Project name: f9dc721d22142c

Chain sequence(s)	A: MERRRITSAARREYVSEGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKEVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3581
• Maximal score value: 1.3934
• Average score: -0.7747
• Total score value: -334.6603

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.9284
2	E	A	-1.9024
3	R	A	-1.9365
4	R	A	-3.3138
5	R	A	-3.1922
6	I	A	-2.0354
7	T	A	-3.0223
8	S	A	-2.7107
9	A	A	-1.9973
10	A	A	-2.1849
11	R	A	-3.0963
12	R	A	-2.8399
13	E	A	-1.0841
14	Y	A	0.1053
15	V	A	0.1214
16	S	A	-0.7113
17	E	A	-1.8028
18	G	A	-1.7506
19	E	A	-2.6059
20	M	A	-1.1491
21	M	A	-0.5784
22	V	A	-1.0539
23	G	A	0.0000
24	G	A	-0.0065
25	L	A	0.4355
26	A	A	0.0000
27	P	A	0.0000
28	G	A	0.0000
29	R	A	0.0000
30	R	A	0.0000
31	L	A	0.0000
32	G	A	0.0000
33	P	A	0.0000
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	0.0000
42	M	A	0.0000
43	P	A	0.0000
44	P	A	0.0000
45	P	A	-0.7010
46	L	A	0.2660
47	P	A	0.0000
48	T	A	-0.8228
49	R	A	-2.4320
50	V	A	-1.6907
51	D	A	-1.7819
52	F	A	0.0000
53	S	A	-0.2150
54	L	A	0.9357
55	A	A	0.1513
56	G	A	-0.4717
57	A	A	-0.0994
58	L	A	0.0000
59	N	A	-1.7800
60	A	A	-1.6733
61	G	A	0.0000
62	F	A	0.0000
63	K	A	-3.3529
64	E	A	-3.2871
65	T	A	0.0000
66	R	A	-2.8332
67	A	A	-2.0195
68	S	A	0.0000
69	E	A	0.0000
70	R	A	-1.2544
71	A	A	-0.3743
72	E	A	0.0000
73	M	A	0.1454
74	M	A	0.3043
75	E	A	-0.7276
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.2517
79	R	A	-1.6767
80	F	A	0.0000
81	A	A	-0.8648
82	S	A	-1.2047
83	Y	A	0.0000
84	I	A	0.0000
85	E	A	-0.7368
86	K	A	-1.6474
87	V	A	0.0000
88	R	A	-0.5529
89	F	A	-0.2615
90	L	A	0.0000
91	E	A	0.0000
92	Q	A	-1.5362
93	Q	A	-1.1274
94	N	A	0.0000
95	K	A	-1.0085
96	A	A	-0.7470
97	L	A	-0.6377
98	A	A	-0.8027
99	A	A	-0.7600
100	E	A	-1.3092
101	L	A	0.0000
102	N	A	-1.5093
103	Q	A	-1.6702
104	L	A	-1.5581
105	R	A	-1.6456
106	A	A	-1.2639
107	K	A	-1.1266
108	E	A	0.0000
109	P	A	-0.8542
110	T	A	-0.4620
111	K	A	-0.6135
112	L	A	0.7398
113	A	A	-0.1872
114	D	A	-1.3001
115	V	A	-0.3388
116	Y	A	-0.8203
117	Q	A	-1.4860
118	A	A	-1.4745
119	E	A	-1.8946
120	L	A	0.0000
121	R	A	-2.6357
122	E	A	-2.2773
123	L	A	0.0000
124	R	A	-1.9408
125	L	A	-1.0588
126	R	A	-1.7016
127	L	A	0.0000
128	D	A	-1.8849
129	Q	A	-1.8263
130	L	A	0.0000
131	T	A	0.0000
132	A	A	-1.4786
133	N	A	-1.2960
134	S	A	0.0000
135	A	A	-0.7567
136	R	A	-1.9565
137	L	A	0.0000
138	E	A	-0.9140
139	V	A	-0.3669
140	E	A	-1.9794
141	R	A	0.0000
142	D	A	-2.6109
143	N	A	-2.4487
144	L	A	0.0000
145	A	A	0.0000
146	Q	A	-2.3546
147	D	A	-1.8567
148	L	A	0.0000
149	A	A	-1.2268
150	T	A	-0.9301
151	V	A	-0.9613
152	R	A	-1.4559
153	Q	A	-1.5818
154	K	A	-1.8097
155	L	A	0.0000
156	Q	A	-1.8035
157	D	A	-2.0561
158	E	A	-1.6698
159	T	A	0.0000
160	N	A	-1.4377
161	L	A	0.0589
162	R	A	0.0000
163	L	A	-0.9653
164	E	A	-1.8249
165	A	A	-0.9966
166	E	A	0.0000
167	N	A	-1.3075
168	N	A	-1.0122
169	L	A	0.0585
170	A	A	0.0000
171	A	A	-0.4171
172	Y	A	0.9069
173	R	A	0.0000
174	Q	A	-1.5920
175	E	A	-2.2192
176	A	A	-2.2218
177	D	A	-2.5158
178	E	A	-2.0801
179	A	A	0.0000
180	T	A	-0.6022
181	L	A	0.5720
182	A	A	-0.4460
183	R	A	0.0000
184	L	A	0.0093
185	D	A	-1.0984
186	L	A	0.0000
187	E	A	-1.5209
188	R	A	-2.7478
189	K	A	-1.7156
190	I	A	-1.4254
191	E	A	-2.8207
192	S	A	-1.6225
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-0.9758
196	E	A	-0.9104
197	I	A	0.0000
198	R	A	-0.3860
199	F	A	-0.1781
200	L	A	0.0000
201	R	A	0.0000
202	K	A	-0.2398
203	I	A	-0.4229
204	H	A	-1.5074
205	E	A	0.0000
206	E	A	-2.6216
207	E	A	-2.1583
208	V	A	0.0000
209	R	A	-0.7975
210	E	A	0.0000
211	L	A	0.0000
212	Q	A	0.0000
213	E	A	0.0000
214	Q	A	0.0000
215	L	A	0.8422
216	A	A	0.1384
217	R	A	-0.3621
218	Q	A	-1.0106
219	Q	A	0.0000
220	V	A	0.6441
221	H	A	-0.2672
222	V	A	0.0000
223	E	A	-1.6812
224	L	A	-0.8822
225	D	A	-1.2201
226	V	A	0.0000
227	A	A	-0.6215
228	K	A	0.0000
229	P	A	0.0000
230	D	A	0.0000
231	L	A	0.4026
232	T	A	0.2414
233	A	A	0.1091
234	A	A	0.0000
235	L	A	-0.3694
236	K	A	-0.9144
237	E	A	-0.7637
238	I	A	0.0000
239	R	A	-0.8919
240	T	A	-0.4658
241	Q	A	-0.0371
242	Y	A	0.8272
243	E	A	-0.1164
244	A	A	0.2812
245	M	A	0.6288
246	A	A	0.0000
247	S	A	-0.3787
248	S	A	-0.6140
249	N	A	-0.8489
250	M	A	0.0000
251	H	A	-1.6501
252	E	A	-1.8445
253	A	A	0.0000
254	E	A	-2.2838
255	E	A	-2.7127
256	W	A	-1.0744
257	Y	A	-0.9604
258	R	A	-1.8965
259	S	A	-0.8197
260	K	A	0.0000
261	F	A	0.8736
262	A	A	0.1638
263	D	A	-0.2552
264	L	A	0.0000
265	T	A	-0.0808
266	D	A	-1.2135
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-0.7600
270	R	A	-1.3357
271	N	A	0.0000
272	A	A	-0.7164
273	E	A	-1.3138
274	L	A	0.4715
275	L	A	0.0473
276	R	A	-2.0609
277	Q	A	-1.9472
278	A	A	-0.9429
279	K	A	0.0000
280	H	A	-1.5955
281	E	A	-1.0496
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-0.8060
285	Y	A	0.0000
286	R	A	0.0000
287	R	A	0.0000
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0000
293	T	A	0.0000
294	C	A	0.0000
295	D	A	-0.6241
296	L	A	0.0000
297	E	A	-1.2117
298	S	A	-0.9101
299	L	A	0.0000
300	R	A	-1.1490
301	G	A	-0.5868
302	T	A	0.0000
303	N	A	0.0000
304	E	A	-1.1304
305	S	A	-1.0342
306	L	A	0.0000
307	E	A	0.0000
308	R	A	-2.5302
309	Q	A	0.0000
310	M	A	0.0000
311	R	A	-3.0833
312	E	A	-2.2750
313	Q	A	0.0000
314	E	A	-2.1154
315	E	A	-2.8046
316	R	A	-1.8652
317	H	A	0.0000
318	V	A	-0.6288
319	R	A	-2.1088
320	E	A	0.0000
321	A	A	0.0000
322	A	A	-0.9972
323	S	A	-1.3960
324	Y	A	0.0000
325	Q	A	-1.8227
326	E	A	-2.7031
327	A	A	-2.3733
328	L	A	-2.1454
329	A	A	-3.0127
330	R	A	-4.1539
331	L	A	0.0000
332	E	A	-4.0626
333	E	A	-4.3581
334	E	A	-4.0055
335	G	A	-3.0980
336	Q	A	-2.5092
337	E	A	-2.2463
338	L	A	-0.4627
339	K	A	0.0000
340	D	A	-2.3410
341	E	A	-1.9322
342	M	A	0.0000
343	A	A	-2.1200
344	R	A	-2.7428
345	H	A	-2.5652
346	L	A	0.0000
347	Q	A	-1.9639
348	E	A	-2.4380
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-1.3359
352	L	A	0.0000
353	L	A	0.0000
354	N	A	-0.8897
355	V	A	0.1846
356	K	A	0.0000
357	L	A	-0.0191
358	A	A	0.2449
359	L	A	0.0000
360	D	A	0.0000
361	I	A	0.4316
362	E	A	-0.3447
363	I	A	0.0000
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	0.0000
367	R	A	0.0000
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	0.0000
372	G	A	0.0000
373	E	A	0.0000
374	E	A	0.0000
375	N	A	0.0000
376	R	A	0.0461
377	I	A	0.0000
378	T	A	0.0000
379	I	A	0.0440
380	P	A	-0.0147
381	V	A	0.7608
382	Q	A	0.1965
383	T	A	0.7890
384	F	A	1.3934
385	S	A	0.1229
386	N	A	0.0000
387	L	A	0.5173
388	Q	A	-0.4312
389	I	A	-0.9111
390	R	A	-2.1563
391	E	A	-1.3360
392	T	A	-0.8727
393	S	A	-1.8447
394	L	A	-1.5702
395	D	A	0.0000
396	T	A	-1.3339
397	K	A	-2.1982
398	E	A	-2.0478
399	V	A	-1.3455
400	S	A	0.0000
401	E	A	-1.8100
402	G	A	0.0000
403	H	A	-1.4246
404	L	A	-0.5089
405	K	A	-2.0638
406	R	A	-1.4401
407	N	A	-1.5233
408	I	A	-0.6286
409	V	A	-0.7778
410	V	A	0.0000
411	K	A	0.0000
412	T	A	-0.9708
413	V	A	-0.8373
414	E	A	-1.0745
415	M	A	0.0000
416	R	A	0.0000
417	D	A	0.0000
418	G	A	0.0000
419	E	A	0.0000
420	V	A	-0.7518
421	I	A	0.0000
422	K	A	-1.3282
423	E	A	-1.8448
424	S	A	-1.4811
425	K	A	-2.1294
426	Q	A	-1.7382
427	E	A	0.0000
428	H	A	0.0000
429	K	A	-2.0435
430	D	A	-0.8796
431	V	A	0.0000
432	M	A	-0.3162