Project name: MONOMER 4MHX sulfamidase san filippoA

Chain sequence(s)	A: PRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNELRS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3168
• Maximal score value: 1.1691
• Average score: -0.6257
• Total score value: -301.5999

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
22	P	A	-1.6058
23	R	A	-2.0722
24	N	A	0.0000
25	A	A	0.0000
26	L	A	0.0000
27	L	A	0.0000
28	L	A	0.0000
29	L	A	0.0000
30	A	A	0.0000
31	D	A	0.0000
32	D	A	0.0000
33	G	A	0.0000
34	G	A	0.1039
35	F	A	-0.0703
36	E	A	0.0000
37	S	A	0.0000
38	G	A	-0.8623
39	A	A	-0.7852
40	Y	A	0.0000
41	N	A	-1.3829
42	N	A	0.0000
43	S	A	-0.4741
44	A	A	-0.4509
45	I	A	0.0000
46	A	A	-0.2853
47	T	A	0.0000
48	P	A	-0.6767
49	H	A	-0.8948
50	L	A	0.0000
51	D	A	-1.5281
52	A	A	-1.3905
53	L	A	0.0000
54	A	A	0.0000
55	R	A	-2.7852
56	R	A	-2.9678
57	S	A	0.0000
58	L	A	0.0000
59	L	A	0.0000
60	F	A	0.0000
61	R	A	-1.7030
62	N	A	-1.3634
63	A	A	0.0000
64	F	A	0.0000
65	T	A	0.0000
66	S	A	0.0000
67	V	A	0.0000
68	S	A	0.0000
69	S	A	0.0000
71	S	A	0.0000
72	P	A	0.0000
73	S	A	0.0000
74	R	A	0.0000
75	A	A	0.0000
76	S	A	0.0000
77	L	A	0.0000
78	L	A	0.0000
79	T	A	0.0000
80	G	A	0.0000
81	L	A	0.0000
82	P	A	0.0000
83	Q	A	0.0000
84	H	A	0.0000
85	Q	A	0.0000
86	N	A	0.0000
87	G	A	0.0000
88	M	A	0.0000
89	Y	A	0.0959
90	G	A	0.0000
91	L	A	-0.4051
92	H	A	-1.2695
93	Q	A	-2.0907
94	D	A	-1.8160
95	V	A	0.4057
96	H	A	-0.3597
97	H	A	-1.3690
98	F	A	-0.7039
99	N	A	-1.5614
100	S	A	0.0000
101	F	A	-1.0686
102	D	A	-2.7885
103	K	A	-2.1024
104	V	A	0.0000
105	R	A	-1.1956
106	S	A	0.0000
107	L	A	0.0000
108	P	A	0.0000
109	L	A	-0.3580
110	L	A	0.0000
111	L	A	0.0000
112	S	A	-0.9061
113	Q	A	-1.1793
114	A	A	-0.6223
115	G	A	-0.8908
116	V	A	0.0000
117	R	A	-1.5123
118	T	A	0.0000
119	G	A	0.0000
120	I	A	0.0000
121	I	A	0.0000
122	G	A	0.0000
123	K	A	0.0000
124	K	A	-0.5266
125	H	A	-0.9246
126	V	A	0.0000
127	G	A	0.0000
128	P	A	-1.5076
129	E	A	-2.1704
130	T	A	-1.4791
131	V	A	0.0000
132	Y	A	0.0000
133	P	A	-0.9385
134	F	A	-0.9177
135	D	A	-1.7226
136	F	A	0.0000
137	A	A	-0.7185
138	Y	A	-0.4118
139	T	A	0.0000
140	E	A	-1.6391
141	E	A	-2.6381
142	N	A	-2.3163
143	G	A	-1.5515
144	S	A	-0.8278
145	V	A	-0.3020
146	L	A	-0.1812
147	Q	A	-0.8914
148	V	A	0.0000
149	G	A	0.0000
150	R	A	0.0000
151	N	A	-1.0723
152	I	A	0.0000
153	T	A	-1.1112
154	R	A	-1.5280
155	I	A	0.0000
156	K	A	-0.7626
157	L	A	-0.3293
158	L	A	0.0000
159	V	A	0.0000
160	R	A	-1.7396
161	K	A	-1.6910
162	F	A	0.0000
163	L	A	0.0000
164	Q	A	-2.0562
165	T	A	-1.7014
166	Q	A	-2.2686
167	D	A	-2.9736
168	D	A	-3.1603
169	R	A	-2.7691
170	P	A	-1.8876
171	F	A	0.0000
172	F	A	0.0000
173	L	A	0.0000
174	Y	A	0.0000
175	V	A	0.0000
176	A	A	0.0000
177	F	A	0.0000
178	H	A	-0.1226
179	D	A	0.0000
180	P	A	0.0000
181	H	A	-0.2097
182	R	A	0.0000
183	C	A	0.0000
184	G	A	-0.7225
185	H	A	-1.0048
186	S	A	-1.0554
187	Q	A	-1.0748
188	P	A	-1.3653
189	Q	A	-1.5469
190	Y	A	-0.9625
191	G	A	-0.8771
192	T	A	-0.5456
193	F	A	0.0000
194	C	A	0.0000
195	E	A	-0.6546
196	K	A	-1.7027
197	F	A	-1.2370
198	G	A	0.0000
199	N	A	-2.0752
200	G	A	-2.6042
201	E	A	-2.8252
202	S	A	-1.8008
203	G	A	-1.5825
204	M	A	-1.7965
205	G	A	-2.1565
206	R	A	-2.9297
207	I	A	0.0000
208	P	A	-1.4378
209	D	A	-1.2105
210	W	A	0.0000
211	T	A	-0.6821
212	P	A	-0.5865
213	Q	A	-0.3544
214	A	A	-0.4668
215	Y	A	-0.9351
216	D	A	-1.8349
217	P	A	-0.6904
218	L	A	0.1883
219	D	A	-1.3467
220	V	A	0.0000
221	L	A	0.8579
222	V	A	0.5345
223	P	A	0.4593
224	Y	A	0.3271
225	F	A	0.0000
226	V	A	0.0000
227	P	A	0.0000
228	N	A	-1.2446
229	T	A	0.0000
230	P	A	-0.4585
231	A	A	-0.5461
232	A	A	0.0000
233	R	A	-0.6514
234	A	A	-0.2898
235	D	A	0.0000
236	L	A	0.0000
237	A	A	0.0000
238	A	A	-0.4243
239	Q	A	0.0000
240	Y	A	0.0000
241	T	A	0.0000
242	T	A	0.0000
243	V	A	0.0000
244	G	A	0.0000
245	R	A	0.0000
246	M	A	0.0000
247	D	A	0.0000
248	Q	A	-0.3630
249	G	A	0.0000
250	V	A	0.0000
251	G	A	-0.3556
252	L	A	-0.4313
253	V	A	0.0000
254	L	A	0.0000
255	Q	A	-1.7438
256	E	A	0.0000
257	L	A	0.0000
258	R	A	-2.9667
259	D	A	-2.8976
260	A	A	-1.8920
261	G	A	-1.9688
262	V	A	-1.5823
263	L	A	-1.8764
264	N	A	-2.5409
265	D	A	-2.6324
266	T	A	0.0000
267	L	A	0.0000
268	V	A	0.0000
269	I	A	0.0000
270	F	A	0.0000
271	T	A	0.0000
272	S	A	0.0000
273	D	A	0.0000
274	N	A	0.0000
275	G	A	0.0000
276	I	A	0.0000
277	P	A	0.0000
278	F	A	0.0000
279	P	A	0.0000
280	S	A	0.0000
281	G	A	0.0000
282	R	A	0.0000
283	T	A	0.0000
284	N	A	0.0000
285	L	A	0.0000
286	Y	A	0.0000
287	W	A	0.0447
288	P	A	0.0000
289	G	A	0.0000
290	T	A	0.0000
291	A	A	0.0000
292	E	A	0.0000
293	P	A	0.0000
294	L	A	0.0000
295	L	A	0.0000
296	V	A	0.0000
297	S	A	0.0000
298	S	A	0.0000
299	P	A	-2.1191
300	E	A	-2.7464
301	H	A	-2.2564
302	P	A	-2.1782
303	K	A	-2.7593
304	R	A	0.0000
305	W	A	-1.5505
306	G	A	-1.6427
307	Q	A	-0.9175
308	V	A	0.3531
309	S	A	0.0000
310	E	A	-1.8317
311	A	A	0.0000
312	Y	A	-0.7024
313	V	A	0.0000
314	S	A	0.0000
315	L	A	0.0000
316	L	A	0.0000
317	D	A	0.0000
318	L	A	0.0000
319	T	A	0.0000
320	P	A	-1.0383
321	T	A	0.0000
322	I	A	0.0000
323	L	A	0.0000
324	D	A	-1.9751
325	W	A	0.0000
326	F	A	-0.7166
327	S	A	-0.7229
328	I	A	-0.4980
329	P	A	-0.4462
330	Y	A	-0.3844
331	P	A	-0.3239
332	S	A	-0.3643
333	Y	A	-0.4489
334	A	A	-0.4445
335	I	A	0.0000
336	F	A	1.0756
337	G	A	-0.0284
338	S	A	-0.5573
339	K	A	-1.3790
340	T	A	-0.9906
341	I	A	0.0000
342	H	A	-1.3661
343	L	A	-0.8705
344	T	A	-0.9080
345	G	A	-1.0565
346	R	A	-2.0910
347	S	A	-1.3712
348	L	A	0.0000
349	L	A	-0.8450
350	P	A	-1.0586
351	A	A	0.0000
352	L	A	0.0000
353	E	A	-2.5120
354	A	A	-1.4141
355	E	A	-1.1575
356	P	A	-0.1684
357	L	A	1.0291
358	W	A	0.3175
359	A	A	-0.3723
360	T	A	-0.3178
361	V	A	0.0000
362	F	A	0.1248
363	G	A	0.0000
364	S	A	0.0000
365	Q	A	0.0000
366	S	A	0.0000
367	H	A	0.1611
368	H	A	0.0000
369	E	A	0.0000
370	V	A	0.9502
371	T	A	0.4837
372	M	A	0.0000
373	S	A	0.0307
374	Y	A	0.0000
375	P	A	0.0000
376	M	A	0.0000
377	R	A	0.0000
378	S	A	0.0000
379	V	A	0.0000
380	Q	A	0.0000
381	H	A	-1.0636
382	R	A	-1.8175
383	H	A	-1.3196
384	F	A	-0.6327
385	R	A	0.0000
386	L	A	0.0000
387	V	A	0.0000
388	H	A	0.0000
389	N	A	0.0000
390	L	A	0.0000
391	N	A	-0.6110
392	F	A	-0.3731
393	K	A	-1.2742
394	M	A	-0.2900
395	P	A	-0.2926
396	F	A	0.0000
397	P	A	0.0465
398	I	A	0.2192
399	D	A	0.0000
400	Q	A	-0.4922
401	D	A	-0.3525
402	F	A	0.0000
403	Y	A	0.9327
404	V	A	1.1691
405	S	A	0.0000
406	P	A	0.1274
407	T	A	0.0000
408	F	A	0.0000
409	Q	A	-0.3793
410	D	A	-0.8368
411	L	A	0.0000
412	L	A	-0.8496
413	N	A	-1.7947
414	R	A	-1.7251
415	T	A	-1.5883
416	T	A	-0.9075
417	A	A	-1.0470
418	G	A	-1.3608
419	Q	A	-1.9171
420	P	A	-1.3153
421	T	A	-1.4605
422	G	A	-1.2872
423	W	A	0.0000
424	Y	A	-0.3960
425	K	A	-1.4927
426	D	A	-2.5271
427	L	A	0.0000
428	R	A	-2.5481
429	H	A	-2.0207
430	Y	A	0.0000
431	Y	A	-0.5817
432	Y	A	-0.1286
433	R	A	0.0000
434	A	A	-0.1867
435	R	A	0.0000
436	W	A	0.0000
437	E	A	0.0000
438	L	A	0.0000
439	Y	A	0.0000
440	D	A	0.0000
441	R	A	-1.4880
442	S	A	-1.5350
443	R	A	-2.2706
444	D	A	0.0000
445	P	A	-1.1913
446	H	A	-1.0134
447	E	A	0.0000
448	T	A	-0.9731
449	Q	A	-1.7315
450	N	A	-0.9989
451	L	A	-0.6788
452	A	A	-0.6000
453	T	A	-0.5982
454	D	A	-0.9279
455	P	A	-1.3022
456	R	A	-2.0501
457	F	A	-1.1929
458	A	A	-1.3409
459	Q	A	-1.8941
460	L	A	-1.1457
461	L	A	-1.4609
462	E	A	-2.7208
463	M	A	-1.6595
464	L	A	0.0000
465	R	A	-2.8938
466	D	A	-3.3168
467	Q	A	-2.4859
468	L	A	0.0000
469	A	A	-2.0337
470	K	A	-2.8569
471	W	A	0.0000
472	Q	A	0.0000
473	W	A	-1.1421
474	E	A	-2.4749
475	T	A	0.0000
476	H	A	-0.9328
477	D	A	0.0000
478	P	A	0.0982
479	W	A	0.3670
480	V	A	0.2366
481	C	A	0.0000
482	A	A	0.2810
483	P	A	-0.3086
484	D	A	-1.1609
485	G	A	-0.1970
486	V	A	0.4583
487	L	A	-0.5818
488	E	A	-2.3228
489	E	A	-3.1368
490	K	A	-2.8312
491	L	A	-1.4655
492	S	A	-1.1711
493	P	A	-1.1793
494	Q	A	-1.7637
495	C	A	-0.4124
496	Q	A	-0.4740
497	P	A	-0.2560
498	L	A	-0.1944
499	H	A	-2.0338
500	N	A	-2.5984
501	E	A	-2.9276
502	L	A	-2.1296
503	R	A	-2.6043
504	S	A	-1.5416