 | |
| 225 | L | B | -0.0226 | |
| 226 | S | B | -0.5646 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -0.9904 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6041 | |
| 231 | P | B | -2.0666 | |
| 232 | G | B | -1.9298 | |
| 233 | Q | B | -2.3268 | |
| 234 | P | B | -2.1089 | |
| 235 | A | B | -1.2952 | |
| 236 | S | B | -0.7924 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8593 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -1.9673 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8177 | |
| 243 | Q | B | -1.3580 | |
| 244 | S | B | -0.7067 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5204 | |
| 247 | H | B | -0.6116 | |
| 248 | S | B | -0.9376 | |
| 249 | N | B | -1.6438 | |
| 250 | G | B | -1.1326 | |
| 251 | N | B | -0.9594 | |
| 252 | T | B | -0.2706 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.0972 | |
| 260 | K | B | -1.7940 | |
| 261 | P | B | -1.4190 | |
| 262 | G | B | -1.6349 | |
| 263 | Q | B | -2.0256 | |
| 264 | S | B | -1.4052 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2745 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4968 | |
| 271 | K | B | -0.9152 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9454 | |
| 274 | N | B | -1.2517 | |
| 275 | R | B | -1.7452 | |
| 276 | F | B | -0.6589 | |
| 277 | S | B | -0.5862 | |
| 278 | G | B | -0.8179 | |
| 279 | V | B | -0.9043 | |
| 280 | P | B | -1.2926 | |
| 281 | D | B | -2.2305 | |
| 282 | R | B | -2.0318 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3109 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7803 | |
| 287 | G | B | -0.9544 | |
| 288 | S | B | -0.6311 | |
| 289 | G | B | -0.5988 | |
| 290 | T | B | -1.3158 | |
| 291 | D | B | -1.9351 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9674 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5609 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2711 | |
| 298 | R | B | -3.0460 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.7793 | |
| 301 | A | B | -2.5694 | |
| 302 | E | B | -2.9821 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.6760 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0865 | |
| 315 | V | B | 0.8625 | |
| 316 | P | B | 0.3362 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1196 | |
| 319 | F | B | 0.1289 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2537 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.6635 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.6050 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.2853 | |
| 329 | R | B | -0.9352 | |
| 330 | T | B | 0.0122 | |
| 331 | V | B | 0.3729 | |
| 332 | A | B | -0.0739 | |
| 333 | A | B | -0.1481 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1374 | |
| 336 | V | B | -0.1807 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.7123 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5469 | |
| 343 | D | B | -3.0083 | |
| 344 | E | B | -2.8481 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.1645 | |
| 347 | K | B | -2.7449 | |
| 348 | S | B | -1.7638 | |
| 349 | G | B | -1.0868 | |
| 350 | T | B | -1.1030 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.1272 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7373 | |
| 363 | R | B | -3.1663 | |
| 364 | E | B | -3.2777 | |
| 365 | A | B | -2.3709 | |
| 366 | K | B | -2.3981 | |
| 367 | V | B | -0.9319 | |
| 368 | Q | B | -0.4827 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.7302 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -1.3049 | |
| 373 | N | B | -1.3164 | |
| 374 | A | B | -0.3736 | |
| 375 | L | B | 0.7139 | |
| 376 | Q | B | -0.2007 | |
| 377 | S | B | -0.4788 | |
| 378 | G | B | -0.9203 | |
| 379 | N | B | -0.8429 | |
| 380 | S | B | -1.0696 | |
| 381 | Q | B | -1.2910 | |
| 382 | E | B | -1.5056 | |
| 383 | S | B | -0.6696 | |
| 384 | V | B | -0.7348 | |
| 385 | T | B | 0.0000 | |
| 386 | E | B | -2.3492 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.4207 | |
| 389 | S | B | -2.6885 | |
| 390 | K | B | -2.9884 | |
| 391 | D | B | -2.2823 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5682 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4615 | |
| 402 | L | B | -0.7736 | |
| 403 | S | B | -1.3558 | |
| 404 | K | B | -2.1211 | |
| 405 | A | B | -2.0561 | |
| 406 | D | B | -2.9013 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -2.9037 | |
| 409 | K | B | -3.0244 | |
| 410 | H | B | -1.6941 | |
| 411 | Y | B | -0.2512 | |
| 412 | V | B | -0.5531 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.7874 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.7560 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.1786 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.7740 | |
| 421 | G | B | -0.4878 | |
| 422 | L | B | -0.2846 | |
| 423 | S | B | -0.4423 | |
| 424 | S | B | -0.4315 | |
| 425 | P | B | -0.5318 | |
| 426 | V | B | 0.1457 | |
| 427 | T | B | -0.3352 | |
| 428 | K | B | -0.7275 | |
| 429 | S | B | -0.9754 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -1.4412 | |
| 432 | R | B | -1.6142 | |
| 433 | G | B | -1.6648 | |
| 434 | E | B | -2.1863 | |
| 435 | C | B | -0.6862 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine