| Chain sequence(s) |
A: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT B: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | A | A | -1.1406 | |
| 2 | S | A | -1.5801 | |
| 3 | K | A | -2.1386 | |
| 4 | G | A | 0.0000 | |
| 5 | E | A | -1.5868 | |
| 6 | E | A | -2.1640 | |
| 7 | L | A | -0.7832 | |
| 8 | F | A | 0.0000 | |
| 9 | T | A | -0.3742 | |
| 10 | G | A | 0.2457 | |
| 11 | V | A | 1.0446 | |
| 12 | V | A | 0.0000 | |
| 13 | P | A | -1.0750 | |
| 14 | I | A | 0.0000 | |
| 15 | L | A | -1.1390 | |
| 16 | V | A | 0.0000 | |
| 17 | E | A | -1.9696 | |
| 18 | L | A | 0.0000 | |
| 19 | D | A | -3.2345 | |
| 20 | G | A | -2.6860 | |
| 21 | D | A | -2.2589 | |
| 22 | V | A | 0.0000 | |
| 23 | N | A | -1.7468 | |
| 24 | G | A | -1.3012 | |
| 25 | H | A | -1.7547 | |
| 26 | K | A | -2.6609 | |
| 27 | F | A | 0.0000 | |
| 28 | S | A | -1.7810 | |
| 29 | V | A | 0.0000 | |
| 30 | S | A | -1.1036 | |
| 31 | G | A | 0.0000 | |
| 32 | E | A | -2.4192 | |
| 33 | G | A | -1.7361 | |
| 34 | E | A | -1.8144 | |
| 35 | G | A | 0.0000 | |
| 36 | D | A | -0.3114 | |
| 37 | A | A | 0.0000 | |
| 38 | T | A | -0.1221 | |
| 39 | Y | A | -0.3369 | |
| 40 | G | A | 0.0000 | |
| 41 | K | A | -0.6529 | |
| 42 | L | A | 0.0000 | |
| 43 | T | A | -1.0913 | |
| 44 | L | A | 0.0000 | |
| 45 | K | A | -1.5330 | |
| 46 | F | A | 0.0000 | |
| 47 | I | A | -1.2185 | |
| 48 | C | A | 0.0000 | |
| 49 | T | A | -0.7477 | |
| 50 | T | A | -1.1625 | |
| 51 | G | A | -1.6617 | |
| 52 | K | A | -2.2851 | |
| 53 | L | A | 0.0000 | |
| 54 | P | A | -1.1286 | |
| 55 | V | A | 0.0000 | |
| 56 | P | A | 0.0000 | |
| 57 | W | A | 0.0000 | |
| 58 | P | A | 0.0000 | |
| 59 | T | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | V | A | 0.0000 | |
| 62 | T | A | 0.0000 | |
| 63 | T | A | 0.0000 | |
| 64 | F | A | 0.0000 | |
| 66 | Y | A | 0.0000 | |
| 67 | G | A | 0.0000 | |
| 68 | V | A | 0.0000 | |
| 69 | Q | A | 0.0000 | |
| 70 | C | A | 0.0000 | |
| 71 | F | A | 0.0000 | |
| 72 | S | A | 0.0000 | |
| 73 | R | A | -0.6722 | |
| 74 | Y | A | 0.0000 | |
| 75 | P | A | -1.6458 | |
| 76 | D | A | -2.7603 | |
| 77 | H | A | -2.3580 | |
| 78 | M | A | 0.0000 | |
| 79 | K | A | -2.3440 | |
| 80 | R | A | -2.7300 | |
| 81 | H | A | -1.6816 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | 0.0000 | |
| 84 | F | A | 0.0000 | |
| 85 | K | A | 0.0000 | |
| 86 | S | A | -0.9731 | |
| 87 | A | A | 0.0000 | |
| 88 | M | A | 0.0000 | |
| 89 | P | A | -1.0116 | |
| 90 | E | A | -1.5956 | |
| 91 | G | A | 0.0000 | |
| 92 | Y | A | 0.0000 | |
| 93 | V | A | -0.6322 | |
| 94 | Q | A | 0.0000 | |
| 95 | E | A | -2.3598 | |
| 96 | R | A | 0.0000 | |
| 97 | T | A | -0.4757 | |
| 98 | I | A | 0.0000 | |
| 99 | F | A | 0.2701 | |
| 100 | F | A | 0.0000 | |
| 101 | K | A | -2.1955 | |
| 102 | D | A | -2.9594 | |
| 103 | D | A | -2.6030 | |
| 104 | G | A | 0.0000 | |
| 105 | N | A | -0.6977 | |
| 106 | Y | A | 0.0000 | |
| 107 | K | A | -1.6372 | |
| 108 | T | A | 0.0000 | |
| 109 | R | A | -3.2618 | |
| 110 | A | A | 0.0000 | |
| 111 | E | A | -1.7787 | |
| 112 | V | A | 0.0000 | |
| 113 | K | A | -1.1616 | |
| 114 | F | A | -1.2838 | |
| 115 | E | A | -1.5841 | |
| 116 | G | A | -1.7118 | |
| 117 | D | A | -2.1363 | |
| 118 | T | A | -1.6119 | |
| 119 | L | A | 0.0000 | |
| 120 | V | A | 0.0000 | |
| 121 | N | A | 0.0000 | |
| 122 | R | A | -2.2695 | |
| 123 | I | A | 0.0000 | |
| 124 | E | A | -3.8366 | |
| 125 | L | A | 0.0000 | |
| 126 | K | A | -2.2184 | |
| 127 | G | A | 0.0000 | |
| 128 | I | A | -1.0944 | |
| 129 | D | A | -2.4720 | |
| 130 | F | A | 0.0000 | |
| 131 | K | A | -3.7750 | |
| 132 | E | A | -3.8652 | |
| 133 | D | A | -3.5290 | |
| 134 | G | A | -2.7794 | |
| 135 | N | A | -2.2212 | |
| 136 | I | A | 0.0000 | |
| 137 | L | A | -1.9515 | |
| 138 | G | A | -2.2760 | |
| 139 | H | A | -2.0927 | |
| 140 | K | A | -2.3370 | |
| 141 | L | A | 0.0000 | |
| 142 | E | A | -1.2538 | |
| 143 | Y | A | -0.3129 | |
| 144 | N | A | 0.0000 | |
| 145 | Y | A | 0.0000 | |
| 146 | N | A | 0.0000 | |
| 147 | S | A | 0.0000 | |
| 148 | H | A | 0.0000 | |
| 149 | N | A | -0.3536 | |
| 150 | V | A | 0.0000 | |
| 151 | Y | A | 0.2663 | |
| 152 | I | A | 0.0000 | |
| 153 | M | A | -0.8487 | |
| 154 | A | A | -1.7834 | |
| 155 | D | A | -2.3686 | |
| 156 | K | A | -3.2489 | |
| 157 | Q | A | -3.1938 | |
| 158 | K | A | -3.4002 | |
| 159 | N | A | -2.7522 | |
| 160 | G | A | 0.0000 | |
| 161 | I | A | 0.0000 | |
| 162 | K | A | -1.1910 | |
| 163 | V | A | 0.0000 | |
| 164 | N | A | -0.3270 | |
| 165 | F | A | 0.0000 | |
| 166 | K | A | -1.3817 | |
| 167 | I | A | 0.0000 | |
| 168 | R | A | -0.6807 | |
| 169 | H | A | 0.0000 | |
| 170 | N | A | -0.8572 | |
| 171 | I | A | 0.0000 | |
| 172 | E | A | -3.1398 | |
| 173 | D | A | -2.9623 | |
| 174 | G | A | -1.8590 | |
| 175 | S | A | -0.7872 | |
| 176 | V | A | 0.0110 | |
| 177 | Q | A | 0.0000 | |
| 178 | L | A | -0.6659 | |
| 179 | A | A | 0.0000 | |
| 180 | D | A | -0.6747 | |
| 181 | H | A | 0.0000 | |
| 182 | Y | A | -0.0575 | |
| 183 | Q | A | 0.0000 | |
| 184 | Q | A | -1.2776 | |
| 185 | N | A | 0.0000 | |
| 186 | T | A | -0.7511 | |
| 187 | P | A | -0.6360 | |
| 188 | I | A | 0.0001 | |
| 189 | G | A | -1.0814 | |
| 190 | D | A | -1.9767 | |
| 191 | G | A | -1.2607 | |
| 192 | P | A | -0.7501 | |
| 193 | V | A | -0.4359 | |
| 194 | L | A | -0.4241 | |
| 195 | L | A | -0.9022 | |
| 196 | P | A | 0.0000 | |
| 197 | D | A | -2.3770 | |
| 198 | N | A | -1.6349 | |
| 199 | H | A | 0.0000 | |
| 200 | Y | A | -0.0154 | |
| 201 | L | A | 0.0000 | |
| 202 | S | A | -0.0838 | |
| 203 | T | A | 0.0000 | |
| 204 | Q | A | 0.0000 | |
| 205 | S | A | 0.0000 | |
| 206 | A | A | 0.0000 | |
| 207 | L | A | 0.0000 | |
| 208 | S | A | -0.5786 | |
| 209 | K | A | -1.5163 | |
| 210 | D | A | -1.7378 | |
| 211 | P | A | -1.5516 | |
| 212 | N | A | -2.2814 | |
| 213 | E | A | -2.5579 | |
| 214 | K | A | -3.1251 | |
| 215 | R | A | -3.1556 | |
| 216 | D | A | -2.1307 | |
| 217 | H | A | 0.0000 | |
| 218 | M | A | 0.0000 | |
| 219 | V | A | 0.0000 | |
| 220 | L | A | 0.0000 | |
| 221 | L | A | -0.0406 | |
| 222 | E | A | 0.0000 | |
| 223 | F | A | 0.0000 | |
| 224 | V | A | 0.0000 | |
| 225 | T | A | -0.1952 | |
| 226 | A | A | 0.0000 | |
| 227 | A | A | -0.2016 | |
| 228 | G | A | -0.5892 | |
| 229 | I | A | -0.6059 | |
| 230 | T | A | -0.2060 | |
| 1 | A | B | -1.1729 | |
| 2 | S | B | -1.6155 | |
| 3 | K | B | -2.2100 | |
| 4 | G | B | 0.0000 | |
| 5 | E | B | -1.6895 | |
| 6 | E | B | -2.2366 | |
| 7 | L | B | -0.8378 | |
| 8 | F | B | 0.0000 | |
| 9 | T | B | -0.3895 | |
| 10 | G | B | 0.2048 | |
| 11 | V | B | 1.0265 | |
| 12 | V | B | 0.0000 | |
| 13 | P | B | -1.0960 | |
| 14 | I | B | 0.0000 | |
| 15 | L | B | -1.1443 | |
| 16 | V | B | 0.0000 | |
| 17 | E | B | -1.9479 | |
| 18 | L | B | 0.0000 | |
| 19 | D | B | -3.1843 | |
| 20 | G | B | 0.0000 | |
| 21 | D | B | -2.1783 | |
| 22 | V | B | 0.0000 | |
| 23 | N | B | -1.7251 | |
| 24 | G | B | -1.2947 | |
| 25 | H | B | -1.7561 | |
| 26 | K | B | -2.6717 | |
| 27 | F | B | 0.0000 | |
| 28 | S | B | -1.7447 | |
| 29 | V | B | 0.0000 | |
| 30 | S | B | -1.0812 | |
| 31 | G | B | 0.0000 | |
| 32 | E | B | -2.4393 | |
| 33 | G | B | -1.7836 | |
| 34 | E | B | -1.8461 | |
| 35 | G | B | 0.0000 | |
| 36 | D | B | -0.3222 | |
| 37 | A | B | 0.0000 | |
| 38 | T | B | -0.1946 | |
| 39 | Y | B | -0.4908 | |
| 40 | G | B | 0.0000 | |
| 41 | K | B | -0.7850 | |
| 42 | L | B | 0.0000 | |
| 43 | T | B | -1.1161 | |
| 44 | L | B | 0.0000 | |
| 45 | K | B | -1.5076 | |
| 46 | F | B | 0.0000 | |
