Project name: model 2 TAU

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.4931
• Maximal score value: 2.428
• Average score: -1.0575
• Total score value: -466.362

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.0705
2	A	A	-0.8669
3	E	A	-1.9286
4	P	A	-2.1986
5	R	A	-2.9249
6	Q	A	-2.0136
7	E	A	-1.4639
8	F	A	-0.5298
9	E	A	-0.7341
10	V	A	0.0000
11	M	A	-1.2241
12	E	A	-2.5157
13	D	A	-2.4991
14	H	A	-2.2037
15	A	A	-1.4360
16	G	A	-1.2042
17	T	A	-1.3889
18	Y	A	0.0000
19	G	A	0.0000
20	L	A	-1.9138
21	G	A	-2.7246
22	D	A	-3.7259
23	R	A	-3.6462
24	K	A	-3.2207
25	D	A	-2.8331
26	Q	A	-2.5784
27	G	A	-1.7932
28	G	A	-1.2378
29	Y	A	-1.2393
30	T	A	-0.3510
31	M	A	0.4443
32	H	A	-0.7778
33	Q	A	-0.7045
34	D	A	-2.2022
35	Q	A	-2.6920
36	E	A	-3.6149
37	G	A	-3.4294
38	D	A	-3.7248
39	T	A	-2.3309
40	D	A	-2.5918
41	A	A	-2.1958
42	G	A	-0.8324
43	L	A	0.2130
44	K	A	-2.0586
45	E	A	-2.6656
46	S	A	-1.6956
47	P	A	-0.7594
48	L	A	0.4894
49	Q	A	-0.8339
50	T	A	-0.8964
51	P	A	-1.1729
52	T	A	-1.6362
53	E	A	-3.6291
54	D	A	-3.9829
55	G	A	-3.3892
56	S	A	-3.6084
57	E	A	-4.4931
58	E	A	-4.0862
59	P	A	-2.6949
60	G	A	-2.1644
61	S	A	-2.1038
62	E	A	-2.9342
63	T	A	-2.4278
64	S	A	-1.8644
65	D	A	-2.6824
66	A	A	-1.7184
67	K	A	-2.4001
68	S	A	-1.3680
69	T	A	-0.7352
70	P	A	-1.2463
71	T	A	-0.8171
72	A	A	-1.1790
73	E	A	-2.3166
74	D	A	-1.5522
75	V	A	0.7179
76	T	A	-0.1404
77	A	A	-0.3867
78	P	A	-0.6299
79	L	A	-0.5378
80	V	A	-0.9574
81	D	A	-2.1224
82	E	A	-2.7702
83	G	A	-1.6538
84	A	A	-0.9399
85	P	A	0.0000
86	G	A	-1.5750
87	K	A	-2.3535
88	Q	A	-2.0620
89	A	A	-1.1651
90	A	A	-0.9037
91	A	A	-1.3932
92	Q	A	-1.5286
93	P	A	-0.9632
94	H	A	-1.7541
95	T	A	-1.8930
96	E	A	-1.9887
97	I	A	0.4602
98	P	A	-0.5558
99	E	A	-0.7721
100	G	A	-0.7666
101	T	A	-0.7927
102	T	A	-1.6403
103	A	A	-1.9703
104	E	A	-2.8204
105	E	A	-2.7162
106	A	A	-1.3339
107	G	A	-0.6579
108	I	A	0.5737
109	G	A	-0.2366
110	D	A	-0.2479
111	T	A	0.2362
112	P	A	0.1114
113	S	A	0.0588
114	L	A	0.3123
115	E	A	-1.1523
116	D	A	-2.2831
117	E	A	-2.5893
118	A	A	-1.3430
119	A	A	-0.8869
120	G	A	-0.9643
121	H	A	-0.7686
122	V	A	0.6983
123	T	A	-0.2794
124	Q	A	-0.2957
125	A	A	0.3030
126	R	A	-0.2438
127	M	A	-0.0044
128	V	A	-0.1096
129	S	A	-1.3330
130	K	A	-2.1974
131	S	A	-1.5945
132	K	A	-1.8295
133	D	A	-2.4623
134	G	A	-1.7067
135	T	A	-0.8690
136	G	A	-1.4395
137	S	A	-1.6997
138	D	A	-3.2549
139	D	A	-4.1592
140	K	A	-4.3884
141	K	A	-3.8300
