Project name: f299913470d2ffa

Chain sequence(s)	P: FVPTNVGSKAF; R: QLGVTRNKIMTAQYECYQKIMQYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKNLYMKAVRATLILVPLLGIEFVLIPWEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQY; E: EANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.0679
• Maximal score value: 3.0038
• Average score: -0.0973
• Total score value: -45.4433

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
29	E	E	-2.1487
30	A	E	-1.4034
31	N	E	-1.5520
32	Y	E	0.0000
33	G	E	-1.0070
34	A	E	-0.9372
35	L	E	-0.1362
36	L	E	-0.6084
37	R	E	-2.1015
38	E	E	-1.9690
39	L	E	-0.0450
40	C	E	0.0000
41	L	E	-0.8086
42	T	E	-1.0548
43	Q	E	-1.2958
44	F	E	0.0000
45	Q	E	-1.4462
46	V	E	0.0762
47	D	E	-1.0511
48	M	E	-1.5994
49	E	E	-2.1139
50	A	E	-0.7295
51	V	E	-0.8160
52	G	E	-1.2932
53	E	E	-2.2010
54	T	E	-0.9974
55	L	E	-1.0222
56	W	E	-0.6734
57	C	E	-0.9845
58	D	E	-1.8451
59	W	E	0.0000
60	G	E	-2.0221
61	R	E	-2.6773
62	T	E	0.0000
63	I	E	-1.9506
64	R	E	-2.7486
65	S	E	0.0000
66	Y	E	0.0000
67	R	E	-1.7784
68	E	E	-1.7229
69	L	E	-0.9637
70	A	E	0.0000
71	D	E	-0.7438
72	C	E	-0.1945
73	T	E	-0.4039
74	W	E	-0.6620
75	H	E	-1.6955
76	M	E	-1.1092
77	A	E	0.0000
78	E	E	-2.6174
79	K	E	-2.6388
80	L	E	-1.4465
81	G	E	-1.2684
82	C	E	-0.7425
83	F	E	0.1124
84	W	E	0.0000
85	P	E	0.0919
86	N	E	-0.6856
87	A	E	-1.0465
88	E	E	-1.1858
89	V	E	0.0000
90	D	E	-1.2170
91	R	E	-1.7697
92	F	E	-0.7620
93	F	E	0.0000
94	L	E	-0.4582
95	A	E	-0.4322
96	V	E	-0.5277
97	H	E	0.0000
98	G	E	-1.3821
99	R	E	-2.0949
100	Y	E	-1.2319
101	F	E	0.0000
102	R	E	-2.2219
103	S	E	-1.0620
104	C	E	0.0000
105	P	E	-0.2269
106	I	E	-0.1119
107	S	E	-0.7198
108	G	E	-1.0226
109	R	E	-0.9140
110	A	E	-0.8426
111	V	E	-0.7820
112	R	E	-2.3195
113	D	E	-2.3363
114	P	E	0.0000
115	P	E	-0.5426
116	G	E	0.0440
117	S	E	0.4233
118	I	E	1.1399
119	L	E	1.0194
120	Y	E	1.9606
121	P	E	1.7357
122	F	E	1.9586
123	I	E	1.9464
124	V	E	2.1455
125	V	E	2.7223
126	P	E	0.0000
127	I	E	2.0346
128	T	E	2.1345
129	V	E	2.3853
130	T	E	0.0000
131	L	E	2.8251
132	L	E	2.7754
133	V	E	1.9227
134	T	E	0.0000
135	A	E	1.5247
136	L	E	1.6423
137	V	E	0.0000
138	V	E	0.0000
139	W	E	0.4348
140	Q	E	-0.6924
141	S	E	0.0000
142	K	E	-2.1594
143	R	E	-2.6547
27	F	P	2.5434
28	V	P	2.2774
29	P	P	0.7699
30	T	P	-0.2339
31	N	P	-1.3495
32	V	P	-0.7486
33	G	P	-1.0813
34	S	P	-1.3483
35	K	P	-1.9409
36	A	P	0.0000
37	F	P	-0.3212
33	Q	R	-0.2578
34	L	R	1.0188
35	G	R	0.3979
36	V	R	1.2671
37	T	R	0.2929
38	R	R	-0.3552
39	N	R	-0.6844
40	K	R	-0.5952
41	I	R	-0.5490
42	M	R	0.0000
43	T	R	-0.7815
44	A	R	-0.4552
