Project name: fcdc2d2a6fae94d

Chain sequence(s)	A: SPEFMVKAKSWTLKKHFQGKPTQSDFELKTVELPPLKNGEVLLEALFLSVDPYMRIASKRLKEGAVMMGQQVARVVESKNSAFPAGSIVLAQSGWTTHFISDGKGLEKLLTEWPDKLPLSLALGTIGMPGLTAYFGLLEVCGVKGGETVLVSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKIAYLKQIGFDAAFNYKTVNSLEEALKKASPDGYDCYFDNVGGEFLNTVLSQMKDFGKIAICGAISVYNRMDQLPPGPSPESIIYKQLRIEGFIVYRWQGDVREKALRDLMKWVLEGKIQYHEHVTKGFENMPAAFIEMLNGANLGKAVVTA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5791
• Maximal score value: 1.5408
• Average score: -0.7878
• Total score value: -262.3494

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
-4	S	A	-0.5821
-3	P	A	-0.7806
-2	E	A	-0.7935
-1	F	A	1.3721
1	M	A	0.9493
2	V	A	-0.0003
3	K	A	-1.3342
4	A	A	0.0000
5	K	A	-1.2763
6	S	A	0.0000
7	W	A	-0.5165
8	T	A	0.0000
9	L	A	0.0000
10	K	A	-2.3911
11	K	A	-2.2890
12	H	A	-2.1165
13	F	A	0.0000
14	Q	A	-2.0629
15	G	A	-1.8715
16	K	A	-2.2502
17	P	A	0.0000
18	T	A	-1.3038
19	Q	A	-1.7150
20	S	A	-1.3802
21	D	A	0.0000
22	F	A	0.0000
23	E	A	-1.4638
24	L	A	-0.7870
25	K	A	-0.4801
26	T	A	-0.5477
27	V	A	0.0617
28	E	A	-1.3538
29	L	A	-0.2798
30	P	A	-0.5845
31	P	A	-0.9313
32	L	A	-1.7750
33	K	A	-2.8318
34	N	A	-2.8354
35	G	A	-2.1616
36	E	A	-2.4282
37	V	A	0.0000
38	L	A	0.0000
39	L	A	0.0000
40	E	A	-0.6791
41	A	A	0.0000
42	L	A	0.0773
43	F	A	0.2645
44	L	A	0.0000
45	S	A	0.0000
46	V	A	0.0000
47	D	A	0.0000
48	P	A	0.4183
49	Y	A	0.6932
50	M	A	0.0000
51	R	A	0.0000
52	I	A	0.1269
53	A	A	-0.5727
54	S	A	0.0000
55	K	A	-2.7809
56	R	A	-2.9850
57	L	A	-2.1826
58	K	A	-2.9994
59	E	A	-2.7851
60	G	A	-1.7007
61	A	A	-0.7169
62	V	A	0.2624
63	M	A	0.0000
64	M	A	0.1586
65	G	A	0.0000
66	Q	A	-0.5595
67	Q	A	0.0000
68	V	A	0.0000
69	A	A	0.0000
70	R	A	-1.0344
71	V	A	0.0000
72	V	A	0.0249
73	E	A	-1.3538
74	S	A	-1.6993
75	K	A	-2.6749
76	N	A	-1.8607
77	S	A	-0.6716
78	A	A	-0.4851
79	F	A	-1.0805
80	P	A	-0.6825
81	A	A	-0.6052
82	G	A	-0.4289
83	S	A	-0.5594
84	I	A	-0.5788
85	V	A	0.0000
86	L	A	-1.0160
87	A	A	0.0000
88	Q	A	-1.4583
89	S	A	-0.2971
90	G	A	0.0000
91	W	A	0.0000
92	T	A	0.0000
93	T	A	-0.7097
94	H	A	-0.0998
95	F	A	0.6441
96	I	A	0.0202
97	S	A	0.0000
98	D	A	-2.2493
99	G	A	-1.7325
100	K	A	-2.4416
101	G	A	-2.1412
102	L	A	-1.9620
103	E	A	-2.5240
104	K	A	-2.1683
105	L	A	-1.0001
106	L	A	-0.9635
107	T	A	-1.1101
108	E	A	-1.9430
109	W	A	-1.3280
110	P	A	-1.7424
111	D	A	-2.7988
112	K	A	-2.4607
113	L	A	0.0000
114	P	A	-0.7574
115	L	A	-0.0669
116	S	A	0.0000
117	L	A	0.0000
118	A	A	0.0000
119	L	A	0.0000
120	G	A	0.0000
121	T	A	0.0000
122	I	A	0.0000
123	G	A	0.0000
124	M	A	0.4096
125	P	A	0.0000
126	G	A	0.0000
127	L	A	0.0000
128	T	A	0.0000
129	A	A	0.0000
130	Y	A	0.0000
131	F	A	0.0000
132	G	A	0.0000
133	L	A	0.0000
134	L	A	-1.1425
135	E	A	-1.7764
136	V	A	0.0000
137	C	A	-0.9791
138	G	A	-1.3165
139	V	A	0.0000
140	K	A	-2.2385
141	G	A	-1.9423
142	G	A	-1.5981
143	E	A	-1.3961
144	T	A	-1.2581
145	V	A	0.0000
146	L	A	0.0000
147	V	A	0.0000
148	S	A	0.0000
149	A	A	0.1434
150	A	A	0.0000
151	A	A	0.0000
152	G	A	-0.1890
153	A	A	-0.0186
154	V	A	0.2524
155	G	A	0.0000
156	S	A	0.0000
157	V	A	0.0000
158	V	A	0.0000
159	G	A	0.0000
160	Q	A	0.0000
161	I	A	0.0000
162	A	A	0.0000
163	K	A	-1.4798
164	L	A	-0.8636
165	K	A	-1.6459
166	G	A	-1.6373
167	C	A	0.0000
168	K	A	-1.5788
169	V	A	0.0000
170	V	A	0.0000
171	G	A	0.0000
172	A	A	0.0000
173	A	A	0.0000
174	G	A	-1.1628
175	S	A	-1.7323
176	D	A	-2.7509
177	E	A	-2.6340
178	K	A	-1.7590
179	I	A	-1.5122
180	A	A	-1.7582
181	Y	A	-1.5665
182	L	A	0.0000
183	K	A	-2.5668
184	Q	A	-2.2024
185	I	A	-1.5722
186	G	A	-1.8891
187	F	A	0.0000
188	D	A	-2.5386
189	A	A	-1.4552
190	A	A	-0.6721
191	F	A	-0.1649
192	N	A	-0.7437
193	Y	A	-0.1863
194	K	A	-1.5847
195	T	A	-0.9733
196	V	A	-0.8008
197	N	A	-1.6624
198	S	A	-1.5630
199	L	A	-1.6313
200	E	A	-3.0265
201	E	A	-3.5791
202	A	A	-2.2263
203	L	A	0.0000
204	K	A	-3.3389
205	K	A	-3.1661
206	A	A	-2.1269
207	S	A	0.0000
208	P	A	-2.1997
209	D	A	-2.5011
210	G	A	-2.0664
211	Y	A	0.0000
212	D	A	-1.0097
213	C	A	0.0000
214	Y	A	0.0000
215	F	A	0.0000
216	D	A	0.0000
217	N	A	0.2534
218	V	A	0.2519
219	G	A	0.0000
220	G	A	-0.3845
221	E	A	-1.1460
222	F	A	-0.4488
223	L	A	-0.3247
224	N	A	-0.8437
225	T	A	-0.7934
226	V	A	0.0000
227	L	A	0.0000
228	S	A	-1.0061
229	Q	A	-1.7728
230	M	A	0.0000
231	K	A	-1.8935
232	D	A	-1.5249
233	F	A	0.3555
234	G	A	0.0000
235	K	A	0.0000
236	I	A	0.0000
237	A	A	0.0000
238	I	A	0.4280
239	C	A	0.4719
240	G	A	0.4628
241	A	A	0.4985
242	I	A	0.4929
243	S	A	0.0739
244	V	A	0.0000
245	Y	A	-0.0627
246	N	A	-1.5417
247	R	A	-1.5859
248	M	A	-0.5277
249	D	A	-1.9353
250	Q	A	-1.4664
251	L	A	0.1344
252	P	A	-0.3483
253	P	A	-0.5950
254	G	A	-0.7171
255	P	A	-0.9377
256	S	A	-0.7210
257	P	A	-0.3608
258	E	A	-1.0660
259	S	A	-0.4990
260	I	A	0.4515
261	I	A	1.3490
262	Y	A	1.1561
263	K	A	-0.5999
264	Q	A	-0.5520
265	L	A	0.0000
266	R	A	-1.3481
267	I	A	-0.2242
268	E	A	-1.0855
269	G	A	-0.2051
270	F	A	0.0000
271	I	A	1.5408
272	V	A	0.0000
273	Y	A	0.4533
274	R	A	-1.1145
275	W	A	-1.1681
276	Q	A	-2.3234
277	G	A	-2.3384
278	D	A	-2.9299
279	V	A	-1.8261
280	R	A	-2.3555
281	E	A	-2.9643
282	K	A	-2.9073
283	A	A	0.0000
284	L	A	-1.4280
285	R	A	-1.7869
286	D	A	-1.6461
287	L	A	0.0000
288	M	A	0.0000
289	K	A	-2.3519
290	W	A	-1.9635
291	V	A	0.0000
292	L	A	-1.3918
293	E	A	-2.5986
294	G	A	-2.0820
295	K	A	-2.5326
296	I	A	0.0000
297	Q	A	-1.6311
298	Y	A	-0.7792
299	H	A	-1.0433
300	E	A	-0.5522
301	H	A	-0.2757
302	V	A	0.4424
303	T	A	-0.6655
304	K	A	-1.7991
305	G	A	-1.4969
306	F	A	0.0000
307	E	A	-2.3778
308	N	A	-2.0362
309	M	A	0.0000
310	P	A	0.0000
311	A	A	-1.0290
312	A	A	0.0000
313	F	A	0.0000
314	I	A	-1.2432
315	E	A	-1.8239
316	M	A	0.0000
317	L	A	-1.1331
318	N	A	-2.0150
319	G	A	-1.1671
320	A	A	-0.9014
321	N	A	-0.6115
322	L	A	-0.2603
323	G	A	0.0000
324	K	A	0.0000
325	A	A	0.0000
326	V	A	0.0000
327	V	A	0.0000
328	T	A	-0.2166
329	A	A	-0.6044