Project name: f2e8a3b7e7be006

Chain sequence(s)	A: AMIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEIS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1624
• Maximal score value: 2.2654
• Average score: -0.9093
• Total score value: -319.1512

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
-1	A	A	0.4809
1	M	A	1.5823
2	I	A	2.2654
3	V	A	0.0000
4	Q	A	-1.0164
5	R	A	-1.4147
6	V	A	0.0000
7	V	A	0.0000
8	L	A	0.0000
9	N	A	-1.7153
10	S	A	-1.1207
11	R	A	-1.5121
12	P	A	-1.5835
13	G	A	-2.6126
14	K	A	-4.1624
15	N	A	-3.7066
16	G	A	-2.5818
17	N	A	-2.1497
18	P	A	0.0000
19	V	A	-0.6498
20	A	A	-1.3982
21	E	A	-2.2856
22	N	A	0.0000
23	F	A	0.0000
24	R	A	-2.7716
25	M	A	-2.1079
26	E	A	-2.0169
27	E	A	-1.2818
28	V	A	0.5453
29	Y	A	1.7681
30	L	A	0.0000
31	P	A	-0.9075
32	D	A	-2.3100
33	N	A	-2.7224
34	I	A	0.0000
35	N	A	-3.2530
36	E	A	-3.3734
37	G	A	-2.6905
38	Q	A	-2.7272
39	V	A	0.0000
40	Q	A	-1.7766
41	V	A	0.0000
42	R	A	-0.9700
43	T	A	0.0000
44	L	A	0.0000
45	Y	A	-0.0523
46	L	A	0.0000
47	S	A	0.0000
48	V	A	0.0000
49	D	A	-0.1305
50	P	A	0.1453
51	Y	A	0.4447
52	M	A	0.0000
53	R	A	0.0000
54	C	A	-1.0460
55	R	A	0.0000
56	M	A	0.0000
57	N	A	0.0000
58	E	A	-3.2406
59	D	A	-3.2149
60	T	A	-1.7568
61	G	A	-1.4651
62	T	A	-0.9491
63	D	A	-1.3897
64	Y	A	0.5455
65	I	A	0.1258
66	T	A	-0.7926
67	P	A	-1.3100
68	W	A	0.0000
69	Q	A	-1.6321
70	L	A	-0.7496
71	S	A	-1.0418
72	Q	A	-1.2507
73	V	A	-0.6124
74	V	A	0.0000
75	D	A	0.1761
76	G	A	0.0000
77	G	A	0.6309
78	G	A	0.0000
79	I	A	0.0000
80	G	A	0.0000
81	I	A	0.0000
82	I	A	0.0000
83	E	A	-1.8303
84	E	A	-2.2849
85	S	A	-2.4712
86	K	A	-3.0610
87	H	A	-2.4927
88	T	A	-1.3640
89	N	A	-1.8192
90	L	A	-1.9821
91	T	A	-1.9332
92	K	A	-2.6341
93	G	A	-1.4654
94	D	A	-1.5109
95	F	A	-1.0508
96	V	A	0.0000
97	T	A	-0.5278
98	S	A	0.0621
99	F	A	1.1061
100	Y	A	1.5259
101	W	A	0.0000
102	P	A	0.1976
103	W	A	0.0000
104	Q	A	0.0000
105	T	A	-0.3880
106	K	A	-0.3324
107	V	A	0.0000
108	I	A	-0.9644
109	L	A	-0.9619
110	D	A	-2.4872
111	G	A	0.0000
112	N	A	-2.3083
113	S	A	-1.2737
114	L	A	-1.5286
115	E	A	-2.7742
116	K	A	-2.8284
117	V	A	-1.7275
118	D	A	-2.1985
119	P	A	-1.9757
120	Q	A	-2.4700
121	L	A	-1.4587
122	V	A	0.0000
123	D	A	-2.8677
124	G	A	-2.0467
125	H	A	-1.3261
126	L	A	0.0000
127	S	A	0.0000
128	Y	A	-0.2173
129	F	A	0.2225
130	L	A	0.0000
131	G	A	0.0000
132	A	A	0.0000
133	I	A	0.0000
134	G	A	0.0000
135	M	A	0.5086
136	P	A	0.1491
137	G	A	0.0000
138	L	A	0.0000
139	T	A	0.1867
140	S	A	0.0000
141	L	A	0.0000
142	I	A	0.0000
143	G	A	0.0000
144	I	A	0.0000
145	Q	A	-1.9639
146	E	A	-2.0504
147	K	A	-1.9205
148	G	A	0.0000
149	H	A	-1.5117
150	I	A	-0.9478
151	T	A	-0.5967
152	A	A	-0.3336
153	G	A	-0.9101
154	S	A	-1.1321
155	N	A	-1.8749
156	K	A	-1.4819
157	T	A	0.0000
158	M	A	0.0000
159	V	A	0.0000
160	V	A	0.0000
161	S	A	0.0000
162	G	A	-0.1399
163	A	A	0.0000
164	A	A	0.0000
165	G	A	-0.2181
166	A	A	-0.0964
167	C	A	0.0703
168	G	A	0.0000
169	S	A	0.0000
170	V	A	0.0000
171	A	A	0.0000
172	G	A	0.0000
173	Q	A	0.0000
174	I	A	0.0000
175	G	A	0.0000
176	H	A	-0.4205
177	F	A	0.4402
178	L	A	0.2843
179	G	A	-0.4564
180	C	A	0.0000
181	S	A	-1.3433
182	R	A	-1.6756
183	V	A	0.0000
184	V	A	0.0000
185	G	A	0.0000
186	I	A	0.0000
187	C	A	0.0000
188	G	A	0.0000
189	T	A	-1.4229
190	H	A	-1.9137
191	E	A	-1.6357
192	K	A	0.0000
193	C	A	-0.0952
194	I	A	0.4278
195	L	A	-0.2708
196	L	A	0.0000
197	T	A	-0.6797
198	S	A	-0.8656
199	E	A	-1.8533
200	L	A	0.0000
201	G	A	-1.7592
202	F	A	0.0000
203	D	A	-1.9032
204	A	A	-0.9921
205	A	A	-0.1020
206	I	A	0.0000
207	N	A	0.0000
208	Y	A	-1.3808
209	K	A	-2.7354
210	K	A	-3.1053
211	D	A	-2.8468
212	N	A	-2.6984
213	V	A	-2.0895
214	A	A	-2.1312
215	E	A	-3.4691
216	Q	A	-2.8758
217	L	A	0.0000
218	R	A	-3.5843
219	E	A	-3.3530
220	S	A	-2.2077
221	C	A	0.0000
222	P	A	-1.5218
223	A	A	-0.8556
224	G	A	-1.2147
225	V	A	0.0000
226	D	A	-1.4078
227	V	A	0.0000
228	Y	A	0.0000
229	F	A	0.0000
230	D	A	0.0000
231	N	A	-0.0503
232	V	A	0.0000
233	G	A	0.0000
234	G	A	-0.9104
235	N	A	-1.5595
236	I	A	0.0000
237	S	A	0.0000
238	D	A	-1.2084
239	T	A	-0.8387
240	V	A	0.0000
241	I	A	0.0000
242	S	A	-0.5719
243	Q	A	-1.1389
244	M	A	0.0000
245	N	A	-2.0387
246	E	A	-3.7125
247	N	A	-3.3062
248	S	A	0.0000
249	H	A	-1.4957
250	I	A	0.0000
251	I	A	0.0000
252	L	A	0.0000
253	C	A	-0.2567
254	G	A	0.0000
255	Q	A	0.0000
256	I	A	0.3505
257	S	A	-0.4447
258	Q	A	-0.8418
259	Y	A	-1.1343
260	N	A	-2.5839
261	K	A	-3.6089
262	D	A	-3.2965
263	V	A	-1.2487
264	P	A	-0.4858
265	Y	A	0.0508
266	P	A	-0.2082
267	P	A	-0.0832
268	P	A	-0.3643
269	L	A	-0.6702
270	S	A	-0.6516
271	P	A	-0.7383
272	A	A	-0.6359
273	I	A	-1.1163
274	E	A	-2.3561
275	A	A	-1.8997
276	I	A	-2.0797
277	Q	A	-2.9939
278	K	A	-3.8900
279	E	A	-3.8624
280	R	A	-3.8451
281	N	A	-3.7428
282	I	A	0.0000
283	T	A	-2.0053
284	R	A	-1.7639
285	E	A	-2.7025
286	R	A	-2.2790
287	F	A	0.0000
288	L	A	-0.1220
289	V	A	0.0000
290	L	A	-0.4873
291	N	A	-1.5850
292	Y	A	-1.8790
293	K	A	-3.1353
294	D	A	-3.3565
295	K	A	-2.5873
296	F	A	-1.9178
297	E	A	-2.4586
298	P	A	-1.2995
299	G	A	0.0000
300	I	A	-0.2266
301	L	A	0.0136
302	Q	A	-0.6708
303	L	A	0.0000
304	S	A	0.0000
305	Q	A	-1.8847
306	W	A	-1.8636
307	F	A	-2.0965
308	K	A	-3.3339
309	E	A	-3.3274
310	G	A	-2.7374
311	K	A	-2.8111
312	L	A	0.0000
313	K	A	-1.6103
314	I	A	-0.5453
315	K	A	-0.8507
316	E	A	-0.4038
317	T	A	0.2583
318	V	A	0.8908
319	I	A	0.2437
320	N	A	-1.1741
321	G	A	-1.1787
322	L	A	0.0000
323	E	A	-2.6154
324	N	A	-1.7421
325	M	A	0.0000
326	G	A	0.0000
327	A	A	-0.7012
328	A	A	0.0000
329	F	A	0.0000
330	Q	A	-0.7611
331	S	A	-0.3298
332	M	A	0.0000
333	M	A	-0.3134
334	T	A	-0.4897
335	G	A	-0.4444
336	G	A	-0.5514
337	N	A	0.0000
338	I	A	-0.0887
339	G	A	0.0000
340	K	A	0.0000
341	Q	A	0.0000
342	I	A	0.0000
343	V	A	0.0000
344	C	A	0.0000
345	I	A	-0.9993
346	S	A	-1.4562
347	E	A	-2.4554
348	E	A	-2.3333
349	I	A	-0.7219
350	S	A	-0.6233