45	Q	R	0.0000
46	Y	R	0.0000
47	E	R	-1.3130
48	C	R	0.0000
49	Y	R	0.0000
50	Q	R	0.0000
51	K	R	-2.0302
52	I	R	0.0000
53	M	R	-0.9388
54	Q	R	-1.6691
64	Y	R	0.2742
65	C	R	0.0000
66	N	R	-1.8229
67	R	R	-2.0089
68	T	R	-1.3739
69	W	R	0.0000
70	D	R	-0.2180
71	G	R	0.0000
72	W	R	0.0000
73	L	R	0.4011
74	C	R	-0.5646
75	W	R	0.0000
76	N	R	-1.9034
77	D	R	-1.3565
78	V	R	-0.7408
79	A	R	-0.2718
80	A	R	-0.8192
81	G	R	-1.4012
82	T	R	-1.0850
83	E	R	-1.8417
84	S	R	-1.0524
85	M	R	-0.4090
86	Q	R	-0.3278
87	L	R	-0.1145
88	C	R	0.0000
89	P	R	0.0000
90	D	R	-2.3523
91	Y	R	-1.1618
92	F	R	-0.9845
93	Q	R	-1.5066
94	D	R	-0.8277
95	F	R	0.0000
96	D	R	-3.0679
97	P	R	-1.8708
98	S	R	-1.6274
99	E	R	-2.4859
100	K	R	-2.1186
101	V	R	0.0000
102	T	R	-0.8605
103	K	R	0.0000
104	I	R	-0.8142
105	C	R	0.0000
106	D	R	-2.2099
110	N	R	-1.8304
111	W	R	-1.2695
112	F	R	-1.1994
113	R	R	-2.4813
114	H	R	-1.3899
115	P	R	-1.1559
116	A	R	-0.8782
117	S	R	-1.4344
118	N	R	-2.0408
119	R	R	0.0000
120	T	R	-0.9664
121	W	R	0.0000
122	T	R	0.0000
123	N	R	-0.5081
124	Y	R	0.0000
125	T	R	-0.2651
126	Q	R	-0.8756
127	C	R	0.0000
128	N	R	-0.4242
129	V	R	0.6748
130	N	R	-1.1700
131	T	R	-1.6197
132	H	R	-2.1520
133	E	R	-3.0457
134	K	R	-2.8914
135	V	R	-0.7874
136	K	R	-1.9954
137	T	R	-1.3485
138	A	R	-0.2577
139	L	R	0.5312
140	N	R	0.1386
141	L	R	0.0000
142	F	R	1.2139
143	Y	R	1.9496
144	L	R	1.6686
145	T	R	0.0000
146	I	R	2.2796
147	I	R	2.5156
148	G	R	0.0000
149	H	R	0.0000
150	G	R	1.4184
151	L	R	1.7029
152	S	R	0.0000
153	I	R	1.9782
154	A	R	1.5772
155	S	R	0.0000
156	L	R	0.0000
157	L	R	2.7124
158	I	R	2.8185
159	S	R	0.0000
160	L	R	2.2007
161	G	R	2.3079
162	I	R	1.9861
163	F	R	0.0000
164	F	R	2.3703
165	Y	R	2.2307
166	F	R	1.1256
167	K	R	-0.4501
168	S	R	-0.1868
169	L	R	-0.2297
170	S	R	-0.1097
171	C	R	-0.2028
172	Q	R	-0.7721
173	R	R	-0.2168
174	I	R	0.0000
175	T	R	-0.0690
176	L	R	0.0000
177	H	R	0.0000
178	K	R	0.0104
179	N	R	0.2686
180	L	R	0.0000
181	F	R	0.0000
182	F	R	1.7093
183	S	R	0.0000
184	F	R	0.0000
185	V	R	1.5498
186	C	R	1.2056
187	N	R	0.0000
188	S	R	0.0000
189	V	R	1.9768
190	V	R	1.7816
191	T	R	0.0000
192	I	R	2.1691
193	I	R	2.6853
194	H	R	0.0000
195	L	R	0.7616
196	T	R	0.3113
197	A	R	0.4105
198	V	R	0.0000
199	A	R	-0.6317
200	N	R	-1.9507
201	N	R	-2.1043
202	Q	R	-2.1402
203	A	R	-1.0666
204	L	R	-0.7905
205	V	R	-0.9976
206	A	R	-0.6740
207	T	R	-0.4667
208	N	R	-0.7443
209	P	R	0.4423
210	V	R	1.7102
211	S	R	0.9547
212	C	R	0.0000
213	K	R	0.8491
214	V	R	1.9300
215	S	R	1.4151
216	Q	R	0.7687
217	F	R	1.3534
218	I	R	1.5188
219	H	R	1.0627
220	L	R	0.0000
221	Y	R	1.0657
222	L	R	0.0000
223	M	R	0.3208
224	G	R	0.0000
225	C	R	0.0000
226	N	R	0.0000
227	Y	R	0.0000
228	F	R	0.0000
229	W	R	0.0000
230	M	R	0.0000
231	L	R	0.0000
232	C	R	0.0000
233	E	R	0.0000
234	G	R	0.0000
235	I	R	0.0000
236	Y	R	0.0000
237	L	R	0.0000
238	H	R	0.6225
239	T	R	0.0000
240	L	R	0.9280
241	I	R	2.2355
242	V	R	2.1354
243	V	R	1.6241
244	A	R	1.0767
245	V	R	3.0038
246	F	R	2.2756
247	A	R	0.2256
248	E	R	-1.7979
249	K	R	-2.5603
250	Q	R	-2.3730
251	H	R	-1.7157
252	L	R	-0.1211
253	M	R	0.7414
254	W	R	1.0139
255	Y	R	0.0000
256	Y	R	1.2924
257	F	R	1.8875
258	L	R	0.0000
259	G	R	0.0000
260	W	R	0.8245
261	G	R	0.7867
262	F	R	0.0000
263	P	R	0.0000
264	L	R	1.4025
265	I	R	1.5089
266	P	R	0.0000
267	A	R	0.0000
268	C	R	1.6574
269	I	R	1.5588
270	H	R	0.0000
271	A	R	1.4846
272	I	R	2.4284
273	A	R	0.0000
274	R	R	0.0000
275	S	R	0.7676
276	L	R	1.8243
277	Y	R	0.6128
278	Y	R	0.0000
279	N	R	-1.0026
280	D	R	-1.4806
281	N	R	-1.6674
282	C	R	0.0000
283	W	R	0.0000
284	I	R	-0.4277
285	S	R	-0.7985
286	S	R	-1.0747
287	D	R	-2.0932
288	T	R	0.0000
289	H	R	-1.2069
290	L	R	0.0000
291	L	R	-0.2481
292	Y	R	0.1505
293	I	R	0.0000
294	I	R	0.0000
295	H	R	0.0931
296	G	R	0.3549
297	P	R	0.0000
298	I	R	0.0000
299	C	R	0.7638
300	A	R	0.9355
301	A	R	0.0000
302	L	R	0.0000
303	L	R	1.9125
304	V	R	2.0171
305	N	R	0.0000
306	L	R	2.1237
307	F	R	2.7517
308	F	R	1.6040
309	L	R	0.0000
310	L	R	1.1969
311	N	R	0.1986
312	I	R	0.0000
313	V	R	-0.0279
314	R	R	-0.8511
315	V	R	0.0882
316	L	R	0.3742
317	I	R	1.1284
318	T	R	-0.1010
319	K	R	-0.9850
329	N	R	-0.4223
330	L	R	0.7386
331	Y	R	0.7604
332	M	R	0.0232
333	K	R	-0.7130
334	A	R	-0.4870
335	V	R	0.0000
336	R	R	-1.0543
337	A	R	-0.1252
338	T	R	0.0000
339	L	R	0.6605
340	I	R	1.3896
341	L	R	0.0000
342	V	R	0.0000
343	P	R	0.9509
344	L	R	0.9807
345	L	R	0.0000
346	G	R	0.0000
347	I	R	1.4375
348	E	R	1.2682
349	F	R	0.0000
350	V	R	2.4865
351	L	R	2.1156
352	I	R	1.9359
353	P	R	1.2371
354	W	R	1.7983
363	E	R	-1.1597
364	V	R	1.0071
365	Y	R	0.6756
366	D	R	-0.2833
367	Y	R	0.9704
368	I	R	1.8149
369	M	R	0.0000
370	H	R	0.8952
371	I	R	1.5101
372	L	R	1.2992
373	M	R	0.8487
374	H	R	0.9320
375	F	R	1.2686
376	Q	R	0.6137
377	G	R	0.0000
378	L	R	0.8573
379	L	R	0.7486
380	V	R	0.0000
381	S	R	0.0000
382	T	R	0.9432
383	I	R	0.0000
384	F	R	0.0000
385	C	R	0.0000
386	F	R	1.1940
387	F	R	1.5858
388	N	R	0.1047
389	G	R	-0.6221
390	E	R	-1.4503
391	V	R	0.0000
392	Q	R	-0.9174
393	A	R	-1.6590
394	I	R	-1.3832
395	L	R	-1.4160
396	R	R	-2.7419
397	R	R	-2.9742
398	N	R	-1.7173
399	W	R	-0.6766
400	N	R	-2.0546
401	Q	R	-1.7078
402	Y	R	0.3322