Project name: f29d1b9c21b23a1

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFNIKEYYMHWVRQAPGKGLEWVGLIDPEQGNTIYDPKFQDRATISADNSKNTAYLQMNSLRAEDTAVYYCARDTAAYFDYWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP; L: DIQMTQSPSSLSASVGDRVTITCRASRDIKSYLNWYQQKPGKAPKVLIYYATSLAEGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQHGESPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6281
• Maximal score value: 1.1264
• Average score: -0.7664
• Total score value: -325.7268

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.6301
2	I	L	0.0000
3	Q	L	-2.3865
4	M	L	0.0000
5	T	L	-1.3592
6	Q	L	0.0000
7	S	L	-0.7212
8	P	L	-0.4954
9	S	L	-0.6181
10	S	L	-0.5010
11	L	L	-0.3198
12	S	L	-0.6618
13	A	L	-0.9585
14	S	L	-0.8418
15	V	L	-0.0820
16	G	L	-0.7225
17	D	L	-1.8948
18	R	L	-2.3564
19	V	L	0.0000
20	T	L	-0.6557
21	I	L	0.0000
22	T	L	-0.8293
23	C	L	0.0000
24	R	L	-2.9427
25	A	L	0.0000
26	S	L	-2.4512
27	R	L	-3.3120
28	D	L	-2.6409
29	I	L	0.0000
30	K	L	-2.2576
31	S	L	-0.8070
32	Y	L	-0.0546
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.5956
40	P	L	-1.4486
41	G	L	-1.5524
42	K	L	-2.4448
43	A	L	-1.3724
44	P	L	0.0000
45	K	L	-1.1289
46	V	L	-0.4274
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.8524
50	Y	L	0.6815
51	A	L	0.0000
52	T	L	0.1480
53	S	L	0.1694
54	L	L	0.1604
55	A	L	0.0000
56	E	L	-1.8848
57	G	L	-1.2056
58	V	L	-0.7193
59	P	L	-0.5004
60	S	L	-0.3608
61	R	L	-0.7046
62	F	L	0.0000
63	S	L	-0.2681
64	G	L	-0.1222
65	S	L	-0.5544
66	G	L	-1.1154
67	S	L	-1.3192
68	G	L	-1.9320
69	T	L	-2.4234
70	D	L	-2.2646
71	Y	L	0.0000
72	T	L	-0.7313
73	L	L	0.0000
74	T	L	-0.6337
75	I	L	0.0000
76	S	L	-1.3954
77	S	L	-1.1495
78	L	L	0.0000
79	Q	L	-0.8611
80	P	L	-1.5609
81	E	L	-1.9070
82	D	L	0.0000
83	F	L	0.0000
84	A	L	0.0000
85	T	L	-0.4845
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	-0.6431
92	G	L	-1.3593
93	E	L	-2.3407
94	S	L	-1.2949
95	P	L	-1.0962
96	W	L	-0.9003
97	T	L	-0.9246
98	F	L	-0.3126
99	G	L	0.0000
100	Q	L	-1.3556
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.7004
104	V	L	0.0000
105	E	L	-1.0875
106	I	L	0.0000
107	K	L	-1.1566
108	R	L	-0.7658
109	T	L	-0.0216
110	V	L	0.4152
111	A	L	-0.0417
112	A	L	-0.1030
113	P	L	0.0000
114	S	L	-0.0898
115	V	L	0.0454
116	F	L	0.1582
117	I	L	0.1056
118	F	L	0.0000
119	P	L	-0.4859
120	P	L	-0.8328
121	S	L	-1.6792
122	D	L	-3.0223
123	E	L	-3.1322
124	Q	L	0.0000
125	L	L	-2.3409
126	K	L	-2.8251
127	S	L	-1.7623
128	G	L	-1.1666
129	T	L	-0.8419
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.9534
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.7479
142	R	L	-3.1181
143	E	L	-3.1990
144	A	L	-2.2491
145	K	L	-2.2831
146	V	L	-1.1686
147	Q	L	-0.9015
148	W	L	0.0000
149	K	L	-0.7940
150	V	L	0.0000
151	D	L	-1.9688
152	N	L	-1.6297
153	A	L	-0.4661
154	L	L	0.2064
155	Q	L	-0.3497
156	S	L	-0.5585
157	G	L	-0.9471
158	N	L	-0.8933
159	S	L	-1.3034
160	Q	L	-1.6489
161	E	L	-2.0788
162	S	L	-1.0978
163	V	L	-1.0990
164	T	L	-1.1948
165	E	L	-2.2601
166	Q	L	0.0000
167	D	L	-2.0684
168	S	L	-2.2534
169	K	L	-2.6105
170	D	L	-1.9662
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.7437
179	L	L	0.0000
180	T	L	-0.4831
181	L	L	-0.6586
182	S	L	-1.2039
183	K	L	-1.8999
184	A	L	-1.8870
185	D	L	-2.8348
186	Y	L	0.0000
187	E	L	-3.4460
188	K	L	-3.6281
189	H	L	-2.8705
190	K	L	-3.2017
191	V	L	-1.2535
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.9735
196	V	L	0.0000
197	T	L	-1.1612
198	H	L	0.0000
199	Q	L	-1.7188
200	G	L	-0.4276
201	L	L	-0.2440
202	S	L	-0.4649
203	S	L	-0.3977
204	P	L	-0.5015
205	V	L	-0.0184
206	T	L	-0.5379
207	K	L	-0.6633
208	S	L	-0.5588
209	F	L	-0.9216
210	N	L	-1.9853
211	R	L	-2.5363
212	G	L	-2.1553
213	E	L	-2.5630
1	E	H	-2.1014
2	V	H	-1.2871
3	Q	H	-1.3577
4	L	H	0.0000
5	V	H	0.2705
6	E	H	0.0000
7	S	H	-0.7175
8	G	H	-1.2399
9	G	H	-0.9499
10	G	H	-0.4958
11	L	H	-0.0382
12	V	H	-0.7966
13	Q	H	-1.5857
14	P	H	-1.5604
15	G	H	-1.4764
16	G	H	-1.1769
17	S	H	-1.4697
18	L	H	0.0000
19	R	H	-2.3272
20	L	H	0.0000
21	S	H	-0.5362
22	C	H	0.0000
23	A	H	-0.3326
24	A	H	0.0000
25	S	H	-1.1492
26	G	H	-1.3058
27	F	H	-1.0708
28	N	H	-1.8117
29	I	H	0.0000
30	K	H	-2.9479
31	E	H	-2.5456
32	Y	H	-0.9670
33	Y	H	-0.2780
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.7419
40	A	H	-1.1497
41	P	H	-0.9578
42	G	H	-1.4766
43	K	H	-2.2818
44	G	H	-1.4492
45	L	H	0.0000
46	E	H	-0.6989
47	W	H	0.0000
48	V	H	0.0000
49	G	H	0.0000
50	L	H	0.0000
51	I	H	0.0000
52	D	H	-1.8305
53	P	H	0.0000
54	E	H	-3.5584
55	Q	H	-2.8527
56	G	H	-2.3160
57	N	H	-1.9693
58	T	H	-0.4353
59	I	H	0.3880
60	Y	H	-0.4524
61	D	H	0.0000
62	P	H	-1.9224
63	K	H	-2.5128
64	F	H	0.0000
65	Q	H	-2.5510
66	D	H	-2.9508
67	R	H	-2.1047
68	A	H	0.0000
69	T	H	-0.9173
70	I	H	0.0000
71	S	H	-0.5935
72	A	H	-1.3055
73	D	H	-1.6377
74	N	H	-2.1387
75	S	H	-1.6912
76	K	H	-2.3273
77	N	H	-1.7592
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.5571
81	L	H	0.0000
82	Q	H	-1.4941
83	M	H	0.0000
84	N	H	-1.7049
85	S	H	-1.4345
86	L	H	0.0000
87	R	H	-2.5207
88	A	H	-1.8243
89	E	H	-2.2790
90	D	H	0.0000
91	T	H	-0.7269
92	A	H	0.0000
93	V	H	0.1400
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	D	H	0.0000
100	T	H	-0.0033
101	A	H	0.1991
102	A	H	0.3161
103	Y	H	0.2498
104	F	H	0.0000
105	D	H	-0.3723
106	Y	H	0.0950
107	W	H	-0.3169
108	G	H	0.0000
109	Q	H	-1.4219
110	G	H	-0.7661
111	T	H	-0.2431
112	L	H	0.0313
113	V	H	0.0000
114	T	H	-0.5083
115	V	H	0.0000
116	S	H	-0.7421
117	S	H	-0.6566
118	A	H	-0.4386
119	S	H	-0.5388
120	T	H	-0.6593
121	K	H	-1.2973
122	G	H	-1.4176
123	P	H	-0.5816
124	S	H	-0.4072
125	V	H	0.0000
126	F	H	-0.7245
127	P	H	-1.0850
128	L	H	0.0000
129	A	H	-0.7736
130	P	H	0.0000
131	S	H	-0.3622
137	G	H	-0.7794
138	G	H	-0.8547
139	T	H	-0.6064
140	A	H	-0.3022
141	A	H	0.0000
142	L	H	0.0000
143	G	H	0.0000
144	C	H	0.0000
145	L	H	0.0000
146	V	H	0.0000
147	K	H	0.0000
148	D	H	-0.3956
149	Y	H	0.0000
150	F	H	0.0000
151	P	H	0.0000
152	E	H	-0.7674
153	P	H	-0.7844
154	V	H	-0.6765
155	T	H	-0.5611
156	V	H	-0.3033
157	S	H	-0.3543
158	W	H	0.0000
159	N	H	-0.8067
160	S	H	-0.6736
161	G	H	-0.4692
162	A	H	-0.2400
163	L	H	-0.0016
164	T	H	-0.1722
165	S	H	-0.1972
166	G	H	-0.2639
167	V	H	0.1008
168	H	H	-0.3608
169	T	H	-0.1541
170	F	H	0.0000
171	P	H	-0.3588
172	A	H	0.1637
173	V	H	0.3840
174	L	H	1.1264
175	Q	H	0.1730
176	S	H	-0.1121
177	S	H	-0.2313
178	G	H	0.0329
179	L	H	0.0599
180	Y	H	0.3667
181	S	H	0.2478
182	L	H	0.1609
183	S	H	0.0000
184	S	H	0.0000
185	V	H	0.0000
186	V	H	0.0000
187	T	H	-0.1206
188	V	H	0.0000
189	P	H	-0.5248
190	S	H	-0.5978
191	S	H	-0.6381
192	S	H	-0.5362
193	L	H	-0.7559
194	G	H	-0.9563
195	T	H	-0.7004
196	Q	H	-1.1855
197	T	H	-1.1122
198	Y	H	0.0000
199	I	H	-1.0242
200	C	H	0.0000
201	N	H	0.0000
202	V	H	0.0000
203	N	H	-1.8738
204	H	H	0.0000
205	K	H	-2.7858
206	P	H	-1.6267
207	S	H	-1.8109
208	N	H	-2.5958
209	T	H	-2.0810
210	K	H	-2.6214
211	V	H	-1.4754
212	D	H	-2.3292
213	K	H	-1.9853
214	K	H	-2.2326
215	V	H	0.0000
216	E	H	-2.4077
217	P	H	-1.2048