Project name: f9e2b1a231f018c

Chain sequence(s)	A: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; C: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; B: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; E: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; D: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; G: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; F: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; I: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; H: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD; J: GVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.89
• Maximal score value: 2.4232
• Average score: -0.5547
• Total score value: -349.4334

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
36	G	A	0.0858
37	V	A	1.4738
38	L	A	0.0000
39	Y	A	1.3922
40	V	A	0.0000
41	G	A	-0.7380
42	S	A	0.0000
43	K	A	-3.2738
44	T	A	0.0000
45	K	A	-3.1321
46	K	A	-2.0134
47	G	A	0.0000
48	V	A	1.0090
49	V	A	0.0000
50	H	A	-0.3233
51	G	A	0.0000
52	V	A	0.0000
53	A	A	0.2619
54	T	A	0.0000
55	V	A	0.9343
56	A	A	0.0000
57	E	A	-3.0280
58	K	A	-4.3578
59	T	A	0.0000
60	K	A	-2.8029
61	E	A	0.0000
62	Q	A	0.0000
63	V	A	0.0000
64	T	A	0.0000
65	N	A	0.0000
66	V	A	0.0000
67	G	A	-0.3668
68	G	A	-0.5000
69	A	A	-0.3279
70	V	A	0.0000
71	V	A	0.0000
72	T	A	0.0000
73	G	A	0.0000
74	V	A	0.0000
75	T	A	0.0000
76	A	A	0.0000
77	V	A	0.0000
78	A	A	0.0000
79	Q	A	-1.0806
80	K	A	-1.2888
81	T	A	-1.2724
82	V	A	0.0000
83	E	A	-2.7517
84	G	A	-1.5700
85	A	A	-0.6455
86	G	A	-0.3452
87	S	A	0.0000
88	I	A	1.4252
89	A	A	0.6579
90	A	A	0.3475
91	A	A	0.0000
92	T	A	0.1601
93	G	A	0.0000
94	F	A	0.0000
95	V	A	-0.2323
96	K	A	-2.4361
97	K	A	-3.8997
98	D	A	-4.5426
36	G	C	0.2954
37	V	C	1.7184
38	L	C	0.0000
39	Y	C	1.7917
40	V	C	0.0000
41	G	C	-0.7303
42	S	C	0.0000
43	K	C	-3.9451
44	T	C	0.0000
45	K	C	-3.8293
46	K	C	-2.4564
47	G	C	0.0000
48	V	C	0.7089
49	V	C	0.0000
50	H	C	-0.3322
51	G	C	0.0000
52	V	C	0.0000
53	A	C	0.4191
54	T	C	0.0000
55	V	C	0.9963
56	A	C	0.0000
57	E	C	-3.1210
58	K	C	-4.7346
59	T	C	0.0000
60	K	C	-3.7360
61	E	C	-1.8361
62	Q	C	0.0000
63	V	C	0.0000
64	T	C	0.0000
65	N	C	0.0000
66	V	C	0.0000
67	G	C	-0.3676
68	G	C	-0.5921
69	A	C	-0.2749
70	V	C	0.0000
71	V	C	0.0000
72	T	C	0.0000
73	G	C	0.0000
74	V	C	0.0000
75	T	C	0.0000
76	A	C	0.0000
77	V	C	0.0000
78	A	C	0.0000
79	Q	C	-1.1616
80	K	C	-1.4370
81	T	C	-1.6627
82	V	C	0.0000
83	E	C	-3.0037
84	G	C	-1.8563
85	A	C	-0.9762
86	G	C	-0.3872
87	S	C	0.0000
88	I	C	1.3475
89	A	C	0.7980
90	A	C	0.4734
91	A	C	0.0000
92	T	C	0.3808
93	G	C	0.0000
94	F	C	0.0000
95	V	C	-0.5757
96	K	C	-2.8749
97	K	C	-4.1711
98	D	C	-4.6145
36	G	E	0.6039
37	V	E	2.4232
38	L	E	2.1936
39	Y	E	2.3964
40	V	E	1.2551
41	G	E	-0.5705
42	S	E	-1.4895
43	K	E	-3.3423
44	T	E	-3.0230
45	K	E	-3.8834
46	K	E	-2.9054
47	G	E	-0.4871
48	V	E	1.5384
49	V	E	0.9087
50	H	E	-0.4226
51	G	E	-0.4000
52	V	E	0.2227
53	A	E	0.6308
54	T	E	0.0000
55	V	E	1.5619
56	A	E	0.0000
57	E	E	-3.2230
58	K	E	-3.9979
59	T	E	-2.8229
60	K	E	-3.1031
61	E	E	-1.3389
62	Q	E	-0.5590
63	V	E	0.2110
64	T	E	0.2031
65	N	E	-0.0268
66	V	E	0.0776
67	G	E	-0.3181
68	G	E	-0.5812
69	A	E	-0.3658
70	V	E	0.0000
71	V	E	0.3465
72	T	E	0.0000
73	G	E	0.2737
74	V	E	0.0000
75	T	E	-0.3958
76	A	E	0.2466
77	V	E	0.2872
78	A	E	-0.4542
79	Q	E	-1.2703
80	K	E	-1.9777
81	T	E	-1.3018
82	V	E	-0.7356
83	E	E	-2.2566
84	G	E	-1.5406
85	A	E	-0.6382
86	G	E	-0.4116
87	S	E	0.3051
88	I	E	1.7909
89	A	E	0.9193
90	A	E	0.5221
91	A	E	0.2182
92	T	E	0.3298
93	G	E	0.4732
94	F	E	0.6589
95	V	E	-0.4295
96	K	E	-3.0053
97	K	E	-4.0327
98	D	E	-3.9207
36	G	G	0.2938
37	V	G	1.7121
38	L	G	0.0000
39	Y	G	1.6799
40	V	G	0.0000
41	G	G	-0.5793
42	S	G	0.0000
43	K	G	-3.5141
44	T	G	0.0000
45	K	G	-4.0022
46	K	G	-2.8201
47	G	G	0.0000
48	V	G	0.4210
49	V	G	0.0000
50	H	G	-0.3058
51	G	G	0.0000
52	V	G	0.0000
53	A	G	0.5366
54	T	G	0.0000
55	V	G	0.9998
56	A	G	0.0000
57	E	G	-2.9875
58	K	G	-4.5455
59	T	G	0.0000
60	K	G	-3.2748
61	E	G	0.0000
62	Q	G	0.0000
63	V	G	0.0000
64	T	G	0.0000
65	N	G	0.0000
66	V	G	0.0000
67	G	G	-0.4251
68	G	G	-0.4755
69	A	G	-0.1442
70	V	G	0.0000
71	V	G	0.0000
72	T	G	0.0000
73	G	G	0.0000
74	V	G	0.0000
75	T	G	0.0000
76	A	G	0.0000
77	V	G	0.0000
78	A	G	0.0000
79	Q	G	-1.2726
80	K	G	-1.7260
81	T	G	-1.7314
82	V	G	0.0000
83	E	G	-2.8506
84	G	G	-1.7017
85	A	G	-0.8757
86	G	G	-0.1366
87	S	G	0.0000
88	I	G	1.5501
89	A	G	1.0063
90	A	G	0.5937
91	A	G	0.0000
92	T	G	0.1564
93	G	G	0.0000
94	F	G	0.0000
95	V	G	-0.5536
96	K	G	-2.9058
97	K	G	-4.3395
98	D	G	-4.8709
36	G	I	0.6049
37	V	I	2.3810
38	L	I	1.9431
39	Y	I	2.1907
40	V	I	1.2905
41	G	I	-0.3372
42	S	I	-1.2246
43	K	I	-3.0411
44	T	I	-2.9426
45	K	I	-3.5990
46	K	I	-2.5481
47	G	I	-0.4616
48	V	I	1.0812
49	V	I	0.7947
50	H	I	-0.4445
51	G	I	0.1595
52	V	I	0.8122
53	A	I	0.5970
54	T	I	0.9451
55	V	I	1.1344
56	A	I	-0.9782
57	E	I	-2.5263
58	K	I	-3.7749
59	T	I	-3.5477
60	K	I	-3.4692
61	E	I	-1.9767
62	Q	I	-0.8217
63	V	I	-0.0439
64	T	I	0.0977
65	N	I	-0.2763
66	V	I	0.1577
67	G	I	-0.3913
68	G	I	-0.5366
69	A	I	0.3951
70	V	I	1.9859
71	V	I	1.3707
72	T	I	0.7939
73	G	I	0.6547
74	V	I	1.0548
75	T	I	0.4577
76	A	I	0.0000
77	V	I	0.8956
78	A	I	-0.3536
79	Q	I	-1.9958
80	K	I	-2.3812
81	T	I	-1.6913
82	V	I	-1.0947
83	E	I	-2.4207
84	G	I	-1.5178
85	A	I	-0.7103
86	G	I	-0.3256
87	S	I	0.4655
88	I	I	2.2926
89	A	I	1.1110
90	A	I	0.6068
91	A	I	0.0000
92	T	I	0.1401
93	G	I	0.2066
94	F	I	0.0000
95	V	I	-0.1585
96	K	I	-2.7396
97	K	I	-4.2434
98	D	I	-4.1240
36	G	F	0.5975
37	V	F	2.3981
38	L	F	2.1790
39	Y	F	2.3793
40	V	F	1.2563
41	G	F	-0.5706
42	S	F	-1.4805
43	K	F	-3.3054
44	T	F	-2.8140
45	K	F	-3.6637
46	K	F	-2.5415
47	G	F	-0.2857
48	V	F	1.5600
49	V	F	0.8855
50	H	F	-0.4749
51	G	F	-0.4000
52	V	F	0.2143
53	A	F	0.5845
54	T	F	0.0000
55	V	F	1.5163
56	A	F	0.0000
57	E	F	-3.3730
58	K	F	-4.1659
59	T	F	-3.1588
60	K	F	-3.6622
61	E	F	-2.0528
62	Q	F	-0.9301
63	V	F	0.0580
64	T	F	0.2020
65	N	F	-0.0423
66	V	F	0.0071
67	G	F	-0.4104
68	G	F	-0.7378
69	A	F	-0.4422
70	V	F	0.0000
71	V	F	0.3299
72	T	F	0.0000
73	G	F	0.2597
74	V	F	0.0000
75	T	F	-0.3936
76	A	F	0.2475
77	V	F	0.2931
78	A	F	-0.4681
79	Q	F	-1.2792
80	K	F	-2.0143
81	T	F	-1.4793
82	V	F	-1.0556
83	E	F	-2.5333
84	G	F	-1.7533
85	A	F	-0.7270
86	G	F	-0.4182
87	S	F	0.2702
88	I	F	1.7507
89	A	F	0.8859
90	A	F	0.5120
91	A	F	0.2045
92	T	F	0.3698
93	G	F	0.5386
94	F	F	0.6881
95	V	F	-0.3747
96	K	F	-2.9566
97	K	F	-3.7941
98	D	F	-4.0357
36	G	J	0.5977
37	V	J	2.3570
38	L	J	1.9168
39	Y	J	2.1507
40	V	J	1.2744
41	G	J	-0.2987
42	S	J	-1.1655
43	K	J	-3.0446
44	T	J	-3.0655
45	K	J	-3.7765
46	K	J	-2.9377
47	G	J	-0.8242
48	V	J	0.9050
49	V	J	0.6922
50	H	J	-0.4353
51	G	J	0.2138
52	V	J	0.8290
53	A	J	0.7074
54	T	J	1.1434
55	V	J	1.6119
56	A	J	-0.8469
57	E	J	-2.6978
58	K	J	-3.8675
59	T	J	-3.5220
60	K	J	-3.4259
61	E	J	-1.8642
62	Q	J	-0.7280
63	V	J	-0.0274
64	T	J	0.0914
65	N	J	-0.2870
66	V	J	0.1386
67	G	J	-0.4203
68	G	J	-0.5937
69	A	J	0.3729
70	V	J	1.9819
71	V	J	1.3714
72	T	J	0.7571
73	G	J	0.5468
74	V	J	0.6936
75	T	J	0.3217
76	A	J	0.0000
77	V	J	0.8769
78	A	J	-0.3550
79	Q	J	-2.0060
80	K	J	-2.4000
81	T	J	-1.7565
82	V	J	-1.1884
83	E	J	-2.4768
84	G	J	-1.5657
85	A	J	-0.6996
86	G	J	-0.2561
87	S	J	0.4534
88	I	J	2.2658
89	A	J	1.0633
90	A	J	0.5796
91	A	J	0.0000
92	T	J	0.1609
93	G	J	0.2277
94	F	J	0.0000
95	V	J	-0.0013
96	K	J	-2.3767
97	K	J	-3.9187
98	D	J	-4.0786
36	G	D	0.3342
37	V	D	1.8428
38	L	D	0.0000
39	Y	D	1.8577
40	V	D	0.0000
41	G	D	-0.6222
42	S	D	0.0000
43	K	D	-3.7588
44	T	D	0.0000
45	K	D	-3.8419
46	K	D	-2.5448
47	G	D	0.0000
48	V	D	0.9756
49	V	D	0.0000
50	H	D	-0.1543
51	G	D	0.0000
52	V	D	0.0000
53	A	D	0.4687
54	T	D	0.0000
55	V	D	1.1479
56	A	D	0.0000
57	E	D	-3.0452
58	K	D	-4.3907
59	T	D	0.0000
60	K	D	-3.1647
61	E	D	0.0000
62	Q	D	0.0000
63	V	D	0.0000
64	T	D	0.0000
65	N	D	0.0000
66	V	D	0.0000
67	G	D	-0.3152
68	G	D	-0.5342
69	A	D	-0.2474
70	V	D	0.0000
71	V	D	0.0000
72	T	D	0.0000
73	G	D	0.0000
74	V	D	0.0000
75	T	D	0.0000
76	A	D	0.0000
77	V	D	0.0000
78	A	D	0.0000
79	Q	D	-1.1598
80	K	D	-1.3672
81	T	D	-1.4975
82	V	D	0.0000
83	E	D	-2.3766
84	G	D	-1.6059
85	A	D	-0.8211
86	G	D	-0.3128
87	S	D	0.0000
88	I	D	1.3659
89	A	D	0.8239
90	A	D	0.4960
91	A	D	0.0000
92	T	D	0.3507
93	G	D	0.0000
94	F	D	0.0000
95	V	D	-0.5540
96	K	D	-2.5920
97	K	D	-4.1824
98	D	D	-4.6623
36	G	H	0.2458
37	V	H	1.7585
38	L	H	0.0000
39	Y	H	1.7515
40	V	H	0.0000
41	G	H	-0.5448
42	S	H	0.0000
43	K	H	-3.4950
44	T	H	0.0000
45	K	H	-3.5685
46	K	H	-2.4048
47	G	H	0.0000
48	V	H	1.1456
49	V	H	0.0000
50	H	H	-0.1227
51	G	H	0.0000
52	V	H	0.0000
53	A	H	0.4830
54	T	H	0.0000
55	V	H	0.9657
56	A	H	0.0000
57	E	H	-3.2254
58	K	H	-4.5274
59	T	H	0.0000
60	K	H	-3.3433
61	E	H	0.0000
62	Q	H	0.0000
63	V	H	0.0000
64	T	H	0.0000
65	N	H	0.0000
66	V	H	0.0000
67	G	H	-0.4066
68	G	H	-0.4493
69	A	H	-0.1198
70	V	H	0.0000
71	V	H	0.0000
72	T	H	0.0000
73	G	H	0.0000
74	V	H	0.0000
75	T	H	0.0000
76	A	H	0.0000
77	V	H	0.0000
78	A	H	0.0000
79	Q	H	-1.2719
80	K	H	-1.6961
81	T	H	-1.7116
82	V	H	0.0000
83	E	H	-2.6436
84	G	H	-1.7133
85	A	H	-0.9309
86	G	H	-0.1958
87	S	H	0.0000
88	I	H	1.6706
89	A	H	1.0853
90	A	H	0.6354
91	A	H	0.0000
92	T	H	0.1523
93	G	H	0.0000
94	F	H	0.0000
95	V	H	-0.5117
96	K	H	-2.5746
97	K	H	-4.2664
98	D	H	-4.8900
36	G	B	0.0359
37	V	B	1.3683
38	L	B	0.0000
39	Y	B	1.2983
40	V	B	0.0000
41	G	B	-0.8525
42	S	B	0.0000
43	K	B	-3.9221
44	T	B	0.0000
45	K	B	-4.1725
46	K	B	-2.8640
47	G	B	0.0000
48	V	B	0.4805
49	V	B	0.0000
50	H	B	-0.7955
51	G	B	0.0000
52	V	B	0.0000
53	A	B	0.2044
54	T	B	0.0000
55	V	B	1.1645
56	A	B	0.0000
57	E	B	-3.0615
58	K	B	-4.4064
59	T	B	0.0000
60	K	B	-2.9496
61	E	B	0.0000
62	Q	B	0.0000
63	V	B	0.0000
64	T	B	0.0000
65	N	B	0.0000
66	V	B	0.0000
67	G	B	-0.3832
68	G	B	-0.5261
69	A	B	-0.3392
70	V	B	0.0000
71	V	B	0.0000
72	T	B	0.0000
73	G	B	0.0000
74	V	B	0.0000
75	T	B	0.0000
76	A	B	0.0000
77	V	B	0.0000
78	A	B	0.0000
79	Q	B	-0.9191
80	K	B	-1.2986
81	T	B	-1.3538
82	V	B	0.0000
83	E	B	-2.7313
84	G	B	-1.6403
85	A	B	-0.7041
86	G	B	-0.3779
87	S	B	0.0000
88	I	B	1.3764
89	A	B	0.6220
90	A	B	0.3241
91	A	B	0.0000
92	T	B	0.1476
93	G	B	0.0000
94	F	B	0.0000
95	V	B	-0.4252
96	K	B	-2.5468
97	K	B	-3.8640
98	D	B	-4.5741