| 47 | I | B | -1.2335 | |
| 48 | C | B | 0.0000 | |
| 49 | T | B | -0.7845 | |
| 50 | T | B | -1.1986 | |
| 51 | G | B | -1.7294 | |
| 52 | K | B | -2.3471 | |
| 53 | L | B | 0.0000 | |
| 54 | P | B | -1.1833 | |
| 55 | V | B | 0.0000 | |
| 56 | P | B | 0.0000 | |
| 57 | W | B | 0.0000 | |
| 58 | P | B | 0.0000 | |
| 59 | T | B | 0.0000 | |
| 60 | L | B | 0.0000 | |
| 61 | V | B | 0.0000 | |
| 62 | T | B | 0.0000 | |
| 63 | T | B | 0.0000 | |
| 64 | F | B | 0.0000 | |
| 66 | Y | B | 0.0000 | |
| 67 | G | B | 0.0000 | |
| 68 | V | B | 0.0000 | |
| 69 | Q | B | 0.0000 | |
| 70 | C | B | 0.0000 | |
| 71 | F | B | 0.0000 | |
| 72 | S | B | 0.0000 | |
| 73 | R | B | -1.0212 | |
| 74 | Y | B | 0.0000 | |
| 75 | P | B | -1.7203 | |
| 76 | D | B | -2.8276 | |
| 77 | H | B | -2.3879 | |
| 78 | M | B | 0.0000 | |
| 79 | K | B | -2.5001 | |
| 80 | R | B | -2.7810 | |
| 81 | H | B | -1.7177 | |
| 82 | D | B | 0.0000 | |
| 83 | F | B | 0.0000 | |
| 84 | F | B | 0.0000 | |
| 85 | K | B | 0.0000 | |
| 86 | S | B | -0.9944 | |
| 87 | A | B | 0.0000 | |
| 88 | M | B | 0.0000 | |
| 89 | P | B | -1.1618 | |
| 90 | E | B | -1.5914 | |
| 91 | G | B | 0.0000 | |
| 92 | Y | B | 0.0000 | |
| 93 | V | B | -0.8105 | |
| 94 | Q | B | 0.0000 | |
| 95 | E | B | -2.9006 | |
| 96 | R | B | 0.0000 | |
| 97 | T | B | -0.5240 | |
| 98 | I | B | 0.0000 | |
| 99 | F | B | 0.4160 | |
| 100 | F | B | 0.0000 | |
| 101 | K | B | -1.8340 | |
| 102 | D | B | -2.8187 | |
| 103 | D | B | -2.5230 | |
| 104 | G | B | 0.0000 | |
| 105 | N | B | -0.5806 | |
| 106 | Y | B | 0.0000 | |
| 107 | K | B | -1.5933 | |
| 108 | T | B | 0.0000 | |
| 109 | R | B | -3.6142 | |
| 110 | A | B | 0.0000 | |
| 111 | E | B | -1.8332 | |
| 112 | V | B | 0.0000 | |
| 113 | K | B | -1.1250 | |
| 114 | F | B | -1.2666 | |
| 115 | E | B | -1.5686 | |
| 116 | G | B | -1.7020 | |
| 117 | D | B | -2.1377 | |
| 118 | T | B | -1.4337 | |
| 119 | L | B | 0.0000 | |
| 120 | V | B | 0.0000 | |
| 121 | N | B | 0.0000 | |
| 122 | R | B | -2.2261 | |
| 123 | I | B | 0.0000 | |
| 124 | E | B | -3.8713 | |
| 125 | L | B | 0.0000 | |
| 126 | K | B | -2.0369 | |
| 127 | G | B | 0.0000 | |
| 128 | I | B | -0.9579 | |
| 129 | D | B | -2.4277 | |
| 130 | F | B | 0.0000 | |
| 131 | K | B | -3.8668 | |
| 132 | E | B | -3.9232 | |
| 133 | D | B | -3.5584 | |
| 134 | G | B | 0.0000 | |
| 135 | N | B | -2.1077 | |
| 136 | I | B | 0.0000 | |
| 137 | L | B | -1.9814 | |
| 138 | G | B | -2.2796 | |
| 139 | H | B | -2.0780 | |
| 140 | K | B | -2.3043 | |
| 141 | L | B | 0.0000 | |
| 142 | E | B | -1.2245 | |
| 143 | Y | B | -0.2903 | |
| 144 | N | B | 0.0000 | |
| 145 | Y | B | 0.0000 | |
| 146 | N | B | 0.0000 | |
| 147 | S | B | 0.0000 | |
| 148 | H | B | 0.0000 | |
| 149 | N | B | -0.7065 | |
| 150 | V | B | 0.0000 | |
| 151 | Y | B | 0.1123 | |
| 152 | I | B | 0.0000 | |
| 153 | M | B | -0.7894 | |
| 154 | A | B | -1.6504 | |
| 155 | D | B | 0.0000 | |
| 156 | K | B | -3.1050 | |
| 157 | Q | B | -3.1423 | |
| 158 | K | B | -3.4342 | |
| 159 | N | B | -2.6660 | |
| 160 | G | B | 0.0000 | |
| 161 | I | B | 0.0000 | |
| 162 | K | B | -1.1978 | |
| 163 | V | B | 0.0000 | |
| 164 | N | B | -0.5912 | |
| 165 | F | B | 0.0000 | |
| 166 | K | B | -1.2912 | |
| 167 | I | B | 0.0000 | |
| 168 | R | B | -0.6129 | |
| 169 | H | B | 0.0000 | |
| 170 | N | B | -0.8106 | |
| 171 | I | B | 0.0000 | |
| 172 | E | B | -3.1315 | |
| 173 | D | B | -2.9555 | |
| 174 | G | B | -1.8234 | |
| 175 | S | B | -0.7917 | |
| 176 | V | B | 0.0871 | |
| 177 | Q | B | 0.0000 | |
| 178 | L | B | -0.4506 | |
| 179 | A | B | 0.0000 | |
| 180 | D | B | -0.5318 | |
| 181 | H | B | 0.0000 | |
| 182 | Y | B | -0.0622 | |
| 183 | Q | B | 0.0000 | |
| 184 | Q | B | -1.7769 | |
| 185 | N | B | 0.0000 | |
| 186 | T | B | -0.8505 | |
| 187 | P | B | -0.6336 | |
| 188 | I | B | -0.0037 | |
| 189 | G | B | -1.0686 | |
| 190 | D | B | -1.9679 | |
| 191 | G | B | -1.2447 | |
| 192 | P | B | -0.7173 | |
| 193 | V | B | -0.3833 | |
| 194 | L | B | -0.4045 | |
| 195 | L | B | -0.7767 | |
| 196 | P | B | 0.0000 | |
| 197 | D | B | -2.3336 | |
| 198 | N | B | -1.5670 | |
| 199 | H | B | 0.0000 | |
| 200 | Y | B | 0.0022 | |
| 201 | L | B | 0.0000 | |
| 202 | S | B | -0.2216 | |
| 203 | T | B | 0.0000 | |
| 204 | Q | B | 0.0000 | |
| 205 | S | B | 0.0000 | |
| 206 | A | B | 0.0000 | |
| 207 | L | B | 0.0000 | |
| 208 | S | B | 0.0000 | |
| 209 | K | B | -1.1390 | |
| 210 | D | B | -1.6802 | |
| 211 | P | B | -1.5058 | |
| 212 | N | B | -2.2889 | |
| 213 | E | B | -2.5510 | |
| 214 | K | B | -3.1433 | |
| 215 | R | B | -3.3897 | |
| 216 | D | B | -2.2834 | |
| 217 | H | B | 0.0000 | |
| 218 | M | B | 0.0000 | |
| 219 | V | B | 0.0000 | |
| 220 | L | B | 0.0000 | |
| 221 | L | B | -0.0442 | |
| 222 | E | B | 0.0000 | |
| 223 | F | B | 0.0000 | |
| 224 | V | B | 0.0000 | |
| 225 | T | B | -0.4358 | |
| 226 | A | B | 0.0000 | |
| 227 | A | B | -0.2147 | |
| 228 | G | B | -0.5231 | |
| 229 | I | B | -0.5519 | |
| 230 | T | B | -0.2004 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine