Project name: AMC-frm_200

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKEPPSSGEPPKSGDRSGYSSPGEPGTPGSRSRTPSLPTPPEREPKKVAVVREPPKSPESAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8983
• Maximal score value: 2.0967
• Average score: -1.0299
• Total score value: -454.1959

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.4399
2	A	A	0.0000
3	E	A	-1.0033
4	P	A	0.0000
5	R	A	-1.6014
6	Q	A	-1.6079
7	E	A	-1.1034
8	F	A	-0.7879
9	E	A	0.0000
10	V	A	-0.7236
11	M	A	-1.1047
12	E	A	-2.4266
13	D	A	-2.3601
14	H	A	-1.3182
15	A	A	-0.5354
16	G	A	-0.0843
17	T	A	0.3387
18	Y	A	0.7157
19	G	A	0.4871
20	L	A	1.3934
21	G	A	0.1350
22	D	A	-1.3666
23	R	A	-3.1233
24	K	A	-3.8983
25	D	A	-3.5937
26	Q	A	-3.0024
27	G	A	-2.0195
28	G	A	-2.0587
29	Y	A	-1.0528
30	T	A	-0.6868
31	M	A	0.3931
32	H	A	-0.8035
33	Q	A	-1.3166
34	D	A	-2.9416
35	Q	A	-2.7994
36	E	A	-2.9587
37	G	A	-2.1002
38	D	A	-3.2445
39	T	A	-2.2880
40	D	A	-2.0597
41	A	A	-0.7898
42	G	A	0.0000
43	L	A	-0.9924
44	K	A	-1.7232
45	E	A	-1.5102
46	S	A	-1.1045
47	P	A	0.0000
48	L	A	0.0000
49	Q	A	-1.5655
50	T	A	-1.1419
51	P	A	-1.3206
52	T	A	-1.9164
53	E	A	-3.4544
54	D	A	-3.4487
55	G	A	-3.2012
56	S	A	-2.6397
57	E	A	-3.1330
58	E	A	-3.3240
59	P	A	-2.2177
60	G	A	-2.1098
61	S	A	-2.7055
62	E	A	-2.7830
63	T	A	-2.1314
64	S	A	-1.9340
65	D	A	-3.1087
66	A	A	-2.3399
67	K	A	-3.4021
68	S	A	-2.4665
69	T	A	0.0000
70	P	A	0.0000
71	T	A	-1.1343
72	A	A	-0.8252
73	E	A	-1.8603
74	D	A	-1.1395
75	V	A	0.7000
76	T	A	-0.3054
77	A	A	0.0000
78	P	A	0.0000
79	L	A	1.0326
80	V	A	0.0000
81	D	A	-1.1630
82	E	A	-2.1217
83	G	A	-1.6154
84	A	A	-1.0583
85	P	A	-0.9921
86	G	A	-1.3891
87	K	A	-2.0617
88	Q	A	-2.0139
89	A	A	0.0000
90	A	A	-0.9055
91	A	A	-0.8910
92	Q	A	-1.1865
93	P	A	-1.1689
94	H	A	-2.1925
95	T	A	-2.1874
96	E	A	-2.6288
97	I	A	-2.0677
98	P	A	-1.8828
99	E	A	-3.0591
100	G	A	0.0000
101	T	A	-2.8082
102	T	A	-1.7353
103	A	A	-1.5970
104	E	A	-1.9382
105	E	A	-1.0958
106	A	A	-0.9891
107	G	A	0.0000
108	I	A	0.3727
109	G	A	-0.7799
110	D	A	-1.4427
111	T	A	-0.9417
112	P	A	-0.5735
113	S	A	-0.2319
114	L	A	0.4474
115	E	A	-1.1860
116	D	A	-2.1933
117	E	A	-2.0342
118	A	A	-1.1706
119	A	A	-0.4926
120	G	A	-0.9212
121	H	A	-1.2858
122	V	A	-0.7653
123	T	A	-0.8446
124	Q	A	-1.0256
125	A	A	0.0000
126	R	A	-2.0268
127	M	A	-1.4385
128	V	A	-1.5291
129	S	A	-2.1919
130	K	A	-2.9347
131	S	A	-2.2070
132	K	A	-3.2441
133	D	A	-3.1377
134	G	A	-1.7206
135	T	A	-1.2828
136	G	A	-1.8989
137	S	A	-2.1201
138	D	A	-3.4957
139	D	A	-3.8142
140	K	A	-3.2998
141	K	A	0.0000
142	A	A	-1.7813
143	K	A	-2.2989
144	G	A	-1.5383
145	A	A	-1.6583
146	D	A	-2.6410
147	G	A	-2.0253
148	K	A	-2.0228
149	T	A	-1.7053
150	K	A	-1.2503
151	I	A	-0.2962
152	A	A	-0.3711
153	T	A	-0.8357
154	P	A	-1.4025
155	R	A	-2.2351
156	G	A	-1.5510
157	A	A	-0.8191
158	A	A	-0.8700
159	P	A	-0.7574
160	P	A	-1.0800
161	G	A	-1.1075
162	Q	A	-1.8449
163	K	A	-2.4177
164	G	A	-1.9335
165	Q	A	-1.9114
166	A	A	-1.1188
167	N	A	0.0000
168	A	A	-0.6285
169	T	A	0.0000
170	R	A	-1.1246
171	I	A	0.0000
172	P	A	-0.6067
173	A	A	0.0000
174	K	A	-1.0088
175	T	A	-0.7585
176	P	A	-0.9396
177	P	A	-1.5252
178	A	A	-1.5756
179	P	A	-1.9636
180	K	A	-3.1416
181	E	A	-3.0332
182	P	A	-1.7537
183	P	A	-0.7665
184	S	A	-0.3721
185	S	A	-0.4713
186	G	A	-0.5654
187	E	A	-0.6370
188	P	A	0.0000
189	P	A	-0.8786
190	K	A	-1.0911
191	S	A	-1.1448
192	G	A	-1.5882
193	D	A	-2.0144
194	R	A	-2.4055
195	S	A	-1.6945
196	G	A	-1.5883
197	Y	A	-1.4092
198	S	A	0.0000
199	S	A	-1.1334
200	P	A	-1.2832
201	G	A	-1.2405
202	E	A	-1.5079
203	P	A	-1.0625
204	G	A	-0.8630
205	T	A	-0.6508
206	P	A	-1.1971
207	G	A	-0.9666
208	S	A	-1.0875
209	R	A	-0.8575
210	S	A	0.0000
211	R	A	-0.7766
212	T	A	0.0000
213	P	A	0.0000
214	S	A	0.0000
215	L	A	-0.1017
216	P	A	-0.3783
217	T	A	-0.6493
218	P	A	-1.1716
219	P	A	-1.5000
220	E	A	-3.1134
221	R	A	-2.8699
222	E	A	-3.3104
223	P	A	-2.6126
224	K	A	-3.2138
225	K	A	-2.9671
226	V	A	-0.7264
227	A	A	0.2763
228	V	A	0.0075
229	V	A	-0.2587
230	R	A	-1.8978
231	E	A	-2.1232
232	P	A	-1.9785
233	P	A	-1.6313
234	K	A	-1.7152
235	S	A	-1.1501
236	P	A	-1.3638
237	E	A	-2.1801
238	S	A	-1.7688
239	A	A	-1.5187
240	K	A	-2.5658
241	S	A	-1.6893
242	R	A	-0.8381
243	L	A	-0.1057
244	Q	A	-0.6100
245	T	A	-0.3507
246	A	A	-0.2108
247	P	A	-0.3952
248	V	A	0.4076
249	P	A	-0.5205
250	M	A	0.0000
251	P	A	-1.4597
252	D	A	-2.5748
253	L	A	-1.8397
254	K	A	-2.1515
255	N	A	-1.9620
256	V	A	-1.5941
257	K	A	-2.0252
258	S	A	-1.0182
259	K	A	-2.0877
260	I	A	0.0000
261	G	A	-2.5370
262	S	A	-1.8400
263	T	A	-1.8249
264	E	A	-2.7654
265	N	A	-2.6240
266	L	A	0.0000
267	K	A	-1.5176
268	H	A	-1.8646
269	Q	A	-2.0410
270	P	A	-1.4637
271	G	A	-0.9131
272	G	A	-0.8442
273	G	A	-0.7914
274	K	A	-0.8995
275	V	A	1.3329
276	Q	A	0.3508
277	I	A	1.8701
278	I	A	1.7198
279	N	A	-0.8647
280	K	A	-2.1091
281	K	A	-2.3734
282	L	A	-0.7774
283	D	A	-1.7671
284	L	A	-1.6185
285	S	A	-1.3733
286	N	A	-1.0765
287	V	A	0.2238
288	Q	A	-1.1342
289	S	A	-1.1297
290	K	A	-1.5929
291	C	A	-1.6751
292	G	A	-1.7131
293	S	A	-1.5763
294	K	A	-2.0521
295	D	A	-2.8108
296	N	A	-2.2581
297	I	A	-1.6387
298	K	A	-1.8218
299	H	A	0.0000
300	V	A	0.0000
301	P	A	0.0000
302	G	A	-0.7326
303	G	A	-0.7594
304	G	A	-0.2991
305	S	A	0.5993
306	V	A	1.5320
307	Q	A	0.5991
308	I	A	1.6058
309	V	A	2.0967
310	Y	A	0.6585
311	K	A	0.0009
312	P	A	-0.8639
313	V	A	0.0000
314	D	A	0.0000
315	L	A	0.0000
316	S	A	-0.7244
317	K	A	0.1994
318	V	A	0.8161
319	T	A	0.5577
320	S	A	0.7512
321	K	A	0.3948
322	C	A	0.3462
323	G	A	-0.4524
324	S	A	-0.7801
325	L	A	0.4259
326	G	A	0.0000
327	N	A	0.0000
328	I	A	0.8710
329	H	A	-0.3412
330	H	A	-1.0730
331	K	A	-0.7294
332	P	A	0.0000
333	G	A	0.0000
334	G	A	-0.4869
335	G	A	-0.7350
336	Q	A	-0.9660
337	V	A	0.4186
338	E	A	-1.1684
339	V	A	-0.5451
340	K	A	-2.2373
341	S	A	-1.9391
342	E	A	-2.0495
343	K	A	-1.7676
344	L	A	-0.2980
345	D	A	-0.4862
346	F	A	0.3269
347	K	A	-1.5207
348	D	A	-2.0149
349	R	A	-1.2838
350	V	A	-0.0528
351	Q	A	-0.8947
352	S	A	-0.6982
353	K	A	-0.4771
354	I	A	1.2974
355	G	A	0.1879
356	S	A	0.3292
357	L	A	1.0438
358	D	A	-0.4557
359	N	A	-0.8269
360	I	A	-0.7138
361	T	A	-0.7654
362	H	A	-1.0824
363	V	A	-0.7451
364	P	A	-0.9537
365	G	A	-1.2153
366	G	A	-0.7785
367	G	A	-0.9847
368	N	A	0.0000
369	K	A	-0.8777
370	K	A	0.0000
371	I	A	0.0000
372	E	A	0.0599
373	T	A	-0.2602
374	H	A	-0.2346
375	K	A	-0.7019
376	L	A	-0.0590
377	T	A	-0.5372
378	F	A	-0.8067
379	R	A	-1.1867
380	E	A	-1.6787
381	N	A	-1.3342
382	A	A	0.0000
383	K	A	-1.1733
384	A	A	-0.9298
385	K	A	-0.9690
386	T	A	-1.1124
387	D	A	-1.2246
388	H	A	-1.2422
389	G	A	0.0000
390	A	A	-0.7177
391	E	A	-0.8965
392	I	A	0.6059
393	V	A	1.5180
394	Y	A	0.0968
395	K	A	-1.2310
396	S	A	-0.9231
397	P	A	-1.0271
398	V	A	0.0000
399	V	A	-0.6537
400	S	A	-0.5358
401	G	A	0.0000
402	D	A	-1.4800
403	T	A	-1.6502
404	E	A	-2.4831
405	P	A	-1.8810
406	R	A	-2.2160
407	H	A	-1.6390
408	L	A	-0.9166
409	S	A	-0.3289
410	N	A	-0.3558
411	V	A	1.4149
412	S	A	0.4791
413	S	A	0.1148
414	T	A	0.0000
415	G	A	-0.7127
416	S	A	-0.3277
417	I	A	0.0000
418	D	A	-0.0249
419	M	A	0.0000
420	V	A	0.0702
421	D	A	-0.4850
422	S	A	-0.9816
423	P	A	-0.8048
424	Q	A	-0.7490
425	L	A	0.1814
426	A	A	0.2304
427	T	A	0.5462
428	L	A	1.2622
429	A	A	0.0626
430	D	A	-0.6715
431	E	A	-1.5271
432	V	A	0.1224
433	S	A	-0.0240
434	A	A	0.1843
435	S	A	0.0931
436	L	A	0.7265
437	A	A	-0.3521
438	K	A	-1.8309
439	Q	A	-1.2430
440	G	A	-0.1445
441	L	A	1.3285