Project name: fa72dfb5f7b27c9
Status: done
submitted: 2018-12-16 21:52:49, status changed: 2018-12-16 22:06:24
Settings
|
Chain sequence(s)
|
B: MNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.6779
-
Maximal score value
-
1.0488
-
Average score
-
-1.9264
-
Total score value
-
-535.5499
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 322 |
M |
B |
-0.2728 |
|
| 323 |
N |
B |
-1.8153 |
|
| 324 |
N |
B |
-2.3750 |
|
| 325 |
N |
B |
-1.9070 |
|
| 326 |
M |
B |
-1.5060 |
|
| 327 |
S |
B |
-1.4289 |
|
| 328 |
L |
B |
-1.2458 |
|
| 329 |
Q |
B |
-2.0185 |
|
| 330 |
D |
B |
-2.3260 |
|
| 331 |
A |
B |
0.0000 |
|
| 332 |
E |
B |
-1.8623 |
|
| 333 |
W |
B |
0.0000 |
|
| 334 |
Y |
B |
-1.0455 |
|
| 335 |
W |
B |
0.0000 |
|
| 336 |
G |
B |
-1.1560 |
|
| 337 |
D |
B |
-2.0748 |
|
| 338 |
I |
B |
-1.7501 |
|
| 339 |
S |
B |
-2.3984 |
|
| 340 |
R |
B |
-3.5799 |
|
| 341 |
E |
B |
-3.9278 |
|
| 342 |
E |
B |
-3.3585 |
|
| 343 |
V |
B |
0.0000 |
|
| 344 |
N |
B |
-4.0307 |
|
| 345 |
E |
B |
-4.1313 |
|
| 346 |
K |
B |
-3.0135 |
|
| 347 |
L |
B |
0.0000 |
|
| 348 |
R |
B |
-3.9567 |
|
| 349 |
D |
B |
-3.4430 |
|
| 350 |
T |
B |
-2.1870 |
|
| 351 |
A |
B |
-1.2467 |
|
| 352 |
D |
B |
-1.7591 |
|
| 353 |
G |
B |
0.0000 |
|
| 354 |
T |
B |
0.0000 |
|
| 355 |
F |
B |
0.0000 |
|
| 356 |
L |
B |
0.0000 |
|
| 357 |
V |
B |
0.0000 |
|
| 358 |
R |
B |
0.0000 |
|
| 359 |
D |
B |
-1.6621 |
|
| 360 |
A |
B |
-1.4410 |
|
| 361 |
S |
B |
-1.3451 |
|
| 362 |
T |
B |
-1.1105 |
|
| 363 |
K |
B |
-1.5104 |
|
| 364 |
M |
B |
-0.5097 |
|
| 365 |
H |
B |
-1.2196 |
|
| 366 |
G |
B |
-1.4136 |
|
| 367 |
D |
B |
-1.4053 |
|
| 368 |
Y |
B |
-1.0088 |
|
| 369 |
T |
B |
0.0000 |
|
| 370 |
L |
B |
0.0000 |
|
| 371 |
T |
B |
0.0000 |
|
| 372 |
L |
B |
0.0000 |
|
| 373 |
R |
B |
-1.8647 |
|
| 374 |
K |
B |
-2.3877 |
|
| 375 |
G |
B |
-1.6917 |
|
| 376 |
G |
B |
-2.4671 |
|
| 377 |
N |
B |
-2.7262 |
|
| 378 |
N |
B |
-1.8667 |
|
| 379 |
K |
B |
-0.8834 |
|
| 380 |
L |
B |
0.1255 |
|
| 381 |
I |
B |
0.0000 |
|
| 382 |
K |
B |
-0.4329 |
