Project name: kaka

Chain sequence(s)	S: VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTCLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGF; C: QALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMDSYVGDEAQSKRGILTLKYPIEGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAALNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAAAAIVRDIKEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8921
• Maximal score value: 1.8275
• Average score: -0.6627
• Total score value: -322.0963

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
5	V	S	-0.2061
6	E	S	-1.4175
7	H	S	0.0000
8	P	S	-0.4716
9	E	S	0.0000
10	F	S	0.0000
11	L	S	0.3088
12	K	S	-1.4349
13	A	S	0.0000
14	G	S	0.0000
15	K	S	-2.7435
16	E	S	-3.2225
17	P	S	-1.8062
18	G	S	-1.0713
19	L	S	-0.2458
20	Q	S	-0.4003
21	I	S	0.0000
22	W	S	0.0000
23	R	S	-0.3506
24	V	S	0.0000
25	E	S	-1.2314
26	K	S	-1.8246
27	F	S	0.0000
28	D	S	-1.0718
29	L	S	0.0000
30	V	S	0.0481
31	P	S	-0.0316
32	V	S	0.4474
33	P	S	0.5570
34	T	S	0.7091
35	C	S	1.2698
36	L	S	1.5038
37	Y	S	0.7853
38	G	S	0.0000
39	D	S	-0.5544
40	F	S	0.0000
41	F	S	-1.0285
42	T	S	0.0000
43	G	S	-1.3316
44	D	S	0.0000
45	A	S	0.0000
46	Y	S	0.0000
47	V	S	0.0000
48	I	S	0.0000
49	L	S	0.0000
50	K	S	-0.4501
51	T	S	0.0000
52	V	S	-0.8157
53	Q	S	-2.2121
54	L	S	-2.0389
55	R	S	-2.8739
56	N	S	-2.8391
57	G	S	-2.4698
58	N	S	-2.5935
59	L	S	-2.1844
60	Q	S	-1.0871
61	Y	S	0.0000
62	D	S	0.0461
63	L	S	0.0000
64	H	S	0.0000
65	Y	S	0.0000
66	W	S	0.0000
67	L	S	0.0000
68	G	S	0.0000
69	N	S	-1.9241
70	E	S	-2.0109
71	C	S	-0.9112
72	S	S	-0.5196
73	Q	S	-0.6330
74	D	S	0.0000
75	E	S	0.0000
76	S	S	-0.2700
77	G	S	0.0000
78	A	S	0.0000
79	A	S	0.0000
80	A	S	0.0000
81	I	S	0.0000
82	F	S	0.0000
83	T	S	0.0000
84	V	S	0.0000
85	Q	S	0.0000
86	L	S	0.0000
87	D	S	0.0000
88	D	S	-1.8673
89	Y	S	-0.3447
90	L	S	-1.0831
91	N	S	-2.0555
92	G	S	-1.7199
93	R	S	-1.4659
94	A	S	0.0000
95	V	S	0.9483
96	Q	S	0.1903
97	H	S	-0.2504
98	R	S	-0.4381
99	E	S	0.0000
100	V	S	0.5763
101	Q	S	-0.0030
102	G	S	0.4000
103	F	S	1.8275
104	E	S	0.0000
105	S	S	0.4234
106	A	S	0.3928
107	T	S	0.0283
108	F	S	0.0000
109	L	S	0.4147
110	G	S	-0.4059
111	Y	S	-0.3308
112	F	S	0.0000
113	K	S	-1.8494
114	S	S	-1.3799
115	G	S	-1.3734
116	L	S	-1.0158
117	K	S	-1.7672
118	Y	S	-1.1885
119	K	S	-1.8628
120	K	S	-2.3676
121	G	S	-1.4504
122	G	S	-0.9340
123	V	S	-0.3018
124	A	S	-0.2592
125	S	S	-0.3390
126	G	S	-0.8246
127	F	S	-0.0578
6	Q	C	-1.4709
7	A	C	0.0000
8	L	C	0.0000
9	V	C	0.0000
10	I	C	0.0000
11	D	C	0.0000
12	N	C	0.0000
13	G	C	-0.3441
14	S	C	0.0000
15	G	C	-0.5341
16	M	C	-0.0560
17	C	C	0.0000
18	K	C	-0.2345
19	A	C	0.0000
20	G	C	0.0000
21	F	C	-0.6788
22	A	C	-0.4030
23	G	C	-0.6362
24	D	C	-1.1338
25	D	C	-2.0013
26	A	C	-1.4034
27	P	C	-1.1225
28	R	C	-2.0428
29	A	C	0.0000
30	V	C	0.2174
31	F	C	0.0000
32	P	C	-0.3302
33	S	C	0.0000
34	I	C	-0.5066
35	V	C	0.0000
36	G	C	0.0000
37	R	C	-1.5821
38	P	C	-1.4720
39	R	C	-2.2767
40	H	C	-1.3296
41	T	C	-0.8850
42	G	C	0.0589
43	V	C	1.8112
44	M	C	1.6081
51	D	C	-1.9390
52	S	C	-1.1895
53	Y	C	-1.2040
54	V	C	0.0000
55	G	C	0.0000
56	D	C	-2.8379
57	E	C	-2.7014
58	A	C	0.0000
59	Q	C	-2.1357
60	S	C	-1.9978
61	K	C	-1.9315
62	R	C	-1.9853
63	G	C	-0.8059
64	I	C	-0.0121
65	L	C	0.0000
66	T	C	-1.1025
67	L	C	-0.5934
68	K	C	-0.7002
69	Y	C	-0.1925
70	P	C	0.0000
71	I	C	0.0000
72	E	C	-1.7652
74	G	C	-0.3279
75	I	C	0.1404
76	V	C	-0.1061
77	T	C	-0.4657
78	N	C	-0.9168
79	W	C	-1.2823
80	D	C	-2.2212
81	D	C	0.0000
82	M	C	0.0000
83	E	C	-1.7691
84	K	C	-1.6595
85	I	C	0.0000
86	W	C	0.0000
87	H	C	-1.5754
88	H	C	-1.4145
89	T	C	0.0000
90	F	C	0.0000
91	Y	C	-1.2258
92	N	C	-2.0548
93	E	C	-1.9601
94	L	C	0.0000
95	R	C	-2.2064
96	V	C	-1.3788
97	A	C	-1.4060
98	P	C	0.0000
99	E	C	-3.0393
100	E	C	-3.0387
101	H	C	-1.9228
102	P	C	-1.2502
103	V	C	0.0000
104	L	C	0.0000
105	L	C	0.0000
106	T	C	0.0000
107	E	C	0.0000
108	A	C	0.4526
109	A	C	0.9020
110	L	C	0.8001
111	N	C	0.1566
112	P	C	-0.6732
113	K	C	-1.8919
114	A	C	-1.2872
115	N	C	-1.0979
116	R	C	0.0000
117	E	C	-1.5322
118	K	C	-1.4365
119	M	C	0.0000
120	T	C	0.0000
121	Q	C	-1.6799
122	I	C	0.0000
123	M	C	0.0000
124	F	C	0.0000
125	E	C	-2.6680
126	T	C	-1.7480
127	F	C	0.0000
128	N	C	-2.9324
129	T	C	0.0000
130	P	C	-1.8719
131	A	C	0.0000
132	M	C	0.0000
133	Y	C	0.0000
134	V	C	0.0000
135	A	C	0.0000
136	I	C	0.7299
137	Q	C	-0.1040
138	A	C	0.0000
139	V	C	0.3044
140	L	C	0.0000
141	S	C	0.0000
142	L	C	0.0000
143	Y	C	0.0000
144	A	C	0.0000
145	S	C	-0.1172
146	G	C	0.0000
147	R	C	-0.3260
148	T	C	0.0000
149	T	C	-0.2576
150	G	C	0.0000
151	I	C	0.0000
152	V	C	0.0000
153	M	C	0.0000
154	D	C	-0.6709
155	S	C	0.0000
156	G	C	-0.6472
157	D	C	-1.1585
158	G	C	-1.4028
159	V	C	-1.2344
160	S	C	0.0000
161	H	C	-1.0614
162	T	C	0.0000
163	V	C	0.0000
164	P	C	0.0000
165	I	C	0.0000
166	Y	C	0.4018
167	E	C	0.1882
168	G	C	0.0000
169	Y	C	0.9476
170	A	C	0.0000
171	L	C	-0.1696
172	P	C	-0.0974
173	H	C	-0.9492
174	A	C	0.0000
175	I	C	-0.3900
176	L	C	-1.1225
177	R	C	-2.0209
178	L	C	0.0000
179	D	C	-2.4713
180	L	C	0.0000
181	A	C	0.0000
182	G	C	0.0000
183	R	C	-2.0664
184	D	C	-1.6916
185	L	C	0.0000
186	T	C	-2.2566
187	D	C	-2.5534
188	Y	C	0.0000
189	M	C	0.0000
190	M	C	-1.6065
191	K	C	-2.2322
192	I	C	0.0000
193	L	C	0.0000
194	T	C	-1.9238
195	E	C	-3.1186
196	R	C	-3.0709
197	G	C	-1.8650
198	Y	C	-0.9807
199	S	C	-0.6551
200	F	C	0.0559
201	T	C	-0.0149
202	T	C	-0.0680
203	T	C	-0.2396
204	A	C	-0.1624
205	A	C	-0.2277
206	A	C	-0.8261
