Project name: B7422

Chain sequence(s)	H: QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGFYWNWIRQPPGKGLEWIGEINHSGTTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGLYTWNLDSWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQAIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPRTSGQGTKVEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1615
• Maximal score value: 1.688
• Average score: -0.5489
• Total score value: -122.9481

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.0378
2	I	L	-1.5881
3	Q	L	-2.3031
4	M	L	0.0000
5	T	L	-1.5746
6	Q	L	0.0000
7	S	L	-0.8670
8	P	L	-0.5900
9	S	L	-0.7994
10	S	L	-0.6712
11	L	L	-0.2875
12	S	L	-0.5766
13	A	L	-0.7877
14	S	L	-0.8610
15	V	L	-0.0083
16	G	L	-0.8454
17	D	L	-1.7882
18	R	L	-2.2962
19	V	L	0.0000
20	T	L	-0.6295
21	I	L	0.0000
22	T	L	-0.9817
23	C	L	0.0000
24	R	L	-3.0510
25	A	L	0.0000
26	S	L	-2.0088
27	Q	L	-2.4145
28	A	L	-1.8652
29	I	L	0.0000
30	R	L	-2.8777
31	N	L	-2.2656
32	D	L	-1.3689
33	L	L	0.0000
34	G	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.3614
40	P	L	-1.0835
41	G	L	-1.6333
42	K	L	-2.5305
43	A	L	-1.6189
44	P	L	0.0000
45	K	L	-1.6825
46	R	L	-1.0635
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.0000
50	A	L	-0.5669
51	A	L	0.0000
52	S	L	-0.4666
53	S	L	-0.0320
54	L	L	0.1920
55	Q	L	-0.2485
56	S	L	-0.4226
57	G	L	-0.5380
58	V	L	-0.3779
59	P	L	-0.3363
60	S	L	-0.4212
61	R	L	-0.7433
62	F	L	0.0000
63	S	L	-0.3419
64	G	L	-0.3206
65	S	L	-0.8966
66	G	L	-1.6837
67	S	L	-2.0853
68	G	L	-2.2030
69	T	L	-2.4524
70	E	L	-3.1615
71	F	L	0.0000
72	T	L	-0.9379
73	L	L	0.0000
74	T	L	-0.6190
75	I	L	0.0000
76	S	L	-1.3494
77	S	L	-1.1570
78	L	L	0.0000
79	Q	L	-0.7492
80	P	L	-0.9207
81	E	L	-1.4667
82	D	L	0.0000
83	F	L	-0.1156
84	A	L	0.0000
85	T	L	-0.5834
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	0.0000
92	N	L	-1.0057
93	S	L	-0.2007
94	Y	L	0.7195
95	P	L	0.0000
96	R	L	-0.2907
97	T	L	-0.7484
98	S	L	-0.6985
99	G	L	0.0000
100	Q	L	-1.8900
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.1146
104	V	L	0.0000
105	E	L	-0.7162
106	I	L	-0.5808
107	K	L	-1.5153
1	Q	H	-1.4528
2	V	H	-0.9216
3	Q	H	-1.5793
4	L	H	0.0000
5	Q	H	-1.1744
6	Q	H	0.0000
7	W	H	0.8725
8	G	H	0.7549
9	A	H	0.7182
10	G	H	0.9533
11	L	H	0.9467
12	L	H	0.0000
13	K	H	-2.0588
14	P	H	-1.4215
15	S	H	-1.4500
16	E	H	-1.9514
17	T	H	-1.4510
18	L	H	0.0000
19	S	H	-0.6202
20	L	H	0.0000
21	T	H	-0.0944
22	C	H	0.0000
23	A	H	0.0000
24	V	H	0.0000
25	Y	H	-0.3028
26	G	H	-0.7105
27	G	H	-0.6431
28	S	H	-0.1445
29	F	H	0.0896
30	S	H	-0.2062
31	G	H	-0.1020
32	F	H	0.5287
33	Y	H	0.3873
34	W	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	0.0000
40	P	H	-0.6938
41	P	H	-0.8402
42	G	H	-1.4463
43	K	H	-2.3318
44	G	H	-1.5452
45	L	H	-0.8358
46	E	H	-0.9399
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	E	H	-0.4606
51	I	H	0.0000
52	N	H	-0.6477
53	H	H	-0.8510
54	S	H	-0.7686
55	G	H	-0.8210
56	T	H	-0.6363
57	T	H	-0.6436
58	N	H	-0.6423
59	Y	H	-0.5810
60	N	H	0.0000
61	P	H	-0.8460
62	S	H	-0.8163
63	L	H	0.0000
64	K	H	-1.5057
65	S	H	-1.0377
66	R	H	-1.2232
67	V	H	0.0000
68	T	H	-0.9644
69	I	H	0.0000
70	S	H	-0.6047
71	V	H	-0.5713
72	D	H	-1.3307
73	T	H	-1.0742
74	S	H	-1.2929
75	K	H	-2.0056
76	N	H	-1.1256
77	Q	H	-0.9983
78	F	H	0.0000
79	S	H	-0.3595
80	L	H	0.0000
81	K	H	-1.4704
82	L	H	0.0000
82A	S	H	-1.0922
82B	S	H	-1.1003
82C	V	H	0.0000
83	T	H	-0.6131
84	A	H	-0.2115
85	A	H	0.0483
86	D	H	0.0000
87	T	H	0.3614
88	A	H	0.0000
89	V	H	0.6076
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0825
95	G	H	0.0000
96	L	H	1.1535
97	Y	H	1.6880
98	T	H	1.1069
99	W	H	0.9149
100	N	H	0.0000
100A	L	H	0.0000
101	D	H	-0.3786
102	S	H	-0.8540
103	W	H	-1.0494
104	G	H	0.0000
105	Q	H	-1.8870
106	G	H	-0.6298
107	T	H	0.4961
108	L	H	1.6366
109	V	H	0.0000
110	T	H	0.4766
111	V	H	0.0000
112	S	H	-0.6041
113	S	H	-0.7904