|
| 383 |
I |
B |
0.0000 |
|
| 384 |
F |
B |
-1.0763 |
|
| 385 |
H |
B |
-2.4560 |
|
| 386 |
R |
B |
-3.4879 |
|
| 387 |
D |
B |
-3.3081 |
|
| 388 |
G |
B |
-2.4251 |
|
| 389 |
K |
B |
-2.3337 |
|
| 390 |
Y |
B |
-1.5377 |
|
| 391 |
G |
B |
0.0000 |
|
| 392 |
F |
B |
0.0000 |
|
| 393 |
S |
B |
-1.0508 |
|
| 394 |
D |
B |
-2.2239 |
|
| 395 |
P |
B |
-1.6923 |
|
| 396 |
L |
B |
0.0000 |
|
| 397 |
T |
B |
-0.8809 |
|
| 398 |
F |
B |
-0.4421 |
|
| 399 |
S |
B |
-1.0485 |
|
| 400 |
S |
B |
-0.9062 |
|
| 401 |
V |
B |
0.0000 |
|
| 402 |
V |
B |
0.0000 |
|
| 403 |
E |
B |
-1.5035 |
|
| 404 |
L |
B |
0.0000 |
|
| 405 |
I |
B |
0.0000 |
|
| 406 |
N |
B |
-1.7028 |
|
| 407 |
H |
B |
-1.8261 |
|
| 408 |
Y |
B |
0.0000 |
|
| 409 |
R |
B |
-1.9756 |
|
| 410 |
N |
B |
-2.5804 |
|
| 411 |
E |
B |
-2.7737 |
|
| 412 |
S |
B |
-2.1808 |
|
| 413 |
L |
B |
0.0000 |
|
| 414 |
A |
B |
-1.9820 |
|
| 415 |
Q |
B |
-1.7152 |
|
| 416 |
Y |
B |
-0.6192 |
|
| 417 |
N |
B |
-1.2771 |
|
| 418 |
P |
B |
-1.8275 |
|
| 419 |
K |
B |
-2.4647 |
|
| 420 |
L |
B |
0.0000 |
|
| 421 |
D |
B |
-2.6969 |
|
| 422 |
V |
B |
0.0000 |
|
| 423 |
K |
B |
-1.9773 |
|
| 424 |
L |
B |
0.0000 |
|
| 425 |
L |
B |
0.2381 |
|
| 426 |
Y |
B |
1.0488 |
|
| 427 |
P |
B |
0.2300 |
|
| 428 |
V |
B |
-0.0470 |
|
| 429 |
S |
B |
-0.6984 |
|
| 430 |
K |
B |
-1.0404 |
|
| 431 |
Y |
B |
-1.0364 |
|
| 432 |
Q |
B |
-1.7084 |
|
| 433 |
Q |
B |
0.0000 |
|
| 434 |
D |
B |
-2.5822 |
|
| 435 |
Q |
B |
-2.1328 |
|
| 436 |
V |
B |
-0.7571 |
|
| 437 |
V |
B |
0.0000 |
|
| 438 |
K |
B |
-2.9710 |
|
| 439 |
E |
B |
-2.4606 |
|
| 440 |
D |
B |
-3.0109 |
|
| 441 |
N |
B |
-2.1237 |
|
| 442 |
I |
B |
-1.4678 |
|
| 443 |
E |
B |
-2.5747 |
|
| 444 |
A |
B |
-2.0927 |
|
| 445 |
V |
B |
0.0000 |
|
| 446 |
G |
B |
0.0000 |
|
| 447 |
K |
B |
-2.8907 |
|
| 448 |
K |
B |
-2.4423 |
|
| 449 |
L |
B |
0.0000 |
|
| 450 |
H |
B |
-2.4239 |
|
| 451 |
E |
B |
-2.4715 |
|
| 452 |
Y |
B |
-1.7657 |
|
| 453 |
N |
B |
0.0000 |
|
| 454 |
T |
B |
-1.7886 |
|
| 455 |
Q |
B |
-2.2446 |
|
| 456 |