207	A	C	-0.7144
208	I	C	0.0000
209	V	C	0.0000
210	R	C	-2.9440
211	D	C	-2.8834
212	I	C	0.0000
213	K	C	0.0000
214	E	C	-3.4289
215	K	C	-3.1193
216	L	C	0.0000
217	A	C	0.0000
218	Y	C	-0.4323
219	V	C	0.0000
220	A	C	0.0000
221	L	C	-0.7356
222	D	C	-1.4049
223	F	C	-1.3206
224	E	C	-2.2544
225	A	C	-1.5198
226	E	C	-1.3093
227	M	C	-1.2447
228	Q	C	-1.6761
229	T	C	-0.9585
230	A	C	-0.8635
231	A	C	-0.5307
232	S	C	-0.6508
233	S	C	-0.6433
234	S	C	-0.6597
235	A	C	-0.4380
236	L	C	-0.5832
237	E	C	-1.4953
238	K	C	-1.4687
239	S	C	-1.0154
240	Y	C	0.0000
241	E	C	-2.1258
242	L	C	-1.6409
243	P	C	-1.6650
244	D	C	-2.5885
245	G	C	-2.1644
246	Q	C	-1.9111
247	V	C	-0.6843
248	I	C	0.0000
249	T	C	-0.8198
250	I	C	0.0000
251	G	C	-1.0227
252	N	C	-0.8554
253	E	C	0.0000
254	R	C	-0.9986
255	F	C	0.0000
256	R	C	-0.3259
257	C	C	0.0000
258	P	C	0.0000
259	E	C	0.0000
260	A	C	0.0000
261	L	C	0.0000
262	F	C	0.0000
263	Q	C	-0.5739
264	P	C	0.0000
265	S	C	-0.5670
266	F	C	0.1697
267	L	C	-0.2336
268	G	C	-0.5848
269	M	C	-1.1108
270	E	C	-2.0558
271	S	C	-1.5071
272	A	C	-1.0901
273	G	C	0.0000
274	I	C	0.0000
275	H	C	-0.7508
276	E	C	-0.8660
277	T	C	0.0000
278	T	C	0.0000
279	Y	C	-0.2767
280	N	C	-0.6281
281	S	C	0.0000
282	I	C	0.0000
283	M	C	-0.3039
284	K	C	-1.1759
285	C	C	0.0000
286	D	C	-1.7265
287	V	C	-0.4291
288	D	C	-2.1322
289	I	C	0.0000
290	R	C	-1.9072
291	K	C	-2.8175
292	D	C	-2.6824
293	L	C	0.0000
294	Y	C	0.0000
295	G	C	-1.8902
296	N	C	-1.2809
297	V	C	0.0000
298	V	C	0.0000
299	L	C	0.0000
300	S	C	0.0000
301	G	C	-0.6483
302	G	C	-0.8861
303	T	C	0.0000
304	T	C	0.0000
305	M	C	-0.5010
306	F	C	0.0000
307	P	C	-0.7733
308	G	C	-0.5532
309	I	C	0.0000
310	A	C	-1.2396
311	D	C	-2.3240
312	R	C	0.0000
313	M	C	0.0000
314	N	C	-1.8914
315	K	C	-1.8394
316	E	C	-1.0909
317	L	C	0.0000
318	T	C	-0.8426
319	A	C	-0.2274
320	L	C	0.1912
321	A	C	0.0000
322	P	C	-0.4015
323	S	C	-0.4550
324	T	C	-0.5566
325	M	C	-1.3472
326	K	C	-2.3818
327	I	C	-1.8479
328	K	C	-1.9424
329	I	C	0.0000
330	I	C	-0.1804
331	A	C	-0.3982
332	P	C	-0.4966
333	P	C	-0.8329
334	E	C	-1.5788
335	R	C	0.0000
336	K	C	-1.1516
337	Y	C	-0.6590
338	S	C	0.0000
339	V	C	0.0000
340	W	C	0.0000
341	I	C	0.0000
342	G	C	0.0000
343	G	C	0.0000
344	S	C	0.0000
345	I	C	0.0000
346	L	C	0.0000
347	A	C	-0.3106
348	S	C	-0.5929
349	L	C	0.0000
350	S	C	-0.8584
351	T	C	0.0000
352	F	C	0.0000
353	Q	C	-1.4208
354	Q	C	-0.9801
355	M	C	-0.2223
356	W	C	0.0000
357	I	C	0.0000
358	S	C	-1.5639
359	K	C	-2.8999
360	E	C	-3.4685
361	E	C	-2.7818
362	Y	C	0.0000
363	D	C	-3.8921
364	E	C	-3.4320
365	S	C	-2.0116
366	G	C	-1.8171
367	P	C	-1.1988
368	S	C	-1.1442
369	I	C	0.0000
370	V	C	0.0000
371	H	C	-1.1692
372	R	C	-1.7682
373	K	C	-0.8470
374	C	C	0.0000
375	F	C	1.5569