142	A	A	-2.6394
143	K	A	-3.5426
144	G	A	-3.2232
145	A	A	-2.4312
146	D	A	-3.1688
147	G	A	-2.3723
148	K	A	-3.3589
149	T	A	-2.2146
150	K	A	-2.0162
151	I	A	0.8240
152	A	A	0.3166
153	T	A	-0.3383
154	P	A	-1.0186
155	R	A	-2.1654
156	G	A	-1.6108
157	A	A	-1.3440
158	A	A	-1.3064
159	P	A	-1.2932
160	P	A	-1.1851
161	G	A	-1.7791
162	Q	A	-2.6732
163	K	A	-2.8739
164	G	A	-2.1320
165	Q	A	-2.0970
166	A	A	-1.4082
167	N	A	-1.1666
168	A	A	-0.8386
169	T	A	-1.1654
170	R	A	-2.0761
171	I	A	-0.5609
172	P	A	-0.0717
173	A	A	-0.8691
174	K	A	-2.5942
175	T	A	0.0000
176	P	A	-1.2449
177	P	A	-1.9931
178	A	A	-0.9354
179	P	A	-1.3009
180	K	A	-1.0632
181	T	A	-0.9916
182	P	A	-0.8346
183	P	A	-0.0013
184	S	A	0.0000
185	S	A	0.0000
186	G	A	-1.1667
187	E	A	-1.7233
188	P	A	-1.4643
189	P	A	-0.9602
190	K	A	-1.6200
191	S	A	0.0000
192	G	A	0.0000
193	D	A	-1.5017
194	R	A	-2.0342
195	S	A	-1.2062
196	G	A	-0.9018
197	Y	A	0.0708
198	S	A	-0.8482
199	S	A	-0.8040
200	P	A	-1.0542
201	G	A	-0.7559
202	S	A	0.0000
203	P	A	-0.8025
204	G	A	-0.5488
205	T	A	0.0000
206	P	A	-0.4248
207	G	A	-1.3091
208	S	A	-1.5639
209	R	A	-2.4302
210	S	A	-1.6197
211	R	A	-1.7347
212	T	A	-0.8979
213	P	A	-0.6842
214	S	A	0.0991
215	L	A	1.1713
216	P	A	0.0000
217	T	A	0.0000
218	P	A	0.0000
219	P	A	0.0000
220	T	A	-1.5981
221	R	A	-2.7665
222	E	A	-3.5693
223	P	A	-2.7045
224	K	A	-2.6297
225	K	A	-1.9570
226	V	A	0.5604
227	A	A	1.0327
228	V	A	2.3243
229	V	A	2.4280
230	R	A	0.0000
231	T	A	0.1481
232	P	A	-0.8214
233	P	A	-1.3702
234	K	A	-2.2851
235	S	A	-1.3625
236	P	A	-1.3419
237	S	A	-0.7269
238	S	A	-0.7245
239	A	A	-1.2202
240	K	A	-2.3250
241	S	A	-1.7748
242	R	A	-2.0381
243	L	A	-0.4965
244	Q	A	-1.0917
245	T	A	0.0012
246	A	A	0.2422
247	P	A	0.4564
248	V	A	1.4587
249	P	A	0.3568
250	M	A	-0.3882
251	P	A	-1.4924
252	D	A	-2.1149
253	L	A	-1.6578
254	K	A	-2.6384
255	N	A	-1.8630
256	V	A	-0.3380
257	K	A	0.0000
258	S	A	-1.2010
259	K	A	-1.6038
260	I	A	-0.4328
261	G	A	-0.7714
262	S	A	-0.6068
263	T	A	0.0000
264	E	A	-1.8031
265	N	A	-2.0487
266	L	A	-1.3233
267	K	A	-2.0602
268	H	A	-2.1786
269	Q	A	-1.3466
270	P	A	0.0000
271	G	A	0.0000
272	G	A	-1.4284
273	G	A	-1.6336
274	K	A	-1.1153
275	V	A	0.0000
276	Q	A	-1.8116
277	I	A	0.0000
278	I	A	-0.2823
279	N	A	-1.8443
280	K	A	-1.7769
281	K	A	-2.7739
282	L	A	0.0000
283	D	A	-2.5081
284	L	A	-1.2495
285	S	A	0.0000
286	N	A	-1.5931
287	V	A	0.0935
288	Q	A	-1.3262
289	S	A	-0.9988
290	K	A	-1.7551
291	C	A	-0.8699
292	G	A	-1.1778
293	S	A	-1.0832
294	K	A	-1.8562
295	D	A	-1.7020
296	N	A	-1.2242
297	I	A	0.5475
298	K	A	-1.1114
299	H	A	-1.0421
300	V	A	0.0000
301	P	A	0.0000
302	G	A	-1.0765
303	G	A	-0.6100
304	G	A	-0.5596
305	S	A	0.1014
306	V	A	1.0481
307	Q	A	-0.2337
308	I	A	0.3333
309	V	A	0.6234
310	Y	A	0.9801
311	K	A	0.0914
312	P	A	-0.6521
313	V	A	-0.8496
314	D	A	-1.9752
315	L	A	-0.6974
316	S	A	-0.8812
317	K	A	-1.7818
318	V	A	-0.5363
319	T	A	-0.5285
320	S	A	-1.3667
321	K	A	-1.5679
322	C	A	-1.4479
323	G	A	-1.8232
324	S	A	-1.1360
325	L	A	-0.3443
326	G	A	-0.8713
327	N	A	-0.9962
328	I	A	0.2315
329	H	A	-1.2747
330	H	A	-2.0159
331	K	A	-2.5961
332	P	A	-2.0794
333	G	A	-1.7539
334	G	A	-0.9328
335	G	A	-0.9247
336	Q	A	-1.4273
337	V	A	-0.0847
338	E	A	-0.8622
339	V	A	0.4659
340	K	A	-0.9144
341	S	A	-0.9274
342	E	A	-1.3836
343	K	A	-1.4002
344	L	A	-0.1067
345	D	A	-1.4692
346	F	A	-0.3258
347	K	A	-2.0444
348	D	A	-2.9309
349	R	A	-2.5441
350	V	A	-0.6787
351	Q	A	-1.3169
352	S	A	-0.8051
353	K	A	-1.0675
354	I	A	0.9708
355	G	A	-0.0485
356	S	A	-0.1532
357	L	A	0.6832
358	D	A	-1.2621
359	N	A	-0.7686
360	I	A	1.2075
361	T	A	0.8684
362	H	A	1.0858
363	V	A	1.5704
364	P	A	-0.1985
365	G	A	-0.5763
366	G	A	-0.6997
367	G	A	-1.3360
368	N	A	-1.7095
369	K	A	-1.7996
370	K	A	-1.3942
371	I	A	-0.2110
372	E	A	-1.6368
373	T	A	0.0000
374	H	A	-1.6075
375	K	A	-1.6877
376	L	A	0.0000
377	T	A	0.0000
378	F	A	-0.5419
379	R	A	-1.7444
380	E	A	-2.5381
381	N	A	-2.1705
382	A	A	-2.0060
383	K	A	-1.5051
384	A	A	0.0000
385	K	A	-1.9800
386	T	A	-1.0276
387	D	A	0.0000
388	H	A	0.0000
389	G	A	0.0000
390	A	A	0.4921
391	E	A	-0.5911
392	I	A	0.9833
393	V	A	2.0975
394	Y	A	0.9449
395	K	A	0.5454
396	S	A	0.0000
397	P	A	0.8477
398	V	A	1.5512
399	V	A	0.0000
400	S	A	-0.2691
401	G	A	-0.5396
402	D	A	-1.4351
403	T	A	-0.8700
404	S	A	-1.0263
405	P	A	-1.2352
406	R	A	-1.8291
407	H	A	-0.4145
408	L	A	1.1651
409	S	A	0.9118
410	N	A	0.0000
411	V	A	1.7629
412	S	A	0.5218
413	S	A	0.0000
414	T	A	0.0000
415	G	A	0.0000
416	S	A	-0.5361
417	I	A	-0.3223
418	D	A	-0.7269
419	M	A	0.0865
420	V	A	1.1496
421	D	A	-0.8871
422	S	A	-0.7991
423	P	A	-0.7046
424	Q	A	-0.3594
425	L	A	1.0881
426	A	A	0.4854
427	T	A	-0.2571
428	L	A	0.1945
429	A	A	-1.1581
430	D	A	-1.9007
431	E	A	-1.1072
432	V	A	0.8008
433	S	A	0.0063
434	A	A	0.0861
435	S	A	0.0571
436	L	A	0.7156
437	A	A	-1.0527
438	K	A	-1.4549
439	Q	A	0.0000
440	G	A	0.0000
441	L	A	-0.6035