F |
B |
-2.2548 |
|
| 457 |
Q |
B |
-2.6396 |
|
| 458 |
E |
B |
-3.5682 |
|
| 459 |
K |
B |
-3.4077 |
|
| 460 |
S |
B |
-3.3763 |
|
| 461 |
R |
B |
-4.5016 |
|
| 462 |
E |
B |
-4.2859 |
|
| 463 |
Y |
B |
-3.5531 |
|
| 464 |
D |
B |
-4.0675 |
|
| 465 |
R |
B |
-4.2753 |
|
| 466 |
L |
B |
-2.9820 |
|
| 467 |
Y |
B |
-2.2842 |
|
| 468 |
E |
B |
-3.4811 |
|
| 469 |
E |
B |
-3.3726 |
|
| 470 |
Y |
B |
-2.4443 |
|
| 471 |
T |
B |
-1.7990 |
|
| 472 |
R |
B |
-3.0640 |
|
| 473 |
T |
B |
0.0000 |
|
| 474 |
S |
B |
-1.9710 |
|
| 475 |
Q |
B |
-2.1511 |
|
| 476 |
E |
B |
-1.6300 |
|
| 477 |
I |
B |
0.0000 |
|
| 478 |
Q |
B |
-1.9336 |
|
| 479 |
M |
B |
-0.4967 |
|
| 480 |
K |
B |
-1.5715 |
|
| 481 |
R |
B |
-2.5302 |
|
| 482 |
T |
B |
-1.4220 |
|
| 483 |
A |
B |
-1.2855 |
|
| 484 |
I |
B |
-1.8248 |
|
| 485 |
E |
B |
-2.6479 |
|
| 486 |
A |
B |
-1.7839 |
|
| 487 |
F |
B |
-1.0057 |
|
| 488 |
N |
B |
-1.7978 |
|
| 489 |
E |
B |
-2.6297 |
|
| 490 |
T |
B |
-1.3049 |
|
| 491 |
I |
B |
0.0000 |
|
| 492 |
K |
B |
-2.6512 |
|
| 493 |
I |
B |
-0.9152 |
|
| 494 |
F |
B |
-1.8003 |
|
| 495 |
E |
B |
-3.1417 |
|
| 496 |
E |
B |
-3.0867 |
|
| 497 |
Q |
B |
-2.3089 |
|
| 498 |
C |
B |
0.0000 |
|
| 499 |
Q |
B |
-2.6177 |
|
| 500 |
T |
B |
-2.0185 |
|
| 501 |
Q |
B |
-2.0412 |
|
| 502 |
E |
B |
-2.9796 |
|
| 503 |
R |
B |
-2.8357 |
|
| 504 |
Y |
B |
-0.9327 |
|
| 505 |
S |
B |
0.0000 |
|
| 506 |
K |
B |
-3.3720 |
|
| 507 |
E |
B |
-3.1733 |
|
| 508 |
Y |
B |
-1.6670 |
|
| 509 |
I |
B |
0.0000 |
|
| 510 |
E |
B |
-3.9364 |
|
| 511 |
K |
B |
-3.9258 |
|
| 512 |
F |
B |
-3.7779 |
|
| 513 |
K |
B |
-4.4969 |
|
| 514 |
R |
B |
-4.3831 |
|
| 515 |
E |
B |
-4.3640 |
|
| 516 |
G |
B |
-3.4020 |
|
| 517 |
N |
B |
-3.7783 |
|
| 518 |
E |
B |
-4.1921 |
|
| 519 |
K |
B |
-3.7728 |
|
| 520 |
E |
B |
-3.1888 |
|
| 521 |
I |
B |
-2.8059 |
|
| 522 |
Q |
B |
-3.4443 |
|
| 523 |
R |
B |
-3.6510 |
|
| 524 |
I |
B |
-2.2466 |
|
| 525 |
M |
B |
-1.7930 |
|
| 526 |
H |
B |
-3.1128 |
|
| 527 |
N |
B |
-2.9759 |
|
| 528 |
Y |
B |
-2.7993 |
|
| 529 |
D |
B |
-3.8707 |
|
| 530 |
K |
B |
-3.7841 |
|
| 531 |
L |
B |
-2.9984 |
|
| 532 |
K |
B |
-3.5826 |
|
| 533 |
S |
B |
-3.1965 |
|
| 534 |
R |
B |
-3.3627 |
|
| 535 |
I |
B |
0.0000 |
|
| 536 |
S |
B |
-1.8904 |
|
| 537 |
E |
B |
-2.8951 |
|
| 538 |
I |
B |
-1.7180 |
|
| 539 |
I |
B |
-1.2903 |
|
| 540 |
D |
B |
-2.5963 |
|
| 541 |
S |
B |
-2.0105 |
|
| 542 |
R |
B |
-2.7091 |
|
| 543 |
R |
B |
-3.8651 |
|
| 544 |
R |
B |
-3.9120 |
|
| 545 |
L |
B |
-3.3532 |
|
| 546 |
E |
B |
-4.2495 |
|
| 547 |
E |
B |
-4.6779 |
|
| 548 |
D |
B |
-3.7234 |
|
| 549 |
L |
B |
-3.5716 |
|
| 550 |
K |
B |
-3.7765 |
|
| 551 |
K |
B |
-3.7968 |
|
| 552 |
Q |
B |
-3.0390 |
|
| 553 |
A |
B |
-2.5605 |
|
| 554 |
A |
B |
-2.8577 |
|
| 555 |
E |
B |
-3.7195 |
|
| 556 |
Y |
B |
-3.1087 |
|
| 557 |
R |
B |
-3.5865 |
|
| 558 |
E |
B |
-3.7681 |
|
| 559 |
I |
B |
0.0000 |
|
| 560 |
D |
B |
-3.4176 |
|
| 561 |
K |
B |
-4.1409 |
|
| 562 |
R |
B |
-3.5540 |
|
| 563 |
M |
B |
0.0000 |
|
| 564 |
N |
B |
-2.6811 |
|
| 565 |
S |
B |
-2.0183 |
|
| 566 |
I |
B |
-1.6035 |
|
| 567 |
K |
B |
-1.5221 |
|
| 568 |
P |
B |
-1.1275 |
|
| 569 |
D |
B |
-1.7244 |
|
| 570 |
L |
B |
-1.2229 |
|
| 571 |
I |
B |
-0.4838 |
|
| 572 |
Q |
B |
-1.8904 |
|
| 573 |
L |
B |
-1.6489 |
|
| 574 |
R |
B |
-2.3417 |
|
| 575 |
K |
B |
-2.6438 |
|
| 576 |
T |
B |
-1.3825 |
|
| 577 |
R |
B |
-1.7715 |
|
| 578 |
D |
B |
-1.7042 |
|
| 579 |
Q |
B |
-1.2670 |
|
| 580 |
Y |
B |
0.0000 |
|
| 581 |
L |
B |
-0.1270 |
|
| 582 |
M |
B |
-0.4582 |
|
| 583 |
W |
B |
0.0000 |
|
| 584 |
L |
B |
0.0000 |
|
| 585 |
T |
B |
-1.1499 |
|
| 586 |
Q |
B |
-1.4256 |
|
| 587 |
K |
B |
-2.2189 |
|
| 588 |
G |
B |
-1.9386 |
|
| 589 |
V |
B |
-1.9822 |
|
| 590 |
R |
B |
-3.5696 |
|
| 591 |
Q |
B |
-3.7633 |
|
| 592 |
K |
B |
-4.1408 |
|
| 593 |
K |
B |
-3.8258 |
|
| 594 |
L |
B |
-2.7570 |
|
| 595 |
N |
B |
-3.5262 |
|
| 596 |
E |
B |
-3.4073 |
|
| 597 |
W |
B |
0.0000 |
|
| 598 |
L |
B |
-1.4545 |
|
| 599 |
G |
B |
-1.4317 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine