| Chain sequence(s) |
A: EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYAMHWVRQAPGKGLEWVSGISSTGSDKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKSTVWWYLADFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDRKLSPNLVTNSH B: DIQMTQSPSSLSASVGDRVTITCRASQSISSWLNWYQQKPGKAPKLLIYATSRLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.8305 | |
| 2 | V | A | -0.9244 | |
| 3 | Q | A | -1.1166 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.9126 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.5368 | |
| 8 | G | A | -0.9542 | |
| 9 | G | A | -0.7614 | |
| 10 | G | A | -0.4303 | |
| 11 | L | A | -0.2340 | |
| 12 | V | A | 0.0000 | |
| 13 | Q | A | -1.5791 | |
| 14 | P | A | -1.4901 | |
| 15 | G | A | -1.3441 | |
| 16 | G | A | -1.0681 | |
| 17 | S | A | -1.1763 | |
| 18 | L | A | -1.1675 | |
| 19 | R | A | -1.9500 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.2411 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | 0.0333 | |
| 24 | A | A | -0.3437 | |
| 25 | S | A | -0.5738 | |
| 26 | G | A | -0.7451 | |
| 27 | F | A | -0.2198 | |
| 28 | T | A | -0.5368 | |
| 29 | F | A | 0.0000 | |
| 30 | S | A | -1.2738 | |
| 31 | N | A | -1.3798 | |
| 32 | Y | A | -0.2492 | |
| 33 | A | A | 0.0209 | |
| 34 | M | A | 0.0000 | |
| 35 | H | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | V | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.9186 | |
| 40 | A | A | -1.2855 | |
| 41 | P | A | -1.0009 | |
| 42 | G | A | -1.5032 | |
| 43 | K | A | -2.4756 | |
| 44 | G | A | -1.7191 | |
| 45 | L | A | -1.0209 | |
| 46 | E | A | -1.1893 | |
| 47 | W | A | 0.0000 | |
| 48 | V | A | 0.0000 | |
| 49 | S | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | -0.8627 | |
| 53 | S | A | -1.3200 | |
| 54 | T | A | -1.0173 | |
| 55 | G | A | -1.3345 | |
| 56 | S | A | -1.6171 | |
| 57 | D | A | -2.4229 | |
| 58 | K | A | -1.7324 | |
| 59 | Y | A | -0.5590 | |
| 60 | Y | A | -0.8884 | |
| 61 | A | A | -1.4718 | |
| 62 | D | A | -2.6516 | |
| 63 | S | A | -1.8470 | |
| 64 | V | A | 0.0000 | |
| 65 | K | A | -2.5128 | |
| 66 | G | A | -1.7944 | |
| 67 | R | A | -1.3702 | |
| 68 | F | A | 0.0000 | |
| 69 | T | A | -0.8375 | |
| 70 | I | A | 0.0000 | |
| 71 | S | A | -0.3477 | |
| 72 | R | A | -1.0180 | |
| 73 | D | A | -1.7830 | |
| 74 | N | A | -2.5070 | |
| 75 | S | A | -1.9767 | |
| 76 | K | A | -2.5546 | |
| 77 | N | A | -2.0828 | |
| 78 | T | A | -1.1454 | |
| 79 | L | A | 0.0000 | |
| 80 | Y | A | -0.2965 | |
| 81 | L | A | 0.0000 | |
| 82 | Q | A | -0.9915 | |
| 83 | M | A | 0.0000 | |
| 84 | N | A | -1.4473 | |
| 85 | S | A | -1.2329 | |
| 86 | L | A | 0.0000 | |
| 87 | R | A | -2.1291 | |
| 88 | A | A | -1.4689 | |
| 89 | E | A | -2.1625 | |
| 90 | D | A | 0.0000 | |
| 91 | T | A | -0.7588 | |
| 92 | A | A | 0.0000 | |
| 93 | V | A | 0.0784 | |
| 94 | Y | A | 0.0000 | |
| 95 | Y | A | 0.0000 | |
| 96 | C | A | 0.0000 | |
| 97 | A | A | 0.0000 | |
| 98 | K | A | -0.3230 | |
| 99 | S | A | 0.0000 | |
| 100 | T | A | 0.4988 | |
| 101 | V | A | 1.8642 | |
| 102 | W | A | 2.0171 | |
| 103 | W | A | 1.6597 | |
| 104 | Y | A | 1.3125 | |
| 105 | L | A | 1.0922 | |
| 106 | A | A | 0.0000 | |
| 107 | D | A | 0.0342 | |
| 108 | F | A | 0.0000 | |
| 109 | D | A | -1.2868 | |
| 110 | V | A | -0.7788 | |
| 111 | W | A | -0.6460 | |
| 112 | G | A | -0.6079 | |
| 113 | Q | A | -1.3946 | |
| 114 | G | A | -0.4599 | |
| 115 | T | A | -0.0596 | |
| 116 | L | A | 0.1131 | |
| 117 | V | A | 0.0000 | |
| 118 | T | A | 0.0000 | |
| 119 | V | A | 0.0000 | |
| 120 | S | A | -0.7841 | |
| 121 | S | A | -0.6321 | |
| 122 | A | A | -0.5454 | |
| 123 | S | A | -0.5875 | |
| 124 | T | A | -0.9974 | |
| 125 | K | A | -2.0263 | |
| 126 | G | A | -1.8032 | |
| 127 | P | A | -1.1846 | |
| 128 | S | A | -0.6214 | |
| 129 | V | A | 0.0000 | |
| 130 | F | A | -0.2576 | |
| 131 | P | A | -0.6956 | |
| 132 | L | A | 0.0000 | |
| 133 | A | A | -0.2222 | |
| 134 | P | A | -0.3136 | |
| 135 | S | A | -0.4704 | |
| 136 | S | A | -0.3762 | |
| 137 | K | A | -1.7322 | |
| 138 | S | A | -1.2593 | |
| 139 | T | A | -0.9972 | |
| 140 | S | A | -0.9016 | |
| 141 | G | A | -0.9416 | |
| 142 | G | A | -0.9386 | |
| 143 | T | A | -0.7101 | |
| 144 | A | A | -0.5060 | |
| 145 | A | A | 0.0000 | |
| 146 | L | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | K | A | 0.0000 | |
| 152 | D | A | -1.2268 | |
| 153 | Y | A | 0.0000 | |
| 154 | F | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | E | A | -0.6463 | |
| 157 | P | A | -0.6561 | |
| 158 | V | A | -0.3807 | |
| 159 | T | A | -0.4997 | |
| 160 | V | A | -0.0257 | |
| 161 | S | A | -0.3240 | |
| 162 | W | A | 0.0000 | |
| 163 | N | A | -0.8197 | |
| 164 | S | A | -0.6832 | |
| 165 | G | A | -0.6483 | |
| 166 | A | A | -0.3309 | |
| 167 | L | A | -0.1004 | |
| 168 | T | A | -0.1867 | |
| 169 | S | A | -0.1876 | |
| 170 | G | A | -0.3604 | |
| 171 | V | A | 0.1378 | |
| 172 | H | A | -0.2597 | |
| 173 | T | A | -0.1700 | |
| 174 | F | A | 0.0000 | |
| 175 | P | A | -0.2487 | |
| 176 | A | A | 0.3630 | |
| 177 | V | A | 0.8620 | |
| 178 | L | A | 1.2867 | |
| 179 | Q | A | 0.0039 | |
| 180 | S | A | -0.3577 | |
| 181 | S | A | -0.4560 | |
| 182 | G | A | -0.3997 | |
| 183 | L | A | 0.0000 | |
| 184 | Y | A | 0.3458 | |
| 185 | S | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | S | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | V | A | 0.0000 | |
| 191 | T | A | -0.1262 | |
| 192 | V | A | 0.0000 | |
| 193 | P | A | -0.4089 | |
| 194 | S | A | -0.7935 | |
| 195 | S | A | -0.5175 | |
| 196 | S | A | -0.5142 | |
| 197 | L | A | -0.4230 | |
| 198 | G | A | -0.6868 | |
| 199 | T | A | -0.6779 | |
| 200 | Q | A | -0.9220 | |
| 201 | T | A | -0.8222 | |
| 202 | Y | A | 0.0000 | |
| 203 | I | A | -0.8316 | |
| 204 | C | A | 0.0000 | |
| 205 | N | A | -1.1810 | |
| 206 | V | A | 0.0000 | |
| 207 | N | A | -1.6281 | |
| 208 | H | A | 0.0000 | |
| 209 | K | A | -2.5497 | |
| 210 | P | A | -1.3602 | |
| 211 | S | A | -1.8188 | |
| 212 | N | A | -2.4077 | |
| 213 | T | A | -1.8787 | |
| 214 | K | A | -2.4741 | |
| 215 | V | A | -1.2062 | |
| 216 | D | A | -1.9645 | |
| 217 | R | A | -1.6897 | |
| 218 | K | A | -2.0560 | |
| 219 | L | A | 0.0000 | |
| 220 | S | A | -1.0150 | |
| 221 | P | A | -0.5898 | |
| 222 | N | A | -0.2055 | |
| 223 | L | A | 1.2253 | |
| 224 | V | A | 1.4652 | |
| 225 | T | A | 0.1058 | |
| 226 | N | A | -1.1699 | |
| 227 | S | A | -1.2885 | |
| 228 | H | A | -1.4031 | |
| 1 | D | B | -2.2988 | |
| 2 | I | B | 0.0000 | |
| 3 | Q | B | -2.2146 | |
| 4 | M | B | 0.0000 | |
| 5 | T | B | -1.2889 | |
| 6 | Q | B | 0.0000 | |
| 7 | S | B | -0.7530 | |
| 8 | P | B | -0.4850 | |
| 9 | S | B | -0.8087 | |
| 10 | S | B | -0.7671 | |
| 11 | L | B | -0.5452 | |
| 12 | S | B | -1.1914 | |
| 13 | A | B | -1.3740 | |
| 14 | S | B | -1.5034 | |
| 15 | V | B | -0.6069 | |
| 16 | G | B | -0.9087 | |
| 17 | D | B | -1.7606 | |
| 18 | R | B | -2.2279 | |
| 19 | V | B | 0.0000 | |
| 20 | T | B | -0.6031 | |
| 21 | I | B | 0.0000 | |
| 22 | T | B | -0.8815 | |
| 23 | C | B | 0.0000 | |
| 24 | R | B | -2.6873 | |
| 25 | A | B | -1.9165 | |
| 26 | S | B | -1.7272 | |
| 27 | Q | B | -1.7983 | |
| 28 | S | B | -1.0314 | |
| 29 | I | B | 0.0000 | |
| 30 | S | B | -0.3262 | |
| 31 | S | B | -0.1651 | |
| 32 | W | B | 0.3512 | |
| 33 | L | B | 0.0000 | |
| 34 | N | B | 0.0000 | |
| 35 | W | B | 0.0000 | |
| 36 | Y | B | 0.0000 | |
| 37 | Q | B | 0.0000 | |
| 38 | Q | B | 0.0000 | |
| 39 | K | B | -1.5217 | |
| 40 | P | B | -1.3374 | |
| 41 | G | B | -1.7094 | |
| 42 | K | B | -2.4498 | |
| 43 | A | B | -1.5549 | |
| 44 | P | B | 0.0000 | |
| 45 | K | B | -1.4236 | |
| 46 | L | B | 0.0000 | |
| 47 | L | B | 0.0000 | |
| 48 | I | B | 0.0000 | |
| 49 | Y | B | -0.2037 | |
| 50 | A | B | -0.2916 | |
| 51 | T | B | -0.4441 | |
| 52 | S | B | -0.8615 | |
| 53 | R | B | -1.3804 | |
| 54 | L | B | 0.0792 | |
| 55 | H | B | -0.4220 | |
| 56 | S | B | -0.4377 | |
| 57 | G | B | -0.4273 | |
| 58 | V | B | -0.1899 | |
| 59 | P | B | -0.2321 | |
| 60 | S | B | -0.3402 | |
| 61 | R | B | -0.6670 | |
| 62 | F | B | 0.0000 | |
| 63 | S | B | -0.4980 | |
| 64 | G | B | -0.4757 | |
| 65 | S | B | -0.6396 | |
| 66 | G | B | -1.0103 | |
| 67 | S | B | -1.0029 | |
| 68 | G | B | -1.1424 | |
| 69 | T | B | -1.8939 | |
| 70 | D | B | -2.5012 | |
| 71 | F | B | 0.0000 | |
| 72 | T | B | -0.8535 | |
| 73 | L | B | 0.0000 | |
| 74 | T | B | -0.6456 | |
| 75 | I | B | 0.0000 | |
| 76 | S | B | -1.2335 | |
| 77 | S | B | -1.0186 | |
| 78 | L | B | 0.0000 | |
| 79 | Q | B | -0.9906 | |
| 80 | P | B | -1.9564 | |
| 81 | E | B | -2.2942 | |
| 82 | D | B | 0.0000 | |
| 83 | F | B | 0.0000 | |
| 84 | A | B | 0.0000 | |
| 85 | T | B | 0.0000 | |
| 86 | Y | B | 0.0000 | |
| 87 | Y | B | 0.0000 | |
| 88 | C | B | 0.0000 | |
| 89 | Q | B | 0.0000 | |
| 90 | Q | B | 0.0000 | |
| 91 | S | B | 0.0000 | |
| 92 | Y | B | 0.5433 | |
| 93 | S | B | -0.2532 | |
| 94 | T | B | -0.2883 | |
| 95 | P | B | -0.6638 | |
| 96 | W | B | 0.0000 | |
| 97 | T | B | -0.8939 | |
| 98 | F | B | 0.0000 | |
| 99 | G | B | 0.0000 | |
| 100 | Q | B | -1.9356 | |
| 101 | G | B | -1.5066 | |
| 102 | T | B | 0.0000 | |
| 103 | K | B | -1.3811 | |
| 104 | V | B | 0.0000 | |
| 105 | E | B | -1.7268 | |
| 106 | I | B | 0.0000 | |
| 107 | K | B | -2.4278 | |
| 108 | R | B | -2.2742 | |
| 109 | T | B | -0.4738 | |
| 110 | V | B | 0.7296 | |
| 111 | A | B | 0.3684 | |
| 112 | A | B | 0.1615 | |
| 113 | P | B | 0.0000 | |
| 114 | S | B | 0.0472 | |
| 115 | V | B | 0.0280 | |
| 116 | F | B | 0.0356 | |
| 117 | I | B | 0.0000 | |
| 118 | F | B | 0.0000 | |
| 119 | P | B | -0.6697 | |
| 120 | P | B | -0.7632 | |
| 121 | S | B | -1.3545 | |
| 122 | D | B | -2.6381 | |
| 123 | E | B | -2.3095 | |
| 124 | Q | B | 0.0000 | |
| 125 | L | B | -1.8494 | |
| 126 | K | B | -2.5018 | |
| 127 | S | B | -1.5044 | |
| 128 | G | B | -1.1616 | |
| 129 | T | B | -0.7948 | |
| 130 | A | B | 0.0000 | |
| 131 | S | B | 0.0000 | |
| 132 | V | B | 0.0000 | |
| 133 | V | B | 0.0000 | |
| 134 | C | B | 0.0000 | |
| 135 | L | B | 0.0000 | |
| 136 | L | B | 0.0000 | |
| 137 | N | B | 0.0000 | |
| 138 | N | B | -0.5786 | |
| 139 | F | B | 0.0000 | |
| 140 | Y | B | -0.7504 | |
| 141 | P | B | -1.4113 | |
| 142 | R | B | -2.2846 | |
| 143 | E | B | -2.7636 | |
| 144 | A | B | -2.0472 | |
| 145 | K | B | -2.2592 | |
| 146 | V | B | -0.9945 | |
| 147 | Q | B | -0.9740 | |
| 148 | W | B | 0.0000 | |
| 149 | K | B | -1.0959 | |
| 150 | V | B | 0.0000 | |
| 151 | D | B | -1.3969 | |
| 152 | N | B | -1.4716 | |
| 153 | A | B | -0.4090 | |
| 154 | L | B | 0.5784 | |
| 155 | Q | B | -0.3219 | |
| 156 | S | B | -0.6098 | |
| 157 | G | B | -1.0209 | |
| 158 | N | B | -1.0057 | |
| 159 | S | B | -1.1069 | |
| 160 | Q | B | -1.1296 | |
| 161 | E | B | -0.9274 | |
| 162 | S | B | -0.3401 | |
| 163 | V | B | -0.5137 | |
| 164 | T | B | 0.0000 | |
| 165 | E | B | -1.3305 | |
| 166 | Q | B | 0.0000 | |
| 167 | D | B | -2.0153 | |
| 168 | S | B | -2.3339 | |
| 169 | K | B | -2.9418 | |
| 170 | D | B | -2.7087 | |
| 171 | S | B | -2.3679 | |
| 172 | T | B | -1.3169 | |
| 173 | Y | B | 0.0000 | |
| 174 | S | B | 0.0000 | |
| 175 | L | B | 0.0000 | |
| 176 | S | B | 0.0000 | |
| 177 | S | B | 0.0000 | |
| 178 | T | B | -0.4505 | |
| 179 | L | B | 0.0000 | |
| 180 | T | B | -0.2053 | |
| 181 | L | B | -0.3373 | |
| 182 | S | B | -1.0093 | |
| 183 | K | B | -2.0358 | |
| 184 | A | B | -1.9052 | |
| 185 | D | B | -2.8740 | |
| 186 | Y | B | 0.0000 | |
| 187 | E | B | -3.8343 | |
| 188 | K | B | -3.6824 | |
| 189 | H | B | -2.8942 | |
| 190 | K | B | -2.5168 | |
| 191 | V | B | -0.9902 | |
| 192 | Y | B | 0.0000 | |
| 193 | A | B | 0.0000 | |
| 194 | C | B | 0.0000 | |
| 195 | E | B | -1.0385 | |
| 196 | V | B | 0.0000 | |
| 197 | T | B | -0.9561 | |
| 198 | H | B | 0.0000 | |
| 199 | Q | B | -1.3976 | |
| 200 | G | B | -0.3150 | |
| 201 | L | B | -0.0713 | |
| 202 | S | B | -0.4228 | |
| 203 | S | B | -0.3229 | |
| 204 | P | B | -0.2814 | |
| 205 | V | B | 0.0806 | |
| 206 | T | B | -0.7432 | |
| 207 | K | B | -1.5254 | |
| 208 | S | B | -0.9543 | |
| 209 | F | B | -1.0857 | |
| 210 | N | B | -1.9202 | |
| 211 | R | B | -3.1759 | |
| 212 | G | B | -2.3298 | |
| 213 | E | B | -1.8748 | |
| 214 | C | B | -0.2104 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine